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  4. Dextran T3 (MW 3,000)

Dextran T3 (MW 3,000)  (Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600))

Cat. No.: HY-112624I
COA
SDS
Handling Instructions Technical Support

Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

For research use only. We do not sell to patients.

Dextran T3 (MW 3,000) Chemical Structure

Dextran T3 (MW 3,000) Chemical Structure

CAS No. : 9004-54-0

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Description

Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance[1][2][3].

In Vivo

Dextran T3 (MW 3,000) (FITC-D3) labeled with fluorescein isothiocyanate (FITC) can be used as a probe molecule to explore the effect of cholera toxin on intestinal permeability in rats. One group was pretreated with Cholera toxin (HY-P1446) 90 minutes in advance by oral tube, and then injected with FITC-D3 (1 mg/mL, 1 mL; ip); the other group was locally combined with Cholera toxin and FITC-D3 in the distal ileum for permeability measurement. Finally, blood was collected from the portal vein and the concentration of FITC-D3 was measured using a fluorescence spectrometer to evaluate intestinal permeability (Ex=483 nm, Em=517 nm)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2400-3600

Formula

(C6H10O5)n
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran T3 (MW 3,000)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation

SDS (393 KB)

COA (243 KB)

Handling Instructions (2659 KB)
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Keywords:

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