2. Metabolic Enzyme/Protease Apoptosis
  3. Proteasome Apoptosis
  4. MG-101

MG-101  (Synonyms: Calpain inhibitor I; Ac-LLnL-CHO; ALLN)

Cat. No.: HY-18964G
Handling Instructions Technical Support

MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer.

For research use only. We do not sell to patients.

MG-101 Chemical Structure

MG-101 Chemical Structure

CAS No. : 110044-82-1

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Description

MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer[1].

In Vitro

MG-101 (GMP) (0-26 μM; 24 h) affects the growth of colon cancer HCT116 cells[1].
MG-101 (GMP) (0-26 μM; 24 h) induces apoptosis of various cancer cells[1].
MG-101 (GMP) (0-26 μM; 24 h) induces Bax-dependent apoptosis in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MG-101 Related Antibodies

Cell Viability Assay[1]

Cell Line: HCT116 cell line
Concentration: 0-26 μM
Incubation Time: 24 hours
Result: Anchorage-independently and significantly decreased the viability of HCT116 cells.

Western Blot Analysis[1]

Cell Line: HCT116, RKO, SW480 and HepG2 cell lines
Concentration: 0-26 μM
Incubation Time: 24 hours
Result: Dose-dependently decreased the concentration of pro-caspase 3 and increased the concentration of cleaved-PARP in HCT116 cells. Induced apoptosis of HCT116, RKO, SW480 and HepG2 cells.

Western Blot Analysis[1]

Cell Line: HCT116, HCT116/p53-/- and HCT116/Bax-/- cell lines
Concentration: 0-26 μM
Incubation Time: 24 hours
Result: Induced apoptosis via a Bax-dependent manner, but not via a p53-dependent manner.
In Vivo

MG-101 (GMP) (10 mg/kg; i.p. once daily for 15 days) inhibits tumor growth in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice with HCT116 cells injection[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg once daily; for 15 days
Result: Significantly decreased tumor weight and volume of treated mice at day 26 compared to control mice, and showed no effect on body weights.
Molecular Weight

383.53

Formula

C20H37N3O4
CAS No.
SMILES

O=C(N[C@H](C=O)CCCC)[C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MG-101 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MG-101 (GMP)110044-82-1Calpain inhibitor I (GMP)Ac-LLnL-CHO (GMP)ALLN (GMP)ProteasomeApoptosisInhibitorinhibitorinhibit

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