2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. L-750667

L-750667 is a selective dopamine D4 receptor antagonist ligand. 125I-labeled L-750667 can specifically bind to dopamine D4 receptors in the rat retina, with a Kd value of 0.06 nM. L-750667 is involved in the regulation of the light-sensitive cAMP pool.

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L-750667

L-750667 Chemical Structure

CAS No. : 158985-08-1

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Based on 1 publication(s) in Google Scholar

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L-750667 Related Antibodies

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Description

L-750667 is a selective dopamine D4 receptor antagonist ligand. 125I-labeled L-750667 can specifically bind to dopamine D4 receptors in the rat retina, with a Kd value of 0.06 nM. L-750667 is involved in the regulation of the light-sensitive cAMP pool[1].

Molecular Weight

418.27

Formula

C18H19IN4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

IC(C=C1)=CC=C1N(CC2)CCN2CC3=CNC4=NC=CC=C43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (59.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3908 mL 11.9540 mL 23.9080 mL
5 mM 0.4782 mL 2.3908 mL 4.7816 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3908 mL 11.9540 mL 23.9080 mL 59.7700 mL
5 mM 0.4782 mL 2.3908 mL 4.7816 mL 11.9540 mL
10 mM 0.2391 mL 1.1954 mL 2.3908 mL 5.9770 mL
15 mM 0.1594 mL 0.7969 mL 1.5939 mL 3.9847 mL
20 mM 0.1195 mL 0.5977 mL 1.1954 mL 2.9885 mL
25 mM 0.0956 mL 0.4782 mL 0.9563 mL 2.3908 mL
30 mM 0.0797 mL 0.3985 mL 0.7969 mL 1.9923 mL
40 mM 0.0598 mL 0.2989 mL 0.5977 mL 1.4943 mL
50 mM 0.0478 mL 0.2391 mL 0.4782 mL 1.1954 mL
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L-750667 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-750667158985-08-1L750667L 750667Dopamine Receptordopamine D4 receptorlight-sensitive cAMP poolInhibitorinhibitorinhibit

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