Link N peptide 

Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases^[1][2].

1921.98

C₈₁H₁₂₀N₂₆O₂₉

197295-74-2

Solid

White to off-white

Asp-His-Leu-Ser-Asp-Asn-Tyr-Thr-Leu-Asp-His-Asp-Arg-Ala-Ile-His

DHLSDNYTLDHDRAIH

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)NC([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC4=CN=CN4)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Petit A, et al. Effect of synthetic link N peptide on the expression of type I and type II collagens in human intervertebral disc cells. Tissue Eng Part A. 2011 Apr;17(7-8):899-904.  [Content Brief]

  [2]. AlGarni N, et al. Short Link N Stimulates Intervertebral Disc Repair in a Novel Long-Term Organ Culture Model that Includes the Bony Vertebrae. Tissue Eng Part A. 2016 Nov;22(21-22):1252-1257.  [Content Brief]