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Results for "

<i>BRCA2</i>-null DLD1

" in MedChemExpress (MCE) Product Catalog:

3066

Inhibitors & Agonists

9

Screening Libraries

154

Fluorescent Dye

97

Biochemical Assay Reagents

286

Peptides

55

MCE Kits

46

Inhibitory Antibodies

484

Natural
Products

404

Recombinant Proteins

116

Isotope-Labeled Compounds

313

Antibodies

44

Click Chemistry

144

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124691
    D-I03
    3 Publications Verification

    		 DNA/RNA Synthesis Cancer
    D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 μM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 μM and 8 μM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin [1] [2].
    D-I03
  • HY-RS16825
    Brca2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Brca2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Brca2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Brca2 Mouse Pre-designed siRNA Set A
    Brca2 Mouse Pre-designed siRNA Set A
  • HY-RS23267
    Brca2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Brca2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Brca2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Brca2 Rat Pre-designed siRNA Set A
    Brca2 Rat Pre-designed siRNA Set A
  • HY-RS01594
    BRCA2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BRCA2 Human Pre-designed siRNA Set A contains three designed siRNAs for BRCA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BRCA2 Human Pre-designed siRNA Set A
    BRCA2 Human Pre-designed siRNA Set A
  • HY-177512
    MSC778

    		FLAP Cancer
    MSC778 is an effective and orally active flap endonuclease 1 (FEN1) inhibitor with an IC50 of 3 nM and a KD of 2.9 nM. MSC778 exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively kills BRCA2-deficient cells and potentiates the activity of Niraparib (HY-10619) to induce tumor stasis in a BRCA2 KO DLD-1 mouse xenograft. MSC778 can be used in the research of colorectal cancer [1].
    MSC778
  • HY-168993
    BRCA2-IN-2

    		Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    BRCA2-IN-2 (Compound 3i) has a strong binding affinity to the BRCA2 protein. BRCA2-IN-2 can inhibit the proliferation of breast cancer cells and scavenge DPPH free radicals. BRCA2-IN-2 has anti-tumor and antioxidant activities [1].
    BRCA2-IN-2
  • HY-173151
    BRCA2-IN-1

    		Reactive Oxygen Species (ROS) Cancer
    BRCA2-IN-1 (Compound 3j) is a potential BRCA2 inhibitor that exhibits antiproliferative activity against the breast cancer MCF-7 cell lines. BRCA2-IN-1 also demonstrates DPPH radical scavenging ability, with an IC50 of 12.36 µM [1].
    BRCA2-IN-1
  • HY-162104
    BRCA2-RAD51-IN-1

    		RAD51 Cancer
    BRCA2-RAD51-IN-1 (Compound 46) is a BRCA2-RAD51 inhibitor with an EC50 value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity [1].
    BRCA2-RAD51-IN-1
  • HY-173345
    BRCA2-RAD51-IN-2

    		RAD51 Cancer
    BRCA2-RAD51-IN-2 (compound S-35d) is a BRCA2-RAD51 inhibitor and inhibits homologous recombination repair in combination with 10 µM olaparib (HY-10162) [1].
    BRCA2-RAD51-IN-2
  • HY-163816
    Antiproliferative agent-53-d3

    		Cytochrome P450 Cancer
    Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC50 of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC50 of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC50 of 8.1 µM for BRCA2 -/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice [1].
    Antiproliferative agent-53-d3
  • HY-150958
    RAD51-IN-8

    		RAD51 Cancer
    RAD51-IN-8, a new RAD51 binder, is a RAD51-BRCA2 inhibitor that inhibits the RAD51 BRCA2 protein protein interaction. RAD51-IN-8 also is a protein−protein interaction (PPI) inhibitor. RAD51-IN-8 has inhibitory activity for H4A4 with an EC50 value of 19 μM [1].
    RAD51-IN-8
  • HY-161431
    RTx-152

    		DNA/RNA Synthesis Cancer
    RTx-152 traps Polθ on DNA and is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM). RTx-152 selectively kills HR-deficient cancer cells, and suppresses PARP inhibitor resistance in multiple genetic backgrounds, including homologous recombination (HR)-proficient cells. RTx-152 selectively kills BRCA2-null cells [1].
    RTx-152
  • HY-40041
    (R)-1-Boc-3-methyl-piperazine

    		Biochemical Assay Reagents Drug Intermediate Cancer
    (R)-1-Boc-3-methyl-piperazine (Compound I3-1) is an intermediate. (R)-1-Boc-3-methyl-piperazine can be used in the preparation of Compound I3. Compound I3 has anticancer effects against BRCA2 gene-deficient colorectal adenocarcinoma [1].
    (R)-1-Boc-3-methyl-piperazine
  • HY-P10951
    (R)-Zadavotide guraxetan

    (R)-PSMA I&T; (R)-PNT-2002

    		 PSMA Cancer
    Zadavotide guraxetan (PSMA I&T; PNT-2002) is a prostate-specific membrane antigen (PSMA) inhibitor. Zadavotide guraxetan has antitumor activity and can be used in prostate cancer-targeted research [1] [2].
    (R)-Zadavotide guraxetan
  • HY-N13886
    Anicequol

