1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Reactive Oxygen Species (ROS)
  3. 1-Oleoyl-2-palmitoylglycerol

1-Oleoyl-2-palmitoylglycerol is a diacylglycerol in which an oleic acid and a palmitic acid are attached to sn-1 and sn-2 position. 1-Oleoyl-2-palmitoylglycerol enhances the inhibition of superoxide anion production induced by fMLF/cytochalasin B (CB) in human neutrophils. 1-Oleoyl-2-palmitoylglycerol can be used in research about lipid metabolism, membrane fluidity, or the distribution and function of lipids in cells.

For research use only. We do not sell to patients.

1-Oleoyl-2-palmitoylglycerol

1-Oleoyl-2-palmitoylglycerol Chemical Structure

CAS No. : 3331-34-8

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Description

1-Oleoyl-2-palmitoylglycerol is a diacylglycerol in which an oleic acid and a palmitic acid are attached to sn-1 and sn-2 position. 1-Oleoyl-2-palmitoylglycerol enhances the inhibition of superoxide anion production induced by fMLF/cytochalasin B (CB) in human neutrophils. 1-Oleoyl-2-palmitoylglycerol can be used in research about lipid metabolism, membrane fluidity, or the distribution and function of lipids in cells[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 8
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28445049]
HepG2 IC50
> 10 μM
Compound: 8
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28445049]
MDA-MB-231 IC50
> 10 μM
Compound: 8
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28445049]
Neutrophil IC50
> 10 μM
Compound: 8
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate preincubated for 5 mins followed by CB/fMLF stimulation
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate preincubated for 5 mins followed by CB/fMLF stimulation
[PMID: 28445049]
Molecular Weight

594.95

Formula

C37H70O5

CAS No.
SMILES

CCCCCCCCCCCCCCCC(OC(CO)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
1-Oleoyl-2-palmitoylglycerol
Cat. No.:
HY-W699318
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