1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. Vorinostat (GMP)

Vorinostat (GMP)  (Synonyms: SAHA (GMP); Suberoylanilide hydroxamic acid (GMP))

Cat. No.: HY-10221G
Handling Instructions Technical Support

Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available HDAC1, HDAC2, HDAC3 (Class I), HDAC6 and Inhibitors of HDAC7 (Class II) and Class IV (HDAC11).

For research use only. We do not sell to patients.

Vorinostat (GMP)

Vorinostat (GMP) Chemical Structure

CAS No. : 149647-78-9

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Description

Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available HDAC1, HDAC2, HDAC3 (Class I), HDAC6 and Inhibitors of HDAC7 (Class II) and Class IV (HDAC11)[1].

Cellular Effect
Cell Line Type Value Description References
4T1 IC50
1.59 μM
Compound: SAHA
Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
[PMID: 33586434]
4T1 IC50
12.12 μM
Compound: SAHA
Antiproliferative activity against mouse 4T1 cells assessed as cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse 4T1 cells assessed as cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36097406]
4T1 IC50
4.317 μM
Compound: SAHA
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
4T1 IC50
4.76 μM
Compound: Vorinostat
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
518A2 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human 518A2 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human 518A2 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
518A2 IC50
0.9 μM
Compound: Vorinostat
Antiproliferative activity against human 518A2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human 518A2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
786-0 GI50
3.2 μM
Compound: SAHA, Zolinza
Growth inhibition of human 786-0 cells after 72 hrs by MTS assay
Growth inhibition of human 786-0 cells after 72 hrs by MTS assay
[PMID: 22435669]
A-375 IC50
1.4 μM
Compound: Vorinostat
Antiproliferative activity against human A-375 cells
Antiproliferative activity against human A-375 cells
[PMID: 37875056]
A-375 IC50
2.68 μM
Compound: SAHA
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
A-375 IC50
2.827 μM
Compound: SAHA
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
A-375 IC50
4.1 μM
Compound: SAHA
Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 28131715]
A-431 GI50
4.48 μM
Compound: SAHA, Vorinostat
Growth inhibition of human A431 cells by MTT assay
Growth inhibition of human A431 cells by MTT assay
[PMID: 23601706]
A-431 IC50
0.63 μM
Compound: SAHA
Antiproliferative activity against human A-431 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells measured after 72 hrs by MTT assay
[PMID: 34847495]
A-431 IC50
1.47 μM
Compound: Vorinostat
Antiproliferative activity against human A431 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A431 cells incubated for 72 hrs by MTT assay
[PMID: 33493830]
A-431 IC50
2.29 μM
Compound: 8
Antiproliferative activity against human A431 cells expressing EGFR/HER2 assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human A431 cells expressing EGFR/HER2 assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 27769671]
A-431 IC50
3.13 μM
Compound: Vorinostat
Antiproliferative activity against human A-431 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human A-431 cells assessed as inhibition of cell growth by MTT assay
[PMID: 37875056]
A-431 IC50
3.5 μM
Compound: SAHA
Antiproliferative activity against human A431 cells after 72 hrs by SRB assay
Antiproliferative activity against human A431 cells after 72 hrs by SRB assay
[PMID: 29150335]
A-431 IC50
3.81 μM
Compound: SAHA
Cytotoxicity against human A-431 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A-431 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
A-431 IC50
4.2 μM
Compound: 2
Cytotoxicity against human A431 cells
Cytotoxicity against human A431 cells
[PMID: 17691763]
A-431 IC50
4.2 μM
Compound: 2a
Cytotoxicity against human A431 cells overexpressing EGFR by resazurin dye reduction assay
Cytotoxicity against human A431 cells overexpressing EGFR by resazurin dye reduction assay
[PMID: 21080629]
A-431 IC50
5.13 μM
Compound: Zolinza, SAHA
Antiproliferative activity against human A431 cells after 48 hrs by MTT assay
Antiproliferative activity against human A431 cells after 48 hrs by MTT assay
[PMID: 22698782]
A20 IC50
0.112 μM
Compound: SAHA
In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells
In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells
[PMID: 11960489]
A20 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against mouse A20 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against mouse A20 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
A2780 CC50
2600 nM
Compound: 1
Antiproliferative activity against human A2780 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human A2780 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19441846]
A2780 EC50
377.48 nM
Compound: SAHA
Inhibition of HDAC1/2/3 in human A2780S cells assessed as histone H3 acetylation incubated for 6 hrs by cytoblot assay
Inhibition of HDAC1/2/3 in human A2780S cells assessed as histone H3 acetylation incubated for 6 hrs by cytoblot assay
[PMID: 27186676]
A2780 EC50
399.25 nM
Compound: SAHA
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay
[PMID: 27186676]
A2780 GI50
3150 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human A2780 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human A2780 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
A2780 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
A2780 IC50
0.43 μM
Compound: 3; SAHA
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36449947]
A2780 IC50
0.44 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
A2780 IC50
0.53 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
A2780 IC50
0.64 μM
Compound: Vorinostat
Inhibition of HDAC in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further incubation for 3 hrs by microplate reader based fluorescence assay
Inhibition of HDAC in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further incubation for 3 hrs by microplate reader based fluorescence assay
[PMID: 31431326]
A2780 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
A2780 IC50
0.91 μM
Compound: 1
Inhibition of HDAC in human A2780 cells
Inhibition of HDAC in human A2780 cells
[PMID: 31787463]
A2780 IC50
0.96 μM
Compound: Vorinostat
Inhibition of HDAC in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and measured after 3 hrs by fluorescence assay
Inhibition of HDAC in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and measured after 3 hrs by fluorescence assay
[PMID: 31762274]
A2780 IC50
1.16 μM
Compound: Vorinostat
Antiproliferative activity against human A2780 cells after 72 hrs by microplate reader based MTT assay
Antiproliferative activity against human A2780 cells after 72 hrs by microplate reader based MTT assay
[PMID: 31431326]
A2780 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human A2780 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human A2780 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
A2780 IC50
1.62 μM
Compound: SAHA
Antiproliferative activity against human A2780 cells
Antiproliferative activity against human A2780 cells
[PMID: 20451378]
A2780 IC50
1.62 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human A2780 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human A2780 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
A2780 IC50
1.9 μM
Compound: SAHA
Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
[PMID: 23906422]
A2780 IC50
2.04 μM
Compound: 1
Cytotoxicity against human A2780 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability by MTT assay
[PMID: 31787463]
A2780 IC50
2.1 μM
Compound: SAHA
Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
[PMID: 29150335]
A2780 IC50
2.1 μM
Compound: SAHA
Antiproliferative activity against human A2780 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human A2780 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
A2780 IC50
2.42 μM
Compound: SAHA, vorinostat
Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
[PMID: 23252603]
A2780 IC50
2.42 μM
Compound: Vorinostat
Cytotoxicity against human A2780 cells assessed as reduction in cell survival measured after 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell survival measured after 72 hrs by MTT assay
[PMID: 31762274]
A2780 IC50
2.42 μM
Compound: Vorinostat
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33360560]
A2780 IC50
2600 nM
Compound: 1, vorinostat
Antiproliferative activity against human A2780 cells by CellTiter-Blue cell viability assay
Antiproliferative activity against human A2780 cells by CellTiter-Blue cell viability assay
[PMID: 18370373]
A2780 IC50
3.12 μM
Compound: SAHA, vorinostat
Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
[PMID: 23252603]
A2780 IC50
380 nM
Compound: Vorinostat
Antiproliferative activity against human A2780 cells
Antiproliferative activity against human A2780 cells
[PMID: 37875056]
A2780 IC50
8.82 μM
Compound: SAHA
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth by MTT assay
[PMID: 37116762]
A2780 IC50
870 nM
Compound: SAHA
Cytotoxicity against human A2780S cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human A2780S cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 27186676]
A2780 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
[PMID: 26443078]
A2780S IC50
5541 nM
Compound: SAHA
Antiproliferative activity against human A2780S cells after 72 hrs by MTT assay
Antiproliferative activity against human A2780S cells after 72 hrs by MTT assay
[PMID: 31177073]
A498 GI50
1.4 μM
Compound: SAHA
Antiproliferative activity against human A498 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human A498 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
A498 GI50
1.6 μM
Compound: SAHA, Zolinza
Growth inhibition of human A498 cells after 72 hrs by MTS assay
Growth inhibition of human A498 cells after 72 hrs by MTS assay
[PMID: 22435669]
A498 IC50
25.08 μM
Compound: SAHA
Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 34111829]
A549 CC50
1800 nM
Compound: 1
Antiproliferative activity against human P53 expressing A549 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human P53 expressing A549 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19441846]
A549 EC50
1 μM
Compound: SAHA
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA
[PMID: 25734520]
A549 EC50
1.03 μM
Compound: SAHA
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay
[PMID: 25238284]
A549 EC50
12 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells measured after 72 hrs by WST1 assay
Antiproliferative activity against human A549 cells measured after 72 hrs by WST1 assay
[PMID: 27597246]
A549 EC50
8.3 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 23820574]
A549 GI50
0.79 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
[PMID: 21712146]
A549 GI50
1.02 μM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 31655430]
A549 GI50
1.02 μM
Compound: 1; SAHA
Growth inhibition of human A549 cells incubated for 48 hrs by SRB assay
Growth inhibition of human A549 cells incubated for 48 hrs by SRB assay
[PMID: 32058238]
A549 GI50
1.02 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
Antiproliferative activity against human A549 cells after 48 hrs by SRB assay
[PMID: 27344487]
A549 GI50
1.02 μM
Compound: SAHA; 1
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 29567459]
A549 GI50
1.6 μM
Compound: SAHA, Zolinza
Growth inhibition of human A549/ATCC cells after 72 hrs by MTS assay
Growth inhibition of human A549/ATCC cells after 72 hrs by MTS assay
[PMID: 22435669]
A549 GI50
1.73 μM
Compound: 1; SAHA
Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 28395150]
A549 GI50
1.78 μM
Compound: SAHA, Vorinostat
Growth inhibition of human A549 cells by MTT assay
Growth inhibition of human A549 cells by MTT assay
[PMID: 23601706]
A549 GI50
1.85 μM
Compound: 1, SAHA
Growth inhibition of human A549 cells after 48 hrs by SRB assay
Growth inhibition of human A549 cells after 48 hrs by SRB assay
[PMID: 22439863]
A549 GI50
19.45 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 28629630]
A549 GI50
2.62 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
[PMID: 31924504]
A549 GI50
3.1 μM
Compound: SAHA, Zolinza
Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
[PMID: 22435669]
A549 GI50
3.13 μM
Compound: 1, SAHA
Growth inhibition of human A549 cells after 96 hrs by MTT assay
Growth inhibition of human A549 cells after 96 hrs by MTT assay
[PMID: 26814680]
A549 GI50
5.02 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells after 96 hrs by MTT assay
Antiproliferative activity against human A549 cells after 96 hrs by MTT assay
[PMID: 29500130]
A549 GI50
5.27 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
A549 GI50
5.4 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 34500130]
A549 GI50
5700 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human A549 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human A549 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
A549 GI50
> 200 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 19822426]
A549 GI50
> 410 nM
Compound: Vorinostat
Cytotoxicity against human A549 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
A549 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
A549 IC50
0.427 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
A549 IC50
0.493 μM
Compound: Vorinostat
Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 37875056]
A549 IC50
0.59 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
[PMID: 34237620]
A549 IC50
0.6 mM
Compound: Vorinostat
Antiproliferative activity against human A549 cells after 2 days by MTT assay
Antiproliferative activity against human A549 cells after 2 days by MTT assay
[PMID: 19608304]
A549 IC50
0.61 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
[PMID: 37875056]
A549 IC50
0.63 μM
Compound: 8
Cytotoxicity against human A549 cells expressing EGFR and KRAS mutant assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells expressing EGFR and KRAS mutant assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 27769671]
A549 IC50
0.64 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability
Antiproliferative activity against human A549 cells assessed as reduction in cell viability
[PMID: 35643262]
A549 IC50
0.68 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
[PMID: 37875056]
A549 IC50
0.69 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 21733698]
A549 IC50
0.74 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 21476600]
A549 IC50
0.76 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs
Antiproliferative activity against human A549 cells after 48 hrs
[PMID: 20576572]
A549 IC50
0.84 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 48 hrs by resazurin based microplate reader analysis
Antiproliferative activity against human A549 cells incubated for 48 hrs by resazurin based microplate reader analysis
[PMID: 37647727]
A549 IC50
0.86 μM
Compound: SAHA
Anti-proliferative activity against human A549 cells after 48 hrs by MTT assay
Anti-proliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 28947154]
A549 IC50
0.868 μM
Compound: SAHA
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 20855208]
A549 IC50
0.89 μM
Compound: 1
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
[PMID: 35238576]
A549 IC50
1.02 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 37875056]
A549 IC50
1.079 μM
Compound: SAHA
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
[PMID: 23644210]
A549 IC50
1.079 μM
Compound: vorinostat
Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by CellTitre-Glo luminescent assay
Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by CellTitre-Glo luminescent assay
[PMID: 26629860]
A549 IC50
1.08 μM
Compound: SAHA
Cytotoxicity against human A549 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human A549 cells after 72 hrs by CellTiter-Glo assay
[PMID: 30245394]
A549 IC50
1.08 μM
Compound: SAHA, Vorinostat
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter-Glo assay
[PMID: 23792316]
A549 IC50
1.1 μM
Compound: 4; SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability
Antiproliferative activity against human A549 cells assessed as reduction in cell viability
[PMID: 34314844]
A549 IC50
1.23 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 36549114]
A549 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
A549 IC50
1.25 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
[PMID: 37086699]
A549 IC50
1.35 μM
Compound: Vorinostat
Cytotoxicity against human A549 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
A549 IC50
1.5 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
A549 IC50
1.54 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
[PMID: 24766560]
A549 IC50
1.62 μM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
A549 IC50
1.65 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
[PMID: 25874326]
A549 IC50
1.65 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 25953722]
A549 IC50
1.67 μM
Compound: SAHA
Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
[PMID: 33744687]
A549 IC50
1.69 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 35858522]
A549 IC50
1.7 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 29223096]
A549 IC50
1.7 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 32738414]
A549 IC50
1.7 μM
Compound: SAHA
Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
[PMID: 33744687]
A549 IC50
1.79 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK-8 assay
[PMID: 37057760]
A549 IC50
1.79 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 38964169]
A549 IC50
1.8 μM
Compound: 2
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
[PMID: 17691763]
A549 IC50
1.8 μM
Compound: 2a
Cytotoxicity against human A549 cells overexpressing HDAC by resazurin dye reduction assay
Cytotoxicity against human A549 cells overexpressing HDAC by resazurin dye reduction assay
[PMID: 21080629]
A549 IC50
1.91 μM
Compound: XII; SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
A549 IC50
12.46 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00247H
A549 IC50
12.5 nM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs in presence of SN-38 by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs in presence of SN-38 by SRB assay
[PMID: 32679451]
A549 IC50
12.6 μM
Compound: SAHA
Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
[PMID: 18247554]
A549 IC50
15.73 μM
Compound: SAHA
Antiproliferative activity in human A549 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human A549 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 32061484]
A549 IC50
17.9 μM
Compound: SAHA, vorinostat
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23707260]
A549 IC50
1746.95 nM
Compound: SAHA
Antiproliferative activity against human A549 cells after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells after 72 hrs by SRB assay
[PMID: 30115492]
A549 IC50
1800 nM
Compound: 1, SAHA
Antiproliferative activity against human A549 cells after 72 hrs by celltiter-blue viability assay
Antiproliferative activity against human A549 cells after 72 hrs by celltiter-blue viability assay
[PMID: 18809328]
A549 IC50
1800 nM
Compound: 1, SAHA
Antiproliferative activity against human A549 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human A549 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19410459]
A549 IC50
1800 nM
Compound: 1, vorinostat
Antiproliferative activity against human A549 cells by CellTiter-Blue cell viability assay
Antiproliferative activity against human A549 cells by CellTiter-Blue cell viability assay
[PMID: 18370373]
A549 IC50
1862 nM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
A549 IC50
2.01 μM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
[PMID: 30045621]
A549 IC50
2.1 μM
Compound: SAHA
Antiproliferative against human A549 cells assessed as reduction in cell viability by MTT assay
Antiproliferative against human A549 cells assessed as reduction in cell viability by MTT assay
[PMID: 33045329]
A549 IC50
2.2 μM
Compound: 6, SAHA
Cytotoxicity against human A549 cells after 72 hrs by alamar-blue cell viability assay
Cytotoxicity against human A549 cells after 72 hrs by alamar-blue cell viability assay
[PMID: 19301902]
A549 IC50
2.24 μM
Compound: SAHA
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 30525585]
A549 IC50
2.27 μM
Compound: Vorinostat
Cytotoxicity against human A549 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
Cytotoxicity against human A549 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
[PMID: 23829483]
A549 IC50
2.36 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
A549 IC50
2.39 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 28987602]
A549 IC50
2.42 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
[PMID: 31413795]
A549 IC50
2.43 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
[PMID: 37875056]
A549 IC50
2.47 μM
Compound: 1; SAHA
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
[PMID: 36215854]
A549 IC50
2.57 μM
Compound: SAHA
Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
[PMID: 32961382]
A549 IC50
2.61 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
A549 IC50
2.63 μM
Compound: 4; SAHA
Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
A549 IC50
2.79 μM
Compound: SAHA
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 35041998]
A549 IC50
2.9 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells by CCK8 assay
Antiproliferative activity against human A549 cells by CCK8 assay
[PMID: 30660827]
A549 IC50
2.92 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37875056]
A549 IC50
2.93 μM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 32180916]
A549 IC50
2651.1 nM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 32679451]
A549 IC50
27.8 μM
Compound: Zolinza, SAHA
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 22698782]
A549 IC50
3 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
A549 IC50
3.14 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 96 hrs by resazurin assay
Antiproliferative activity against human A549 cells incubated for 96 hrs by resazurin assay
[PMID: 32435375]
A549 IC50
3.29 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
A549 IC50
3.5 μM
Compound: 2; SAHA
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 34634618]
A549 IC50
3.7 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs
Antiproliferative activity against human A549 cells after 48 hrs
[PMID: 24262004]
A549 IC50
3.7 μM
Compound: Vorinostat
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
A549 IC50
3.8 μM
Compound: 1, SAHA
Inhibition of human A549 cell proliferation after 48 hrs by MTT assay
Inhibition of human A549 cell proliferation after 48 hrs by MTT assay
[PMID: 23493449]
A549 IC50
3.9 μM
Compound: SA, SAHA
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 24694055]
A549 IC50
3.9 μM
Compound: SAHA
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 25462271]
A549 IC50
35 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
A549 IC50
4.11 μM
Compound: SAHA
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 38452727]
A549 IC50
4.12 μM
Compound: 1; SAHA
Cytotoxicity against human A549 cells assessed as decrease in cell viability measured after 72 hrs by CellTiter-Glo Luminescent assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability measured after 72 hrs by CellTiter-Glo Luminescent assay
[PMID: 31223439]
A549 IC50
4.25 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 33493830]
A549 IC50
4.3 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
[PMID: 34624191]
A549 IC50
4.33 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
A549 IC50
4.372 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
A549 IC50
4.4 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 29348808]
A549 IC50
4.4 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
A549 IC50
4.5 μM
Compound: SAHA
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 23570542]
A549 IC50
4.97 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
10.1039/C4MD00203B
A549 IC50
476.86 nM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells measured after 48 hrs by sulforhodamine-B assay
Antiproliferative activity against human A549 cells measured after 48 hrs by sulforhodamine-B assay
[PMID: 27886544]
A549 IC50
5 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 28057407]
A549 IC50
5 μM
Compound: SAHA
Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
[PMID: 31546197]
A549 IC50
5.32 μM
Compound: SAHA
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26149591]
A549 IC50
5.37 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
10.1039/C5MD00247H
A549 IC50
5.48 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay
[PMID: 39145486]
A549 IC50
5.74 μM
Compound: I-1; SAHA
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 35245830]
A549 IC50
6.74 μM
Compound: SAHA; 6
Antiproliferative activity against human A549 cells incubated for 72 hrs by celltiter-glo luminescent assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by celltiter-glo luminescent assay
[PMID: 39178382]
A549 IC50
7.06 μM
Compound: SAHA
Antiproliferative activity against human A549 cells incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human A549 cells incubated for 24 hrs by CCK8 assay
[PMID: 32247729]
A549 IC50
7.32 μM
Compound: 1; SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
[PMID: 34656899]
A549 IC50
7.44 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
[PMID: 35043615]
A549 IC50
7.49 μM
Compound: SAHA
Antiproliferative activity against human A549 cells measured after 72 hrs
Antiproliferative activity against human A549 cells measured after 72 hrs
