2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation
  3. VD/VDR Interleukin Related
  4. Tacalcitol monohydrate

Tacalcitol monohydrate  (Synonyms: 1,24(R)-Dihydroxyvitamin D3 monohydrate)

Cat. No.: HY-32338 Purity: 99.85%
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Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 monohydrate) can promote normal bone growth by regulating calcium ions. Tacalcitol monohydrate inhibits cancer cell proliferation and migration. Tacalcitol monohydrate can be used in the research of inflammation, cancer, and skin diseases.

For research use only. We do not sell to patients.

Tacalcitol monohydrate

Tacalcitol monohydrate Chemical Structure

CAS No. : 93129-94-3

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Based on 3 publication(s) in Google Scholar

Other Forms of Tacalcitol monohydrate:

Tacalcitol monohydrate Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 monohydrate) can promote normal bone growth by regulating calcium ions. Tacalcitol monohydrate inhibits cancer cell proliferation and migration. Tacalcitol monohydrate can be used in the research of inflammation, cancer, and skin diseases[1][2][3][4][5].

In Vitro

Tacalcitol (0.1-100 μM, 24 h) monohydrate inhibits synthesis of both IL-6 and IL-8 in cultures derived from nasal polyps in dose-dependent manner[1].
Tacalcitol (10-4-1 μM, 48 h or one week) monohydrate induces cell differentiation in normal human keratinocytes. Tacalcitol inhibits the growth of normal and psoriatic human keratinocytes[2][3].
Tacalcitol (0-1 μM, 48 h) monohydrate inhibits DNA synthesis in normal human keratinocytes[3].
Tacalcitol (0.001-10 μM, 6 days) monohydrate strongly reduces proliferation of human glioblastoma[4].
Tacalcitol (10 μM, 41 h) monohydrate inhibits human glioblastoma migration[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tacalcitol monohydrate Related Antibodies

Cell Proliferation Assay[3]

Cell Line: normal human keratinocytes
Concentration: 10-10, 10-9, 10-8, 10-7, 10-6 M
Incubation Time: one week
Result: Significantly inhibited the growth of human keratinocytes at concentrations higher than 10-8 M.
The growth of keratinocytes was 65% inhibited by 10-8 M and 90% inhibited by 10-7 M

Cell Viability Assay[4]

Cell Line: T98G cells
Concentration: 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 6 days
Result: Treatment for 6 days resulted in a significant, dose-dependent inhibitory effect on cell viability/growth.
Treatment of cells for less than 6 days did not influence cell viability/growth.

Cell Migration Assay [4]

Cell Line: T98G cells
Concentration: 10 μM
Incubation Time: 41 h (pre-treated for 24 h, then cells were scraped and monitore for 17 h)
Result: Reduced the migration rate.
After 17 hr, the wound closure of control cells was about 60%, while treated cells had a wound closure of about 35-45%.
In Vivo

Tacalcitol (0.2-20 μg/g; applied to the cutaneous inflammation area) monohydrate ointment has a marked effect on cutaneous inflammation caused by TPA, and improves effect on epidermal differentiation in hairless mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SKH1 (hr/hr) hairless mice (7-8 weeks old, Phorbol 12-myristate 13-acetate (HY-18739) (12-Otetradecanoylphorbol 13-acetate (TPA)) was topically applied to 6 cm2 area of the dorsal skin to induce cutaneous inflammation)[5]
Dosage: 0.2, 2, 20 μg/g
Administration: Applied to the cutaneous inflammation area
Result: Significantly inhibited TPA-induced cutaneous inflammation, histopathologically.
The effect of 20 μg/g on cutaneous inflammation was much stronger than that of 2 μg/g.
20 μg/g also significantly inhibited TPA-induced myeloperoxidase (MPO) activity.
The effect on epidermal proliferation was significant at the doses of 2 μg/g and 20 μg/g, and that on epidermal differentiation was significant at the doses of 0.2 μg/g or more.
Clinical Trial
Molecular Weight

434.65

Formula

C27H46O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC([C@@H](CC[C@H]([C@@H](CC[C@]1/2[H])[C@@]1(C)CCCC2=C/C=C3C[C@@H](C[C@H](C/3=C)O)O)C)O)C.[H]O[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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Tacalcitol monohydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tacalcitol93129-94-31,24(R)-Dihydroxyvitamin D3VD/VDRInterleukin RelatedVitamin DVitamin D receptorILInhibitorinhibitorinhibit

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