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  5. IL-1RAcP/IL-1 R3 Protein, Cynomolgus (HEK293, His)

IL-1RAcP/IL-1 R3 Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P703751
Handling Instructions Technical Support

IL-1RAcP/IL-1 R3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-1R3/IL-1 RAcP protein, expressed by HEK293, with C-His tag.

For research use only. We do not sell to patients.

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Description

IL-1RAcP/IL-1 R3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-1R3/IL-1 RAcP protein, expressed by HEK293, with C-His tag.
Background

IL-1R3/IL-1 RAcP associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B. This complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Additionally, IL-1R3/IL-1 RAcP enhances the ability of secreted IL1R1 to inhibit IL-33 signaling.
Species

Cynomolgus
Source

HEK293
Tag

C-8*His
Accession

G7NYP7 (S21-C362)
Protein Length

Partial
Synonyms
IL1RAP
Predicted Molecular Mass
40.5 kDa
Molecular Weight

Approximately 55-70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

IL-1RAcP/IL-1 R3 Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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