Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)

Cat. No.: HY-P990791: Data Sheet
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Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71⁺ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft.

For research use only. We do not sell to patients.

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) Chemical Structure

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Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD71/TfR1

In Vitro

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (10 μg/mL, 18-72 h) reduces transferrin receptor 1 expression and inhibits transferrin uptake in Group 2 innate lymphoid cells (ILC2s)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (150 μg, i.p., daily for 2 days) depletes CD71⁺ erythroid splenocytes and enhances bacterial clearance in endotoxemia neonatal mice models^[1].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (0.5 or 1.0 mg/mouse, i.v., at day 21 after tumor cell inoculation) inhibits anti-virus responses in P14 CD8⁺ T cells transferred lymphocytic choriomeningitis virus (LCMV)-infected mice bearing lewis lung cancer tumor^[2].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (100 μg, i.p., before each intranasal challenge) reduces lung ILC2s accumulation in Group 2 innate lymphoid cells (ILC2s)-dependent airway inflammation mice^[3].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (100 μg, i.v., daily from day 0 to 3) prolongs graft survival in Cardiac allograft mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cardiac allograft mice models^[1]
Dosage:	100 μg
Administration:	Intravenously injection, at day 0 and 1
Result:	Prolonged graft survival. Increased the CTL response to donor-specific alloantigen. Suppressed the MLR to donor-specific alloantigen. Reduced B7-expressing cells. Inhibited activation of allo-reactive T cells and migration of T cells into the allograft site. Suppressed the IL-15 mRNA and increased the Th2 cytokine IL-4 mRNA expression.

Gene ID

22042 [NCBI]

Accession

Q62351

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Wynn JL, et al. Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality. J Immunol. 2015 Aug 1;195(3):1064-70. [Content Brief]

[2]. Zhao L, et al. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nat Med. 2018 Oct;24(10):1536-1544. [Content Brief]

[3]. Hurrell BP, et al. Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function. Sci Transl Med. 2024 May 8;16(746):eadk4728. [Content Brief]

[4]. Bayer AL, et al. Differential effects of transferrin receptor blockade on the cellular mechanisms involved in graft rejection. Transpl Immunol. 1999 Sep;7(3):131-9. [Content Brief]

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)Transferrin ReceptorTfRCD71TransferrinTransferrin receptorLung cancerLCMVILC2sGraftInhibitorinhibitorinhibit

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