[PMID: 35697181]
A549 IC50
78.76 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
10.1039/C5MD00247H
A549 IC50
80.3 μM
Compound: SAHA, vorinostat
Cytotoxicity against SAHA-resistant human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against SAHA-resistant human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23707260]
A549 IC50
9.13 μM
Compound: Vorinostat
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 74 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 74 hrs by SRB assay
[PMID: 35255412]
A549 IC50
9.484 μM
Compound: SAHA
Anticancer activity against human A549 cells assessed as inhibition of cell growth measured for 48 hrs by MTT assay
Anticancer activity against human A549 cells assessed as inhibition of cell growth measured for 48 hrs by MTT assay
[PMID: 38897139]
A549 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 34116381]
A549 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 35272009]
A549 IC50
> 100 μM
Compound: SAHA
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
A549 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 26443078]
ACHN GI50
0.65 μM
Compound: SAHA
Growth inhibition of human ACHN cells after 21 hrs by MTT assay
Growth inhibition of human ACHN cells after 21 hrs by MTT assay
[PMID: 17662606]
ACHN GI50
0.73 μM
Compound: 1, SAHA
Growth inhibition of ACHN cells by SRB assay
Growth inhibition of ACHN cells by SRB assay
[PMID: 17477518]
ACHN GI50
0.73 μM
Compound: 2, SAHA
Antiproliferative activity against human ACHN cells by SRB assay
Antiproliferative activity against human ACHN cells by SRB assay
[PMID: 16723227]
ACHN GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human ACHN cells after 72 hrs by MTS assay
Growth inhibition of human ACHN cells after 72 hrs by MTS assay
[PMID: 22435669]
ACHN GI50
2.22 μM
Compound: 2, SAHA
Growth inhibition of human ACHN cells by SRB assay
Growth inhibition of human ACHN cells by SRB assay
[PMID: 17904843]
ACHN GI50
4.22 μM
Compound: 1, SAHA
Growth inhibition of human ACHN cells
Growth inhibition of human ACHN cells
[PMID: 20850971]
ACHN GI50
4.22 μM
Compound: 1, SAHA, Zolinza, Vorinostat
Cytotoxicity against human ACHN cells assessed as growth inhibition by SRB assay
Cytotoxicity against human ACHN cells assessed as growth inhibition by SRB assay
[PMID: 23163332]
ACHN GI50
4.22 μM
Compound: SAHA
Growth inhibition of human ACHN cells after 5 days by sulforhodamine B assay
Growth inhibition of human ACHN cells after 5 days by sulforhodamine B assay
[PMID: 25811792]
ACHN GI50
4.22 μM
Compound: SAHA
Growth inhibition of human ACHN cells measured after 5 days by sulforhodamine-B assay
Growth inhibition of human ACHN cells measured after 5 days by sulforhodamine-B assay
[PMID: 28011426]
ACHN IC50
2.08 μM
Compound: SAHA
Antiproliferative activity against human ACHN cells after 72 hrs by MTT assay
Antiproliferative activity against human ACHN cells after 72 hrs by MTT assay
[PMID: 29787262]
AGS IC50
4 μM
Compound: SAHA
Cytotoxicity against human AGS cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human AGS cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34628244]
AGS IC50
4.23 μM
Compound: SAHA
Antiproliferative activity against human AGS cells after 72 hrs by MTT assay
Antiproliferative activity against human AGS cells after 72 hrs by MTT assay
[PMID: 29787262]
AGS IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human AGS cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human AGS cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
AML12 IC50
> 5 μM
Compound: SAHA
Cytotoxicity against AML12 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against AML12 cells incubated for 72 hrs measured by MTT assay
[PMID: 37498552]
ASPC1 GI50
2.09 μM
Compound: 1, SAHA
Growth inhibition of human Aspc-1 cells after 96 hrs by MTT assay
Growth inhibition of human Aspc-1 cells after 96 hrs by MTT assay
[PMID: 26814680]
ASPC1 GI50
5.44 μM
Compound: 1; SAHA
Growth inhibition of human AsPC1 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human AsPC1 cells after 48 hrs by sulforhodamine B assay
[PMID: 28395150]
ASPC1 IC50
0.69 μg/mL
Compound: SAHA
Cytotoxicity against human AsPC1 cells
Cytotoxicity against human AsPC1 cells
[PMID: 22036991]
ASPC1 IC50
100 μM
Compound: 2
Cytotoxicity against human AsPC1 cells
Cytotoxicity against human AsPC1 cells
[PMID: 17691763]
ASPC1 IC50
3.09 μM
Compound: SAHA
Antiproliferative activity against human ASPC1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human ASPC1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36097406]
ASPC1 IC50
3.2 μM
Compound: SAHA
Antiproliferative activity against human Aspc-1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human Aspc-1 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31546197]
ASPC1 IC50
3.2 μM
Compound: Vorinostat
Cytotoxicity against human ASPC1 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human ASPC1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
ASPC1 IC50
3.66 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human AsPC1 cells after 48 hrs by SRB assay
Antiproliferative activity against human AsPC1 cells after 48 hrs by SRB assay
[PMID: 24185378]
ASPC1 IC50
> 411 nM
Compound: Vorinostat
Cytotoxicity against human ASPC1 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human ASPC1 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
B16 IC50
2.26 μM
Compound: I-1; SAHA
Antiproliferative activity against mouse B16 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse B16 cells after 72 hrs by MTT assay
[PMID: 35245830]
B16 IC50
4.44 μM
Compound: 1, SAHA
Cytotoxicity against mouse B16 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against mouse B16 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26122774]
B16-F10 IC50
11.36 μM
Compound: SAHA
Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
[PMID: 35043615]
B16-F10 IC50
13.1 μM
Compound: SAHA
Cytotoxicity against mouse B16F10 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against mouse B16F10 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 28131715]
B16-F10 IC50
13.52 μM
Compound: SAHA
Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
B16-F10 IC50
2.067 μM
Compound: SAHA
Cytotoxicity against human B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
BE(2)-C IC50
1.1 μM
Compound: SAHA
Antiproliferative activity against human BE(2)-C cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human BE(2)-C cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25238284]
BE(2)-C IC50
2 μM
Compound: SAHA, vorinostat
Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
[PMID: 22932316]
BE(2)-C IC50
2.112 μM
Compound: SAHA
Antiproliferative activity against human BE2C cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human BE2C cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
BEAS-2B IC50
> 50 μM
Compound: 1; SAHA
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 32180916]
BGC-823 GI50
3.09 μM
Compound: SAHA, Vorinostat
Growth inhibition of human BGC823 cells by MTT assay
Growth inhibition of human BGC823 cells by MTT assay
[PMID: 23601706]
BGC-823 GI50
4.26 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human BGC823 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human BGC823 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
BGC-823 IC50
12.98 μM
Compound: SAHA
Cytotoxicity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34628244]
BGC-823 IC50
2.94 μM
Compound: SAHA
Antiproliferative activity against human BGC823 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human BGC823 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
BGC-823 IC50
9.34 μM
Compound: SAHA
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
BJ IC50
> 100 μM
Compound: SAHA
Growth inhibition of human BJ cells after 48 hrs by MTT assay
Growth inhibition of human BJ cells after 48 hrs by MTT assay
[PMID: 20143840]
BMDM CC50
5 μM
Compound: 1
Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability measured after 72 hrs by tryphan blue assay
Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability measured after 72 hrs by tryphan blue assay
[PMID: 32392053]
BT-474 IC50
2.67 μM
Compound: 8
Cytotoxicity against human BT474 cells expressing HER2 assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human BT474 cells expressing HER2 assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 27769671]
BT-549 GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human BT549 cells after 72 hrs by MTS assay
Growth inhibition of human BT549 cells after 72 hrs by MTS assay
[PMID: 22435669]
BT-549 IC50
2.3 μM
Compound: SAHA
Cytotoxicity against human BT-549 cells harboring wild type BRCA1 and wild type BRCA2 assessed as reduction in cell viability
Cytotoxicity against human BT-549 cells harboring wild type BRCA1 and wild type BRCA2 assessed as reduction in cell viability
[PMID: 36053318]
BT-549 IC50
2.96 μM
Compound: SAHA
Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
[PMID: 33586434]
BT-549 IC50
8.67 μM
Compound: SAHA
Cytotoxicity against human BT-549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human BT-549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
BXPC-3 GI50
5.56 μM
Compound: Vorin
Cytotoxicity against human BxPC3 cells after 72 hrs by MTS assay
Cytotoxicity against human BxPC3 cells after 72 hrs by MTS assay
[PMID: 24900743]
BXPC-3 IC50
2.1 μM
Compound: SAHA
Antiproliferative activity against human BXPC-3 cells incubated for 48 hrs by resazurin based microplate reader analysis
Antiproliferative activity against human BXPC-3 cells incubated for 48 hrs by resazurin based microplate reader analysis
[PMID: 37647727]
BXPC-3 IC50
2.7 μM
Compound: SAHA
Antiproliferative activity against human BxPC3 cells after hrs by ATP content assay
Antiproliferative activity against human BxPC3 cells after hrs by ATP content assay
[PMID: 20143778]
BXPC-3 IC50
4.74 μM
Compound: SAHA
Antiproliferative activity against human BXPC-3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human BXPC-3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36097406]
BXPC-3 IC50
5 μM
Compound: 1a, SAHA
Growth inhibition of human BxPC3 cells after 72 hrs by MTS assay
Growth inhibition of human BxPC3 cells after 72 hrs by MTS assay
[PMID: 20055418]
BXPC-3 IC50
5 μM
Compound: SAHA
Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay
Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay
[PMID: 18494463]
BXPC-3 IC50
5 μM
Compound: SAHA
Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
[PMID: 18642892]
BXPC-3 IC50
5 μM
Compound: SAHA
Antiproliferative activity against human BxPC3 cells by MTT assay
Antiproliferative activity against human BxPC3 cells by MTT assay
[PMID: 19419863]
BaF3 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
BaF3 IC50
0.8 μM
Compound: SAHA
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
Bcap37 IC50
3.098 μM
Compound: SAHA
Cytotoxicity against human Bcap37 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human Bcap37 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
Bel-7402 IC50
1.8 μM
Compound: SAHA
Cytotoxicity against human Bel-7402 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against human Bel-7402 cells incubated for 72 hrs measured by MTT assay
[PMID: 37498552]
Bel-7402 IC50
27.35 μM
Compound: SAHA
Antiproliferative activity against human Bel-7402 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
Bel-7402 IC50
4.207 μM
Compound: SAHA
Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
Bel-7402 IC50
4.7 μM
Compound: SAHA
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
[PMID: 31120744]
Bel-7402 IC50
4.72 μM
Compound: SAHA
Antiproliferative activity against human Bel7402 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells incubated for 48 hrs by MTT assay
[PMID: 30851694]
Bel-7402 IC50
7.1 μM
Compound: 5; SAHA
Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay
Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay
[PMID: 31117517]
Bel7402/5-FU IC50
9.83 μM
Compound: SAHA
Antiproliferative activity against human Bel7402/5-FU cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human Bel7402/5-FU cells incubated for 48 hrs by MTT assay
[PMID: 30851694]
C6 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
C6 IC50
2.97 μM
Compound: Vorinostat
Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 37875056]
CAKI-1 GI50
1.2 μM
Compound: SAHA
Antiproliferative activity against human Caki1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human Caki1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
CAKI-1 IC50
32.46 μM
Compound: SAHA
Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 34111829]
CAKI-1 IC50
517 nM
Compound: 1; SAHA
Antiproliferative activity against human CAKI-1 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human CAKI-1 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
CAL-27 IC50
0.36 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in cisplatin sensitive human CAL27 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in cisplatin sensitive human CAL27 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
CAL-27 IC50
0.59 μM
Compound: 1
Inhibition of HDAC in human Cal27 cells
Inhibition of HDAC in human Cal27 cells
[PMID: 31787463]
CAL-27 IC50
0.61 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in cisplatin resistant human CAL27 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in cisplatin resistant human CAL27 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
CAL-27 IC50
1.5 μM
Compound: 1
Cytotoxicity against human CAL27 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human CAL27 cells assessed as reduction in cell viability by MTT assay
[PMID: 31787463]
CAL-27 IC50
1.96 μM
Compound: Vorinostat
Inhibition of class 1 HDAC in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and measured after 72 hrs by MTT assay (Rvb = 9.79 uM)
Inhibition of class 1 HDAC in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and measured after 72 hrs by MTT assay (Rvb = 9.79 uM)
[PMID: 31762274]
CAL-27 IC50
1.98 μM
Compound: Vorinostat
Antiproliferative activity against human CAL27 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human CAL27 cells measured after 72 hrs by MTT assay
[PMID: 28581289]
CAL-27 IC50
1.98 μM
Compound: Vorinostat
Antiproliferative activity against human CAL-27 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human CAL-27 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33360560]
CAL-27 IC50
1.99 μM
Compound: Vorinostat
Antiproliferative activity against human CAL27 cells after 72 hrs by microplate reader based MTT assay
Antiproliferative activity against human CAL27 cells after 72 hrs by microplate reader based MTT assay
[PMID: 31431326]
CAL-27 IC50
2.08 μM
Compound: SAHA, vorinostat
Cytotoxicity against cisplatin resistant human CAL27 cells after 72 hrs by MTT assay
Cytotoxicity against cisplatin resistant human CAL27 cells after 72 hrs by MTT assay
[PMID: 23252603]
CAL-27 IC50
2.64 μM
Compound: SAHA, vorinostat
Cytotoxicity against cisplatin sensitive human CAL27 cells after 72 hrs by MTT assay
Cytotoxicity against cisplatin sensitive human CAL27 cells after 72 hrs by MTT assay
[PMID: 23252603]
CAL-27 IC50
2.64 μM
Compound: Vorinostat
Cytotoxicity against human CAL27 cells assessed as reduction in cell survival measured after 72 hrs by MTT assay
Cytotoxicity against human CAL27 cells assessed as reduction in cell survival measured after 72 hrs by MTT assay
[PMID: 31762274]
CAL-27 IC50
3.2 μM
Compound: 2
Cytotoxicity against human Cal27 cells
Cytotoxicity against human Cal27 cells
[PMID: 17691763]
CAL-27 IC50
3.2 μM
Compound: 2a
Cytotoxicity against human CAL27 cells overexpressing EGFR by resazurin dye reduction assay
Cytotoxicity against human CAL27 cells overexpressing EGFR by resazurin dye reduction assay
[PMID: 21080629]
CAL-27 IC50
3.72 μM
Compound: SAHA
Antiproliferative activity against human CAL27 cells
Antiproliferative activity against human CAL27 cells
[PMID: 20143778]
CAL-51 IC50
1.04 μM
Compound: SAHA
Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
[PMID: 33586434]
CAPAN-1 IC50
1.8 μM
Compound: SAHA
Antiproliferative activity against human Capan1 cells after 72 hrs by SRB assay
Antiproliferative activity against human Capan1 cells after 72 hrs by SRB assay
[PMID: 29150335]
CAPAN-1 IC50
1.89 μM
Compound: SAHA
Antiproliferative activity against human CAPAN-1 cells assessed as reduction in cell viability
Antiproliferative activity against human CAPAN-1 cells assessed as reduction in cell viability
[PMID: 35643262]
CAPAN-1 IC50
5.4 μM
Compound: SAHA
Anticancer activity against human CAPAN-1 cells
Anticancer activity against human CAPAN-1 cells
[PMID: 34107385]
CAPAN-1 IC50
5.4 μM
Compound: Vorinostat
Antiproliferative activity against human CAPAN-1 cells
Antiproliferative activity against human CAPAN-1 cells
[PMID: 37875056]
CAPAN-1 IC50
7.3 μM
Compound: SAHA
Antiproliferative activity against human Capan1 cells after hrs by ATP content assay
Antiproliferative activity against human Capan1 cells after hrs by ATP content assay
[PMID: 20143778]
CCRF-CEM CC50
2.5 μM
Compound: SAHA
Cytotoxicity against human CEM cells assessed as cell death incubated for 20 hrs measured by DNS assay
Cytotoxicity against human CEM cells assessed as cell death incubated for 20 hrs measured by DNS assay
[PMID: 34006099]
CCRF-CEM GI50
0.7 μM
Compound: SAHA
Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
CCRF-CEM GI50
0.8 μM
Compound: SAHA, Zolinza
Growth inhibition of human CCRF-CEM cells after 72 hrs by MTS assay
Growth inhibition of human CCRF-CEM cells after 72 hrs by MTS assay
[PMID: 22435669]
CCRF-CEM IC50
0.33 μM
Compound: SAHA
Inhibition of HDAC in human leukemic CEM cells
Inhibition of HDAC in human leukemic CEM cells
[PMID: 16420064]
CCRF-CEM IC50
0.33 μM
Compound: SAHA
Inhibition of HDAC in human CEM cells
Inhibition of HDAC in human CEM cells
[PMID: 18247554]
CCRF-CEM IC50
0.8 μM
Compound: 2
Cytotoxicity against human CCRF-CEM cells
Cytotoxicity against human CCRF-CEM cells
[PMID: 17691763]
CCRF-CEM IC50
0.8 μM
Compound: 6, SAHA
Cytotoxicity against human CCRF-CEM cells after 72 hrs by alamar-blue cell viability assay
Cytotoxicity against human CCRF-CEM cells after 72 hrs by alamar-blue cell viability assay
[PMID: 19301902]
CCRF-CEM IC50
0.95 μM
Compound: 2
Cytotoxicity against vincristine resistant human CCRF-CEM cells
Cytotoxicity against vincristine resistant human CCRF-CEM cells
[PMID: 17691763]
CCRF-CEM IC50
1.9 μM
Compound: SAHA
Inhibition of human leukemic CEM cell viability
Inhibition of human leukemic CEM cell viability
[PMID: 16420064]
CCRF-CEM IC50
1.9 μM
Compound: SAHA
Inhibition of human CEM cells assessed as viability
Inhibition of human CEM cells assessed as viability
[PMID: 18247554]
CESS IC50
1.78 μM
Compound: SAHA; 6
Antiproliferative activity against human CESS cells incubated for 72 hrs by celltiter-glo luminescent assay
Antiproliferative activity against human CESS cells incubated for 72 hrs by celltiter-glo luminescent assay
[PMID: 39178382]
CHP-134 IC50
1.74 μM
Compound: Vorinostat
Antiproliferative activity against human CHP134 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
Antiproliferative activity against human CHP134 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
[PMID: 31391882]
CMK IC50
439.3 nM
Compound: SAHA
Antiproliferative activity against human CMK cells after 72 hrs by MTT assay
Antiproliferative activity against human CMK cells after 72 hrs by MTT assay
[PMID: 27505848]
CMK IC50
490.2 nM
Compound: SAHA
Antiproliferative activity against Ara-C resistant human CMK cells after 72 hrs by MTT assay
Antiproliferative activity against Ara-C resistant human CMK cells after 72 hrs by MTT assay
[PMID: 27505848]
CNE-2 IC50
1.3 μM
Compound: SAHA
Antiproliferative activity against human CNE-2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human CNE-2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
COLO 205 GI50
0.79 μM
Compound: SAHA, Zolinza
Growth inhibition of human COLO205 cells after 72 hrs by MTS assay
Growth inhibition of human COLO205 cells after 72 hrs by MTS assay
[PMID: 22435669]
COLO 205 GI50
4 μM
Compound: SAHA, Zolinza
Growth inhibition of human COLO205 cells after 72 hrs by MTS assay
Growth inhibition of human COLO205 cells after 72 hrs by MTS assay
[PMID: 22435669]
COLO 205 IC50
1.8 μM
Compound: SAHA
Cytotoxicity against human COLO205 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human COLO205 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
COLO 205 IC50
2.12 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human COLO205 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human COLO205 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
COLO 205 IC50
2.2 μM
Compound: SAHA
Inhibition of HDAC1 in human COLO205 cells assessed as induction of histone H3 acetylation
Inhibition of HDAC1 in human COLO205 cells assessed as induction of histone H3 acetylation
[PMID: 20451378]
COLO 205 IC50
2.9 μM
Compound: SAHA
Antiproliferative activity against human COLO205 cells after 96 hrs by celltiter assay
Antiproliferative activity against human COLO205 cells after 96 hrs by celltiter assay
[PMID: 19181524]
COR-L23 GI50
1100 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human COR-L23 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human COR-L23 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
COR-L23 GI50
3300 nM
Compound: SAHA, vorinostat
Antiproliferative activity against doxorubicin-resistant human COR-L23 cells after 72 hrs by WST-1 assay
Antiproliferative activity against doxorubicin-resistant human COR-L23 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
CT26 GI50
2.35 μM
Compound: 3; SAHA
Antiproliferative activity against mouse CT26 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against mouse CT26 cells after 72 hrs by CCK-8 assay
[PMID: 35390714]
CT26 GI50
2.7 μM
Compound: 7; SAHA
Antiproliferative activity against mouse CT26 cells measured after 72 hrs by CCK8 assay
Antiproliferative activity against mouse CT26 cells measured after 72 hrs by CCK8 assay
[PMID: 34783558]
CT26 IC50
5.65 μM
Compound: I-1; SAHA
Antiproliferative activity against mouse CT26 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse CT26 cells after 72 hrs by MTT assay
[PMID: 35245830]
CT26 IC50
5.97 μM
Compound: 4; SAHA
Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
Caco-2 IC50
0.037 μM
Compound: SAHA
Induction of HDAC-mediated histone acetylation in human Caco-2 cells at 5 uM after 6 hrs by indirect ELISA
Induction of HDAC-mediated histone acetylation in human Caco-2 cells at 5 uM after 6 hrs by indirect ELISA
[PMID: 20143840]
Caco-2 IC50
0.119 μM
Compound: SAHA
Ex vivo inhibition of human HDAC1 in human Caco-2 cells by fluorometric cellular activity assay
Ex vivo inhibition of human HDAC1 in human Caco-2 cells by fluorometric cellular activity assay
[PMID: 20143840]
Caco-2 IC50
0.147 μM
Compound: SAHA
Ex vivo inhibition of human HDAC3 in human Caco-2 cells by fluorometric cellular activity assay
Ex vivo inhibition of human HDAC3 in human Caco-2 cells by fluorometric cellular activity assay
[PMID: 20143840]
Caco-2 IC50
12.6 μM
Compound: SAHA
Ex vivo inhibition of human HDAC5 in human Caco-2 cells by fluorometric cellular activity assay
Ex vivo inhibition of human HDAC5 in human Caco-2 cells by fluorometric cellular activity assay
[PMID: 20143840]
Caco-2 IC50
3 μM
Compound: SAHA
Cytotoxicity against human Caco2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human Caco2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
Caco-2 IC50
41 μM
Compound: SAHA
Ex vivo inhibition of human HDAC7 in human Caco-2 cells by fluorometric cellular activity assay
Ex vivo inhibition of human HDAC7 in human Caco-2 cells by fluorometric cellular activity assay
[PMID: 20143840]
Caco-2 IC50
8.1 μM
Compound: SAHA
Growth inhibition of human Caco-2 cells after 48 hrs by MTT assay
Growth inhibition of human Caco-2 cells after 48 hrs by MTT assay
[PMID: 20143840]
Calu-3 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human Calu-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human Calu-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
Capan-2 IC50
3 μM
Compound: 5; SAHA
Antiproliferative activity against human Capan2 cells after 96 hrs by MTT assay
Antiproliferative activity against human Capan2 cells after 96 hrs by MTT assay
[PMID: 31117517]
DG-75 IC50
2.1 μM
Compound: SAHA
Antiproliferative activity against human DG75 cells after 72 hrs by MTT assay
Antiproliferative activity against human DG75 cells after 72 hrs by MTT assay
[PMID: 29150335]
DLD-1 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human DLD-1 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human DLD-1 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
DLD-1 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human DLD1 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human DLD1 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
[PMID: 32153186]
DMS-114 GI50
2.9 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human DMS114 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human DMS114 cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
DOHH-2 IC50
0.58 μM
Compound: SAHA
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
DOHH-2 IC50
366 nM
Compound: 1; SAHA
Antiproliferative activity against human DOHH-2 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human DOHH-2 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
DU-145 EC50
1.6 μM
Compound: SAHA
Inhibition of human DU145 cells
Inhibition of human DU145 cells
[PMID: 18247554]
DU-145 EC50
1.6 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human DU-145 cells
Effective Concentration of compound to inhibit the growth of human DU-145 cells
