1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  2. Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
  3. 3'-Deoxyuridine-5'-triphosphate

3'-Deoxyuridine-5'-triphosphate  (Synonyms: 3'-dUTP)

Cat. No.: HY-135780
Handling Instructions

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (3'-Deoxyuridine-5'-triphosphate trisodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

3'-Deoxyuridine-5'-triphosphate Chemical Structure

3'-Deoxyuridine-5'-triphosphate Chemical Structure

CAS No. : 69199-40-2

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Description

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].

In Vitro

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

468.14

Formula

C9H15N2O14P3

CAS No.
SMILES

O=P(O)(O)OP(OP(OC[C@@H](O1)C[C@@H](O)[C@@H]1N2C(NC(C=C2)=O)=O)(O)=O)(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
3'-Deoxyuridine-5'-triphosphate
Cat. No.:
HY-135780
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