2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Dextran T5 (MW 5,000)

Dextran T5 (MW 5,000)  (Synonyms: Dextran 5; Dextran D5; Dextran T5(MW 4500-5500))

Cat. No.: HY-112624K
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Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

For research use only. We do not sell to patients.

Dextran T5 (MW 5,000) Chemical Structure

Dextran T5 (MW 5,000) Chemical Structure

CAS No. : 9004-54-0

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Based on 1 publication(s) in Google Scholar

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Dextran T5 (MW 5,000) Related Antibodies

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Description

Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance[1][2][3].

In Vitro

Dextran T5 (MW 5,000) (100 mg/L; 4 days) increases the viable cell count and recombinant EPO production of CHO cells[1].
Dextran T5 (MW 5,000) (100 mg/L; 48 h) inhibits DNA fragmentation and apoptosis of CHO cells[1].
Dextran T5 (MW 5,000) (100 mg/L; 48 h) decreases p53 expression and increases Hsc70 in CHO and HeLa cells, and increases the number of autophagosomes labeled by HcRed-hLC3 in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran T5 (MW 5,000) Related Antibodies

Apoptosis Analysis[1]

Cell Line: CHO cells producing EPO
Concentration: 100 mg/L
Incubation Time: 48 h
Result: Reduced early apoptosis and late apoptosis/necrosis, resulted 2-fold decrease in DNA fragmentation in DS-treated cells.
Molecular Weight

4500-5500

Formula

(C6H10O5)n
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran T5 (MW 5,000)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Dextran T5 (MW 5,000) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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