    		Endogenous Metabolite Cancer
    Anicequol, a microbial secondary metabolites, is an anchorage-independent growth of tumor cells inhibitor. Anicequol inhibits the anchorage-independent growth of human colon cancer DLD-1 cells with the IC50 of 1.2 μM [1].
    Anicequol
  • HY-150147
    CAM833
    1 Publications Verification

    		 RAD51 Apoptosis Cancer
    CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833 increases the progression of G2/M-arrested cells into apoptosis [1].
    CAM833
  • HY-170845
    MU1409

    		Endonuclease Cancer
    MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers [1].
    MU1409
  • HY-122312
    BAY-8002
    3 Publications Verification

    		 Monocarboxylate Transporter Cancer
    BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity [1].
    BAY-8002
  • HY-147986
    hCA I-IN-2

    		Carbonic Anhydrase Cancer
    hCA I-IN-2 (Compound 6d) is a selective human carbonic anhydrase I (hCA I) inhibitor with Ki values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively [1].
    hCA I-IN-2
  • HY-147985
    hCA I-IN-1

    		Carbonic Anhydrase Cancer
    hCA I-IN-1 (Compound 6q) is a human carbonic anhydrase I (hCA I) inhibitor with Ki values of 38.3, 716.4, 940.1 and 192.8 nM against hCA I, hCA II, hCAIX and hCAXII, respectively [1].
    hCA I-IN-1
  • HY-N7305
    Jatrophane 5

    		P-glycoprotein Cancer
    Jatrophane 5 is a natural product of Jatropha carcas L. Jatrophane 5 has powerful inhibition of P-gp, higher than R(+)-verapamil (HY-14275) and Tariquidar (HY-10550) in colorectal multi-drug resistant cells (DLD1-TxR) [1].
    Jatrophane 5
  • HY-162091
    Topoisomerase I inhibitor 13

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 13 (Compound G11) is a Topo I inhibitor that inhibits cancer cell proliferation. Topoisomerase I inhibitor 13 significantly inhibits tumor growth in vivo [1].
    Topoisomerase I inhibitor 13
  • HY-156969
    Topoisomerase I inhibitor 11

    		Topoisomerase Btk Cancer
    Topoisomerase I inhibitor 11 is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 11 can bind to BTK [1].
    Topoisomerase I inhibitor 11
  • HY-148183
    Homologous recombination-IN-1

    		RAD51 Cancer
    Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination [1].
    Homologous recombination-IN-1
  • HY-168733
    LDHA-IN-9

    		Lactate Dehydrogenase Apoptosis Cancer
    LDHA-IN-9 (Compound 1g) is an inhibitor for LDH-A with an IC50 of 25 nM. LDHA-IN-9 inhibits the proliferation of DLD-1 cell (GI50 of 27 μM) through apoptosis induction. LDHA-IN-9 exhibits antitumor activity in mouse model without significant toxicity (25 mg/kg) [1].
    LDHA-IN-9
  • HY-N12370
    Tenaxin I

    		Others Others
    Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity [1].
    Tenaxin I
  • HY-146437
    Topoisomerase I inhibitor 6

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases [1].
    Topoisomerase I inhibitor 6
  • HY-P1032F
    Biotinyl-Angiotensin I (human, mouse, rat)

    		Endogenous Metabolite Endocrinology
    Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE) [1].
    Biotinyl-Angiotensin I (human, mouse, rat)
  • HY-161654
    PROTAC SOS1 degrader-10

    		SOS1 PROTACs Ras Cancer
    PROTAC SOS1 degrader-10 (Compound 11o) is a degrader for son of sevenless 1 (SOS1) in a CRBN and proteasome dependent manner. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS mutant cancer cells SW620, A549 and DLD-1, with DC50s of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits the proliferations of cells SW620, A549 and DLD-1, with IC50s of 36.7, 52.2 and 107 nM, respectively. PROTAC SOS1 degrader-10 inhibits phosphorylation of ERK. (Pink: SOS1 ligand (HY-161655); Black: linker (HY-161656); Blue: E3 ligase ligand (HY-W249500)) [1]
    PROTAC SOS1 degrader-10
  • HY-121619
    Jacaric acid

    		Apoptosis Inflammation/Immunology Cancer
    Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis [1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma [2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator . Jacaric acid is orally active.
    Jacaric acid
  • HY-149002
    Topoisomerase I/II inhibitor 4

    		Topoisomerase Apoptosis Cancer
    Topoisomerase I/II inhibitor 4 (compound F16) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 4 inhibits cell proliferation, invasion and migration and induces apoptosis. Topoisomerase I/II inhibitor 4 can be used for liver cancer research [1].
    Topoisomerase I/II inhibitor 4
  • HY-P10516
    BRC4 peptide

