2. Metabolic Enzyme/Protease
  3. MMP
  4. Anti-Human/Mouse denatured collagen type-I Antibody (XL313)

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 

Cat. No.: HY-P990251 Purity: ≥95%
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Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor.

For research use only. We do not sell to patients.

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) Chemical Structure

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) Chemical Structure

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Description

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor[1][2][3].

In Vitro

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (16 h) exhibits selective binding for proteolyzed collagen type I[1].
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (10 μg, daily for 3 times) significantly inhibits the number of FGF-2-induced chick chorioallantoic membranes exhibiting inflammation and reduces the levels of inflammatory infiltrates[1].
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (10 μg/mL, 24 h) shows no cytotoxicity in Β16F10 melanoma cells[2].
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (100 μg/mL, 15 mins or 1 h) reduces PD L1 and nuclear YAP levels by a proteasome dependent mechanism in Β16F10, YUMM1.7, C32 and A375 tumor cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) Related Antibodies

Western Blot Analysis[2]

Cell Line: Β16F10, YUMM1.7, C32 and A375 tumor cells
Concentration: 100 μg/mL
Incubation Time: 15 min or 1 h
Result: Reduceds PD L1 and nuclear YAP levels.
In Vivo

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (250 μg, i.p., 3 times a week for 14 or 21 days) suppresses tumor growth inΒ16F10/4T1 tumor mice models[2].
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (100 μg, i.p., 1-2 times a week) shows anti-tumor effect in intraperitoneal ID8 tumor and ID8-VEGF ovarian tumor mice models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Β16F10/4T1 tumor mice models[2]
Dosage: 250 μg
Administration: Intraperitoneally injection, 3 times a week for 14 or 21 days
Result: Inhibited tumor growth.
Animal Model: Intraperitoneal ID8 tumor mice models[3]
Dosage: 100 μg
Administration: Intraperitoneally injection, once per week for 7 weeks
Result: Showed a significant inhibition of approximately 80% in the tumor burden.
Reduced CD4+ T cells, F4/80 expressing macrophages and PDGFRa expressing cells in spleens.
Animal Model: ID8-VEGF ovarian tumor mice models[3]
Dosage: 100 μg
Administration: Intraperitoneally injection, twice per week
Result: Inhibited the growth of ID8-VEGF ovarian tumors.
Significantly inhibited the binding of the RGDKGE containing collagen fragment to ID8-VEGF cells.
Reduced abdominal distension and ascites volume.
Reduced levels of LAG-3 expressing cells.
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Human/Mouse denatured collagen type-I Antibody (XL313)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Human/Mouse denatured collagen type-I Antibody (XL313) Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Human/Mouse denatured collagen type-I Antibody (XL313)MMPMatrix metalloproteinasesDenatured collagen type-IPD-L1Ovarian tumorΒ16F10YUMM1.7C32A375Inhibitorinhibitorinhibit

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