2. PROTAC Immunology/Inflammation
  3. Molecular Glues IKZF Family
  4. (S,S)-PLX-4545

(S,S)-PLX-4545 (Compound I) is an orally active and cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). (S,S)-PLX-4545 can be used for the study of IKZF2-mediated diseases or disorders, such as proliferative diseases or disorders and/or cancer.

For research use only. We do not sell to patients.

(S,S)-PLX-4545 Chemical Structure

(S,S)-PLX-4545 Chemical Structure

CAS No. : 2892065-49-3

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Other Forms of (S,S)-PLX-4545:

(S,S)-PLX-4545 Related Antibodies

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Description

(S,S)-PLX-4545 (Compound I) is an orally active and cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). (S,S)-PLX-4545 can be used for the study of IKZF2-mediated diseases or disorders, such as proliferative diseases or disorders and/or cancer[1].

Molecular Weight

473.56

Formula

C28H31N3O4
CAS No.
SMILES

O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC(O[C@H]4CCCC[C@@H]4N5CC(C5)C6=CC=CC=C6)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S,S)-PLX-4545 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,S)-PLX-45452892065-49-3Molecular GluesIKZF FamilyIkaros zinc finger protein familymolecular glueIKZF2 degraderIKZF2-mediated diseasesInhibitorinhibitorinhibit

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