2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Fungal
  4. Eupolauridine

Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases.

For research use only. We do not sell to patients.

Eupolauridine Chemical Structure

Eupolauridine Chemical Structure

CAS No. : 58786-39-3

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Eupolauridine Related Antibodies

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Topoisomerase Topo I Topo II

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Description

Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases[1][2].

IC50 & Target

Topoisomerase I

 

Topoisomerase II

 

Molecular Weight

204.23

Synonyms

Canangine

Formula

C14H8N2
CAS No.
SMILES

C1(C2=CC=CC=C23)=NC=CC4=C1C3=NC=C4
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eupolauridine Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eupolauridine58786-39-3CanangineTopoisomeraseFungalDNA topoisomerase IItopoisomerase Ifungal infectious diseasesInhibitorinhibitorinhibit

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