2. NF-κB Apoptosis
  3. NF-κB Apoptosis
  4. Amorfrutin A

Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis.

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Amorfrutin A

Amorfrutin A Chemical Structure

CAS No. : 80489-90-3

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Amorfrutin A Related Antibodies

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Description

Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
0.458 μM
Compound: amorfrutin 1
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
[PMID: 23286787]
HEK293 EC50
0.458 μM
Compound: amorfrutin 1
Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay
Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay
[PMID: 25734377]
HT-29 IC50
50.8 μM
Compound: 1
Reduction in TNFalpha-induced PPARgamma expression in human HT-29 cells after 48 hrs by Western blotting analysis
Reduction in TNFalpha-induced PPARgamma expression in human HT-29 cells after 48 hrs by Western blotting analysis
[PMID: 25938459]
HeLa IC50
0.84 μM
Compound: 6
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
[PMID: 18841906]
RAW264.7 IC50
4.17 μM
Compound: 6
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
[PMID: 18841906]
THP-1 IC50
50 μM
Compound: 22
Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis
Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis
[PMID: 28075580]
Molecular Weight

340.41

Formula

C21H24O4
CAS No.
SMILES

O=C(O)C1=C(CCC2=CC=CC=C2)C=C(OC)C(C/C=C(C)\C)=C1O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Amorfrutin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amorfrutin A80489-90-3NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBHeLaT47DInhibitorinhibitorinhibit

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