[PMID: 15715470]
DU-145 EC50
2.11 μM
Compound: SAHA
Viability of human DU145 cells after 72 hrs by MTS assay
Viability of human DU145 cells after 72 hrs by MTS assay
[PMID: 18397827]
DU-145 EC50
2.12 μM
Compound: SAHA
Viability of human DU145 cells after 72 hrs by trypan blue staining
Viability of human DU145 cells after 72 hrs by trypan blue staining
[PMID: 18397827]
DU-145 EC50
2.12 μM
Compound: SAHA
Cytotoxicity against human DU145 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human DU145 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19093884]
DU-145 GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human DU145 cells after 72 hrs by MTS assay
Growth inhibition of human DU145 cells after 72 hrs by MTS assay
[PMID: 22435669]
DU-145 GI50
1.36 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 24015327]
DU-145 GI50
1050 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human DU145 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human DU145 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
DU-145 GI50
1590 nM
Compound: SAHA
Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
[PMID: 26331334]
DU-145 GI50
6.86 μM
Compound: SAHA, Vorinostat
Growth inhibition of human DU145 cells by MTT assay
Growth inhibition of human DU145 cells by MTT assay
[PMID: 23601706]
DU-145 IC50
0.47 μM
Compound: SAHA
Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability
Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability
[PMID: 35643262]
DU-145 IC50
0.64 μM
Compound: 1; SAHA
Antiproliferative activity against human DU-145 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human DU-145 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
DU-145 IC50
0.68 μM
Compound: Vorinostat
Cytotoxicity against human DU-145 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
Cytotoxicity against human DU-145 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
[PMID: 37875056]
DU-145 IC50
0.79 μM
Compound: 1; SAHA
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
[PMID: 33077264]
DU-145 IC50
0.87 μM
Compound: SAHA
Antiproliferative activity against human DU145 cells after 72 hrs by SRB assay
Antiproliferative activity against human DU145 cells after 72 hrs by SRB assay
[PMID: 29150335]
DU-145 IC50
1.2 μM
Compound: SAHA
Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
[PMID: 25993269]
DU-145 IC50
1.2 μM
Compound: SAHA
Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33965842]
DU-145 IC50
1.8 μM
Compound: 5; SAHA
Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay
[PMID: 31117517]
DU-145 IC50
2.12 μM
Compound: SAHA
Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay
[PMID: 22260166]
DU-145 IC50
2.12 μM
Compound: SAHA, Vorinostat
Cytotoxicity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Cytotoxicity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 23622981]
DU-145 IC50
2.49 μM
Compound: SAHA
Cytotoxicity against androgen-independent human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against androgen-independent human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 24304348]
DU-145 IC50
2.49 μM
Compound: SAHA
Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
[PMID: 25240614]
DU-145 IC50
2.58 μM
Compound: Vorinostat
Cytotoxicity against human DU145 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
Cytotoxicity against human DU145 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
[PMID: 23829483]
DU-145 IC50
24.19 μM
Compound: SAHA
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 3 to 5 days by CCK-8 assay
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 3 to 5 days by CCK-8 assay
[PMID: 38367494]
DU-145 IC50
27.2 μM
Compound: SAHA, vorinostat
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23707260]
DU-145 IC50
3.45 μM
Compound: SAHA
Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 28057407]
DU-145 IC50
3.7 μM
Compound: SAHA, vorinostat
Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23786452]
Daudi IC50
0.493 μM
Compound: Vorinostat
Cytotoxicity against human Daudi cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human Daudi cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 37875056]
EA.hy 926 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human EA.hy 926 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human EA.hy 926 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
EB-3 GI50
2.8 μM
Compound: 1, SAHA
Cytotoxic activity against human EB3 cells after 3 days by MTT assay
Cytotoxic activity against human EB3 cells after 3 days by MTT assay
[PMID: 25380299]
EB-3 GI50
2.8 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human EB3 cells assessed as growth inhibition incubated for 3 days by MTT assay
Antiproliferative activity against human EB3 cells assessed as growth inhibition incubated for 3 days by MTT assay
10.1039/C4MD00252K
EBC-1 IC50
1.3 μM
Compound: SAHA
Antiproliferative activity against human EBC1 cells after 72 hrs by SRB assay
Antiproliferative activity against human EBC1 cells after 72 hrs by SRB assay
[PMID: 28835797]
EJ IC50
5.46 μM
Compound: Vorinostat
Cytotoxicity against human EJ cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human EJ cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
EKVX GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human EKVX cells after 72 hrs by MTS assay
Growth inhibition of human EKVX cells after 72 hrs by MTS assay
[PMID: 22435669]
EL4 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against mouse EL4 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against mouse EL4 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
EL4 IC50
1.9 μM
Compound: SAHA
Antiproliferative activity against mouse EL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse EL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
EOL1 IC50
1 μM
Compound: 2
Cytotoxicity against human EOL1cells
Cytotoxicity against human EOL1cells
[PMID: 17691763]
EOL1 IC50
1 μM
Compound: 6, SAHA
Cytotoxicity against human EOL-1 cells after 72 hrs by alamar-blue cell viability assay
Cytotoxicity against human EOL-1 cells after 72 hrs by alamar-blue cell viability assay
[PMID: 19301902]
ES-2 IC50
0.53 μM
Compound: SAHA
Antiproliferative activity against human ES2 cells assessed as reduction in cell viability measured after 7 days
Antiproliferative activity against human ES2 cells assessed as reduction in cell viability measured after 7 days
[PMID: 35643262]
ES-2 IC50
414 nM
Compound: 1; SAHA
Antiproliferative activity against human ES2 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human ES2 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
Epithelial cell IC50
1.3 μM
Compound: SAHA
Cytotoxicity against nontransformed human microvascular epithelial cells
Cytotoxicity against nontransformed human microvascular epithelial cells
[PMID: 18494463]
Epithelial cell IC50
14000 nM
Compound: 1, vorinostat
Antiproliferative activity against human renal epithelial cells by CellTiter-Blue cell viability assay
Antiproliferative activity against human renal epithelial cells by CellTiter-Blue cell viability assay
[PMID: 18370373]
Erythrocyte IC50
> 2.2 μM
Compound: SAHA, Vorinostat
Cytotoxicity against erythrocytes (unknown origin)
Cytotoxicity against erythrocytes (unknown origin)
[PMID: 24904967]
Erythroleukemia cell line IC50
2 μM
Compound: SAHA
Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
[PMID: 34591474]
FHC IC50
2.59 μM
Compound: Vorinostat
Cytotoxicity against human FHC cells assessed as reduction of cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human FHC cells assessed as reduction of cell viability incubated for 72 hrs by MTT assay
[PMID: 33493830]
FaDu IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human FaDu cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human FaDu cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
FaDu IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human FaDu cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human FaDu cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
FaDu IC50
5.42 μM
Compound: XII; SAHA
Antiproliferative activity against human FaDu cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human FaDu cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
Fibroblast EC50
> 10 μM
Compound: SAHA
Cytotoxicity against human primary lung fibroblasts after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human primary lung fibroblasts after 72 hrs by trypan blue exclusion assay
[PMID: 19093884]
Fibroblast IC50
> 300 μM
Compound: SBHA
Toxicity in neonatal foreskin fibroblasts
Toxicity in neonatal foreskin fibroblasts
[PMID: 18212103]
Friend leukemia cell line IC50
0.11 μM
Compound: SAHA
Antiproliferative activity against mouse Friend leukemia cell line assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse Friend leukemia cell line assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
Friend leukemia cell line IC50
0.99 μM
Compound: 1 (SAHA)
Inhibitory concentration against friend cells proliferation
Inhibitory concentration against friend cells proliferation
[PMID: 14613312]
Friend leukemia cell line IC50
0.99 μM
Compound: 6a
Tested in vivo for the inhibition of proliferation of friend leukemic cells
Tested in vivo for the inhibition of proliferation of friend leukemic cells
[PMID: 12109913]
G-401 CC50
1000 nM
Compound: 1
Antiproliferative activity against human G401 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human G401 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19441846]
G-401 IC50
1000 nM
Compound: 1, vorinostat
Antiproliferative activity against human G401 cells by CellTiter-Blue cell viability assay
Antiproliferative activity against human G401 cells by CellTiter-Blue cell viability assay
[PMID: 18370373]
G55T2 IC50
0.78 μM
Compound: Vorinostat
Antiproliferative activity against human G55T2 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
Antiproliferative activity against human G55T2 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
[PMID: 31391882]
GES1 IC50
0.61 μM
Compound: SAHA
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of fedratinib by MTT assay
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of fedratinib by MTT assay
[PMID: 37796543]
GES1 IC50
233 μM
Compound: SAHA
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34628244]
GES1 IC50
4690 nM
Compound: SAHA
Antiproliferative activity against human GES-1 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human GES-1 cells incubated for 48 hrs by MTT assay
[PMID: 32267687]
GES1 IC50
48.3 μM
Compound: SAHA
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human GES1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37796543]
GES1 IC50
9.18 μM
Compound: SAHA
Cytotoxicity against human GES1 cells harboring low LSD1 expression assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
Cytotoxicity against human GES1 cells harboring low LSD1 expression assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
[PMID: 37086699]
HAL-01 IC50
0.299 μM
Compound: Vorinostat
Cytotoxicity against human HAL-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human HAL-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
[PMID: 36351184]
HAL-01 IC50
0.3 μM
Compound: Vorinostat
Cytotoxicity against human HAL-01 cells measured for 72 hrs by celltiter-glo assay
Cytotoxicity against human HAL-01 cells measured for 72 hrs by celltiter-glo assay
[PMID: 38714044]
HCC 2998 GI50
1.9 μM
Compound: SAHA
Antiproliferative activity against human HCC2998 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human HCC2998 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
HCC1937 IC50
3.73 μM
Compound: SAHA
Antiproliferative activity against human HCC1937 cells assessed as reduction in cell viability
Antiproliferative activity against human HCC1937 cells assessed as reduction in cell viability
[PMID: 35643262]
HCC1937 IC50
4.23 μM
Compound: SAHA
Antiproliferative activity against human HCC1937 cells after 3 days by MTT assay
Antiproliferative activity against human HCC1937 cells after 3 days by MTT assay
[PMID: 28601509]
HCC827 IC50
1.18 μM
Compound: SAHA
Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
[PMID: 28601509]
HCC827 IC50
1.8 μM
Compound: SAHA
Antiproliferative activity against human HCC827 cells after hrs by ATP content assay
Antiproliferative activity against human HCC827 cells after hrs by ATP content assay
[PMID: 20143778]
HCCLM3 IC50
6.52 μM
Compound: 1; SAHA
Antiproliferative activity against human HCCLM3 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCCLM3 cells after 48 hrs by MTT assay
[PMID: 30455152]
HCT-116 CC50
1000 nM
Compound: 1
Antiproliferative activity against human P53 expressing HCT116 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human P53 expressing HCT116 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19441846]
HCT-116 EC50
0.57 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 23820574]
HCT-116 EC50
0.58 μM
Compound: SAHA
Inhibition of human HCT116 cells
Inhibition of human HCT116 cells
[PMID: 18247554]
HCT-116 EC50
0.58 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human HCT116 cells
Effective Concentration of compound to inhibit the growth of human HCT116 cells
[PMID: 15715470]
HCT-116 EC50
1.6 μM
Compound: 1, SAHA
Cytotoxicity against human HCT116 cells
Cytotoxicity against human HCT116 cells
[PMID: 18954984]
HCT-116 EC50
2 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells after 71 hrs by MTS assay
Cytotoxicity against human HCT116 cells after 71 hrs by MTS assay
[PMID: 20392638]
HCT-116 EC50
3 μM
Compound: Vorinostat
Antiproliferative activity against human HCT116 cells measured after 72 hrs by WST1 assay
Antiproliferative activity against human HCT116 cells measured after 72 hrs by WST1 assay
[PMID: 27597246]
HCT-116 GI50
0.15 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay
Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay
[PMID: 27344487]
HCT-116 GI50
0.15 μM
Compound: SAHA; 1
Antiproliferative activity against human HCT116 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HCT116 cells after 48 hrs by sulforhodamine B assay
[PMID: 29567459]
HCT-116 GI50
0.37 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
[PMID: 24015327]
HCT-116 GI50
0.4 μM
Compound: 2, SAHA, Vorinostat
Cytotoxicity against human HCT116 cells after 96 hrs by MTS-PMS assay
Cytotoxicity against human HCT116 cells after 96 hrs by MTS-PMS assay
[PMID: 24164245]
HCT-116 GI50
0.4 μM
Compound: SAHA, Zolinza
Growth inhibition of human HCT116 cells after 72 hrs by MTS assay
Growth inhibition of human HCT116 cells after 72 hrs by MTS assay
[PMID: 22435669]
HCT-116 GI50
0.44 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
[PMID: 31924504]
HCT-116 GI50
0.55 μM
Compound: 1; SAHA
Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 31655430]
HCT-116 GI50
0.58 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
HCT-116 GI50
0.6 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 20605448]
HCT-116 GI50
0.6 μM
Compound: SAHA
Growth inhibition of human HCT116 cells after 5 days by alamar blue assay
Growth inhibition of human HCT116 cells after 5 days by alamar blue assay
[PMID: 21978679]
HCT-116 GI50
0.65 μM
Compound: Vorinostat
Growth inhibition of human HCT116 cells after 72 hrs by CellTiter Glo assay
Growth inhibition of human HCT116 cells after 72 hrs by CellTiter Glo assay
[PMID: 25182565]
HCT-116 GI50
0.878 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells after 48 hrs by Sulforhodamine B assay
Cytotoxicity against human HCT116 cells after 48 hrs by Sulforhodamine B assay
[PMID: 23639537]
HCT-116 GI50
0.94 μM
Compound: 1, SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HCT116 cells after 48 hrs by sulforhodamine B assay
[PMID: 24119555]
HCT-116 GI50
1 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
[PMID: 23538115]
HCT-116 GI50
1.04 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 25800646]
HCT-116 GI50
2.03 μM
Compound: 1, SAHA
Growth inhibition of human HCT116 cells after 96 hrs by MTT assay
Growth inhibition of human HCT116 cells after 96 hrs by MTT assay
[PMID: 26814680]
HCT-116 GI50
2.5 μM
Compound: Vorin
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
[PMID: 24900743]
HCT-116 GI50
2.69 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 19822426]
HCT-116 GI50
4.64 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26555243]
HCT-116 GI50
740 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human HCT116 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human HCT116 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
HCT-116 GI50
750 nM
Compound: SAHA
Growth inhibition of human HCT116 cells after 72 hrs by SRB assay
Growth inhibition of human HCT116 cells after 72 hrs by SRB assay
[PMID: 20884208]
HCT-116 GI50
> 410 nM
Compound: Vorinostat
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
HCT-116 IC50
0.08 mM
Compound: Vorinostat
Antiproliferative activity against human HCT116 cells after 2 days by MTT assay
Antiproliferative activity against human HCT116 cells after 2 days by MTT assay
[PMID: 19608304]
HCT-116 IC50
0.15 μM
Compound: Vorinostat
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay
[PMID: 37875056]
HCT-116 IC50
0.27 μM
Compound: 1
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
[PMID: 35238576]
HCT-116 IC50
0.3 μM
Compound: 1; SAHA
Antiproliferative activity against human HCT-116 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
HCT-116 IC50
0.31 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs
Antiproliferative activity against human HCT116 cells after 72 hrs
[PMID: 19084294]
HCT-116 IC50
0.31 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs
[PMID: 24742384]
HCT-116 IC50
0.31 μM
Compound: SAHA
Antiproliferative activity human HCT116 cells assessed as reduction in cell number after 72 hrs by cell counter analysis
Antiproliferative activity human HCT116 cells assessed as reduction in cell number after 72 hrs by cell counter analysis
[PMID: 26890116]
HCT-116 IC50
0.33 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 26100440]
HCT-116 IC50
0.34 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 21733698]
HCT-116 IC50
0.49 μM
Compound: 3; SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36449947]
HCT-116 IC50
0.55 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 32738414]
HCT-116 IC50
0.6 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 5 days by Alamar blue assay
Antiproliferative activity against human HCT116 cells after 5 days by Alamar blue assay
[PMID: 21420859]
HCT-116 IC50
0.6 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 5 days by Alamar Blue assay
Antiproliferative activity against human HCT116 cells after 5 days by Alamar Blue assay
[PMID: 22877635]
HCT-116 IC50
0.6 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 5 days by Alamar Blue assay
Antiproliferative activity against human HCT116 cells after 5 days by Alamar Blue assay
[PMID: 25746815]
HCT-116 IC50
0.61 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
[PMID: 24766560]
HCT-116 IC50
0.67 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
HCT-116 IC50
0.68 μM
Compound: Vorinostat
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
[PMID: 37875056]
HCT-116 IC50
0.69 μM
Compound: 1; SAHA
Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
HCT-116 IC50
0.7 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
[PMID: 21745740]
HCT-116 IC50
0.7 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 36549114]
HCT-116 IC50
0.72 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
HCT-116 IC50
0.757 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells
Cytotoxicity against human HCT116 cells
[PMID: 23644210]
HCT-116 IC50
0.757 μM
Compound: vorinostat
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by CellTitre-Glo luminescent assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by CellTitre-Glo luminescent assay
[PMID: 26629860]
HCT-116 IC50
0.76 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HCT116 cells after 72 hrs by CellTiter-Glo assay
[PMID: 30245394]
HCT-116 IC50
0.76 μM
Compound: SAHA, Vorinostat
Antiproliferative activity against human HCT116 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HCT116 cells after 72 hrs by CellTiter-Glo assay
[PMID: 23792316]
HCT-116 IC50
0.79 mM
Compound: vorinostat, SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 20171895]
HCT-116 IC50
0.797 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 35272009]
HCT-116 IC50
0.8 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 24095018]
HCT-116 IC50
0.81 μM
Compound: 1, SAHA, Zolinza
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
[PMID: 21742496]
HCT-116 IC50
0.877 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 29100734]
HCT-116 IC50
0.89 μM
Compound: 4; SAHA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
[PMID: 34314844]
HCT-116 IC50
0.9 μM
Compound: SAHA
Inhibition of human HCT116 cells
Inhibition of human HCT116 cells
[PMID: 18247554]
HCT-116 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
HCT-116 IC50
0.9 μM
Compound: Vorinostat
Antiproliferative activity against human wild type HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human wild type HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
HCT-116 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 29100734]
HCT-116 IC50
1 μM
Compound: Vorinostat
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by SRB assay
[PMID: 30660827]
HCT-116 IC50
1.03 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
HCT-116 IC50
1.03 μM
Compound: Vorinostat
Antiproliferative activity against human HCT-116 cells
Antiproliferative activity against human HCT-116 cells
[PMID: 37875056]
HCT-116 IC50
1.08 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
[PMID: 34847495]
HCT-116 IC50
1.18 μM
Compound: 1; SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human HCT116 cells after 72 hrs by CCK8 assay
[PMID: 30045621]
HCT-116 IC50
1.18 μM
Compound: SAHA
Anticancer activity against human HCT-116 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
Anticancer activity against human HCT-116 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
[PMID: 36244186]
HCT-116 IC50
1.2 μM
Compound: 2, SAHA
Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
[PMID: 21073160]
HCT-116 IC50
1.2 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells after 24 hrs by sulforhodamine B assay
Cytotoxicity against human HCT116 cells after 24 hrs by sulforhodamine B assay
[PMID: 19359173]
HCT-116 IC50
1.2 μM
Compound: SAHA
Growth inhibition of human HCT116 cells after 72 hrs
Growth inhibition of human HCT116 cells after 72 hrs
[PMID: 26376355]
HCT-116 IC50
1.2 μM
Compound: SAHA, vorinostat
Growth inhibition of human HCT116 cells by SRB assay
Growth inhibition of human HCT116 cells by SRB assay
[PMID: 17892933]
HCT-116 IC50
1.26 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
HCT-116 IC50
1.27 μM
Compound: 1; SAHA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36153841]
HCT-116 IC50
1.28 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
[PMID: 25874326]
HCT-116 IC50
1.31 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by CellTiter 96 AQueous Non-Radioactive assay
Antiproliferative activity against human HCT116 cells after 72 hrs by CellTiter 96 AQueous Non-Radioactive assay
[PMID: 28213282]
HCT-116 IC50
1.31 μM
Compound: SAHA
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
[PMID: 35984756]
HCT-116 IC50
1.39 μM
Compound: Vorinostat
Cytotoxicity against human HCT116 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
[PMID: 23829483]
HCT-116 IC50
1.4 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 28057407]
HCT-116 IC50
1.4 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay
Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay
[PMID: 28835797]
HCT-116 IC50
1.41 μM
Compound: Vorinostat
Antiproliferative activity against human HCT-116 cells by MTT assay
Antiproliferative activity against human HCT-116 cells by MTT assay
[PMID: 37875056]
HCT-116 IC50
1.43 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
[PMID: 20451378]
HCT-116 IC50
1.47 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells measured after 72 hrs
Antiproliferative activity against human HCT-116 cells measured after 72 hrs
[PMID: 35697181]
HCT-116 IC50
1.489 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
HCT-116 IC50
1.55 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 48 hrs by MTT assay
[PMID: 35041998]
HCT-116 IC50
1.8 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells after 48 hrs by CCK-8 assay
[PMID: 35939996]
HCT-116 IC50
1.8 μM
Compound: SAHA, 3
Cytotoxicity against human HCT116 cells assessed as cell viability after 96 hrs by MTS reduction assay
Cytotoxicity against human HCT116 cells assessed as cell viability after 96 hrs by MTS reduction assay
[PMID: 18348516]
HCT-116 IC50
1.81 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells assessed as cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human HCT116 cells assessed as cell viability after 72 hrs by CCK8 assay
[PMID: 26211462]
HCT-116 IC50
1.81 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
[PMID: 31413795]
HCT-116 IC50
1.85 μM
Compound: 1; SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 27541357]
HCT-116 IC50
1.85 μM
Compound: 2
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 28953386]
HCT-116 IC50
1.85 μM
Compound: 4
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
[PMID: 29945795]
HCT-116 IC50
1.85 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 33957387]
HCT-116 IC50
1.9 μM
Compound: 4
Concentration required to inhibit the HCT116 cell growth by 50%.
Concentration required to inhibit the HCT116 cell growth by 50%.
