2. PI3K/Akt/mTOR
  3. Akt
  4. (R)-Capivasertib

(R)-Capivasertib  (Synonyms: (R)-AZD5363)

Cat. No.: HY-15431A Purity: 99.56% ee.: 99.52%
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(R)-Capivasertib ((R)-AZD5363) is the R-enantiomer of Capivasertib (HY-15431).

For research use only. We do not sell to patients.

(R)-Capivasertib

(R)-Capivasertib Chemical Structure

CAS No. : 1143532-51-7

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Capivasertib:

(R)-Capivasertib Related Antibodies

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Description

(R)-Capivasertib ((R)-AZD5363) is the R-enantiomer of Capivasertib (HY-15431)[1].

Molecular Weight

428.92

Formula

C21H25ClN6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@@H](C4=CC=C(Cl)C=C4)CCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (233.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3314 mL 11.6572 mL 23.3144 mL
5 mM 0.4663 mL 2.3314 mL 4.6629 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3314 mL 11.6572 mL 23.3144 mL 58.2859 mL
5 mM 0.4663 mL 2.3314 mL 4.6629 mL 11.6572 mL
10 mM 0.2331 mL 1.1657 mL 2.3314 mL 5.8286 mL
15 mM 0.1554 mL 0.7771 mL 1.5543 mL 3.8857 mL
20 mM 0.1166 mL 0.5829 mL 1.1657 mL 2.9143 mL
25 mM 0.0933 mL 0.4663 mL 0.9326 mL 2.3314 mL
30 mM 0.0777 mL 0.3886 mL 0.7771 mL 1.9429 mL
40 mM 0.0583 mL 0.2914 mL 0.5829 mL 1.4571 mL
50 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
60 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.9714 mL
80 mM 0.0291 mL 0.1457 mL 0.2914 mL 0.7286 mL
100 mM 0.0233 mL 0.1166 mL 0.2331 mL 0.5829 mL
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(R)-Capivasertib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Capivasertib1143532-51-7(R)-AZD5363AktPKBProtein kinase BR-EnantiomerCapivasertibInhibitorinhibitorinhibit

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