2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Microtubule/Tubulin Topoisomerase
  4. VcMMAE-Deruxtecan

VcMMAE-Deruxtecan  (Synonyms: SMP-54418)

Cat. No.: HY-164835 Purity: 98.10%
COA
SDS
Handling Instructions Technical Support

VcMMAE-Deruxtecan is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule MMAE (HY-15162) (Microtubule inhibitor) and Exatecan (HY-13631) (DNA topoisomerase I inhibitor). VcMMAE-Deruxtecan can be used for ADC synthesis.

For research use only. We do not sell to patients.

VcMMAE-Deruxtecan

VcMMAE-Deruxtecan Chemical Structure

CAS No. : 2760408-75-9

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

VcMMAE-Deruxtecan Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

VcMMAE-Deruxtecan is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule MMAE (HY-15162) (Microtubule inhibitor) and Exatecan (HY-13631) (DNA topoisomerase I inhibitor). VcMMAE-Deruxtecan can be used for ADC synthesis.

IC50 & Target

Topoisomerase I

 

Dual payloads

 

Molecular Weight

2360.67

Formula

C121H159FN20O28
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C3=CC=CC=C3)=O)([H])CCC2)=O)C)=O)=O)=O)C=C1)=O)=O)NC(C(NC(CCCCCN4C(C=CC4=O)=O)=O)CC(C=C5)=CC=C5OCC(NCC(NCC(N[C@@H](CC6=CC=CC=C6)C(NCC(NCOCC(N[C@@H]7C8=C9C(C(N%10C9)=CC([C@](O)(C(OC%11)=O)CC)=C%11C%10=O)=NC%12=CC(F)=C(C)C(CC7)=C%128)=O)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (21.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4236 mL 2.1180 mL 4.2361 mL
5 mM 0.0847 mL 0.4236 mL 0.8472 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4236 mL 2.1180 mL 4.2361 mL 10.5902 mL
5 mM 0.0847 mL 0.4236 mL 0.8472 mL 2.1180 mL
10 mM 0.0424 mL 0.2118 mL 0.4236 mL 1.0590 mL
15 mM 0.0282 mL 0.1412 mL 0.2824 mL 0.7060 mL
20 mM 0.0212 mL 0.1059 mL 0.2118 mL 0.5295 mL
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VcMMAE-Deruxtecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VcMMAE-Deruxtecan2760408-75-9SMP-54418SMP54418SMP 54418Drug-Linker Conjugates for ADCMicrotubule/TubulinTopoisomeraseExatecanMMAEADCInhibitorinhibitorinhibit

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