[PMID: 11831887]
HCT-116 IC50
1.9 μM
Compound: 5; SAHA
Antiproliferative activity against human HCT116 cells after 96 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 96 hrs by MTT assay
[PMID: 31117517]
HCT-116 IC50
1.93 μM
Compound: 3, SAHA
Antiproliferative activity against HCT116 cells
Antiproliferative activity against HCT116 cells
[PMID: 16904890]
HCT-116 IC50
1000 nM
Compound: 1, SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by celltiter-blue viability assay
Antiproliferative activity against human HCT116 cells after 72 hrs by celltiter-blue viability assay
[PMID: 18809328]
HCT-116 IC50
1000 nM
Compound: 1, SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human HCT116 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19410459]
HCT-116 IC50
1000 nM
Compound: 1, vorinostat
Antiproliferative activity against human HCT116 cells by CellTiter-Blue cell viability assay
Antiproliferative activity against human HCT116 cells by CellTiter-Blue cell viability assay
[PMID: 18370373]
HCT-116 IC50
11.8 nM
Compound: 1; SAHA
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs in presence of SN-38 by SRB assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs in presence of SN-38 by SRB assay
[PMID: 32679451]
HCT-116 IC50
1450 nM
Compound: SAHA
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 27186676]
HCT-116 IC50
1488.6 nM
Compound: 1; SAHA
Antiproliferative activity against human HCT116 cells measured after 48 hrs by sulforhodamine-B assay
Antiproliferative activity against human HCT116 cells measured after 48 hrs by sulforhodamine-B assay
[PMID: 27886544]
HCT-116 IC50
1617.76 nM
Compound: SAHA
Cytotoxicity against human HCT-116 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT-116 cells after 72 hrs by SRB assay
[PMID: 30819618]
HCT-116 IC50
1930 nM
Compound: SAHA (1)
Inhibitory activity against HCT116 human colon cell growth
Inhibitory activity against HCT116 human colon cell growth
[PMID: 14521422]
HCT-116 IC50
2 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
HCT-116 IC50
2.2 μM
Compound: 4
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 30243158]
HCT-116 IC50
2.35 μM
Compound: SAHA
Anti-proliferative activity against human HCT116 cells after 48 hrs by MTT assay
Anti-proliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 28947154]
HCT-116 IC50
2.41 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
[PMID: 35043615]
HCT-116 IC50
2.43 μM
Compound: Vorinostat
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
[PMID: 37875056]
HCT-116 IC50
2.5 μM
Compound: Vorinostat
Antiproliferative activity against human HCT-116 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 24 hrs by MTT assay
[PMID: 37875056]
HCT-116 IC50
2.52 μM
Compound: SAHA
Inhibition of HCT116 cell proliferation (mean of two experiments)
Inhibition of HCT116 cell proliferation (mean of two experiments)
[PMID: 17095213]
HCT-116 IC50
2.52 μM
Compound: SAHA
Inhibition of HCT116 cell proliferation (mean of two experiments)
Inhibition of HCT116 cell proliferation (mean of two experiments)
[PMID: 17107790]
HCT-116 IC50
2.59 μM
Compound: SAHA
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34043359]
HCT-116 IC50
2.7 μM
Compound: 1; SAHA
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36242988]
HCT-116 IC50
2.8 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 24296013]
HCT-116 IC50
2.81 μM
Compound: SA, SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 24694055]
HCT-116 IC50
2.81 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 25462271]
HCT-116 IC50
2.85 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human HCT116 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human HCT116 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
HCT-116 IC50
3.05 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
[PMID: 37086699]
HCT-116 IC50
3.07 μM
Compound: 4; SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
HCT-116 IC50
3.1 μM
Compound: 1; SAHA
Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28885834]
HCT-116 IC50
3.13 μM
Compound: Vorinostat
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
[PMID: 37875056]
HCT-116 IC50
3.45 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by WST8 assay
Antiproliferative activity against human HCT116 cells after 72 hrs by WST8 assay
[PMID: 25261927]
HCT-116 IC50
3.59 μM
Compound: 1; SAHA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
[PMID: 34656899]
HCT-116 IC50
3.7 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 25815139]
HCT-116 IC50
3.7 μM
Compound: SAHA
Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
[PMID: 33744687]
HCT-116 IC50
3.75 μM
Compound: SAHA
Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
[PMID: 33744687]
HCT-116 IC50
32.46 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 24 hrs by MTT assay
10.1039/C5MD00247H
HCT-116 IC50
4.2 μM
Compound: 1; SAHA
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
HCT-116 IC50
4.2 μM
Compound: Vorinostat
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
HCT-116 IC50
4.23 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
HCT-116 IC50
4.25 μM
Compound: 1, SAHA
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26122774]
HCT-116 IC50
4.25 μM
Compound: 6, SAHA
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25906087]
HCT-116 IC50
4.9 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32151834]
HCT-116 IC50
4.95 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells by MTT assay
Antiproliferative activity against human HCT116 cells by MTT assay
[PMID: 31546197]
HCT-116 IC50
4.97 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
[PMID: 30851694]
HCT-116 IC50
5 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
[PMID: 29100734]
HCT-116 IC50
5.06 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
10.1039/C5MD00247H
HCT-116 IC50
5.53 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26555243]
HCT-116 IC50
5.53 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 29288941]
HCT-116 IC50
5.53 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 30108831]
HCT-116 IC50
5.66 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
[PMID: 37116762]
HCT-116 IC50
561.32 nM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay
Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay
[PMID: 30115492]
HCT-116 IC50
6 μM
Compound: 1, SAHA
Inhibition of human HCT116 cell proliferation after 48 hrs by MTT assay
Inhibition of human HCT116 cell proliferation after 48 hrs by MTT assay
[PMID: 23493449]
HCT-116 IC50
6.15 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26349626]
HCT-116 IC50
720 nM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 31177073]
HCT-116 IC50
810 nM
Compound: 1, SAHA
Antiproliferative activity against human HCT116 cells assessed as growth inhibition
Antiproliferative activity against human HCT116 cells assessed as growth inhibition
[PMID: 21650221]
HCT-116 IC50
882.5 nM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 30629434]
HCT-116 IC50
895 nM
Compound: 1; SAHA
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 32679451]
HCT-116 IC50
9.6 μM
Compound: SAHA
Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 29348808]
HCT-116 IC50
< 1 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 29954683]
HCT-116 IC50
< 1.18 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00247H
HCT-116 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
[PMID: 32153186]
HCT-116 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
HCT-116 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 26443078]
HCT-15 GI50
0.82 μM
Compound: 1, SAHA
Growth inhibition of HCT15 cells by SRB assay
Growth inhibition of HCT15 cells by SRB assay
[PMID: 17477518]
HCT-15 GI50
0.82 μM
Compound: 2, SAHA
Antiproliferative activity against human HCT15 cells by SRB assay
Antiproliferative activity against human HCT15 cells by SRB assay
[PMID: 16723227]
HCT-15 GI50
0.95 μM
Compound: SAHA
Growth inhibition of human HCT15 cells after 21 hrs by MTT assay
Growth inhibition of human HCT15 cells after 21 hrs by MTT assay
[PMID: 17662606]
HCT-15 GI50
2.49 μM
Compound: 1, SAHA
Growth inhibition of human HCT15 cells
Growth inhibition of human HCT15 cells
[PMID: 20850971]
HCT-15 GI50
2.49 μM
Compound: 1, SAHA, Zolinza, Vorinostat
Cytotoxicity against human HCT15 cells assessed as growth inhibition by SRB assay
Cytotoxicity against human HCT15 cells assessed as growth inhibition by SRB assay
[PMID: 23163332]
HCT-15 GI50
2.49 μM
Compound: 2, SAHA
Growth inhibition of human HCT15 cells by SRB assay
Growth inhibition of human HCT15 cells by SRB assay
[PMID: 17904843]
HCT-15 GI50
2.49 μM
Compound: SAHA
Growth inhibition of human HCT15 cells after 5 days by sulforhodamine B assay
Growth inhibition of human HCT15 cells after 5 days by sulforhodamine B assay
[PMID: 25811792]
HCT-15 GI50
2.49 μM
Compound: SAHA
Growth inhibition of human HCT15 cells measured after 5 days by sulforhodamine-B assay
Growth inhibition of human HCT15 cells measured after 5 days by sulforhodamine-B assay
[PMID: 28011426]
HCT-15 GI50
2.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human HCT15 cells after 72 hrs by MTS assay
Growth inhibition of human HCT15 cells after 72 hrs by MTS assay
[PMID: 22435669]
HCT-15 IC50
3.9 μM
Compound: 2
Cytotoxicity against human HCT15 cells
Cytotoxicity against human HCT15 cells
[PMID: 17691763]
HCT-8 IC50
0.35 μM
Compound: 5; SAHA
Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay
Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay
[PMID: 31117517]
HEC-1-A IC50
1 μM
Compound: 2
Cytotoxicity against human Hec-1-A cells
Cytotoxicity against human Hec-1-A cells
[PMID: 17691763]
HEK-293T EC50
> 1 μM
Compound: SAHA
Cytotoxicity against human HEK293T cells assessed as cell growth inhibition
Cytotoxicity against human HEK293T cells assessed as cell growth inhibition
[PMID: 33356214]
HEK-293T IC50
4.5 μM
Compound: Vorinostat
Cytotoxicity against HEK293T cells incubated for 72 hrs by CCK-8 assay
Cytotoxicity against HEK293T cells incubated for 72 hrs by CCK-8 assay
[PMID: 35175762]
HEK-293T IC50
8.221 μM
Compound: SAHA
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
HEK293 CC50
100 μM
Compound: SAHA, Vorinostat
Cytotoxicity against HEK293 cells assessed as reduction in cell viability
Cytotoxicity against HEK293 cells assessed as reduction in cell viability
[PMID: 26264503]
HEK293 CC50
2.3 μM
Compound: Vorinostat
Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay
Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay
[PMID: 30973727]
HEK293 GI50
13 μM
Compound: 1, SAHA
Growth inhibition of human HEK293 cells after 72 hrs by XTT assay
Growth inhibition of human HEK293 cells after 72 hrs by XTT assay
[PMID: 24900500]
HEK293 GI50
3.38 μM
Compound: 1, SAHA
Cytotoxicity against HEK293 cells assessed as growth inhibition after 96 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as growth inhibition after 96 hrs by MTT assay
[PMID: 26814680]
HEK293 IC50
0.01 μM
Compound: SAHA
Inhibition of recombinant human GST-fused HDAC1 expressed in HEK293 cells Fluor-de-lys as substrate measured after 60 mins by fluorescence assay
Inhibition of recombinant human GST-fused HDAC1 expressed in HEK293 cells Fluor-de-lys as substrate measured after 60 mins by fluorescence assay
[PMID: 30245394]
HEK293 IC50
0.013 μM
Compound: 2, SAHA
Inhibition of human recombinant HDAC1 expressed in human HEK293 cells using Ac-NH-GGK(Ac)-AMC as substrate after 180 mins by fluorescence assay
Inhibition of human recombinant HDAC1 expressed in human HEK293 cells using Ac-NH-GGK(Ac)-AMC as substrate after 180 mins by fluorescence assay
10.1039/C2MD00317A
HEK293 IC50
0.016 μM
Compound: SAHA
Inhibition of full length human N-terminal FLAG-tagged HDAC6 (1 to 1215 residues) expressed in HEK293 cells preincubated for 15 mins followed by acetyl-Gly-Ala-[acetyl-Lys]-AMC substrate addition measured after 30 mins by fluorimetric method
Inhibition of full length human N-terminal FLAG-tagged HDAC6 (1 to 1215 residues) expressed in HEK293 cells preincubated for 15 mins followed by acetyl-Gly-Ala-[acetyl-Lys]-AMC substrate addition measured after 30 mins by fluorimetric method
[PMID: 30613344]
HEK293 IC50
0.019 μM
Compound: SAHA
Inhibition of recombinant HDAC6 expressed in HEK293 cells
Inhibition of recombinant HDAC6 expressed in HEK293 cells
[PMID: 18558669]
HEK293 IC50
0.02 μM
Compound: 6, SAHA
Inhibition of human recombinant HDAC1 expressed in HEK293 cells
Inhibition of human recombinant HDAC1 expressed in HEK293 cells
[PMID: 19301902]
HEK293 IC50
0.021 μM
Compound: 2a
Inhibition of human recombinant HDAC1 expressed in HEK293 cells
Inhibition of human recombinant HDAC1 expressed in HEK293 cells
[PMID: 21080629]
HEK293 IC50
0.025 μM
Compound: 2a
Inhibition of human recombinant HDAC6 expressed in HEK293 cells
Inhibition of human recombinant HDAC6 expressed in HEK293 cells
[PMID: 21080629]
HEK293 IC50
0.033 μM
Compound: SAHA
Inhibition of recombinant HDAC1 expressed in HEK293 cells
Inhibition of recombinant HDAC1 expressed in HEK293 cells
[PMID: 18558669]
HEK293 IC50
0.052 μM
Compound: 6, SAHA
Inhibition of human recombinant HDAC6 expressed in HEK293 cells
Inhibition of human recombinant HDAC6 expressed in HEK293 cells
[PMID: 19301902]
HEK293 IC50
0.122 μM
Compound: SAHA
Inhibition of HDAC1 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBRET assay
Inhibition of HDAC1 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBRET assay
[PMID: 31414801]
HEK293 IC50
0.241 μM
Compound: SAHA
Inhibition of HDAC6 CD2 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBRET assay
Inhibition of HDAC6 CD2 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBRET assay
[PMID: 31414801]
HEK293 IC50
0.669 μM
Compound: SAHA
Inhibition of full length human N-terminal FLAG-tagged HDAC8 (1 to 377 residues) expressed in HEK293 cells preincubated for 15 mins followed by Boc-[trifluoroacetyl-Lys]-AMC substrate addition measured after 30 mins by fluorimetric method
Inhibition of full length human N-terminal FLAG-tagged HDAC8 (1 to 377 residues) expressed in HEK293 cells preincubated for 15 mins followed by Boc-[trifluoroacetyl-Lys]-AMC substrate addition measured after 30 mins by fluorimetric method
[PMID: 30613344]
HEK293 IC50
1637 nM
Compound: 1; SAHA
Antiproliferative activity against human HEK293 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HEK293 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
HEK293 IC50
2.48 μM
Compound: SAHA
Cytotoxicity against HEK293 cells
Cytotoxicity against HEK293 cells
[PMID: 34107385]
HEK293 IC50
2.48 μM
Compound: SAHA
Cytotoxicity HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs
Cytotoxicity HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs
[PMID: 38056296]
HEK293 IC50
30 nM
Compound: 1
Inhibition of human C-terminal FLAG-tagged HDAC1 in HEK293 cells
Inhibition of human C-terminal FLAG-tagged HDAC1 in HEK293 cells
[PMID: 19441846]
HEK293 IC50
30 nM
Compound: vorinostat, zolinza, SAHA
Inhibition of HDAC1 in HEK293 cells
Inhibition of HDAC1 in HEK293 cells
[PMID: 18308563]
HEK293 IC50
43 nM
Compound: vorinostat, zolinza, SAHA
Inhibition of HDAC6 in HEK293 cells
Inhibition of HDAC6 in HEK293 cells
[PMID: 18308563]
HEK293 IC50
5170 nM
Compound: SAHA
Cytotoxicity against HEK293 cells after 48 hrs by resazurin dye based assay
Cytotoxicity against HEK293 cells after 48 hrs by resazurin dye based assay
[PMID: 30245402]
HEK293 IC50
57 nM
Compound: 1
Inhibition of human C-terminal FLAG-tagged HDAC3 in HEK293 cells
Inhibition of human C-terminal FLAG-tagged HDAC3 in HEK293 cells
[PMID: 19441846]
HEK293 IC50
57 nM
Compound: vorinostat, zolinza, SAHA
Inhibition of HDAC3 in HEK293 cells
Inhibition of HDAC3 in HEK293 cells
[PMID: 18308563]
HEK293 IC50
82 nM
Compound: 1
Inhibition of human C-terminal FLAG-tagged HDAC2 in HEK293 cells
Inhibition of human C-terminal FLAG-tagged HDAC2 in HEK293 cells
[PMID: 19441846]
HEK293 IC50
> 250 μM
Compound: SAHA
Cytotoxicity against HEK293 cells incubated for 24 hrs by Neutral Red Uptake assay
Cytotoxicity against HEK293 cells incubated for 24 hrs by Neutral Red Uptake assay
[PMID: 39208744]
HEK293 IC50
> 30 μM
Compound: SAHA
Inhibition of recombinant human ERG expressed in HEK293 cells at -80 mV holding potential measured for 9 mins by Qpatch clamp method
Inhibition of recombinant human ERG expressed in HEK293 cells at -80 mV holding potential measured for 9 mins by Qpatch clamp method
[PMID: 28947154]
HEL GI50
0.76 μM
Compound: SAHA
Antiproliferative activity against human HEL cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
Antiproliferative activity against human HEL cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
[PMID: 25800646]
HEL IC50
0.02 μM
Compound: SAHA
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
HEL IC50
0.15 μM
Compound: SAHA
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
[PMID: 29533873]
HEL IC50
0.18 μM
Compound: 1; SAHA
Antiproliferative activity against human HEL cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HEL cells incubated for 48 hrs by CCK8 assay
[PMID: 37037787]
HEL IC50
0.18 μM
Compound: SAHA
Antiproliferative activity against HEL cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against HEL cells incubated for 72 hrs by CCK-8 assay
[PMID: 37057760]
HEL IC50
0.18 μM
Compound: SAHA
Cytotoxicity against HEL cells assessed as reduction in cell growth incubated for 72 hrs by WST assay
Cytotoxicity against HEL cells assessed as reduction in cell growth incubated for 72 hrs by WST assay
[PMID: 38964169]
HEL IC50
0.19 μM
Compound: SAHA
Antiproliferative activity against human HEL cells after 72 hrs by MTT assay
Antiproliferative activity against human HEL cells after 72 hrs by MTT assay
[PMID: 29787262]
HEL IC50
0.21 μM
Compound: SAHA
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
[PMID: 28336407]
HEL IC50
0.21 μM
Compound: Vorinostat
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
HEL IC50
0.21 μM
Compound: Vorinostat
Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by WST assay
Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by WST assay
[PMID: 38107170]
HEL IC50
0.25 μM
Compound: Vorinostat
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
[PMID: 28371677]
HEL IC50
0.3 μM
Compound: 3; SAHA
Synergistic antiproliferative activity against HEL cells harboring JAK2 V617F mutant assessed as reduction in cell viability after 48 hrs in presence of ruxolitinib by MTT assay
Synergistic antiproliferative activity against HEL cells harboring JAK2 V617F mutant assessed as reduction in cell viability after 48 hrs in presence of ruxolitinib by MTT assay
[PMID: 30901208]
HEL IC50
0.4 μM
Compound: 1; SAHA
Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
[PMID: 36622852]
HEL IC50
0.49 μM
Compound: SA, SAHA
Antiproliferative activity against HEL cells after 48 hrs by MTT assay
Antiproliferative activity against HEL cells after 48 hrs by MTT assay
[PMID: 24694055]
HEL IC50
0.49 μM
Compound: SAHA
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
[PMID: 25462271]
HEL IC50
0.5 μM
Compound: 1; SAHA
Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
[PMID: 36622852]
HEL IC50
0.52 μM
Compound: SAHA
Antiproliferative activity against human HEL cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HEL cells after 48 hrs by CCK-8 assay
[PMID: 35939996]
HEL IC50
0.65 μM
Compound: 1
Antiproliferative activity against HEL cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
Antiproliferative activity against HEL cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
[PMID: 35238576]
HEL IC50
0.65 μM
Compound: 3; SAHA
Antiproliferative activity against HEL cells harboring JAK2 V617F mutant assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against HEL cells harboring JAK2 V617F mutant assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30901208]
HEL IC50
0.72 μM
Compound: SAHA
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
HEL IC50
0.79 μM
Compound: SAHA
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
[PMID: 29500131]
HEL IC50
0.86 μM
Compound: 2; SAHA
Antiproliferative activity against human HEL cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HEL cells after 48 hrs by CCK-8 assay
[PMID: 29940115]
HEL IC50
0.89 μM
Compound: SAHA
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
[PMID: 30879863]
HEL IC50
1.27 μM
Compound: SAHA
Cytotoxicity against human HEL cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HEL cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26349626]
HEL IC50
1.74 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
Antiproliferative activity against human HEL cells after 48 hrs by MTT assay
[PMID: 26100440]
HEL IC50
2.42 μM
Compound: 1, SAHA
Cytotoxicity against HEL cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against HEL cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26122774]
HEL IC50
2.42 μM
Compound: 6, SAHA
Cytotoxicity against human HEL cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HEL cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25906087]
HEL 92.1.7 IC50
0.49 μM
Compound: 1; SAHA
Antiproliferative activity against HEL 92.1.7 cells harboring JAK2 V617F mutant after 36 hrs by PrestoBlue dye based assay
Antiproliferative activity against HEL 92.1.7 cells harboring JAK2 V617F mutant after 36 hrs by PrestoBlue dye based assay
[PMID: 27541357]
HEL 92.1.7 IC50
0.49 μM
Compound: 2
Antiproliferative activity against human HEL 92.1.7 cells after 36 hrs by PrestoBlue dye based assay
Antiproliferative activity against human HEL 92.1.7 cells after 36 hrs by PrestoBlue dye based assay
[PMID: 28953386]
HEL 92.1.7 IC50
0.49 μM
Compound: 4
Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by MTT assay
Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by MTT assay
[PMID: 30243158]
HET-1A IC50
960 nM
Compound: SAHA
Antiproliferative activity against human HET-1A cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HET-1A cells incubated for 48 hrs by MTT assay
[PMID: 32267687]
HGC-27 IC50
0.35 μM
Compound: 5; SAHA
Antiproliferative activity against human HGC27 cells after 96 hrs by MTT assay
Antiproliferative activity against human HGC27 cells after 96 hrs by MTT assay
[PMID: 31117517]
HGC-27 IC50
3 μM
Compound: Vorinostat
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
HGC-27 IC50
5.4 μM
Compound: SAHA, vorinostat
Cytotoxicity against human HGC27 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HGC27 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23707260]
HGC-27 IC50
5.79 μM
Compound: SAHA
Cytotoxicity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34628244]
HGC-27 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
HH EC50
1.03 μM
Compound: SAHA
Cytotoxicity against human HH cells assessed as cell proliferation after 70 hrs by MTS assay
Cytotoxicity against human HH cells assessed as cell proliferation after 70 hrs by MTS assay
[PMID: 25974739]
HH IC50
0.86 μM
Compound: 1; SAHA
Cytotoxicity against human HH cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human HH cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
HH IC50
2.53 μM
Compound: XII; SAHA
Antiproliferative activity against human HH cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HH cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
HL-60 EC50
1.2 μM
Compound: 1a, SAHA
Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
HL-60 EC50
1.3 μM
Compound: SAHA
Induction of ATRA-induced human HL60 cell differentiation pretreated for 1 hr followed by ATRA addition measured after 3 days by Wright-Giemsa staining based microscopic analysis
Induction of ATRA-induced human HL60 cell differentiation pretreated for 1 hr followed by ATRA addition measured after 3 days by Wright-Giemsa staining based microscopic analysis
[PMID: 28549889]
HL-60 GI50
0.08 μM
Compound: SAHA
Cytotoxicity against human HL60 cells after 72 hrs by cell titre 96 aqueous cell proliferation assay
Cytotoxicity against human HL60 cells after 72 hrs by cell titre 96 aqueous cell proliferation assay
[PMID: 26653328]
HL-60 GI50
0.55 μM
Compound: SAHA
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
Antiproliferative activity against human HL60 cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
[PMID: 25800646]
HL-60 GI50
0.75 μM
Compound: Vorinostat
Growth inhibition of human HL60 cells after 72 hrs by CellTiter Glo assay
Growth inhibition of human HL60 cells after 72 hrs by CellTiter Glo assay
[PMID: 25182565]
HL-60 GI50
0.93 μM
Compound: 1, SAHA
Growth inhibition of human HL60 cells after 72 hrs by XTT assay
Growth inhibition of human HL60 cells after 72 hrs by XTT assay
[PMID: 24900500]
HL-60 GI50
1.74 μM
Compound: SAHA
Antiproliferative activity against human HL60 cells after 48 hrs by SRB assay
Antiproliferative activity against human HL60 cells after 48 hrs by SRB assay
[PMID: 27344487]
HL-60 GI50
1.74 μM
Compound: SAHA; 1
Antiproliferative activity against human HL60 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HL60 cells after 48 hrs by sulforhodamine B assay
[PMID: 29567459]
HL-60 IC50
0.18 μg/mL
Compound: Vorinostat
Antiproliferative activity against human HL-60 cells
Antiproliferative activity against human HL-60 cells
[PMID: 31945642]
HL-60 IC50
0.18 μg/mL
Compound: Vorinostat
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
HL-60 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
HL-60 IC50
0.22 μM
Compound: Vorinostat
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
[PMID: 36351184]
HL-60 IC50
0.22 μM
Compound: Vorinostat
Cytotoxicity against human HL-60 cells measured for 72 hrs by celltiter-glo assay
Cytotoxicity against human HL-60 cells measured for 72 hrs by celltiter-glo assay
[PMID: 38714044]
HL-60 IC50
0.32 μM
Compound: SAHA
Inhibition of cell viability in human HL-60 cells incubated for 4 days in presence of GSK5032 by CCK8 assay
Inhibition of cell viability in human HL-60 cells incubated for 4 days in presence of GSK5032 by CCK8 assay
[PMID: 39264152]
HL-60 IC50
0.39 μM
Compound: SAHA
Antiproliferative activity against human HL-60 cells incubated for 48 hrs by resazurin based microplate reader analysis
Antiproliferative activity against human HL-60 cells incubated for 48 hrs by resazurin based microplate reader analysis
[PMID: 37647727]
HL-60 IC50
0.42 μM
Compound: SAHA
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition after 72 hrs by trypan blue staining based cell counting assay
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition after 72 hrs by trypan blue staining based cell counting assay
[PMID: 31883490]
HL-60 IC50
0.48 μM
Compound: 1; SAHA
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
HL-60 IC50
0.5 μM
Compound: SAHA
Antiproliferative activity against human HL-60 cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells incubated for 72 hrs by CCK-8 assay
[PMID: 37057760]
HL-60 IC50
0.52 μM
Compound: SAHA
Antiproliferative activity against human HL60 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells incubated for 48 hrs by MTT assay
[PMID: 31413795]
HL-60 IC50
0.54 μM
Compound: 1; SAHA
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36153841]
HL-60 IC50
0.64 μM
Compound: SAHA
Inhibition of cell viability in human HL-60 cells incubated for 4 days by CCK8 assay
Inhibition of cell viability in human HL-60 cells incubated for 4 days by CCK8 assay
[PMID: 39264152]
HL-60 IC50
0.69 μM
Compound: 1; SAHA
Antiproliferative activity against human HL-60 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HL-60 cells incubated for 48 hrs by CCK8 assay
[PMID: 37037787]
HL-60 IC50
0.69 μM
Compound: Vorinostat
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
HL-60 IC50
0.9 μM
Compound: SAHA
Cytotoxicity against human HL-60 cells assessed as inhibition of cell proliferation measured after 72 hrs by ATPlite assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell proliferation measured after 72 hrs by ATPlite assay
[PMID: 34185525]
HL-60 IC50
0.93 μM
Compound: 1; SAHA
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
[PMID: 34656899]
HL-60 IC50
1 μM
Compound: SAHA
Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
HL-60 IC50
1.1 μM
Compound: SAHA
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
HL-60 IC50
1.3 μM
Compound: 1; SAHA
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
[PMID: 36622852]
HL-60 IC50
1.4 μM
Compound: 1; SAHA
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
[PMID: 36622852]
HL-60 IC50
1.4 μM
Compound: Vorinostat
Antiproliferative activity against human HL-60 cells
Antiproliferative activity against human HL-60 cells
[PMID: 37875056]
HL-60 IC50
1.5 μM
Compound: 2; SAHA
Antiproliferative activity against human HL60 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HL60 cells after 48 hrs by CCK-8 assay
[PMID: 29940115]
HL-60 IC50
1.52 μM
Compound: SAHA
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 36272186]
HL-60 IC50
1331 nM
Compound: SAHA
Antiproliferative activity against Ara-C resistant human HL60 cells after 72 hrs by MTT assay
Antiproliferative activity against Ara-C resistant human HL60 cells after 72 hrs by MTT assay
[PMID: 27505848]
HL-60 IC50
2.21 μM
Compound: 1; SAHA
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
[PMID: 36215854]
HL-60 IC50
2.28 μM
Compound: 1; SAHA
Antiproliferative activity against human HL60 cells
Antiproliferative activity against human HL60 cells
[PMID: 27541357]
HL-60 IC50
2.28 μM
Compound: 2
Antiproliferative activity against human HL60 cells
Antiproliferative activity against human HL60 cells
[PMID: 28953386]
HL-60 IC50
2.91 μM
Compound: XII; SAHA
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
HL-60 IC50
3 μM
Compound: Vorinostat
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
HL-60 IC50
3.04 μM
Compound: SAHA
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
HL-60 IC50
4.26 μM
Compound: SA, SAHA
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 24694055]
HL-60 IC50
4.26 μM
Compound: SAHA
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 25462271]
HL-60 IC50
570.5 nM
Compound: SAHA
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
[PMID: 27505848]
HL-60 IC50
729 nM
Compound: SAHA
Growth inhibition of human HL60 cells assessed as ATP level after 72 hrs by CellTiterGlo assay
Growth inhibition of human HL60 cells assessed as ATP level after 72 hrs by CellTiterGlo assay
10.1039/C3MD00285C
HL-60 IC50
76.5 μM
Compound: Zolinza, SAHA
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 22698782]
HL-60 IC50
> 200 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 21476600]
HL-60 IC50
> 3.78 mM
Compound: vorinostat, SAHA
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 20171895]
HL-60(TB) GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human HL-60(TB) cells after 72 hrs by MTS assay
Growth inhibition of human HL-60(TB) cells after 72 hrs by MTS assay
[PMID: 22435669]
HMEC EC50
> 10 μM
Compound: SAHA
Cytotoxicity against HMEC after 72 hrs by trypan blue exclusion assay
Cytotoxicity against HMEC after 72 hrs by trypan blue exclusion assay
[PMID: 19093884]
HMEC GI50
5.8 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human HMEC after 72 hrs by WST1 assay
Cytotoxicity against human HMEC after 72 hrs by WST1 assay
[PMID: 24015327]
HMEC IC50
1.3 μM
Compound: SAHA
Cytotoxicity against HMEC after 72 hrs by MTT assay
Cytotoxicity against HMEC after 72 hrs by MTT assay
[PMID: 18642892]
HMEC IC50
10.7 μM
Compound: Vorinostat
Cytotoxicity against HMEC cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay
Cytotoxicity against HMEC cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay
[PMID: 36262394]
HMEC IC50
4.41 μM
Compound: 1; SAHA
Cytotoxicity against human HMEC cells assessed as inhibition of cell viability incubated for 3 days by AlamarBlue based fluorescence analysis
Cytotoxicity against human HMEC cells assessed as inhibition of cell viability incubated for 3 days by AlamarBlue based fluorescence analysis
[PMID: 37847303]
HOP-62 GI50
1.6 μM
Compound: SAHA
Antiproliferative activity against human HOP62 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human HOP62 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
HOP-62 IC50
2.91 μM
Compound: SAHA
Cytotoxicity against human HOP-62 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HOP-62 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 35858522]
HOP-92 GI50
2.9 μM
Compound: SAHA
Antiproliferative activity against human HOP92 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human HOP92 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
HOP-92 GI50
4 μM
Compound: SAHA, Zolinza
Growth inhibition of human HOP92 cells after 72 hrs by MTS assay
Growth inhibition of human HOP92 cells after 72 hrs by MTS assay
[PMID: 22435669]
HSC-3 IC50
0.71 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human HSC3 cells by MTT assay
Cytotoxicity against human HSC3 cells by MTT assay
[PMID: 24766560]
HT-1080 GI50
1.79 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human HT1080 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human HT1080 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
HT-1080 GI50
4.87 μM
Compound: SAHA, Vorinostat
Growth inhibition of human HT1080 cells by MTT assay
Growth inhibition of human HT1080 cells by MTT assay
[PMID: 23601706]
HT-1080 IC50
2.4 nM
Compound: SAHA
Inhibition of human HT1080 cells
Inhibition of human HT1080 cells
[PMID: 18247554]
HT-1080 IC50
2.4 μM
Compound: 1
Concentration required for the antiproliferation of Human HT1080 fibrosarcoma cells
Concentration required for the antiproliferation of Human HT1080 fibrosarcoma cells
[PMID: 12270175]
HT-1080 IC50
2.4 μM
Compound: 1
Antiproliferative activity against human HT1080 fibrosarcoma cell line
Antiproliferative activity against human HT1080 fibrosarcoma cell line
[PMID: 14552787]
HT-1080 IC50
2.4 μM
Compound: 3 (SAHA)
Antiproliferative activity against HT1080 (human fibrosarcoma) cell line.
