SQDG 

SQDG inhibits topoisomerase I and P-selectin receptor, exhibits anti-inflammatory, antiviral and antitumor activities. SQDG is a glycolipid that possesses sugar moieties in their head groups. SQDG is a membrane lipid that can be used to investigate the effects of structural lipid in LNP formulations^[1][2][3].

SQDG is an acidic lipid that can be found in the thylakoid membrane of photosynthetic organisms such as plants and cyanobacteria. SQDG is the composition of the thylakoid membrane, provides a stable environment for membrane proteins and maintains the integrity of the membrane^[2].
SQDG binds to four sites of photosystem II (PSII) and affects PSII activity. SQDG regulates the efficiency of photosynthesis. SQDG loss leads to growth inhibition in some cyanobacteria^[2].
SQDG inhibits herpes simplex virus type 2 (HSV-1), HSV-2 (IC₅₀=15.6 μg/mL) and Coxsackie virus B3 (Cox B3)^[3].
SQDG (0-25 μM, 72 h) exhibits cytotoxicity in acute lymphoblastic leukemia (ALL) cells, IC₅₀s for MOLT-4, MOLT-3 and Reh are 15.32 μM, 22.52 μM and 19.63 μM^[4].
SQDG (0-25 μM, 24-48 h) arrests the cell cycle at S phase, and induces apoptosis in MOLT-4 through p53-dependent pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SQDG (2 mg/kg, ip, two doses in a week) exhibits antitumor efficacy in MOLT-4 xenograft mouse models^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

817.12

C₄₃H₇₆O₁₂S

123036-44-2

Solid

White to light yellow

CC/C=C\C/C=C\C/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)CO[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CS(=O)(O)=O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Jeonghwan Kim, et al. Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery. Cell Mol Bioeng. 2020 May 26;13(5):463-474.  [Content Brief]

  [2]. Nakajima Y, et al., Thylakoid membrane lipid sulfoquinovosyl-diacylglycerol (SQDG) is required for full functioning of photosystem II in Thermosynechococcus elongatus. J Biol Chem. 2018 Sep 21;293(38):14786-14797.  [Content Brief]

  [3]. Wang H, et al. Antiviral activity of a sulfoquinovosyldiacylglycerol (SQDG) compound isolated from the green alga Caulerpa racemosa[J]. 2007.

  [4]. Jain CK, et al., Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo. Sci Rep. 2015 Jul 20;5:12082.  [Content Brief]