2. Immunology/Inflammation Apoptosis
  3. Transmembrane Glycoprotein TNF Receptor
  4. Anti-Mouse CD40 Antibody (FGK4.5/FGK45)

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) 

Cat. No.: HY-P990680 Purity: 95.00%
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Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is an agonistic rat-derived IgG2a monoclonal antibody targeting mouse CD40. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) enhances T cells responses, dendritic cells maturation and NK cells activation. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) can be used for the researches of cancer, infection, inflammation and immunology, such as CT26 tumor, vesicular stomatitis virus (VSV) infection and transplantation.

For research use only. We do not sell to patients.

Anti-Mouse CD40 Antibody (FGK4.5/FGK45)

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) Chemical Structure

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Description

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is an agonistic rat-derived IgG2a monoclonal antibody targeting mouse CD40. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) enhances T cells responses, dendritic cells maturation and NK cells activation. Anti-Mouse CD40 Antibody (FGK4.5/FGK45) can be used for the researches of cancer, infection, inflammation and immunology, such as CT26 tumor, vesicular stomatitis virus (VSV) infection and transplantation[1][2][3].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
In Vivo

Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (200 μg at day 0 and 100 μg at day 3, 7, 10, i.p.) induces the expression of IL-15Rα in C57BL/6 mice[1].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (200 μg at day 0 and 100 μg at day 3, 7, 10, i.p.) inhibits tumor growth and prolongs survival in CT26/MC38 tumor mice models[1].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (100 μg, i.p., 1 day after infection) enhances CD8+ T cell response and dendritic cell maturation in vesicular stomatitis virus (VSV)-infected mice models[2].
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) (100 μg, i.v., at day 0 and 1) promotes the accumulation of immunogenic macrophages and abrogates the induction of tolerance in vascularized heart transplanted mice models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26/MC38 tumor mice models[1]
Dosage: 200 μg at day 0 and 100 μg at day 3, 7, 10
Administration: Intraperitoneally injection, companied with anti-IL-15
Result: Prolonged survival of mice.
Suppressed tumor growth.
Showed increased lysis activity of NK cells at days 2 and 5.
Animal Model: Vesicular stomatitis virus (VSV)- infected mice models[2]
Dosage: 100 μg
Administration: Intraperitoneally injection, 1 day after infection
Result: Resulted in a nearly three-fold larger memory CD8+ T cell population.
Increased proportion of IFNγ+ TNFα+dual producing CD8+ T cells.
Animal Model: Vascularized heart transplanted mice models[3]
Dosage: 100 μg
Administration: Intravenously injection, at day 0 and 1
Result: Increased immunogenic macrophages and IFN-γ expression.
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD40 Antibody (FGK4.5/FGK45)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD40 Antibody (FGK4.5/FGK45) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD40 Antibody (FGK4.5/FGK45)Transmembrane GlycoproteinTNF ReceptorTumor Necrosis Factor ReceptorTNFRCD40T cellsDendritic cellsNK cellsCT26MC38Vesicular stomatitis virusMacrophagesInhibitorinhibitorinhibit

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