2. Stem Cell/Wnt
  3. β-catenin
  4. (Z)-Zolucatetide

(Z)-Zolucatetide ((Z)-FOG-001; I-67), a structural isomer of Zolucatetide (HY-P10925), is a potent β-catenin inhibitor with an IC50 of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer.

For research use only. We do not sell to patients.

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(Z)-Zolucatetide

(Z)-Zolucatetide Chemical Structure

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(Z)-Zolucatetide Related Antibodies

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Description

(Z)-Zolucatetide ((Z)-FOG-001; I-67), a structural isomer of Zolucatetide (HY-P10925), is a potent β-catenin inhibitor with an IC50 of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer[1].

In Vitro

Zolucatetide (1-5 μM, 4-24 h) selectively inhibits beta-catenin-driven endogenous gene (SP5, AXIN2) expression in wild-type (WT) HAPI isogenic cells expressing beta-catenin, but not in CTNNB1 knockout (KO) cells[1].
Zolucatetide (24 h) reduces total beta-catenin levels in the nuclear fraction of relevant cells[1].
Zolucatetide (1-10 μM, 24 h) inhibits cell proliferation, and induces cell cycle arrest in target cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Z)-Zolucatetide Related Antibodies
In Vivo

Zolucatetide (30-75 mg/kg, i.p., Q4D) exerts robust, dose-dependent anti-tumor effects in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: COLO320DM colon cancer cells (with APC, TP53 mutations) were implanted into relevant sites of experimental mice[1]
Dosage: 30, 75 mg/kg
Administration: i.p., Q4D
Result: Achieved tumor growth inhibition.
Molecular Weight

2076.39

Formula

C102H134N18O25S2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(Z)-Zolucatetide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-Zolucatetide(Z)-FOG-001 I-67I67I 67I-67β-cateninBeta cateninβ-catenin Inhibitorβ-catenin and T-cell factor (TCF) transcription factor interactionanticancer effectsInhibitorinhibitorinhibit

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