2. Immunology/Inflammation
  3. Complement System
  4. Anti-GC1q R/C1QBP Antibody (60.11)

Anti-GC1q R/C1QBP Antibody (60.11) 

Cat. No.: HY-P990844
Technical Support

Anti-GC1q R/C1QBP Antibody (60.11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human GC1q R/C1QBP. Anti-GC1q R/C1QBP Antibody (60.11) can neutralize GC1q R. Anti-GC1q R/C1QBP Antibody (60.11) can be used for the researches of cancer, infection and inflammation, such as MDA231 tumor and S. aureus induced infective endocarditis (IE).

For research use only. We do not sell to patients.

Anti-GC1q R/C1QBP Antibody (60.11)

Anti-GC1q R/C1QBP Antibody (60.11) Chemical Structure

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Anti-GC1q R/C1QBP Antibody (60.11) Related Antibodies

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Description

Anti-GC1q R/C1QBP Antibody (60.11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human GC1q R/C1QBP. Anti-GC1q R/C1QBP Antibody (60.11) can neutralize GC1q R. Anti-GC1q R/C1QBP Antibody (60.11) can be used for the researches of cancer, infection and inflammation, such as MDA231 tumor and S. aureus induced infective endocarditis (IE)[1][2].

Isotype

Mouse IgG1 kappa
Species Reactivity

Human
IC50 & Target

GC1q R/C1QBP
In Vitro

Anti-GC1q R/C1QBP Antibody (60.11) (10 μg/mL) inhibits gC1qR-mediated S. aureus interactions with fibrinogen[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-GC1q R/C1QBP Antibody (60.11) Related Antibodies
In Vivo

Anti-GC1q R/C1QBP Antibody (60.11) (100 mg/kg, i.p., twice a week from 3 or 13 days after MDA231 cell implantation) inhibits tumor growth in MDA231 breast cancer mice (athymic nu/nu mice)[1].
Anti-GC1q R/C1QBP Antibody (60.11) (100 or 200 mg/kg, i.p., a single dose) exerts anti-infection effects in S. aureus strain RN6390 induced infective endocarditis (IE) rat[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA231 breast cancer mice models(5-6 week, female, athymic nu/nu mice)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneally injection, twice a week from 3 days after MDA231 cell implantation
Result: Reduced MDA231 tumor volume.
Increased early and late apoptosis markers, cleaved caspase 3 and TUNEL.
Reduced CD31-positive structures.
Animal Model: S. aureus strain RN6390 induced infective endocarditis (IE) rat[2]
Dosage: 100 or 200 mg/kg
Administration: Intraperitoneally injection, a single dose
Result: Reduced S. aureus densities in aortic valve vegetations, kidneys, and spleens.
Gene ID

12261  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-GC1q R/C1QBP Antibody (60.11)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-GC1q R/C1QBP Antibody (60.11) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-GC1q R/C1QBP Antibody (60.11)Complement SystemGC1q RC1QBPMDA231S. aureusInfective endocarditisInhibitorinhibitorinhibit

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Anti-GC1q R/C1QBP Antibody (60.11)
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