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  4. Monoclonal Antibodies Recombinant Antibodies
  5. ABCE1 Antibody (YA1699)

ABCE1 Antibody (YA1699)

Cat. No.: HY-P81954
COA
SDS
User Guide for Antibodies Technical Support

ABCE1 Antibody (YA1699) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ABCE1.

For research use only. We do not sell to patients.

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10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

ABCE1 Antibody (YA1699) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ABCE1.
Background

ABCE1 is a nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (which splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits). It is able to hydrolyze ATP, GTP, UTP and CTP. Its action occurs either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). ABCE1 is involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, it drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. It also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. In the PINK1-regulated signaling, it is ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. Moreover, ABCE1 is an RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL, and a negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (by similar) In terms of microbial infection, ABCE1 may act as a chaperone for post-translational events during HIV-1 capsid assembly and plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
Gene ID
SwissProt ID
Synonyms
ABC38; ABCE1; HuHP68; OABP; RLI; RNASEL1; RNASELI; RNS4I
Molecular Weight

Predicted band size: 67 kDa; Observed band size: 67 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IP: 1/20
Application

WB, IP
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human ABCE1 aa586-599.
Database

Entrez Gene: 6059 Human ; 24015 Mouse ; 361390 Rat

SwissProt: P61221 Human ; P61222 Mouse ;

OMIM: 601213 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

ABCE1 Antibody (YA1699) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ABCE1 Antibody (YA1699)
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