2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. Mc-PEG4-Val-Ala-PAB-Exatecan

Mc-PEG4-Val-Ala-PAB-Exatecan is a Drug-linker conjugate for ADC. Mc-PEG4-Val-Ala-PAB-Exatecan contains the ADC linker (Mc-PEG4-Val-Ala-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631).

For research use only. We do not sell to patients.

Mc-PEG4-Val-Ala-PAB-Exatecan Chemical Structure

Mc-PEG4-Val-Ala-PAB-Exatecan Chemical Structure

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Based on 1 publication(s) in Google Scholar

Mc-PEG4-Val-Ala-PAB-Exatecan Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mc-PEG4-Val-Ala-PAB-Exatecan is a Drug-linker conjugate for ADC. Mc-PEG4-Val-Ala-PAB-Exatecan contains the ADC linker (Mc-PEG4-Val-Ala-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631)[1].

Molecular Weight

1153.21

Formula

C58H69FN8O16
Appearance

Solid

Color

White to yellow

SMILES

O=C(OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O)=O)=O)N[C@@H]3C(C4=C5CC3)=C(CN6C7=CC([C@@]8(O)CC)=C(COC8=O)C6=O)C7=NC4=CC(F)=C5C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (86.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8671 mL 4.3357 mL 8.6714 mL
5 mM 0.1734 mL 0.8671 mL 1.7343 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8671 mL 4.3357 mL 8.6714 mL 21.6786 mL
5 mM 0.1734 mL 0.8671 mL 1.7343 mL 4.3357 mL
10 mM 0.0867 mL 0.4336 mL 0.8671 mL 2.1679 mL
15 mM 0.0578 mL 0.2890 mL 0.5781 mL 1.4452 mL
20 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0839 mL
25 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8671 mL
30 mM 0.0289 mL 0.1445 mL 0.2890 mL 0.7226 mL
40 mM 0.0217 mL 0.1084 mL 0.2168 mL 0.5420 mL
50 mM 0.0173 mL 0.0867 mL 0.1734 mL 0.4336 mL
60 mM 0.0145 mL 0.0723 mL 0.1445 mL 0.3613 mL
80 mM 0.0108 mL 0.0542 mL 0.1084 mL 0.2710 mL
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Mc-PEG4-Val-Ala-PAB-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mc-PEG4-Val-Ala-PAB-ExatecanDrug-Linker Conjugates for ADCTopoisomeraseDrug-linker conjugate for ADCExatecanInhibitorinhibitorinhibit

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