Annexin-2/ANXA2 Antibody (YA5571)

Annexin-2/ANXA2 Antibody (YA5571) is a mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to Annexin II. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.

Annexin A2 is a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity and may be involved in heat-stress response. The protein inhibits PCSK9-enhanced LDLR degradation, likely by reducing PCSK9 protein levels via a translational mechanism while also competing with LDLR for PCSK9 binding. Annexin A2 binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (by similarity). It is required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (by similarity). In microbial infection, Annexin A2 binds M. pneumoniae CARDS toxin, probably serving as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells, and vacuolization (a symptom of M. pneumoniae infection) is reduced.

P07355

Predicted band size: 38 kDa; Observed band size: 37 kDa

Protein G

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:500-2000; ICC/IF: 1:100-500; ELISA: 1:1000-5000

WB, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG3

Synthesized peptide derived from human protein. AA range: 100-200