SN-38 glucuronide-d₃

Cat. No.: HY-W653919: Data Sheet Handling Instructions
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SN-38 glucuronide-d₃ is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.

For research use only. We do not sell to patients.

SN-38 glucuronide-d<sub>3</sub> Chemical Structure

SN-38 glucuronide-d₃ Chemical Structure

Size	Stock	Quantity
1 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Other Forms of SN-38 glucuronide-d₃:

SN-38 glucuronide In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

571.55

Formula

C₂₈H₂₅D₃N₂O₁₁

Unlabeled CAS

121080-63-5

SMILES

O=C1C2=C(C=C3C4=NC5=CC=C(C=C5C(CC([2H])([2H])[2H])=C4CN31)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(O)=O)O)O)O)[C@@](CC)(C(OC2)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (174.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 6.25 mg/mL (10.94 mM; ultrasonic and warming and heat to 60°C)

H2O : 2.5 mg/mL (4.37 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7496 mL	8.7481 mL	17.4963 mL
5 mM	0.3499 mL	1.7496 mL	3.4993 mL
10 mM	0.1750 mL	0.8748 mL	1.7496 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Atasilp C, et al. Determination of irinotecan, SN-38 and SN-38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients. J Clin Lab Anal. 2018 Jan;32(1):e22217. [Content Brief]

[3]. Pellock SJ, et al. Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018;293(48):18559-18573. [Content Brief]

[4]. Wallace BD, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010 Nov 5;330(6005):831-5. [Content Brief]

[5]. Ohtsuka K, et al. Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer[J]. Lung Cancer, 2003, 41(2): 187-198.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O / Methanol / DMSO	1 mM	1.7496 mL	8.7481 mL	17.4963 mL	43.7407 mL
Methanol / DMSO	5 mM	0.3499 mL	1.7496 mL	3.4993 mL	8.7481 mL
Methanol / DMSO	10 mM	0.1750 mL	0.8748 mL	1.7496 mL	4.3741 mL
DMSO	15 mM	0.1166 mL	0.5832 mL	1.1664 mL	2.9160 mL
	20 mM	0.0875 mL	0.4374 mL	0.8748 mL	2.1870 mL
	25 mM	0.0700 mL	0.3499 mL	0.6999 mL	1.7496 mL
	30 mM	0.0583 mL	0.2916 mL	0.5832 mL	1.4580 mL
	40 mM	0.0437 mL	0.2187 mL	0.4374 mL	1.0935 mL
	50 mM	0.0350 mL	0.1750 mL	0.3499 mL	0.8748 mL
	60 mM	0.0292 mL	0.1458 mL	0.2916 mL	0.7290 mL
	80 mM	0.0219 mL	0.1094 mL	0.2187 mL	0.5468 mL
	100 mM	0.0175 mL	0.0875 mL	0.1750 mL	0.4374 mL