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  4. XVA143

XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo.

For research use only. We do not sell to patients.

XVA143

XVA143 Chemical Structure

CAS No. : 264275-77-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

XVA143 Related Antibodies

Top Publications Citing Use of Products

View All Integrin Isoform Specific Products:

View All Isoforms
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo[1].

In Vitro

XVA143 (1 μM) completely abolishes binding of ICAM-1 to LFA-1 in Mn2+ and Mg2+/EGTA, with no hint of agonism[1]. XVA143 restores rolling of the αL-E310A β2 mutant by inducing extension of αL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XVA143 Related Antibodies

Cell Viability Assay[1]

Cell Line: K562 cells.
Concentration: 0, 0.2, 0.5 and 1 μM.
Incubation Time:
Result: Potent against the weakest activator (2 mM Mg2+/1 mM EGTA, IC50 ~10-3 nM) and least potent against the strongest activator (1 mM Mn2+, IC50 ~10-3 nM).

Cell Viability Assay[1]

Cell Line: Wild-type murine lymphocytes[1].
Concentration: 100 μM.
Incubation Time:
Result: Induced a 50% increase in rolling fraction compared to vehicle-treated control cells ((from 27±5% to 41±7%).
Molecular Weight

562.36

Formula

C25H21Cl2N3O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CNC(C1=CC(O)=CC(O)=C1)=O)NC(C2=C(Cl)C=C(C(NCC3=CC=CC(O)=C3)=O)C=C2Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (177.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7782 mL 8.8911 mL 17.7822 mL
5 mM 0.3556 mL 1.7782 mL 3.5564 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7782 mL 8.8911 mL 17.7822 mL 44.4555 mL
5 mM 0.3556 mL 1.7782 mL 3.5564 mL 8.8911 mL
10 mM 0.1778 mL 0.8891 mL 1.7782 mL 4.4456 mL
15 mM 0.1185 mL 0.5927 mL 1.1855 mL 2.9637 mL
20 mM 0.0889 mL 0.4446 mL 0.8891 mL 2.2228 mL
25 mM 0.0711 mL 0.3556 mL 0.7113 mL 1.7782 mL
30 mM 0.0593 mL 0.2964 mL 0.5927 mL 1.4819 mL
40 mM 0.0445 mL 0.2223 mL 0.4446 mL 1.1114 mL
50 mM 0.0356 mL 0.1778 mL 0.3556 mL 0.8891 mL
60 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7409 mL
80 mM 0.0222 mL 0.1111 mL 0.2223 mL 0.5557 mL
100 mM 0.0178 mL 0.0889 mL 0.1778 mL 0.4446 mL
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XVA143 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XVA143264275-77-6XVA 143XVA-143IntegrinICAM-1EGTALFA-1α/β IintegrinHIVInhibitorinhibitorinhibit

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