HXK I Antibody (YA5220)

HXK I Antibody (YA5220) is a mouse-derived and non-conjugated monoclonal antibody, targeting to HXK I. It can be applicated for WB assays, in the background of human, mouse, rat.

HK1 is a hexokinase that catalyzes the phosphorylation of various hexoses (e.g., D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose) to their corresponding hexose 6-phosphates (e.g., D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate, and 2-deoxy-D-glucose 6-phosphate), but it does not act on N-acetyl-D-glucosamine. By similarity: It mediates the initial step of glycolysis by phosphorylating D-glucose to D-glucose 6-phosphate. Additionally, HK1 is involved in innate immunity and inflammation, functioning as a pattern recognition receptor for bacterial peptidoglycan. When N-acetyl-D-glucosamine is released into the cytosol, it inhibits HK1's hexokinase activity and triggers its dissociation from the mitochondrial outer membrane, thereby activating the NLRP3 inflammasome.

P19367

Observed band size: 102 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human Hexokinase 1 protein fragments expressed in E.coli