2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. PTBP1 Antibody (YA3189)

PTBP1 Antibody (YA3189)

Cat. No.: HY-P83444
User Guide for Antibodies Technical Support

PTBP1 Antibody (YA3189) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3189), targeting PTBP1, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). PTBP1 Antibody (YA3189) can be used for WB, IHC-P experiment in human, mouse, hamster background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.
or Bulk Inquiry

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

PTBP1 Antibody (YA3189) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3189), targeting PTBP1, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). PTBP1 Antibody (YA3189) can be used for WB, IHC-P experiment in human, mouse, hamster background.
Background

PTBP1 is a protein involved in pre-mRNA splicing and the regulation of alternative splicing events. It activates exon skipping of its own pre-mRNA during muscle cell differentiation and binds to the polypyrimidine tract of introns. When bound to two separate polypyrimidine tracts in the same pre-mRNA, it may promote RNA looping and facilitate U2 snRNP binding to pre-mRNA. PTBP1 cooperates with RAVER1 to modulate switching between mutually exclusive exons during TPM1 pre-mRNA maturation and represses the splicing of MAPT/Tau exon 10. Additionally, it binds to the polypyrimidine-rich controlling element (PCE) of CFTR, promoting exon 9 skipping and antagonizing TIA1's role in exon inclusion. In pyruvate kinase PKM splicing, PTBP1 repressively binds to a polypyrimidine tract flanking exon 9, inhibiting its inclusion and favoring exon 10 inclusion to produce the PKM M2 isoform. During picornavirus infection, PTBP1 binds to the viral internal ribosome entry site (IRES), stimulating IRES-mediated translation.
Gene ID
SwissProt ID
Synonyms
PTB; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; PTB-T; HNRNPI; HNRNP-I
Molecular Weight

Predicted band size: 57 kDa; Observed band size: 57 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Hamster
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human PTBP1
Database

Entrez Gene: 5725 Human ; 19205 Mouse ; 29497 Rat

SwissProt: P26599 Human ; P17225 Mouse ; Q00438 Rat

OMIM: 600693 Human

Documentation
User Guide for Antibodies (1077 KB)

PTBP1 Antibody (YA3189) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PTBP1 Antibody (YA3189)
Cat. No.:
HY-P83444
Quantity:
MCE Japan Authorized Agent:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Country or Region *

Email Address *

     

Phone Number *

 

Organization Name *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.