Antiproliferative activity against HT1080 (human fibrosarcoma) cell line.
[PMID: 12749893]
HT-1080 IC50
2.54 μM
Compound: SAHA
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 29787262]
HT-1080 IC50
24 nM
Compound: 1; SAHA
Antiproliferative activity against human HT1080 cells
Antiproliferative activity against human HT1080 cells
[PMID: 31655430]
HT-1080 IC50
2400 nM
Compound: 1 (SAHA)
Inhibitory concentration against HT1080 cells proliferation
Inhibitory concentration against HT1080 cells proliferation
[PMID: 14613312]
HT-1080 IC50
3.56 μM
Compound: SAHA
Anticancer activity against human HT-1080 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
Anticancer activity against human HT-1080 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
[PMID: 36244186]
HT-1080 IC50
7.5 μM
Compound: SAHA
Cytotoxicity against human HT1080 cells
Cytotoxicity against human HT1080 cells
[PMID: 23953690]
HT-29 EC50
2 μM
Compound: 1a, SAHA
Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
HT-29 GI50
0.79 μM
Compound: SAHA, Zolinza
Growth inhibition of human HT-29 cells after 72 hrs by MTS assay
Growth inhibition of human HT-29 cells after 72 hrs by MTS assay
[PMID: 22435669]
HT-29 GI50
2.88 μM
Compound: 1, SAHA
Growth inhibition of human HT-29 cells after 96 hrs by MTT assay
Growth inhibition of human HT-29 cells after 96 hrs by MTT assay
[PMID: 26814680]
HT-29 IC50
0.56 μM
Compound: SAHA
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
[PMID: 34847495]
HT-29 IC50
0.72 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human HT-29 cells by MTT assay
Cytotoxicity against human HT-29 cells by MTT assay
[PMID: 24766560]
HT-29 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
HT-29 IC50
1.51 μM
Compound: SAHA
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 29787262]
HT-29 IC50
1.59 μM
Compound: SAHA
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
HT-29 IC50
1.78 μM
Compound: 4; SAHA
Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
HT-29 IC50
2.2 μM
Compound: SAHA
Antiproliferative activity against human HT-29 cells after 72 hrs by SRB assay
Antiproliferative activity against human HT-29 cells after 72 hrs by SRB assay
[PMID: 29150335]
HT-29 IC50
2.33 μM
Compound: 1; SAHA
Antiproliferative activity against human HT-29 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human HT-29 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
HT-29 IC50
2.37 μM
Compound: SAHA
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 30879863]
HT-29 IC50
2.57 μM
Compound: SAHA
Anticancer activity against human HT-29 cells assessed as inhibition of cell growth measured for 48 hrs by MTT assay
Anticancer activity against human HT-29 cells assessed as inhibition of cell growth measured for 48 hrs by MTT assay
[PMID: 38897139]
HT-29 IC50
3.33 μM
Compound: SAHA
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
HT-29 IC50
5.01 μM
Compound: Vorinostat
Antiproliferative activity against human HT-29 cells
Antiproliferative activity against human HT-29 cells
[PMID: 37875056]
HT-29 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 26443078]
HUVEC GI50
8.13 μM
Compound: SAHA, Vorinostat
Growth inhibition of HUVEC by MTT assay
Growth inhibition of HUVEC by MTT assay
[PMID: 23601706]
HUVEC IC50
0.85 μM
Compound: SAHA
Inhibition of HDAC in HUVEC using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition and measured after 4 hrs by fluorimetry
Inhibition of HDAC in HUVEC using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition and measured after 4 hrs by fluorimetry
[PMID: 32347094]
HUVEC IC50
120 nM
Compound: 1; SAHA
Inhibition of total HDAC in human HUVEC cells using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition measured after 6 hrs by microtiter plate reader analysis
Inhibition of total HDAC in human HUVEC cells using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition measured after 6 hrs by microtiter plate reader analysis
[PMID: 37037787]
HUVEC IC50
2.72 μM
Compound: SAHA
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth by MTT assay
[PMID: 37116762]
HUVEC IC50
2.84 μM
Compound: SAHA
Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
HUVEC IC50
26.4 μM
Compound: SAHA
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth
[PMID: 35944852]
HUVEC IC50
3610 nM
Compound: SAHA
Antiproliferative activity against HUVEC cells incubated for 48 hrs by MTT assay
Antiproliferative activity against HUVEC cells incubated for 48 hrs by MTT assay
[PMID: 32267687]
HUVEC IC50
5.9 μM
Compound: 1; SAHA
Cytotoxicity against HUVECs assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Cytotoxicity against HUVECs assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 37037787]
HUVEC IC50
8.58 μM
Compound: SAHA
Cytotoxicity against HUVEC cells incubated for 72 hrs by CCK-8 assay
Cytotoxicity against HUVEC cells incubated for 72 hrs by CCK-8 assay
[PMID: 36182802]
HUVEC IC50
> 50 μM
Compound: SAHA
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 37079967]
HaCaT IC50
1.85 μM
Compound: SAHA
Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth
Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth
[PMID: 34742014]
HeLa CC50
2.8 μM
Compound: SAHA
Cytotoxicity against human HeLa cells assessed as cell death incubated for 20 hrs measured by DNS assay
Cytotoxicity against human HeLa cells assessed as cell death incubated for 20 hrs measured by DNS assay
[PMID: 34006099]
HeLa CC50
460 nM
Compound: 1
Antiproliferative activity against human P53-deficient HeLa cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human P53-deficient HeLa cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19441846]
HeLa EC50
0.0217 μM
Compound: 1; SAHA; vorinostat
Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
[PMID: 26611919]
HeLa EC50
0.55 μM
Compound: 1, SAHA
Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylation
Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylation
[PMID: 18954984]
HeLa EC50
14.2 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs by XTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by XTT assay
[PMID: 21548582]
HeLa EC50
4.7 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 72 hrs by XTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by XTT assay
[PMID: 21548582]
HeLa EC50
4.8 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cells assessed as induction of histone H3 hyperacetylation after 24 hrs
Inhibition of HDAC in human HeLa cells assessed as induction of histone H3 hyperacetylation after 24 hrs
[PMID: 18558669]
HeLa EC50
43 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 24 hrs by XTT assay
Antiproliferative activity against human HeLa cells after 24 hrs by XTT assay
[PMID: 21548582]
HeLa EC50
6.67 μM
Compound: 2
Inhibition of HDAC in HeLa cells assessed as induction of human histone H3 hyperacetylation
Inhibition of HDAC in HeLa cells assessed as induction of human histone H3 hyperacetylation
[PMID: 17691763]
HeLa EC50
6.7 μM
Compound: 6, SAHA
Inhibition of HDAC in human HeLa cells assessed as induction of cellular histone H3 hyperacetylation
Inhibition of HDAC in human HeLa cells assessed as induction of cellular histone H3 hyperacetylation
[PMID: 19301902]
HeLa GI50
1460 nM
Compound: SAHA
Growth inhibition of human HeLa cells after 72 hrs by SRB assay
Growth inhibition of human HeLa cells after 72 hrs by SRB assay
[PMID: 20884208]
HeLa GI50
19.21 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 28629630]
HeLa GI50
2.5 μM
Compound: 1, SAHA
Growth inhibition of human HeLa cells after 72 hrs by XTT assay
Growth inhibition of human HeLa cells after 72 hrs by XTT assay
[PMID: 24900500]
HeLa GI50
2.7 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 34500130]
HeLa GI50
3.2 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
HeLa GI50
3.36 μM
Compound: SAHA, Vorinostat
Growth inhibition of human HeLa cells by MTT assay
Growth inhibition of human HeLa cells by MTT assay
[PMID: 23601706]
HeLa IC50
0.02 μM
Compound: 2
Inhibition of recombinant HDAC1 in HeLa cells
Inhibition of recombinant HDAC1 in HeLa cells
[PMID: 17691763]
HeLa IC50
0.053 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell extract using Fluor deLys as substrate by fluorimetric assay
Inhibition of HDAC in human HeLa cell extract using Fluor deLys as substrate by fluorimetric assay
[PMID: 23820574]
HeLa IC50
0.055 μM
Compound: 1, SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence-based assay
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence-based assay
[PMID: 26814680]
HeLa IC50
0.063 μM
Compound: 2, SAHA
Inhibition of HDAC in human HeLa cells using Boc-K(Ac)-AMC as substrate preincubated for 4 hrs before substrate addition measured after 3 hrs by fluorescence assay
Inhibition of HDAC in human HeLa cells using Boc-K(Ac)-AMC as substrate preincubated for 4 hrs before substrate addition measured after 3 hrs by fluorescence assay
10.1039/C2MD00317A
HeLa IC50
0.07 μM
Compound: 2
Inhibition of HDAC in HeLa cells
Inhibition of HDAC in HeLa cells
[PMID: 17691763]
HeLa IC50
0.07 μM
Compound: 2a
Inhibition of HDAC in human HeLa cell nuclear extracts
Inhibition of HDAC in human HeLa cell nuclear extracts
[PMID: 21080629]
HeLa IC50
0.076 μM
Compound: SAHA
Inhibition of HDAC6 in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
Inhibition of HDAC6 in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
[PMID: 26555243]
HeLa IC50
0.079 μM
Compound: 2, SAHA
Inhibition of HDAC in human HeLa cell nuclear extracts using Ac-NH-GGK(Ac)-AMC as substrate after 180 mins by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extracts using Ac-NH-GGK(Ac)-AMC as substrate after 180 mins by fluorescence assay
10.1039/C2MD00317A
HeLa IC50
0.079 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cells by fluorescent activity assay
Inhibition of HDAC in human HeLa cells by fluorescent activity assay
[PMID: 21420859]
HeLa IC50
0.079 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell extract assessed as fluorophore release by fluorescence spectrophotometry
Inhibition of HDAC in human HeLa cell extract assessed as fluorophore release by fluorescence spectrophotometry
[PMID: 21978679]
HeLa IC50
0.079 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell extracts using Fluor de Lys as substrate by fluorescence assay
Inhibition of HDAC in human HeLa cell extracts using Fluor de Lys as substrate by fluorescence assay
[PMID: 22877635]
HeLa IC50
0.083 μM
Compound: SAHA
Inhibition of nuclear HDAC isolated from human HeLa cells
Inhibition of nuclear HDAC isolated from human HeLa cells
[PMID: 18558669]
HeLa IC50
0.09 μM
Compound: SAHA, Vorinostat
Inhibition of human HDAC in HeLa cells after 30 mins by Fluor de Lys fluorescence assay
Inhibition of human HDAC in HeLa cells after 30 mins by Fluor de Lys fluorescence assay
[PMID: 21889343]
HeLa IC50
0.1 μM
Compound: SAHA
Inhibition of HDAC2 in human HeLa cells
Inhibition of HDAC2 in human HeLa cells
[PMID: 19084294]
HeLa IC50
0.1 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cells extracts after 60 mins by fluorescence assay
Inhibition of HDAC in human HeLa cells extracts after 60 mins by fluorescence assay
[PMID: 20576572]
HeLa IC50
0.1 μM
Compound: SAHA
Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis
Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysis
[PMID: 24742384]
HeLa IC50
0.102 μM
Compound: SAHA
Inhibition of HDAC in human Hela cell nuclear extract after 15 mins
Inhibition of HDAC in human Hela cell nuclear extract after 15 mins
[PMID: 23644210]
HeLa IC50
0.102 μM
Compound: vorinostat
Inhibition of HDAC in human HeLa cells nuclear extract using Fluor de lys as substrate after 15 mins by fluorometric analysis
Inhibition of HDAC in human HeLa cells nuclear extract using Fluor de lys as substrate after 15 mins by fluorometric analysis
[PMID: 26629860]
HeLa IC50
0.106 μM
Compound: Vorinostat, SAHA, Zolinza
Inhibition of full length FLAG-tagged recombinant HDAC3 (unknown origin) transfected in human HeLa cells assessed as deacetylation of [3H]-acetylated histones after 2 hrs by scintillation counting analysis
Inhibition of full length FLAG-tagged recombinant HDAC3 (unknown origin) transfected in human HeLa cells assessed as deacetylation of [3H]-acetylated histones after 2 hrs by scintillation counting analysis
[PMID: 23964961]
HeLa IC50
0.107 μM
Compound: 1, SAHA, Vorinostat
Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
[PMID: 21476600]
HeLa IC50
0.11 μM
Compound: 1, SAHA
Inhibition of HDAC in HeLa cells by fluorescent activity assay
Inhibition of HDAC in HeLa cells by fluorescent activity assay
[PMID: 17477518]
HeLa IC50
0.11 μM
Compound: 2, SAHA
Inhibition of HeLa cell HDAC
Inhibition of HeLa cell HDAC
[PMID: 16723227]
HeLa IC50
0.11 μM
Compound: 2, SAHA
Inhibition of HDAC in HeLa cell lysates
Inhibition of HDAC in HeLa cell lysates
[PMID: 17904843]
HeLa IC50
0.11 μM
Compound: 6, SAHA
Inhibition of HDAC1/HDAC2 in human HeLa cells using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay
Inhibition of HDAC1/HDAC2 in human HeLa cells using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay
[PMID: 25906087]
HeLa IC50
0.11 μM
Compound: SAHA
Inhibition of HDAC1/3/5/8 in human HeLa cell extract using Boc-Lys-(acetyl)-AMC as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluorometric analysis
Inhibition of HDAC1/3/5/8 in human HeLa cell extract using Boc-Lys-(acetyl)-AMC as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluorometric analysis
[PMID: 23510562]
HeLa IC50
0.11 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using Fluor de Lys as substrate incubated with compound for 30 mins by microtiter-plate reading flourimeter analysis
Inhibition of HDAC in human HeLa cell nuclear extract using Fluor de Lys as substrate incubated with compound for 30 mins by microtiter-plate reading flourimeter analysis
[PMID: 25811792]
HeLa IC50
0.11 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using acetylated lysine side chain of histone as substrate measured after 30 mins by fluorometric assay
Inhibition of HDAC in human HeLa cell nuclear extract using acetylated lysine side chain of histone as substrate measured after 30 mins by fluorometric assay
[PMID: 28011426]
HeLa IC50
0.11 μM
Compound: SAHA, Zolinza
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins before substrate addition measured after 20 mins by UV-vis spectrophotometer analysis
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins before substrate addition measured after 20 mins by UV-vis spectrophotometer analysis
[PMID: 26100440]
HeLa IC50
0.119 μM
Compound: Vorinostat, SAHA, Zolinza
Inhibition of full length FLAG-tagged recombinant HDAC1 (unknown origin) transfected in human HeLa cells assessed as deacetylation of [3H]-acetylated histones after 2 hrs by scintillation counting analysis
Inhibition of full length FLAG-tagged recombinant HDAC1 (unknown origin) transfected in human HeLa cells assessed as deacetylation of [3H]-acetylated histones after 2 hrs by scintillation counting analysis
[PMID: 23964961]
HeLa IC50
0.12 μM
Compound: SAHA
Inhibition of HDAC1/HDAC2 in human HeLa cells nuclear extract preincubated for 5 mins before Boc-Lys (acetyl)-AMC substrate addition for 30 mins by microplate reader analysis
Inhibition of HDAC1/HDAC2 in human HeLa cells nuclear extract preincubated for 5 mins before Boc-Lys (acetyl)-AMC substrate addition for 30 mins by microplate reader analysis
[PMID: 26629857]
HeLa IC50
0.122 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cells using Fluor de Lys as substrate by fluorescence assay
Inhibition of HDAC in human HeLa cells using Fluor de Lys as substrate by fluorescence assay
[PMID: 23639537]
HeLa IC50
0.13 μM
Compound: 1, SAHA
Inhibition of HDAC1/2 in human HeLa cell extracts using acetylated histone peptide as substrate after 30 mins
Inhibition of HDAC1/2 in human HeLa cell extracts using acetylated histone peptide as substrate after 30 mins
[PMID: 24525003]
HeLa IC50
0.13 μM
Compound: SAHA, Vorinostat
Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysis
Inhibition of HDAC in human HeLa cell extract using fluor de Lys as substrate after 15 mins by fluorometric analysis
[PMID: 23792316]
HeLa IC50
0.14 μM
Compound: SAHA
Inhibition of HDAC1/HDAC2 isolated from human HeLa cells incubated for 30 mins by Color de Lys assay
Inhibition of HDAC1/HDAC2 isolated from human HeLa cells incubated for 30 mins by Color de Lys assay
10.1039/C4MD00203B
HeLa IC50
0.14 μM
Compound: SAHA
Inhibition of HDAC in HeLa cells
Inhibition of HDAC in HeLa cells
[PMID: 17662606]
HeLa IC50
0.147 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cytosolic extract using Fluor-de-lys as substrate measured after 60 mins by fluorescence assay
Inhibition of HDAC in human HeLa cytosolic extract using Fluor-de-lys as substrate measured after 60 mins by fluorescence assay
[PMID: 30245394]
HeLa IC50
0.16 μM
Compound: SAHA
Inhibition of HDAC6 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
Inhibition of HDAC6 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
[PMID: 30245394]
HeLa IC50
0.16 μM
Compound: SAHA
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
[PMID: 30879863]
HeLa IC50
0.168 μM
Compound: 3; SAHA
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
[PMID: 30901208]
HeLa IC50
0.17 μM
Compound: 2
Inhibition of HDAC in human HeLa cells nuclear extracts by fluorometric assay
Inhibition of HDAC in human HeLa cells nuclear extracts by fluorometric assay
[PMID: 23116147]
HeLa IC50
0.18 μM
Compound: SAHA
Inhibition of HDAC2 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
Inhibition of HDAC2 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
[PMID: 30245394]
HeLa IC50
0.19 μM
Compound: 1, SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 30 mins by fluorescence assay
[PMID: 23493449]
HeLa IC50
0.19 μM
Compound: SAHA
Inhibition of HDAC1 in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
Inhibition of HDAC1 in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
[PMID: 26555243]
HeLa IC50
0.19 μM
Compound: SAHA
Inhibition of HDAC1/HDAC2 in human HeLa nuclear extract
Inhibition of HDAC1/HDAC2 in human HeLa nuclear extract
[PMID: 30245394]
HeLa IC50
0.193 μM
Compound: SAHA
Inhibition of HDAC1/2 in human HeLa cells nuclear extracts using acetylated histone peptide as substrate after 30 mins by Color de Lys assay
Inhibition of HDAC1/2 in human HeLa cells nuclear extracts using acetylated histone peptide as substrate after 30 mins by Color de Lys assay
[PMID: 26216016]
HeLa IC50
0.195 μM
Compound: 1, SAHA, Vorinostat
Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
[PMID: 21476600]
HeLa IC50
0.231 μM
Compound: SAHA
Inhibition of HDAC in human HeLa nuclear extract using Fluor-de-lys as substrate measured after 60 mins by fluorescence assay
Inhibition of HDAC in human HeLa nuclear extract using Fluor-de-lys as substrate measured after 60 mins by fluorescence assay
[PMID: 30245394]
HeLa IC50
0.26 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using acetylated lysine as substrate after 30 mins by spectrophotometric analysis
Inhibition of HDAC in human HeLa cell nuclear extract using acetylated lysine as substrate after 30 mins by spectrophotometric analysis
[PMID: 24702857]
HeLa IC50
0.28 μM
Compound: 2, (SAHA, vorinostat)
Inhibition of HDAC in human HeLa cell nuclear extracts by fluorimetry
Inhibition of HDAC in human HeLa cell nuclear extracts by fluorimetry
[PMID: 19419205]
HeLa IC50
0.28 μM
Compound: SAHA
Inhibitory concentration against histone deacetylase of HeLa cells
Inhibitory concentration against histone deacetylase of HeLa cells
[PMID: 15603949]
HeLa IC50
0.28 μM
Compound: SAHA
Inhibition of HDAC from human HeLa cells
Inhibition of HDAC from human HeLa cells
[PMID: 18247554]
HeLa IC50
0.33 μM
Compound: SAHA
Inhibition of HDAC8 in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
Inhibition of HDAC8 in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
[PMID: 26555243]
HeLa IC50
0.35 μM
Compound: SAHA
Inhibition of class 1 HDAC n human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (acetyl)-AMC addition and measured after 30 mins by fluorescence based assay
Inhibition of class 1 HDAC n human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (acetyl)-AMC addition and measured after 30 mins by fluorescence based assay
[PMID: 32267687]
HeLa IC50
0.48 μM
Compound: 1, SAHA, Vorinostat
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorimetric analysis
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorimetric analysis
[PMID: 24766560]
HeLa IC50
0.48 μM
Compound: SAHA
Inhibition of HDAC in human HeLa nuclear extract
Inhibition of HDAC in human HeLa nuclear extract
[PMID: 30245394]
HeLa IC50
0.48 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay
[PMID: 34847495]
HeLa IC50
0.56 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
[PMID: 26555243]
HeLa IC50
0.6 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell extract incubated for 1 hr by colorimetric activity assay
Inhibition of HDAC in human HeLa cell extract incubated for 1 hr by colorimetric activity assay
10.1039/C4MD00350K
HeLa IC50
0.7 μM
Compound: SAHA
Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
[PMID: 19457659]
HeLa IC50
0.72 μM
Compound: SAHA
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
[PMID: 24702857]
HeLa IC50
0.98 μM
Compound: Zolinza, SAHA
Inhibition of HDAC derived from human HeLa cell nuclear extract using Boc-Lys(acetyl)-AMC as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluorimetry
Inhibition of HDAC derived from human HeLa cell nuclear extract using Boc-Lys(acetyl)-AMC as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluorimetry
[PMID: 22698782]
HeLa IC50
1.1 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extract by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extract by fluorescence assay
[PMID: 20036560]
HeLa IC50
1.17 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
HeLa IC50
1.41 μM
Compound: SAHA
Inhibition of HDAC8 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
Inhibition of HDAC8 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
[PMID: 30245394]
HeLa IC50
1.5 μM
Compound: 2a
Cytotoxicity against human HeLa cells overexpressing HDAC by resazurin dye reduction assay
Cytotoxicity against human HeLa cells overexpressing HDAC by resazurin dye reduction assay
[PMID: 21080629]
HeLa IC50
1.72 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 28336407]
HeLa IC50
1.72 μM
Compound: Vorinostat
Cytotoxicity against human HeLa cells assessed as cell growth inhibition
Cytotoxicity against human HeLa cells assessed as cell growth inhibition
[PMID: 38107170]
HeLa IC50
1.75 μM
Compound: 2
Cytotoxicity against HeLa cells
Cytotoxicity against HeLa cells
[PMID: 17691763]
HeLa IC50
1.84 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 29500131]
HeLa IC50
1.9 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 29533873]
HeLa IC50
107.8 nM
Compound: 1, SAHA
Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence assay
Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence assay
[PMID: 26122774]
HeLa IC50
11 nM
Compound: Vorinostat
Inhibition of HDAC1/HDAC2 in human HeLa cell nuclear extract preincubated for 20 mins followed by addition of HDAC green as substrate measured after 60 mins by fluorescence analysis
Inhibition of HDAC1/HDAC2 in human HeLa cell nuclear extract preincubated for 20 mins followed by addition of HDAC green as substrate measured after 60 mins by fluorescence analysis
[PMID: 27597246]
HeLa IC50
11.5 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assay
[PMID: 27186676]
HeLa IC50
12 nM
Compound: Vorinostat
Inhibition of human HDAC in HeLa cell nuclear extract by fluorometric assay using Fluor de Lys substrate
Inhibition of human HDAC in HeLa cell nuclear extract by fluorometric assay using Fluor de Lys substrate
[PMID: 26475519]
HeLa IC50
12.28 μM
Compound: 1, SAHA
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26122774]
HeLa IC50
12.28 μM
Compound: 6, SAHA
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25906087]
HeLa IC50
120.06 nM
Compound: 1; SAHA
Inhibition of HDAC activity in human HeLa cell nuclear extract using fluorometric substrate measured after 30 mins by fluorescence assay
Inhibition of HDAC activity in human HeLa cell nuclear extract using fluorometric substrate measured after 30 mins by fluorescence assay
[PMID: 27886544]
HeLa IC50
121 nM
Compound: SAHA
Inhibition of HDAC1/2 in human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (acetyl)-AMC or Boc-Lys (triflouroacetyl)-AMC addition and measured after 30 mins by fluorescence based assay
Inhibition of HDAC1/2 in human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (acetyl)-AMC or Boc-Lys (triflouroacetyl)-AMC addition and measured after 30 mins by fluorescence based assay
[PMID: 32267687]
HeLa IC50
1270 nM
Compound: 1; SAHA
Antiproliferative activity against human HeLa cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
HeLa IC50
131.26 nM
Compound: 1; SAHA
Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Lys(Ac)-pNA as substrate after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Lys(Ac)-pNA as substrate after 30 mins by fluorescence assay
