2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. l-Naproxen

l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID).

For research use only. We do not sell to patients.

l-Naproxen Chemical Structure

l-Naproxen Chemical Structure

CAS No. : 23979-41-1

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10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

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Description

l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID)[1][2][3].

In Vitro

l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in HeLa cells[3].
l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3].
l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

l-Naproxen Related Antibodies

Cell Viability Assay[3]

Cell Line: HeLa cells
Concentration: 30-1000 μM
Incubation Time: 2 hour
Result: Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50 values of 212 μM and 96 μM, respectively.

Cell Migration Assay [3]

Cell Line: OvCa429 and OvCa433 cells
Concentration: 0-300 μM
Incubation Time: 48 hour
Result: Inhibited migration of immortalized human ovarian cancer cells at 300 μM.

Western Blot Analysis[3]

Cell Line: OvCa433 cells
Concentration: 300 μM
Incubation Time: 48 hour
Result: Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls.
Molecular Weight

230.26

Formula

C14H14O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C2C(C=CC([C@H](C(O)=O)C)=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.63%

SDS (392 KB)

COA (246 KB)

Handling Instructions (2659 KB)
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l-Naproxen Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

l-Naproxen23979-41-1(R)-NaproxenRasanti-tumor activityHeLaOvCa429OvCa433Inhibitorinhibitorinhibit

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