Tolvaptan phosphate ester sodium

Cat. No.: HY-157220 Purity: 99.85%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation.

For research use only. We do not sell to patients.

Tolvaptan phosphate ester sodium Chemical Structure

CAS No. : 942619-79-6

Size	Stock	Quantity
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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V1a Receptor V1b Receptor V2 Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

572.88

Formula

C₂₆H₂₄ClN₂Na₂O₆P

CAS No.

942619-79-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)C=CC=C1)NC2=CC=C(C(C)=C2)C(N3C4=CC=C(C=C4C(CCC3)OP(O[Na])(O[Na])=O)Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (87.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 4.17 mg/mL (7.28 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7456 mL	8.7278 mL	17.4557 mL
5 mM	0.3491 mL	1.7456 mL	3.4911 mL
10 mM	0.1746 mL	0.8728 mL	1.7456 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

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Data Sheet (281 KB) SDS (252 KB)

COA (263 KB) HNMR (307 KB) CNMR (292 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150(3):163-172. [Content Brief]

[2]. Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.7456 mL	8.7278 mL	17.4557 mL	43.6392 mL
H₂O / DMSO	5 mM	0.3491 mL	1.7456 mL	3.4911 mL	8.7278 mL
DMSO	10 mM	0.1746 mL	0.8728 mL	1.7456 mL	4.3639 mL
	15 mM	0.1164 mL	0.5819 mL	1.1637 mL	2.9093 mL
	20 mM	0.0873 mL	0.4364 mL	0.8728 mL	2.1820 mL
	25 mM	0.0698 mL	0.3491 mL	0.6982 mL	1.7456 mL
	30 mM	0.0582 mL	0.2909 mL	0.5819 mL	1.4546 mL
	40 mM	0.0436 mL	0.2182 mL	0.4364 mL	1.0910 mL
	50 mM	0.0349 mL	0.1746 mL	0.3491 mL	0.8728 mL
	60 mM	0.0291 mL	0.1455 mL	0.2909 mL	0.7273 mL
	80 mM	0.0218 mL	0.1091 mL	0.2182 mL	0.5455 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.