2. Recombinant Proteins
  3. Receptor Proteins
  4. Killer-Cell Immunoglobulin-like Receptors
  5. CD158b1/KIR2DL2
  6. KIR2DL2/CD158b1 Protein, Human (HEK293, Fc)

KIR2DL2/CD158b1 Protein, Human (HEK293, Fc)

Cat. No.: HY-P704733
Handling Instructions Technical Support

KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (HEK293, Fc) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293, with C-hFc labeled tag.

For research use only. We do not sell to patients.

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Description

KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (HEK293, Fc) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293, with C-hFc labeled tag.
Background

KIR2DL2/CD158b1, located on natural killer (NK) cells, serves as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its primary function is to exert inhibitory effects on NK cell activity, acting as a regulator to prevent cellular lysis. Through specific interactions with distinct HLA-C molecules, KIR2DL2/CD158b1 contributes to the finely tuned balance of inhibitory signals within the immune system, influencing the responsiveness of NK cells to potential targets.
Species

Human
Source

HEK293
Tag

C-hFc
Accession

P43627 (H22-H245)
Gene ID

3803
Molecular Construction
N-term
CD158b1 (H22-H245)
Accession # P43627
hFc
C-term
Synonyms
Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6
Predicted Molecular Mass
51.0 kDa.
Molecular Weight

Approximately 60-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Glycosylation
Yes
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

KIR2DL2/CD158b1 Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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KIR2DL2/CD158b1 Protein, Human (HEK293, Fc)
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