1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Epithelial cell CD Proteins
  4. LIF-R/CD118
  5. LIFR Protein, Human (HEK293, His)

LIFR Protein, Human (HEK293, His)

Cat. No.: HY-P77059
COA Handling Instructions

LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, His) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
10 μg $93 In-stock
50 μg $260 In-stock
100 μg $400 In-stock
> 100 μg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, His) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-His labeled tag.

Background

LIFR protein acts as a signal-transducing molecule that may share a common pathway with IL6ST. Its soluble form functions as an inhibitor by blocking the binding of LIF to receptors on target cells, thereby suppressing its biological activity. LIFR forms a heterodimer with IL6ST, and this heterodimer interacts with the complex formed by CNTF and CNTFR, suggesting potential crosstalk and collaborative actions in cellular processes.

Biological Activity

Immobilized LIF Protein, Human, Recombinant (hFc Tag) at 2 μg/mL (100 μL/well) can bind LIFR Protein, Human, Recombinant (His Tag), the EC50 is ≤360 ng/mL.

Species

Human

Source

HEK293

Tag

C-His

Accession

P42702-1/NP_001121143.1 (M45-S833)

Gene ID
Molecular Construction
N-term
LIFR (M45-S833)
Accession # P42702-1/NP_001121143.1
His
C-term
Synonyms
Leukemia inhibitory factor receptor; LIF-R; CD118
Molecular Weight

125-135 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Appearance

Solution

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

LIFR Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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LIFR Protein, Human (HEK293, His)
Cat. No.:
HY-P77059
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