Blimp-1 Antibody (YA4747)

Blimp-1 Antibody (YA4747) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Blimp-1. It can be applicated for WB, ELISA assays, in the background of human, mouse.

Blimp-1 is a transcription factor that mediates transcriptional programs in various innate and adaptive immune tissue-resident lymphocyte T cell types, including tissue-resident memory T (Trm), natural killer (trNK), and natural killer T (NKT) cells, while negatively regulating genes promoting egress of tissue-resident T-cell populations from non-lymphoid organs. It plays a role in the development, retention, and long-term establishment of adaptive and innate tissue-resident lymphocyte T cells in non-lymphoid organs (e.g., skin, gut, liver, kidney), potentially providing immediate immunological protection against reactivating infections or viral reinfection (By similarity). Blimp-1 specifically binds the PRDI element in the beta-interferon gene promoter and drives B-lymphocyte maturation into Ig-secreting cells. It associates with the transcriptional repressor ZNF683 at chromatin promoter regions (By similarity) and binds the IRF8 promoter to repress its transcription, thereby promoting osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity).

O75626

Predicted band size: 92 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human Blimp-1 expressed in E. Coli.