Anti-MHC Class I Antibody (W6/32) 

Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology^[1][2].

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Human

MHC Class I

Anti-MHC Class I Antibody (W6/32) (5 μg/mL, 1 h) significantly increases von Willebrand Factor secretion and monocyte adherence in human aortic endothelial cells^[1].
Anti-MHC Class I Antibody (W6/32) (1 μg/mL, 30 mins) increases the number of Mono Mac 6 adherent through Mac-1/ICAM-1 interactions in human endothelial monolayer^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-MHC Class I Antibody (W6/32)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Valenzuela NM, et al. Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo. Am J Transplant. 2013 Feb;13(2):299-311.  [Content Brief]

  [2]. Valenzuela et al. HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcγRs. J Immunol. 2013 Jun 15;190(12):6635-50.  [Content Brief]