Desmin Antibody (YA5746)

Desmin Antibody (YA5746) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Desmin. It can be applicated for IHC-P, ELISA assays, in the background of human, mouse, rat.

Desmin is a muscle-specific type III intermediate filament essential for proper muscular structure and function. It plays a crucial role in maintaining sarcomere structure by interconnecting Z-disks and forming myofibrils, linking them to the sarcolemmal cytoskeleton, nucleus, and mitochondria, thereby providing strength during muscle activity. In adult striated muscle, Desmin forms a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of Z-line structures. It may act as a sarcomeric microtubule-anchoring protein, specifically associating with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Additionally, Desmin is required for nuclear membrane integrity via anchoring at the cell tip and nuclear envelope, maintaining microtubule-derived intracellular mechanical forces (by similar). It contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during cardiomyogenesis and in cardiac side population stem cells, and plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (by similar).

P17661

Predicted band size: 53 kDa; Observed band size: 60 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

IHC: 1:200-400; ELISA: 1:500-5000

IHC-P, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Synthesized peptide derived from human Desmin AA range: 400-470