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  4. Dextran T4 (MW 4,000)

Dextran T4 (MW 4,000)  (Synonyms: Dextran 4; Dextran D4; Dextran T4(MW 3200-4800))

Cat. No.: HY-112624J
COA
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Handling Instructions Technical Support

Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

For research use only. We do not sell to patients.

Dextran T4 (MW 4,000) Chemical Structure

Dextran T4 (MW 4,000) Chemical Structure

CAS No. : 9004-54-0

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Based on 1 publication(s) in Google Scholar

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Dextran T4 (MW 4,000) Related Antibodies

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Description

Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance[1][2][3].

In Vitro

Dextran 4,000 (0.4% (4 mg/mL), 4% (40 mg/mL); 30 min) reduces sputum viscoelasticity, decreased spinnability, and increases mucociliary clearance index (MCI) and cough clearance index (CCI) in in vitro experiments with cystic fibrosis sputum and healthy dog ??mucus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran T4 (MW 4,000) Related Antibodies
Molecular Weight

3200-4800

Synonyms

Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)

Formula

(C6H10O5)n
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran T4 (MW 4,000)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation

SDS (252 KB)

COA (243 KB)

Handling Instructions (2659 KB)
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Dextran T4 (MW 4,000) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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