[PMID: 28395150]
HeLa IC50
135 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell extracts assessed as inhibition of substrate deacetylation using Boc-Lys (acetyl)-AMC as substrate by fluorescence based assay
Inhibition of HDAC in human HeLa cell extracts assessed as inhibition of substrate deacetylation using Boc-Lys (acetyl)-AMC as substrate by fluorescence based assay
[PMID: 32247729]
HeLa IC50
141 nM
Compound: 1, SAHA
Inhibition of HDAC in human HeLa cell nuclear extracts using Fluor de Lys as substrate by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extracts using Fluor de Lys as substrate by fluorescence assay
[PMID: 24119555]
HeLa IC50
144.8 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell extract using Boc-Lys (acetyl)-AMC as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa cell extract using Boc-Lys (acetyl)-AMC as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by fluorescence assay
[PMID: 25462271]
HeLa IC50
147 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 21476600]
HeLa IC50
15 nM
Compound: Vorinostat
Inhibition of HDAC in human HeLa cell nuclear extracts preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorometric assay
Inhibition of HDAC in human HeLa cell nuclear extracts preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorometric assay
[PMID: 26741358]
HeLa IC50
154.8 nM
Compound: SAHA
Inhibition of Class 1 histone deacetylase isolated from human HeLa cell nuclear extracts using Boc-Lys (acetyl)-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescence assay
Inhibition of Class 1 histone deacetylase isolated from human HeLa cell nuclear extracts using Boc-Lys (acetyl)-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescence assay
[PMID: 26349626]
HeLa IC50
159 nM
Compound: Vorinostat
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using COLOR DE LYS as substrate pretreated for 5 mins followed by substrate addition measured after 30 mins by UV-absorption method
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using COLOR DE LYS as substrate pretreated for 5 mins followed by substrate addition measured after 30 mins by UV-absorption method
[PMID: 28371677]
HeLa IC50
160.8 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extracts using (Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extracts using (Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay
[PMID: 28336407]
HeLa IC50
161 nM
Compound: SAHA
Inhibition of HDAC1/2 in human HeLa cell nuclear extracts preincubated for 5 mins followed by substrate addition measured after 0.5 hrs by Color de Lys assay
Inhibition of HDAC1/2 in human HeLa cell nuclear extracts preincubated for 5 mins followed by substrate addition measured after 0.5 hrs by Color de Lys assay
[PMID: 26149591]
HeLa IC50
176.6 μM
Compound: SAHA
Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate incubated for 2 hrs prior to substrate addition measured after 30 mins by fluorescence assay
Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate incubated for 2 hrs prior to substrate addition measured after 30 mins by fluorescence assay
[PMID: 26386821]
HeLa IC50
18 nM
Compound: 2, SAHA
Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry
Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry
[PMID: 21984958]
HeLa IC50
18.9 μM
Compound: SAHA
Inhibition of class 2 HDAC n human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (triflouroacetyl)-AMC addition and measured after 30 mins by fluorescence based assay
Inhibition of class 2 HDAC n human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (triflouroacetyl)-AMC addition and measured after 30 mins by fluorescence based assay
[PMID: 32267687]
HeLa IC50
1860 nM
Compound: SAHA
Inhibition of HDAC8 from human HeLa cells nuclear extract by cell free fluorimetric assay
Inhibition of HDAC8 from human HeLa cells nuclear extract by cell free fluorimetric assay
[PMID: 19093884]
HeLa IC50
196 nM
Compound: SAHA
Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
[PMID: 20167479]
HeLa IC50
1989 nM
Compound: SAHA
Inhibition of HDAC8 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
Inhibition of HDAC8 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
[PMID: 22260166]
HeLa IC50
1989 nM
Compound: SAHA, Vorinostat
Inhibition of HDAC8 in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
Inhibition of HDAC8 in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
[PMID: 23622981]
HeLa IC50
2.04 μM
Compound: SAHA
Anticancer activity against human HeLa cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
Anticancer activity against human HeLa cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
[PMID: 36244186]
HeLa IC50
2.06 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 28601509]
HeLa IC50
2.06 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 29787262]
HeLa IC50
2.12 μM
Compound: SAHA
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 28057407]
HeLa IC50
2.2 μM
Compound: 6, SAHA
Cytotoxicity against human HeLa cells after 72 hrs by alamar-blue cell viability assay
Cytotoxicity against human HeLa cells after 72 hrs by alamar-blue cell viability assay
[PMID: 19301902]
HeLa IC50
2.41 μM
Compound: SAHA
Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
HeLa IC50
2.5 μM
Compound: Vorinostat
Antiproliferative activity against human HeLa cells measured after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells measured after 24 hrs by MTT assay
[PMID: 37875056]
HeLa IC50
2.59 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK-8 assay
[PMID: 37057760]
HeLa IC50
2.59 μM
Compound: SAHA, Vorinostat
Inhibition of HDAC in human HeLa cell nuclear extracts using Color de LysTM after 30 mins
Inhibition of HDAC in human HeLa cell nuclear extracts using Color de LysTM after 30 mins
[PMID: 24095016]
HeLa IC50
2.6 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs
Antiproliferative activity against human HeLa cells after 48 hrs
[PMID: 24262004]
HeLa IC50
2.6 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells after 48 hrs by CCK-8 assay
[PMID: 35939996]
HeLa IC50
2.65 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33021789]
HeLa IC50
2.7 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 24296013]
HeLa IC50
2.7 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
[PMID: 29150335]
HeLa IC50
2.7 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
[PMID: 34624191]
HeLa IC50
2.74 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay
[PMID: 39145486]
HeLa IC50
2.8 μM
Compound: SAHA, vorinostat
Inhibition of HDAC isolated from human HeLa cell nuclear extract after 30 mins by fluorescence assay
Inhibition of HDAC isolated from human HeLa cell nuclear extract after 30 mins by fluorescence assay
[PMID: 23707260]
HeLa IC50
2.85 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
HeLa IC50
2.9 μM
Compound: Vorinostat
Antiproliferative activity against human HeLa cells by CCK8 assay
Antiproliferative activity against human HeLa cells by CCK8 assay
[PMID: 30660827]
HeLa IC50
2000 nM
Compound: 2, SAHA
Inhibition of HDAC8 in human HeLa cells nuclear extract using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by spectrophotometry
Inhibition of HDAC8 in human HeLa cells nuclear extract using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by spectrophotometry
[PMID: 21984958]
HeLa IC50
27 nM
Compound: SAHA
Inhibition of HDAC6 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
Inhibition of HDAC6 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
[PMID: 22260166]
HeLa IC50
27 nM
Compound: SAHA, Vorinostat
Inhibition of HDAC6 in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
Inhibition of HDAC6 in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
[PMID: 23622981]
HeLa IC50
29 nM
Compound: SAHA
Selectivity ratio IC50 for HDAC8 to IC50 for HDAC in human HeLa cells nuclear extract
Selectivity ratio IC50 for HDAC8 to IC50 for HDAC in human HeLa cells nuclear extract
[PMID: 20669972]
HeLa IC50
3.1 μM
Compound: II, SAHA
Antiproliferative activity against human HeLa cells after 4 hrs by WST-1 assay
Antiproliferative activity against human HeLa cells after 4 hrs by WST-1 assay
[PMID: 18672316]
HeLa IC50
3.55 μM
Compound: Vorinostat
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 28371677]
HeLa IC50
3.56 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
HeLa IC50
3.7 μM
Compound: SAHA
Cytotoxicity against human HeLa cells after 72 hrs by MTS assay
Cytotoxicity against human HeLa cells after 72 hrs by MTS assay
[PMID: 25899338]
HeLa IC50
3.823 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
HeLa IC50
38 nM
Compound: SAHA
Inhibition of HDAC1 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
Inhibition of HDAC1 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
[PMID: 22260166]
HeLa IC50
38 nM
Compound: SAHA, Vorinostat
Inhibition of HDAC1 in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
Inhibition of HDAC1 in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
[PMID: 23622981]
HeLa IC50
4.5 μM
Compound: SAHA
Inhibition of HDAC in human HeLa cells
Inhibition of HDAC in human HeLa cells
[PMID: 18558669]
HeLa IC50
4.52 μM
Compound: SAHA
Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation
Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation
[PMID: 35944852]
HeLa IC50
4.52 μM
Compound: Vorinostat
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 5 days by beckman coulter counting method
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 5 days by beckman coulter counting method
[PMID: 33261898]
HeLa IC50
4.52 μM
Compound: Vorinostat
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 74 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 74 hrs by SRB assay
[PMID: 35255412]
HeLa IC50
4.52 μM
Compound: Vorinostat
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
[PMID: 35477142]
HeLa IC50
4.61 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 30879863]
HeLa IC50
4.66 μM
Compound: SAHA
Antiproliferative activity against siRNA-induced BAX knock down human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against siRNA-induced BAX knock down human HeLa cells after 48 hrs by MTT assay
[PMID: 33021789]
HeLa IC50
40 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extract
Inhibition of HDAC in human HeLa cell nuclear extract
[PMID: 20143778]
HeLa IC50
41 nM
Compound: 2, SAHA
Inhibition of HDAC1 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry
Inhibition of HDAC1 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry
[PMID: 21984958]
HeLa IC50
41 nM
Compound: 2, SAHA
Inhibition of HDAC3-NCoR2 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry
Inhibition of HDAC3-NCoR2 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry
[PMID: 21984958]
HeLa IC50
416 nM
Compound: SAHA
Inhibition of HDAC1/HDAC2 in human HeLa cell extract incubated for 5 mins prior to substrate addition measured after 30 mins by microtitre plate reader analysis
Inhibition of HDAC1/HDAC2 in human HeLa cell extract incubated for 5 mins prior to substrate addition measured after 30 mins by microtitre plate reader analysis
[PMID: 25311567]
HeLa IC50
460 nM
Compound: 1, SAHA
Antiproliferative activity against human HeLa cells after 72 hrs by celltiter-blue viability assay
Antiproliferative activity against human HeLa cells after 72 hrs by celltiter-blue viability assay
[PMID: 18809328]
HeLa IC50
460 nM
Compound: 1, vorinostat
Antiproliferative activity against human HeLa cells by CellTiter-Blue cell viability assay
Antiproliferative activity against human HeLa cells by CellTiter-Blue cell viability assay
[PMID: 18370373]
HeLa IC50
460 nM
Compound: SAHA
Inhibition of HeLa cell proliferation
Inhibition of HeLa cell proliferation
[PMID: 16987657]
HeLa IC50
49 nM
Compound: SAHA
Inhibition of HDAC1/2 from human HeLa cells
Inhibition of HDAC1/2 from human HeLa cells
[PMID: 19854643]
HeLa IC50
5 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32151834]
HeLa IC50
5.21 μM
Compound: 1; SAHA
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36242988]
HeLa IC50
5.45 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 26100440]
HeLa IC50
6.07 μM
Compound: SAHA
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
10.1039/C4MD00203B
HeLa IC50
65 nM
Compound: SAHA
Inhibition of human HDAC in HeLa cells by flour de lys assay
Inhibition of human HDAC in HeLa cells by flour de lys assay
[PMID: 18397827]
HeLa IC50
65 nM
Compound: SAHA
Inhibition of HDAC1/2 from human HeLa cells nuclear extract by cell free fluorimetric assay
Inhibition of HDAC1/2 from human HeLa cells nuclear extract by cell free fluorimetric assay
[PMID: 19093884]
HeLa IC50
65 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
[PMID: 19914074]
HeLa IC50
65 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extracts
Inhibition of HDAC in human HeLa cell nuclear extracts
[PMID: 20669972]
HeLa IC50
65 nM
Compound: SAHA
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using Fluor de Lys as substrate after 15 mins by fluorometric analysis
[PMID: 22260166]
HeLa IC50
65 nM
Compound: SAHA, Vorinostat
Inhibition of HDAC in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
Inhibition of HDAC in human HeLa cells using Fluor-de-Lys as substrate after 15 mins by fluorescence assay
[PMID: 23622981]
HeLa IC50
67 nM
Compound: SAHA, Vorinostat
Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
[PMID: 21621883]
HeLa IC50
67 nM
Compound: SAHA, Zolinza
Inhibition of HDAC in human HeLa cell nuclear extracts using Ac-Arg-Gly-Lys(Ac)-AMC substrate by fluorimetry
Inhibition of HDAC in human HeLa cell nuclear extracts using Ac-Arg-Gly-Lys(Ac)-AMC substrate by fluorimetry
[PMID: 22435669]
HeLa IC50
7.13 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
10.1039/C5MD00247H
HeLa IC50
711 nM
Compound: SAHA
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 26443078]
HeLa IC50
73.2 nM
Compound: SAHA
Inhibition of HDAC in human HeLA cell nuclear extracts
Inhibition of HDAC in human HeLA cell nuclear extracts
[PMID: 31400938]
HeLa IC50
8.96 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00247H
HeLa IC50
80 nM
Compound: SAHA
Inhibition of human HDAC in HeLa cells by fluorescent activity assay
Inhibition of human HDAC in HeLa cells by fluorescent activity assay
[PMID: 19223622]
HeLa IC50
85.5 nM
Compound: SAHA
Inhibition of HDAC6 from human HeLa cells nuclear extract by cell free fluorimetric assay
Inhibition of HDAC6 from human HeLa cells nuclear extract by cell free fluorimetric assay
[PMID: 19093884]
HeLa IC50
86 nM
Compound: SAHA
Inhibition of HDAC in human Hela cell lysate using Fluor-de-Lys as substrate compound pretreated for 30 mins before substrate addition by fluorescence assay
Inhibition of HDAC in human Hela cell lysate using Fluor-de-Lys as substrate compound pretreated for 30 mins before substrate addition by fluorescence assay
[PMID: 23089527]
HeLa IC50
87 nM
Compound: II, SAHA
Inhibition of HDAC from human HeLa cells
Inhibition of HDAC from human HeLa cells
[PMID: 18672316]
HeLa IC50
87 nM
Compound: SAHA
Inhibition of HDAC in human HeLa cell nuclear extracts by fluorimetric assay
Inhibition of HDAC in human HeLa cell nuclear extracts by fluorimetric assay
[PMID: 20884208]
HeLa IC50
87 nM
Compound: SAHA, vorinostat
Inhibition of HDAC in human HeLa cells nuclear extract using fluor de Lys as substrate preincubated for 5 mins by fluorometric analysis
Inhibition of HDAC in human HeLa cells nuclear extract using fluor de Lys as substrate preincubated for 5 mins by fluorometric analysis
[PMID: 21080647]
HeLa IC50
9.19 μM
Compound: SAHA
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
10.1039/C5MD00247H
HeLa IC50
9.69 μM
Compound: SAHA, Vorinostat
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
[PMID: 24095016]
HeLa IC50
91 nM
Compound: SAHA
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using color de Lys as substrate preincubated for 5 mins followed by substrate addition measured after 30 min by microtiter plate reader analysis
Inhibition of HDAC1/2 in human HeLa cell nuclear extract using color de Lys as substrate preincubated for 5 mins followed by substrate addition measured after 30 min by microtiter plate reader analysis
[PMID: 26907204]
HeLa IC50
96.4 nM
Compound: 1, SAHA
Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
[PMID: 22439863]
HeLa IC50
98.35 μM
Compound: 1; SAHA
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay
[PMID: 31655430]
HeLa IC50
>= 0.05 μM
Compound: SAHA, vorinostat
Inhibition of HDAC2 in HeLa cell lysates
Inhibition of HDAC2 in HeLa cell lysates
[PMID: 17892933]
HeLa S3 IC50
0.02 μM
Compound: SAHA
Inhibition of HDAC3 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
Inhibition of HDAC3 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
[PMID: 28337317]
HeLa S3 IC50
0.033 μM
Compound: SAHA
Inhibition of HDAC1 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
Inhibition of HDAC1 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
[PMID: 28337317]
HeLa S3 IC50
0.033 μM
Compound: SAHA
Inhibition of HDAC6 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
Inhibition of HDAC6 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
[PMID: 28337317]
HeLa S3 IC50
0.096 μM
Compound: SAHA
Inhibition of HDAC2 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
Inhibition of HDAC2 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISA
[PMID: 28337317]
Hep 3B2 GI50
0.69 μM
Compound: 1, SAHA
Growth inhibition of human Hep3B cells after 48 hrs by SRB assay
Growth inhibition of human Hep3B cells after 48 hrs by SRB assay
[PMID: 22439863]
Hep 3B2 GI50
1.21 μM
Compound: SAHA
Antiproliferative activity against human Hep3B cells after 48 hrs by SRB assay
Antiproliferative activity against human Hep3B cells after 48 hrs by SRB assay
[PMID: 21712146]
Hep 3B2 GI50
> 410 nM
Compound: Vorinostat
Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
Hep 3B2 IC50
2.1 μM
Compound: SAHA
Cytotoxicity against human Hep3B cells
Cytotoxicity against human Hep3B cells
[PMID: 23906422]
Hep 3B2 IC50
2.3 μM
Compound: Vorinostat
Cytotoxicity against human Hep3B cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human Hep3B cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
Hep 3B2 IC50
2.44 μM
Compound: SAHA
Antiproliferative activity against human Hep3B2 cells after hrs by ATP content assay
Antiproliferative activity against human Hep3B2 cells after hrs by ATP content assay
[PMID: 20143778]
Hep 3B2 IC50
2.6 μM
Compound: Vor; SAHA
Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
Hep 3B2 IC50
5.4 μM
Compound: SAHA, vorinostat
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23707260]
Hep 3B2 IC50
5.58 μM
Compound: SAHA
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
HepG2 CC50
12 μM
Compound: Vorinostat
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay
[PMID: 30973727]
HepG2 EC50
12.2 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 23820574]
HepG2 EC50
2.5 μM
Compound: suberoylanilide
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
3.8 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 72 hrs by XTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by XTT assay
[PMID: 21548582]
HepG2 EC50
35.5 μM
Compound: suberoylanilide
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
8.4 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 48 hrs by XTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by XTT assay
[PMID: 21548582]
HepG2 EC50
> 50 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 24 hrs by XTT assay
Antiproliferative activity against human HepG2 cells after 24 hrs by XTT assay
[PMID: 21548582]
HepG2 GI50
21.96 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells after 96 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 96 hrs by MTT assay
[PMID: 29500130]
HepG2 GI50
3.4 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 34500130]
HepG2 GI50
3.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
[PMID: 22435669]
HepG2 GI50
4600 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human HepG2 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human HepG2 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
HepG2 GI50
63.48 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 19822426]
HepG2 IC50
0.14 μM
Compound: SAHA, Vorinostat
Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs
Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs
[PMID: 24904967]
HepG2 IC50
0.15 μM
Compound: SAHA, Vorinostat
Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells
Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells
[PMID: 24904967]
HepG2 IC50
0.18 μM
Compound: Vorinostat
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
HepG2 IC50
0.18 μg/mL
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells
Antiproliferative activity against human HepG2 cells
[PMID: 31945642]
HepG2 IC50
0.18 μg/mL
Compound: Vorinostat
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
HepG2 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
HepG2 IC50
0.41 μM
Compound: 1
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
[PMID: 35238576]
HepG2 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
HepG2 IC50
0.6 nM
Compound: SAHA
Inhibition of human HepG2 cells
Inhibition of human HepG2 cells
[PMID: 18247554]
HepG2 IC50
0.61 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells
Antiproliferative activity against human HepG2 cells
[PMID: 37875056]
HepG2 IC50
0.68 μM
Compound: Vorinostat
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
[PMID: 37875056]
HepG2 IC50
0.85 μM
Compound: SAHA
Cytotoxicity against human Hep-G2 cells assessed as inhibition of cell proliferation measured after 72 hrs by ATPlite assay
Cytotoxicity against human Hep-G2 cells assessed as inhibition of cell proliferation measured after 72 hrs by ATPlite assay
[PMID: 34185525]
HepG2 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
HepG2 IC50
1.14 μM
Compound: SAHA
Cytotoxicity against human HepG2 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against human HepG2 cells incubated for 72 hrs measured by MTT assay
[PMID: 37498552]
HepG2 IC50
1.18 μM
Compound: Vorinostat
Cytotoxicity against human HepG2 cells incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human HepG2 cells incubated for 72 hrs by CCK-8 assay
[PMID: 35175762]
HepG2 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
HepG2 IC50
1.27 μM
Compound: Vor; SAHA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
HepG2 IC50
1.43 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
[PMID: 34237620]
HepG2 IC50
1.49 μM
Compound: SAHA, Vorinostat
Cytotoxicity against human HepG2 cells after 48 hrs
Cytotoxicity against human HepG2 cells after 48 hrs
[PMID: 24904967]
HepG2 IC50
1.54 μM
Compound: 1; SAHA
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
[PMID: 36215854]
HepG2 IC50
1.54 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay
Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay
[PMID: 29150335]
HepG2 IC50
1.66 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after hrs by ATP content assay
Antiproliferative activity against human HepG2 cells after hrs by ATP content assay
[PMID: 20143778]
HepG2 IC50
1.7 μM
Compound: SAHA; 112
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 31881454]
HepG2 IC50
1.7 μM
Compound: Vorinostat
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
[PMID: 30660827]
HepG2 IC50
10.52 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
10.1039/C5MD00247H
HepG2 IC50
10.77 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
10.1039/C5MD00247H
HepG2 IC50
13 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
HepG2 IC50
2 μM
Compound: 5; SAHA
Antiproliferative activity against human HepG2 cells after 96 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 96 hrs by MTT assay
[PMID: 31117517]
HepG2 IC50
2.1 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
HepG2 IC50
2.26 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
HepG2 IC50
2.265 μM
Compound: SAHA
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
HepG2 IC50
2.4 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
HepG2 IC50
2.43 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
[PMID: 37875056]
HepG2 IC50
2.5 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 24 hrs by MTT assay
[PMID: 37875056]
HepG2 IC50
2.57 μM
Compound: Vorinostat
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
HepG2 IC50
2.8 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
HepG2 IC50
2.9 μM
Compound: Vorinostat
Antiproliferative activity against human HepG2 cells by CCK8 assay
Antiproliferative activity against human HepG2 cells by CCK8 assay
[PMID: 30660827]
HepG2 IC50
23.62 μM
Compound: SAHA
Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by CCK8 assay
[PMID: 26211462]
HepG2 IC50
3.2 ng/mL
Compound: SAHA; 1
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 3 days by trypan blue assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 3 days by trypan blue assay
[PMID: 35586423]
HepG2 IC50
3.33 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 29396364]
HepG2 IC50
3.4 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