    		DNA/RNA Synthesis RAD51 Cancer
    BRC4 peptide is a specific peptide in BRCA2 protein that interacts with RAD51 protein to help repair broken DNA chains. BRC4 peptide can be used to study DNA repair mechanisms and cancer occurrence [1].
    BRC4 peptide
  • HY-P3006
    Des-Leu10-angiotensin I

    		Drug Metabolite Cardiovascular Disease
    Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell [1].
    Des-Leu10-angiotensin I
  • HY-P99135
    Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3)

    		MHC Inflammation/Immunology
    Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) is a mouse-derived IgG2b antibody inhibitor, targeting to mouse MHC Class I (H-2Kb). Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) reacts with the mouse H-2Kb, H-2Kk, H-2Kq, H-2Kr, H-2ks MHC class I alloantigens and not H-2Kd. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can block MHC Class I. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can be used for immunology research [1].
    Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3)
  • HY-146497
    Topoisomerase I inhibitor 7

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones [1].
    Topoisomerase I inhibitor 7
  • HY-120667
    DS-5272

    		MDM-2/p53 Apoptosis Cancer
    DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice [1].
    DS-5272
  • HY-150685
    Topo I/COX-2-IN-1

    		Topoisomerase Prostaglandin Receptor Apoptosis Inflammation/Immunology Cancer
    Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC50 value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity [1].
    Topo I/COX-2-IN-1
  • HY-P990195
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8)

    		MHC Others
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) reacts with the mouse H-2 MHC class I alloantigen (all haplotypes). Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) can be used for the flow cytometry and immunofluorescence experiments [1].
    Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8)
  • HY-P990192
    Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3)

    		MHC Inflammation/Immunology
    Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) reacts with the mouse H-2Kk MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) can be used for the researches of inflammation and immunology, such as obliterative airway disease [1].
    Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3)
  • HY-P990832
    Anti-MHC Class I Antibody (W6/32)

    		MHC Inflammation/Immunology
    Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology [1] [2].
    Anti-MHC Class I Antibody (W6/32)
  • HY-143265
    Topoisomerase I inhibitor 2

    		Topoisomerase Apoptosis Caspase Cancer
    Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect [1].
    Topoisomerase I inhibitor 2
  • HY-P990194
    Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)

    		MHC Inflammation/Immunology
    Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft [1].
    Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)
  • HY-122583
    D-G23

    		RAD51 Cancer
    D-G23 is a selective RAD52 inhibitor. D-G23 disrupts RAD52-mediated DNA repair pathways and suppresses the growth of BRCA1- and BRCA2-deficient cancer cells. D-G23 is promising for research of homologous recombination-related cancers, such as hereditary breast cancer and ovarian cancer caused by BRCA1/2 mutations [1].
    D-G23
  • HY-P990190
    Anti-Swine MHC Class I (SLAd) Antibody (74-11-10)

    		MHC Others
    Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to Swine MHC Class I. Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) reacts with the swine leucocyte antigen (SLA) class I. Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) can be used for the research of flow cytometry experiments [1].
    Anti-Swine MHC Class I (SLAd) Antibody (74-11-10)
  • HY-156375
    PKM2 activator 6

    		Pyruvate Kinase PDK-1 Cancer
    PKM2 activator 6 (Compound Z10) is a PKM2 activator and PDK1 inhibitor (KD: 121 and 19.6 μM respectively). PKM2 activator 6 induces colorectal cell apoptosis, and inhibits cell proliferation and migration . PKM2 activator 6 inhibits glycolysis. PKM2 activator 6 inhibits proliferation of DLD-1, HCT-8, HT-29, MCF-10A cells (IC50: 10.04, 2.16, 3.57, 66.39 μM) [1].
    PKM2 activator 6
  • HY-169652
    NPC26

    		Reactive Oxygen Species (ROS) AMPK Cancer
    NPC26 is a small molecule mitochondrial disruptor with anti-tumor activity. NPC-26 shows significant anti-proliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 can damage mitochondrial function, leading to the opening of the mitochondrial permeability transition pore (mPTP) and the production of reactive oxygen species, ultimately inducing cell death. NPC-26 can kill CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway [1].
    NPC26
  • HY-P3446A
    Big Gastrin I (human) TFA

    		Cholecystokinin Receptor Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Big Gastrin I, human (TFA) is a gastrointestinal hormone consisting of 34 amino acids. Big Gastrin I, human (TFA) can be used as a potential substance for the study of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological diseases or cardiovascular diseases [1].
    Big Gastrin I (human) TFA
  • HY-170844
    MU147

    		Endonuclease Cancer
    MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells [1].
    MU147
  • HY-168094
    PARP1-IN-30

    		PARP Cancer
    PARP1-IN-30 (Compound 3) is a specific and potent PARP1 inhibitor with cytotoxicity. PARP1-IN-30 allows precise inhibition of PARP1 in tumor cells with breast cancer 1 protein (BRCA1) or BRCA2 deficiencies. PARP1-IN-30 is promising for research of cancers [1].
    PARP1-IN-30
  • HY-119257
    ABT-100

    		Farnesyl Transferase Apoptosis Cancer
    ABT-100, a chemical probe, is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity [1].
    ABT-100

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