2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. APP-018

APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I). APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL). APP-018 can be used in researches of cardiovascular diseases.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

APP-018 Chemical Structure

APP-018 Chemical Structure

CAS No. : 452782-06-8

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Based on 1 publication(s) in Google Scholar

Other Forms of APP-018:

APP-018 Related Antibodies

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apoE apoB apoC3

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Description

APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I). APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL). APP-018 can be used in researches of cardiovascular diseases[1].

Molecular Weight

2310.60

Formula

C114H156N24O28
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-d(Asp-Trp-Phe-Lys-Ala-Phe-Tyr-Asp-Lys-Val-Ala-Glu-Lys-Phe-Lys-Glu-Ala-Phe)-NH2
Sequence Shortening

Ac-d(DWFKAFYDKVAEKFKEAF)-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (21.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4328 mL 2.1639 mL 4.3279 mL
5 mM 0.0866 mL 0.4328 mL 0.8656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4328 mL 2.1639 mL 4.3279 mL 10.8197 mL
5 mM 0.0866 mL 0.4328 mL 0.8656 mL 2.1639 mL
10 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0820 mL
15 mM 0.0289 mL 0.1443 mL 0.2885 mL 0.7213 mL
20 mM 0.0216 mL 0.1082 mL 0.2164 mL 0.5410 mL
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APP-018 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APP-018452782-06-8D-4FAPP018APP 018Apolipoproteinanti-inflammatoryapolipoproteinInhibitorinhibitorinhibit

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