Tetracosactide acetate  (Synonyms: Tetracosactrin acetate; ACTH(1–24) acetate)

Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis^[1][3].

Tetracosactide (11 nM, 3-60 h) promotes the protein synthesis in rats/mice adrenal slices, promotes the secretion of cortisol, 11-deoxycorticosterone, and aldosterone^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetracosactide acetate (0.5 mg/kg, iv, single dose) reduces malondialdehyde (MDA), xanthine oxidase (XO), myeloperoxidase (MPO), caspase-3 in tissue and serum, inproves the levels of catalase in rabbits spinal cord IR injury models, exhibits neuroprotective and antioxidant activities^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₁₃₆H₂₁₀N₄₀O₃₁S.xC₂H₄O₂

60189-34-6

Solid

White to off-white

SYSMEHFRWGKPVGKKRRPVKVYP

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Francesco Iuliano, et al. Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation. 2018 Nov 29;132(1).

  [2]. Kertmen H, et al., Comparative effects of methylprednisolone and tetracosactide (ACTH1-24) on ischemia/reperfusion injury of the rabbit spinal cord. Arch Med Sci. 2018 Oct;14(6):1459-1470.  [Content Brief]

  [3]. Haslach EM, et al., Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs). J Med Chem. 2014 Jun 12;57(11):4615-28.  [Content Brief]

  [4]. Lindhe O, et al., Irreversible binding and adrenocorticolytic activity of the DDT metabolite 3-methylsulfonyl-DDE examined in tissue-slice culture. Environ Health Perspect. 2001 Feb;109(2):105-10.  [Content Brief]