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  4. c-MPL/Thrombopoietin R Protein, Canine (HEK293, His)

c-MPL/Thrombopoietin R Protein, Canine (HEK293, His)

Cat. No.: HY-P703708
Handling Instructions Technical Support

c-MPL/Thrombopoietin R Protein, Canine (HEK293, His) is the recombinant canine-derived c-MPL/Thrombopoietin R protein, expressed by HEK293, with C-His tag.

For research use only. We do not sell to patients.

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Description

c-MPL/Thrombopoietin R Protein, Canine (HEK293, His) is the recombinant canine-derived c-MPL/Thrombopoietin R protein, expressed by HEK293, with C-His tag.
Background

c-MPL/Thrombopoietin R is a receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, it induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1, and PI3K. These signaling cascades promote megakaryocyte proliferation, survival, and differentiation, ultimately enhancing platelet production.
Species

Canine
Source

HEK293
Tag

C-8*His
Accession

XP_038543911 (Q22-W489)
Protein Length

Partial
Predicted Molecular Mass
54.5 kDa
Molecular Weight

Approximately 65-75 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

c-MPL/Thrombopoietin R Protein, Canine (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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