[PMID: 34624191]
HepG2 IC50
3.81 μM
Compound: SAHA
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
HepG2 IC50
3385 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
HepG2 IC50
4.1 μM
Compound: 1; SAHA
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28885834]
HepG2 IC50
4.5 μM
Compound: 1; SAHA
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 30455152]
HepG2 IC50
4.95 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells by MTT assay
Antiproliferative activity against human HepG2 cells by MTT assay
[PMID: 31546197]
HepG2 IC50
5.75 μM
Compound: 1; SAHA
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36242988]
HepG2 IC50
5.9 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 31120744]
HepG2 IC50
5.94 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
[PMID: 30851694]
HepG2 IC50
514.5 nM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 31177073]
HepG2 IC50
6 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells after 48 hrs by CCK-8 assay
[PMID: 35939996]
HepG2 IC50
6.26 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 29288941]
HepG2 IC50
6.26 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 30108831]
HepG2 IC50
7.19 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 35041998]
HepG2 IC50
7.6 μM
Compound: SAHA
Cytotoxicity against human HepG2-A16-CD81EGFP cells assessed as inhibition of cell growth incubated for 24 hrs followed by medium transfer and incubation in multimode plate for 48 hrs by CellTiterGlo reagent based luminescence assay
Cytotoxicity against human HepG2-A16-CD81EGFP cells assessed as inhibition of cell growth incubated for 24 hrs followed by medium transfer and incubation in multimode plate for 48 hrs by CellTiterGlo reagent based luminescence assay
[PMID: 33360801]
HepG2 IC50
8.78 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00247H
HepG2 IC50
9.06 μM
Compound: I-1; SAHA
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 35245830]
HepG2 IC50
9.1 μM
Compound: SAHA
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 29348808]
HepG2 IC50
9.3 μM
Compound: SAHA
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
[PMID: 20143840]
HepG2 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 26443078]
HepG2 IC50
> 50 μM
Compound: SAHA
Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay
[PMID: 34847495]
Hepatocyte EC50
> 500 μM
Compound: SAHA
Compound was tested for anti-proliferative activity in human hepatocytes
Compound was tested for anti-proliferative activity in human hepatocytes
[PMID: 14698179]
Hepatocyte GI50
> 500 μM
Compound: SAHA
Growth inhibition of human hepatocytes after 21 hrs by MTT assay
Growth inhibition of human hepatocytes after 21 hrs by MTT assay
[PMID: 17662606]
Hs-578T GI50
3.6 μM
Compound: SAHA
Antiproliferative activity against human Hs578T cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human Hs578T cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
Hs-578T GI50
4.83 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human Hs578T cells after 48 hrs by SRB assay
Cytotoxicity against human Hs578T cells after 48 hrs by SRB assay
[PMID: 24015327]
Hs-578T GI50
5 μM
Compound: SAHA, Zolinza
Growth inhibition of human Hs 578T cells after 72 hrs by MTS assay
Growth inhibition of human Hs 578T cells after 72 hrs by MTS assay
[PMID: 22435669]
Hs68 IC50
4.6 μM
Compound: SAHA
Cytotoxicity against human HS68 cells after 72 hrs by MTT assay
Cytotoxicity against human HS68 cells after 72 hrs by MTT assay
[PMID: 23570542]
HuP-T3 IC50
0.8 μM
Compound: 1a, SAHA
Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay
Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay
[PMID: 20055418]
HuP-T3 IC50
0.8 μM
Compound: SAHA
Cytotoxicity against human Hup T3 cells after 72 hrs by MTT assay
Cytotoxicity against human Hup T3 cells after 72 hrs by MTT assay
[PMID: 18494463]
HuP-T3 IC50
0.8 μM
Compound: SAHA
Antiproliferative activity against human HupT3 cells after 72 hrs by MTT assay
Antiproliferative activity against human HupT3 cells after 72 hrs by MTT assay
[PMID: 18642892]
HuP-T3 IC50
0.8 μM
Compound: SAHA
Antiproliferative activity against human HUPT3 cells by MTT assay
Antiproliferative activity against human HUPT3 cells by MTT assay
[PMID: 19419863]
HuT78 EC50
290 nM
Compound: 1
Pro-apoptotic activity in human HUT78 cells after 18 hrs by caspase-Glo 3/7 assay
Pro-apoptotic activity in human HUT78 cells after 18 hrs by caspase-Glo 3/7 assay
[PMID: 30122227]
HuT78 GI50
2.1 μM
Compound: Vorin
Cytotoxicity against human HUT78 cells after 72 hrs by MTS assay
Cytotoxicity against human HUT78 cells after 72 hrs by MTS assay
[PMID: 24900743]
HuT78 GI50
295 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human HUT78 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human HUT78 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
HuT78 GI50
3 μM
Compound: 2, SAHA, Vorinostat
Cytotoxicity against human HUT78 cells after 72 hrs by MTS-PMS assay
Cytotoxicity against human HUT78 cells after 72 hrs by MTS-PMS assay
[PMID: 24164245]
HuT78 GI50
300 nM
Compound: SAHA
Growth inhibition of human HUT78 cells after 72 hrs by SRB assay
Growth inhibition of human HUT78 cells after 72 hrs by SRB assay
[PMID: 20884208]
HuT78 IC50
0.68 μM
Compound: Vorinostat
Cytotoxicity against human HuT78 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
Cytotoxicity against human HuT78 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
[PMID: 37875056]
HuT78 IC50
0.71 μM
Compound: 1; SAHA
Cytotoxicity against human HuT78 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human HuT78 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
Huh-7 CC50
0.64 μM
Compound: Vorinostat
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by MTT assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by MTT assay
[PMID: 31201063]
Huh-7 CC50
1.9 μM
Compound: 5, SAHA
Cytotoxicity against human HuH7 cells assessed as inhibition of cell viability after 3 days by CellTiter 96 assay
Cytotoxicity against human HuH7 cells assessed as inhibition of cell viability after 3 days by CellTiter 96 assay
[PMID: 25490700]
Huh-7 EC50
0.36 μM
Compound: 5, SAHA
Antiviral activity against HCV genotype 1b infected in human Huh7 cells after 3 days by luciferase reporter gene assay
Antiviral activity against HCV genotype 1b infected in human Huh7 cells after 3 days by luciferase reporter gene assay
[PMID: 25490700]
Huh-7 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human Huh-7 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human Huh-7 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
Huh-7 IC50
0.9 μM
Compound: Vorinostat
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
Huh-7 IC50
1.2 μM
Compound: SAHA
Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter blue-reagent based assay
Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter blue-reagent based assay
[PMID: 30645113]
Huh-7 IC50
1.65 μM
Compound: SAHA
Cytotoxicity against human Huh-7 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against human Huh-7 cells incubated for 72 hrs measured by MTT assay
[PMID: 37498552]
Huh-7 IC50
1.95 μM
Compound: Vor; SAHA
Antiproliferative activity against human HuH-7 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human HuH-7 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
Huh-7 IC50
3.88 μM
Compound: SAHA
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
Huh-7 IC50
4.3 μM
Compound: 5; SAHA
Antiproliferative activity against human HuH7 cells after 96 hrs by MTT assay
Antiproliferative activity against human HuH7 cells after 96 hrs by MTT assay
[PMID: 31117517]
Huh-7 IC50
4.95 μM
Compound: SAHA
Antiproliferative activity against human HuH7 cells after 48 hrs by MTT assay
Antiproliferative activity against human HuH7 cells after 48 hrs by MTT assay
[PMID: 29288941]
Huh-7 IC50
5.1 μM
Compound: SAHA
Antiproliferative activity against human HuH7 cells after 72 hrs by MTT assay
Antiproliferative activity against human HuH7 cells after 72 hrs by MTT assay
[PMID: 31120744]
IGROV-1 GI50
1.1 μM
Compound: SAHA
Antiproliferative activity against human IGROV1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human IGROV1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
IGROV-1 GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human IGROV1 cells after 72 hrs by MTS assay
Growth inhibition of human IGROV1 cells after 72 hrs by MTS assay
[PMID: 22435669]
IGROV-1 IC50
2.2 μM
Compound: SAHA
Antiproliferative activity against cisplatin-resistant human IGROV1 cells after 72 hrs
Antiproliferative activity against cisplatin-resistant human IGROV1 cells after 72 hrs
[PMID: 19084294]
IGROV-1 IC50
2.2 μM
Compound: SAHA
Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
[PMID: 19084294]
IGROV-1 IC50
2.2 μM
Compound: SAHA
Antiproliferative activity against human IGROV1 cells assessed as growth inhibition after 72 hrs
Antiproliferative activity against human IGROV1 cells assessed as growth inhibition after 72 hrs
[PMID: 24742384]
IGROV-1 IC50
2.2 μM
Compound: SAHA
Antiproliferative activity against p53 defective cis-platinum-resistant human IGROV1/Pt1 cells assessed as growth inhibition after 72 hrs
Antiproliferative activity against p53 defective cis-platinum-resistant human IGROV1/Pt1 cells assessed as growth inhibition after 72 hrs
[PMID: 24742384]
IGROV-1 IC50
2.2 μM
Compound: SAHA
Growth inhibition of human IGROV1 cells after 72 hrs
Growth inhibition of human IGROV1 cells after 72 hrs
[PMID: 26376355]
IGROV-1 IC50
2.2 μM
Compound: SAHA
Growth inhibition of human IGROV1/Pt1 cells after 72 hrs
Growth inhibition of human IGROV1/Pt1 cells after 72 hrs
[PMID: 26376355]
IGROV-1 IC50
2.2 μM
Compound: SAHA
Antiproliferative activity against human IGROV1 cells assessed as reduction in cell number after 72 hrs by cell counter analysis
Antiproliferative activity against human IGROV1 cells assessed as reduction in cell number after 72 hrs by cell counter analysis
[PMID: 26890116]
IMR-32 IC50
0.62 μM
Compound: Vorinostat
Antiproliferative activity against human IMR32 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
Antiproliferative activity against human IMR32 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
[PMID: 31391882]
JeKo-1 IC50
0.18 μM
Compound: SAHA
Antiproliferative activity against human JeKo-1 cells incubated for 48 hrs by resazurin based microplate reader analysis
Antiproliferative activity against human JeKo-1 cells incubated for 48 hrs by resazurin based microplate reader analysis
[PMID: 37647727]
JeKo-1 IC50
0.42 μM
Compound: SAHA
Antiproliferative activity against human JeKo1 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
Antiproliferative activity against human JeKo1 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
[PMID: 26890114]
JeKo-1 IC50
285 nM
Compound: 1; SAHA
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
[PMID: 39047608]
JeKo-1 IC50
3.5 μM
Compound: SAHA
Antiproliferative activity against human JeKo1 cells after 72 hrs by MTT assay
Antiproliferative activity against human JeKo1 cells after 72 hrs by MTT assay
[PMID: 29150335]
JeKo-1 IC50
638.6 nM
Compound: SAHA
Antiproliferative activity against human JeKo1 cells after 72 hrs by MTT assay
Antiproliferative activity against human JeKo1 cells after 72 hrs by MTT assay
[PMID: 31177073]
Jurkat EC50
0.72 μM
Compound: SAHA
Growth inhibition of human Jurkat cells after 44 hrs by MTT assay
Growth inhibition of human Jurkat cells after 44 hrs by MTT assay
[PMID: 28337317]
Jurkat EC50
0.87 μM
Compound: 1a, SAHA
Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
Jurkat EC50
1.66 μM
Compound: SAHA
Cytotoxicity against human Jurkat cells assessed as cell proliferation after 70 hrs by MTS assay
Cytotoxicity against human Jurkat cells assessed as cell proliferation after 70 hrs by MTS assay
[PMID: 25974739]
Jurkat EC50
1600 nM
Compound: Vorinostat
Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by Steady-Glo luciferase assay
Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by Steady-Glo luciferase assay
[PMID: 32676157]
Jurkat EC50
2.3 μM
Compound: SAHA
Compound was tested for anti-proliferative activity in Jurkat human leukemia cell line
Compound was tested for anti-proliferative activity in Jurkat human leukemia cell line
[PMID: 14698179]
Jurkat GI50
0.9 μM
Compound: Vorin
Cytotoxicity against human Jurkat cells after 72 hrs by MTS assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTS assay
[PMID: 24900743]
Jurkat GI50
1.1 μM
Compound: 1, SAHA
Growth inhibition of human Jurkat cells after 72 hrs by XTT assay
Growth inhibition of human Jurkat cells after 72 hrs by XTT assay
[PMID: 24900500]
Jurkat GI50
2.4 μM
Compound: 1
Growth inhibition of human Jurkat cells
Growth inhibition of human Jurkat cells
[PMID: 37429084]
Jurkat IC50
0.04 μM
Compound: 4, SAHA
Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-Ac as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay
Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-Ac as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay
[PMID: 24261862]
Jurkat IC50
0.1 μM
Compound: 1; SAHA
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
Jurkat IC50
0.1 μM
Compound: Vorinostat
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
Jurkat IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
Jurkat IC50
0.27 μM
Compound: 3; SAHA
Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30901208]
Jurkat IC50
0.3 μM
Compound: SAHA
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 35043615]
Jurkat IC50
0.35 μM
Compound: SAHA
Antiproliferative activity against human Jurkat cells after 48 hrs by MTT assay
Antiproliferative activity against human Jurkat cells after 48 hrs by MTT assay
[PMID: 29533873]
Jurkat IC50
0.38 μM
Compound: SAHA
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
Jurkat IC50
0.47 μM
Compound: Vorinostat
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
[PMID: 36351184]
Jurkat IC50
0.47 μM
Compound: Vorinostat
Cytotoxicity against human Jurkat cells measured for 72 hrs by celltiter-glo assay
Cytotoxicity against human Jurkat cells measured for 72 hrs by celltiter-glo assay
[PMID: 38714044]
Jurkat IC50
0.59 μM
Compound: 1; SAHA
Antiproliferative activity against human Jurkat cells
Antiproliferative activity against human Jurkat cells
[PMID: 27541357]
Jurkat IC50
0.59 μM
Compound: 2
Antiproliferative activity against human Jurkat cells
Antiproliferative activity against human Jurkat cells
[PMID: 28953386]
Jurkat IC50
0.59 μM
Compound: 4
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 30243158]
Jurkat IC50
0.61 μM
Compound: Vorinostat
Antiproliferative activity against human Jurkat cells
Antiproliferative activity against human Jurkat cells
[PMID: 37875056]
Jurkat IC50
0.68 μM
Compound: Vorinostat
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based assay
[PMID: 37875056]
Jurkat IC50
0.7 μM
Compound: 1; SAHA
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 48 hrs MTT assay
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 48 hrs MTT assay
[PMID: 33668008]
Jurkat IC50
1.18 μM
Compound: SAHA
Antiproliferative activity against human Jurkat cells after 48 hrs by MTT assay
Antiproliferative activity against human Jurkat cells after 48 hrs by MTT assay
[PMID: 29500131]
Jurkat IC50
1.49 μM
Compound: SAHA
Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 23547652]
Jurkat IC50
1.49 μM
Compound: SAHA
Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 24304348]
Jurkat IC50
1.49 μM
Compound: SAHA
Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
[PMID: 25240614]
Jurkat IC50
10 nM
Compound: 5; SAHA
Inhibition of HDAC1 in human Jurkat cells extract after 30 mins by immunoprecipitation assay
Inhibition of HDAC1 in human Jurkat cells extract after 30 mins by immunoprecipitation assay
[PMID: 27177826]
Jurkat IC50
20 nM
Compound: 5; SAHA
Inhibition of HDAC3 in human Jurkat cells extract after 30 mins by immunoprecipitation assay
Inhibition of HDAC3 in human Jurkat cells extract after 30 mins by immunoprecipitation assay
[PMID: 27177826]
Jurkat IC50
3.62 μM
Compound: SAHA
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 37079967]
Jurkat IC50
32 μM
Compound: 1; SAHA
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 24 hrs MTT assay
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 24 hrs MTT assay
[PMID: 33668008]
Jurkat IC50
702 nM
Compound: 1; SAHA
Antiproliferative activity against human Jurkat cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Jurkat cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
Jurkat IC50
9.33 μM
Compound: SAHA
Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay
[PMID: 39145486]
Jurkat IC50
> 10 μM
Compound: 4, SAHA
Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-TFA as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay
Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-TFA as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay
[PMID: 24261862]
Jurkat IC50
> 30 μM
Compound: 3; SAHA
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36449947]
K562 EC50
2.2 μM
Compound: 1a, SAHA
Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
K562 ED50
0.45791 μM
Compound: 5; SAHA
Potentiation of (-)-lomaiviticin A-induced cytotoxicity against human K562 cells assessed as (-)-lomaiviticin A ED50 at compound to (-)-lomaiviticin A ratio of 5000:1 after 48 hrs by cell titer-glo luminescence assay (Rvb = 0.23776 nM)
Potentiation of (-)-lomaiviticin A-induced cytotoxicity against human K562 cells assessed as (-)-lomaiviticin A ED50 at compound to (-)-lomaiviticin A ratio of 5000:1 after 48 hrs by cell titer-glo luminescence assay (Rvb = 0.23776 nM)
[PMID: 27177826]
K562 ED50
1.24803 μM
Compound: 5; SAHA
Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by cell titer-glo luminescence assay
Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by cell titer-glo luminescence assay
[PMID: 27177826]
K562 GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human K562 cells after 72 hrs by MTS assay
Growth inhibition of human K562 cells after 72 hrs by MTS assay
[PMID: 22435669]
K562 GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human K562 cells after 72 hrs by MTS assay
Growth inhibition of human K562 cells after 72 hrs by MTS assay
[PMID: 22435669]
K562 GI50
0.52 μM
Compound: SAHA
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
[PMID: 25800646]
K562 GI50
0.9 μM
Compound: SAHA
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 34500130]
K562 GI50
1.97 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
K562 GI50
3.66 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 28629630]
K562 IC50
0.11 μM
Compound: SAHA
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
K562 IC50
0.14 μM
Compound: SAHA
Inhibition of HDAC in human K562 cell extract using Fluor-de-Lys deacetylase as substrate preincubated for 45 mins measured after 15 mins by fluorescence assay
Inhibition of HDAC in human K562 cell extract using Fluor-de-Lys deacetylase as substrate preincubated for 45 mins measured after 15 mins by fluorescence assay
[PMID: 24328302]
K562 IC50
0.17 μM
Compound: 1; SAHA
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay
[PMID: 27142751]
K562 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
K562 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
K562 IC50
0.21 nM
Compound: 1; SAHA
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
[PMID: 36622852]
K562 IC50
0.35 μM
Compound: SAHA
Antiproliferative activity against human K562 cells incubated for 48 hrs by resazurin based microplate reader analysis
Antiproliferative activity against human K562 cells incubated for 48 hrs by resazurin based microplate reader analysis
[PMID: 37647727]
K562 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human K562 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human K562 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
K562 IC50
0.52 μM
Compound: 1
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
[PMID: 35238576]
K562 IC50
0.54 μM
Compound: SAHA
Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 36549114]
K562 IC50
0.55 μM
Compound: 1; SAHA
Antiproliferative activity against human K562 cells incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human K562 cells incubated for 48 hrs by CCK8 assay
[PMID: 37037787]
K562 IC50
0.56 μM
Compound: SAHA
Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay
[PMID: 35041998]
K562 IC50
0.64 μM
Compound: SAHA, Vorinostat
Antiproliferative activity against human K562 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human K562 cells after 72 hrs by CellTiter-Glo assay
[PMID: 23792316]
K562 IC50
0.645 μM
Compound: SAHA
Cytotoxicity against human K562 cells
Cytotoxicity against human K562 cells
[PMID: 23644210]
K562 IC50
0.645 μM
Compound: vorinostat
Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by CellTitre-Glo luminescent assay
Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by CellTitre-Glo luminescent assay
[PMID: 26629860]
K562 IC50
0.65 μM
Compound: SAHA
Cytotoxicity against human K562 cells after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human K562 cells after 72 hrs by CellTiter-Glo assay
[PMID: 30245394]
K562 IC50
0.67 μM
Compound: 2
Cytotoxicity against human K562 cells
Cytotoxicity against human K562 cells
[PMID: 17691763]
K562 IC50
0.67 μM
Compound: 6, SAHA
Cytotoxicity against human K562 cells after 72 hrs by alamar-blue cell viability assay
Cytotoxicity against human K562 cells after 72 hrs by alamar-blue cell viability assay
[PMID: 19301902]
K562 IC50
0.68 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 29533873]
K562 IC50
0.68 μM
Compound: SAHA
Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay
[PMID: 34847495]
K562 IC50
0.75 μM
Compound: 3, SAHA
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
[PMID: 18038969]
K562 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
K562 IC50
0.9 μM
Compound: SAHA
Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
[PMID: 34624191]
K562 IC50
0.98 μM
Compound: SAHA
Anti-proliferative activity against human K562 cells after 48 hrs by MTT assay
Anti-proliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 28947154]
K562 IC50
1 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
[PMID: 25221651]
K562 IC50
1.02 μM
Compound: Vor; SAHA
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
K562 IC50
1.03 μM
Compound: 3; SAHA
Synergistic antiproliferative activity against human K562 cells assessed as reduction in cell viability after 48 hrs in presence of ruxolitinib by MTT assay
Synergistic antiproliferative activity against human K562 cells assessed as reduction in cell viability after 48 hrs in presence of ruxolitinib by MTT assay
[PMID: 30901208]
K562 IC50
1.11 μM
Compound: 3; SAHA
Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30901208]
K562 IC50
1.17 μM
Compound: SAHA
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 36272186]
K562 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human K562 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
K562 IC50
1.29 μM
Compound: SAHA
Antiproliferative activity against human K562 cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells incubated for 72 hrs by CCK-8 assay
[PMID: 37057760]
K562 IC50
1.35 μM
Compound: SAHA
Antiproliferative activity against human K562 cells by MTT assay
Antiproliferative activity against human K562 cells by MTT assay
[PMID: 33132117]
K562 IC50
1.35 μM
Compound: Vorinostat
Cytotoxicity against human K562 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human K562 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
K562 IC50
1.391 μM
Compound: SAHA
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 35926141]
K562 IC50
1.41 μM
Compound: Vorinostat
Antiproliferative activity against human K562 cells by MTT assay
Antiproliferative activity against human K562 cells by MTT assay
[PMID: 37875056]
K562 IC50
1.44 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 26100440]
K562 IC50
1.45 μM
Compound: SAHA
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
[PMID: 31413795]
K562 IC50
1.49 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 28336407]
K562 IC50
1.49 μM
Compound: Vorinostat
Cytotoxicity against human K562 cells assessed as cell growth inhibition
Cytotoxicity against human K562 cells assessed as cell growth inhibition
[PMID: 38107170]
K562 IC50
1.51 μM
Compound: SAHA
Antiproliferative activity against human K562 cells incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human K562 cells incubated for 24 hrs by CCK8 assay
[PMID: 32247729]
K562 IC50
1.52 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 29787262]
K562 IC50
1.61 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 25311567]
K562 IC50
1.8 μM
Compound: 1; SAHA
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
[PMID: 36622852]
K562 IC50
1.91 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 28419930]
K562 IC50
1.91 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 28601509]
K562 IC50
1.95 μM
Compound: Vorinostat
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 28371677]
K562 IC50
10 nM
Compound: SAHA
Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells.
Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells.
[PMID: 12419380]
K562 IC50
10 μM
Compound: 5; SAHA
Antiproliferative activity against human K562 cells after 96 hrs by MTT assay
Antiproliferative activity against human K562 cells after 96 hrs by MTT assay
[PMID: 31117517]
K562 IC50
120 nM
Compound: 1
Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cells
Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cells
[PMID: 12270175]
K562 IC50
140 nM
Compound: 1
Inhibitory activity against histone deacetylase (HDAC1 and HDAC2) isolated from K562 erythroleukemia cells
Inhibitory activity against histone deacetylase (HDAC1 and HDAC2) isolated from K562 erythroleukemia cells
[PMID: 14552787]
K562 IC50
140 nM
Compound: 1; SAHA
Inhibition of HDAC in human K562 nuclear extract
Inhibition of HDAC in human K562 nuclear extract
[PMID: 31655430]
K562 IC50
140 nM
Compound: SAHA
Inhibition of HDAC from human K562 cells
Inhibition of HDAC from human K562 cells
[PMID: 18247554]
K562 IC50
143 nM
Compound: 24; SAHA
Inhibition of HDAC in human K562 cell extracts using (QSY-7)-RGGRGLGK(Ac)-GGARRHRK(TAMRA)NH2 as substrate preincubated for 30 mins followed by addition of endoproteinase Lys-C and measured after 2 hrs by fluorescence assay
Inhibition of HDAC in human K562 cell extracts using (QSY-7)-RGGRGLGK(Ac)-GGARRHRK(TAMRA)NH2 as substrate preincubated for 30 mins followed by addition of endoproteinase Lys-C and measured after 2 hrs by fluorescence assay
[PMID: 31536895]
K562 IC50
2 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells after 48 hrs by CCK-8 assay
[PMID: 35939996]
K562 IC50
2.24 μM
Compound: 3; SAHA
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36449947]
K562 IC50
2.26 μM
Compound: SAHA
Cytotoxicity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
K562 IC50
2.9 μM
Compound: SAHA
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
K562 IC50
2.93 μM
Compound: XII; SAHA
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
K562 IC50
3.24 μM
Compound: SA, SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 24694055]
K562 IC50
3.24 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 25462271]
K562 IC50
3.32 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 21476600]
K562 IC50
3.77 μM
Compound: 1, SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 24525003]
K562 IC50
3.88 μM
Compound: SAHA
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
[PMID: 30879863]
K562 IC50
3.89 μM
Compound: SAHA
Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26349626]
K562 IC50
3.94 μM
Compound: SAHA
Cytotoxicity against human K562 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26149591]
K562 IC50
370 nM
Compound: 1; SAHA
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
[PMID: 39047608]
K562 IC50
38 μM
Compound: SAHA, Vorinostat
Cytotoxicity against human K562 cells assessed as reduction in cell viability
Cytotoxicity against human K562 cells assessed as reduction in cell viability
[PMID: 26264503]
K562 IC50
4.95 μM
Compound: SAHA
Antiproliferative activity against human K562 cells by MTT assay
Antiproliferative activity against human K562 cells by MTT assay
[PMID: 31546197]
K562 IC50
444 nM
Compound: SAHA
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 26443078]
K562 IC50
7.7 μM
Compound: 2; SAHA
Antiproliferative activity against human K562 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells after 48 hrs by CCK-8 assay
[PMID: 29940115]
K562 IC50
828 nM
Compound: 1; SAHA
Antiproliferative activity against human K562 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
K562/A02 IC50
3.13 μM
Compound: SAHA
Antiproliferative activity against human K562/A02 cells overexpressing P-gp by MTT assay
Antiproliferative activity against human K562/A02 cells overexpressing P-gp by MTT assay
[PMID: 33132117]
KB IC50
0.75 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human KB cells by MTT assay
Cytotoxicity against human KB cells by MTT assay
[PMID: 24766560]
KB IC50
1.8 μM
Compound: SAHA
Cytotoxicity against human KB cells after 72 hrs by MTS assay
Cytotoxicity against human KB cells after 72 hrs by MTS assay
[PMID: 25899338]
KB-V1 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human KB-V1 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human KB-V1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
KB-V1 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human vinblastine resistant KB-V1 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human vinblastine resistant KB-V1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
KG-1 IC50
0.07 μM
Compound: SAHA
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
KG-1 IC50
0.21 μM
Compound: Vorinostat
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
KG-1 IC50
0.59 μM
Compound: 1; SAHA
Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
KG-1 IC50
0.64 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
[PMID: 26100440]
KG-1 IC50
0.68 μM
Compound: 1, SAHA
Cytotoxicity against human KG1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human KG1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26122774]
KG-1 IC50
0.68 μM
Compound: 6, SAHA
Cytotoxicity against human KG1 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human KG1 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25906087]
KG-1 IC50
0.79 μM
Compound: SAHA; 6
Antiproliferative activity against human KG-1 cells incubated for 72 hrs by celltiter-glo luminescent assay
Antiproliferative activity against human KG-1 cells incubated for 72 hrs by celltiter-glo luminescent assay
[PMID: 39178382]
KG-1 IC50
0.9 μM
Compound: SAHA
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
[PMID: 26907204]
KG-1 IC50
1.11 μM
Compound: SAHA
Cytotoxicity against human KG1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human KG1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
10.1039/C4MD00203B
KG-1 IC50
1.15 μM
Compound: 1, SAHA
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
[PMID: 24525003]
KG-1 IC50
1.52 μM
Compound: SAHA
Antiproliferative activity against human KG1 cells after 72 hrs by MTT assay
Antiproliferative activity against human KG1 cells after 72 hrs by MTT assay
[PMID: 29787262]
KG-1 IC50
1.59 μM
Compound: SA, SAHA
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
[PMID: 24694055]
KG-1 IC50
1.59 μM
Compound: SAHA
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
[PMID: 25462271]
KG-1 IC50
1.59 μM
Compound: SAHA
Antiproliferative activity against human KG-1 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human KG-1 cells incubated for 72 hrs by MTT assay
[PMID: 32961382]
KG-1 IC50
2.75 μM
Compound: SAHA
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
Antiproliferative activity against human KG1 cells after 48 hrs by MTT assay
[PMID: 26216016]
KM-H2 IC50
1.54 μM
Compound: SAHA
Antiproliferative activity against human KM-H2 cells after 72 hrs by MTT assay
Antiproliferative activity against human KM-H2 cells after 72 hrs by MTT assay
[PMID: 29150335]
KM12 GI50
0.8 μM
Compound: SAHA
Antiproliferative activity against human KM12 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human KM12 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
KM12 GI50
1.88 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human KM12 cells after 48 hrs by SRB assay
Cytotoxicity against human KM12 cells after 48 hrs by SRB assay
[PMID: 24015327]
KM12 GI50
2 μM
Compound: SAHA, Zolinza
Growth inhibition of human KM12 cells after 72 hrs by MTS assay
Growth inhibition of human KM12 cells after 72 hrs by MTS assay
[PMID: 22435669]
KM3/BTZ IC50
78.2 nM
Compound: SAHA
Antiproliferative activity against bortezomib resistant human KM3/BTZ cells in presence of bortezomib incubated for 48 hrs by MTT assay
Antiproliferative activity against bortezomib resistant human KM3/BTZ cells in presence of bortezomib incubated for 48 hrs by MTT assay
[PMID: 32267687]
KM3/BTZ IC50
860 nM
Compound: SAHA
Antiproliferative activity against bortezomib resistant human KM3/BTZ cells incubated for 48 hrs by MTT assay
Antiproliferative activity against bortezomib resistant human KM3/BTZ cells incubated for 48 hrs by MTT assay
[PMID: 32267687]
KMS-12-BM EC50
0.94 μM
Compound: 3; SAHA
Antiproliferative activity against human KMS-12-BM cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human KMS-12-BM cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 31627059]
KMS-12-BM IC50
0.94 μM
Compound: 1; SAHA
Antiproliferative activity against human KMS-12-BM cells after 48 hrs by CellTiter-Glo assay
Antiproliferative activity against human KMS-12-BM cells after 48 hrs by CellTiter-Glo assay
[PMID: 27541357]
KMS-12-BM IC50
0.94 μM
Compound: 2
Antiproliferative activity against human KMS-12-BM cells after 48 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human KMS-12-BM cells after 48 hrs by CellTiter-Glo luminescent assay
[PMID: 28953386]
KMS-12-BM IC50
0.94 μM
Compound: 4
Antiproliferative activity against human KMS-12-BM cells after 72 hrs by MTT assay
Antiproliferative activity against human KMS-12-BM cells after 72 hrs by MTT assay
[PMID: 30243158]
KYSE-30 IC50
3 μM
Compound: Vorinostat
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
KYSE-450 IC50
6.478 μM
Compound: Vorinostat
Antiproliferative activity against human KYSE-450 cells
Antiproliferative activity against human KYSE-450 cells
[PMID: 37875056]
KYSE-510 IC50
0.59 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in cisplatin resistant human KYSE-510 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in cisplatin resistant human KYSE-510 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
KYSE-510 IC50
0.7 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in cisplatin sensitive human KYSE-510 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in cisplatin sensitive human KYSE-510 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
KYSE-510 IC50
4.62 μM
Compound: SAHA, vorinostat
Cytotoxicity against cisplatin sensitive human KYSE-510 cells after 72 hrs by MTT assay
Cytotoxicity against cisplatin sensitive human KYSE-510 cells after 72 hrs by MTT assay
[PMID: 23252603]
KYSE-510 IC50
4.66 μM
Compound: SAHA, vorinostat
Cytotoxicity against cisplatin resistant human KYSE-510 cells after 72 hrs by MTT assay
Cytotoxicity against cisplatin resistant human KYSE-510 cells after 72 hrs by MTT assay
[PMID: 23252603]
Kasumi 1 IC50
0.38 μM
Compound: SAHA
Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days in presence of GSK5032 by CCK8 assay
Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days in presence of GSK5032 by CCK8 assay
[PMID: 39264152]
Kasumi 1 IC50
0.65 μM
Compound: SAHA
Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days by CCK8 assay
Inhibition of cell viability in human Kasumi 1 cells incubated for 4 days by CCK8 assay
[PMID: 39264152]
Kasumi 1 IC50
620 nM
Compound: Vorinostat
Cytotoxicity against human Kasumi 1 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human Kasumi 1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
L-363 IC50
0.48 μM
Compound: 4; SAHA
Antiproliferative activity against human L-363 cells
Antiproliferative activity against human L-363 cells
[PMID: 37652098]
L-428 IC50
0.87 μM
Compound: SAHA
Antiproliferative activity against human L428 cells after 72 hrs by MTT assay
Antiproliferative activity against human L428 cells after 72 hrs by MTT assay
[PMID: 29150335]
L-428 IC50
2.3 μM
Compound: SAHA
Antiproliferative activity against human L-428 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human L-428 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
L02 IC50
0.948 μM
Compound: SAHA
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
L02 IC50
1.35 μM
Compound: SAHA
Cytotoxicity against human HL7702 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HL7702 cells measured after 72 hrs by MTT assay
[PMID: 34847495]
L02 IC50
27.4 μM
Compound: SAHA
Cytotoxicity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33021789]
L02 IC50
5.45 μM
Compound: Vorinostat
cytotoxicity against human HL-7702 cells assessed as reduction of cell viability incubated for 72 hrs by MTT assay
cytotoxicity against human HL-7702 cells assessed as reduction of cell viability incubated for 72 hrs by MTT assay
[PMID: 33493830]
L02 IC50
7.23 μM
Compound: SAHA
Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
L02 IC50
> 10 μM
Compound: SAHA
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
L02 IC50
> 100 μM
Compound: SAHA
Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin based microplate reader analysis
Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin based microplate reader analysis
[PMID: 37647727]
L02 IC50
> 50 μM
Compound: SAHA
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 34509167]
L02 IC50
> 50000 nM
Compound: SAHA
Antiproliferative activity against human HL7702 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HL7702 cells incubated for 48 hrs by MTT assay
[PMID: 32267687]
L1210 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
L1210 IC50
1.5 μM
Compound: SAHA
Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse L1210 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
L6 IC50
266 nM
Compound: 1, SAHA
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
[PMID: 25563890]
LNCaP GI50
1.3 μM
Compound: SAHA
Antiproliferative activity against human LNCaP cells assessed as growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as growth inhibition incubated for 72 hrs by MTT assay
[PMID: 37633202]
LNCaP IC50
0.58 μM
Compound: SAHA
Antiproliferative activity against human LNCAP cells
Antiproliferative activity against human LNCAP cells
[PMID: 20143778]
LNCaP IC50
0.69 μM
Compound: SAHA
Antiproliferative activity against human LNCAP cells incubated for 96 hrs by resazurin assay
Antiproliferative activity against human LNCAP cells incubated for 96 hrs by resazurin assay
[PMID: 32435375]
LNCaP IC50
1 μM
Compound: 5, SAHA
Antiproliferative activity against human LNCap by MTT assay
Antiproliferative activity against human LNCap by MTT assay
[PMID: 18166465]
LNCaP IC50
1 μM
Compound: SAHA
Concentration required to inhibit human LNCaP prostate carcinoma cells
Concentration required to inhibit human LNCaP prostate carcinoma cells
[PMID: 16033284]
LNCaP IC50
1.22 μM
Compound: SAHA
Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 28057407]
LNCaP IC50
1.34 μM
Compound: 1; SAHA
Antiproliferative activity against human LNCaP cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human LNCaP cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
LNCaP IC50
1.8 μM
Compound: SAHA
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 28131715]
LNCaP IC50
2.31 μM
Compound: SAHA
Cytotoxicity against human LNCAP cells assessed as growth inhibition by MTS assay
Cytotoxicity against human LNCAP cells assessed as growth inhibition by MTS assay
[PMID: 23547652]
LNCaP IC50
2.31 μM
Compound: SAHA
Cytotoxicity against androgen-dependent human LNCAP cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against androgen-dependent human LNCAP cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 24304348]
LNCaP IC50
2.31 μM
Compound: SAHA
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
[PMID: 25240614]
LNCaP IC50
2.31 μM
Compound: SAHA
Inhibition of HDAC6 in human LNCAP cells assessed as tubulin acetylation by Western blot analysis
Inhibition of HDAC6 in human LNCAP cells assessed as tubulin acetylation by Western blot analysis
[PMID: 25240614]
LOX IMVI EC50
1.3 μM
Compound: SAHA
Inhibition of human LOX-IMVI cells
Inhibition of human LOX-IMVI cells
[PMID: 18247554]
LOX IMVI EC50
1.3 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human LOX-IMVI cells
Effective Concentration of compound to inhibit the growth of human LOX-IMVI cells
[PMID: 15715470]
LOX IMVI GI50
1 μM
Compound: SAHA, Zolinza
Growth inhibition of human LOXIMVI cells after 72 hrs by MTS assay
Growth inhibition of human LOXIMVI cells after 72 hrs by MTS assay
[PMID: 22435669]
LOX IMVI GI50
1.2 μM
Compound: SAHA
Antiproliferative activity against human LOXIMVI cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human LOXIMVI cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
LOX IMVI GI50
1.3 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
LOX IMVI GI50
1.39 μM
Compound: 1, SAHA
Growth inhibition of LOX-IMVI cells by SRB assay
Growth inhibition of LOX-IMVI cells by SRB assay
[PMID: 17477518]
LOX IMVI GI50
1.39 μM
Compound: 2, SAHA
Antiproliferative activity against human LOX-IMVI cells by SRB assay
Antiproliferative activity against human LOX-IMVI cells by SRB assay
[PMID: 16723227]
LOX IMVI GI50
1.6 μM
Compound: SAHA
Growth inhibition of human LOX-IMVI cells after 21 hrs by MTT assay
Growth inhibition of human LOX-IMVI cells after 21 hrs by MTT assay
[PMID: 17662606]
LP-1 IC50
1.39 μM
Compound: SAHA
Antiproliferative activity against human LP-1 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
Antiproliferative activity against human LP-1 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
[PMID: 26890114]
LoVo GI50
1700 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human LoVo cells after 72 hrs by WST-1 assay
Antiproliferative activity against human LoVo cells after 72 hrs by WST-1 assay
[PMID: 21080647]
LoVo IC50
2.15 μM
Compound: SAHA
Antiproliferative activity against human LoVo cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human LoVo cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
LoVo IC50
3.7 μM
Compound: SAHA
Antiproliferative activity against human LoVo cells assessed as reduction in cell number after 72 hrs by cell counter analysis
Antiproliferative activity against human LoVo cells assessed as reduction in cell number after 72 hrs by cell counter analysis
[PMID: 26890116]
LoVo IC50
4.95 μM
Compound: SAHA
Antiproliferative activity against human LoVo cells by MTT assay
Antiproliferative activity against human LoVo cells by MTT assay
[PMID: 31546197]
LoVo IC50
6.75 μM
Compound: SAHA
Antiproliferative activity against human LoVo cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human LoVo cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26555243]
LoVo IC50
6.75 μM
Compound: SAHA
Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay
Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay
[PMID: 30108831]
M14 GI50
1.3 μM
Compound: SAHA
Antiproliferative activity against human M14 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human M14 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
M14 GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human M14 cells after 72 hrs by MTS assay
Growth inhibition of human M14 cells after 72 hrs by MTS assay
[PMID: 22435669]
MC-38 GI50
2.4 μM
Compound: 7; SAHA
Antiproliferative activity against mouse MC38 cells measured after 72 hrs by CCK8 assay
Antiproliferative activity against mouse MC38 cells measured after 72 hrs by CCK8 assay
[PMID: 34783558]
MC-38 GI50
2.74 μM
Compound: 3; SAHA
Antiproliferative activity against mouse MC38 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against mouse MC38 cells after 72 hrs by CCK-8 assay
[PMID: 35390714]
MC-38 IC50
1.26 μM
Compound: SAHA
Antiproliferative activity against mouse MC38 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against mouse MC38 cells after 48 hrs by CCK-8 assay
[PMID: 35939996]
MC-38 IC50
2.22 μM
Compound: 1; SAHA
Antiproliferative activity against mouse MC38 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse MC38 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
MCF-10A GI50
9.6 μM
Compound: SAHA, Zolinza
Growth inhibition of human MCF10A cells after 48 hrs by MTT assay
Growth inhibition of human MCF10A cells after 48 hrs by MTT assay
[PMID: 22435669]
MCF-10A IC50
0.42 μM
Compound: 6; SAHA
Cytotoxicity against ER negative human MCF10A cells treated every 2 days for 4 days measured after 7 days by CellTiter-Glo luminescence assay
Cytotoxicity against ER negative human MCF10A cells treated every 2 days for 4 days measured after 7 days by CellTiter-Glo luminescence assay
[PMID: 30078609]
MCF-10A IC50
1.1 μM
Compound: 6; SAHA
Cytotoxicity against ER negative human MCF10A cells treated every 2 days for 4 days measured post last dose by CellTiter-Glo luminescence assay
Cytotoxicity against ER negative human MCF10A cells treated every 2 days for 4 days measured post last dose by CellTiter-Glo luminescence assay
[PMID: 30078609]
MCF-10A IC50
2.11 μM
Compound: SAHA
Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay
[PMID: 28601509]
MCF-10A IC50
28 μM
Compound: SAHA
Cytotoxicity against human MCF10A cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MCF10A cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
MCF-10A IC50
31 μM
Compound: 3, SAHA
Cytotoxicity against human MCF10A cells after 96 hrs by MTA reduction assay
Cytotoxicity against human MCF10A cells after 96 hrs by MTA reduction assay
[PMID: 23293738]
MCF-10A IC50
31 μM
Compound: 81, SAHA
Antitumor activity against human MCF10A cells
Antitumor activity against human MCF10A cells
[PMID: 19534534]
MCF-10A IC50
> 50 μM
Compound: 1; SAHA
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 32180916]
MCF7 CC50
3000 nM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human MCF7 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19441846]
MCF7 EC50
0.01 μM
Compound: 25a
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
[PMID: 34591488]
MCF7 EC50
0.65 μM
Compound: 3; SAHA
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 31627059]
MCF7 GI50
0.45 μM
Compound: 1, SAHA
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 24119555]
MCF7 GI50
0.61 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 25800646]
MCF7 GI50
0.689 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells after 48 hrs by Sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by Sulforhodamine B assay
[PMID: 23639537]
MCF7 GI50
1.25 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured after 6 days by WST8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured after 6 days by WST8 assay
[PMID: 34610548]
MCF7 GI50
1.34 μM
Compound: 1, SAHA
Growth inhibition of human MCF7 cells after 96 hrs by MTT assay
Growth inhibition of human MCF7 cells after 96 hrs by MTT assay
[PMID: 26814680]
MCF7 GI50
17.9 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 28629630]
MCF7 GI50
2 μM
Compound: SAHA, Zolinza
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
[PMID: 22435669]
MCF7 GI50
2.19 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 24015327]
MCF7 GI50
2.2 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
MCF7 GI50
2.6 μM
Compound: SAHA
Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 34500130]
MCF7 GI50
29.1 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay
[PMID: 27614919]
MCF7 GI50
3.02 μM
Compound: 1; SAHA
Anticancer activity against human MCF7 cells overexpressing HDAC1 and HDAC2 assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B assay
Anticancer activity against human MCF7 cells overexpressing HDAC1 and HDAC2 assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B assay
[PMID: 37847303]
MCF7 GI50
8.6 μM
Compound: 1, SAHA
Growth inhibition of human MCF7 cells after 72 hrs by XTT assay
Growth inhibition of human MCF7 cells after 72 hrs by XTT assay
[PMID: 24900500]
MCF7 IC50
0.13 μg/mL
Compound: SAHA
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 22036991]
MCF7 IC50
0.16 μM
Compound: 1
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 8 hrs by CCK8 assay
[PMID: 35238576]
MCF7 IC50
0.18 μg/mL
Compound: Vorinostat
Anticancer activity against human MCF7 cells
Anticancer activity against human MCF7 cells
[PMID: 31945642]
MCF7 IC50
0.21 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
MCF7 IC50
0.294 μM
Compound: SAHA
Inhibition of cell viability in human MCF7 cells incubated for 12 days with every 3 day treatment by Alamar blue staining based analysis
Inhibition of cell viability in human MCF7 cells incubated for 12 days with every 3 day treatment by Alamar blue staining based analysis
[PMID: 38838548]
MCF7 IC50
0.32 μM
Compound: 6; SAHA
Antiproliferative activity against human MCF7 cells treated for 48 hrs followed by refreshed every 96 hrs measured on day 10 by Lowry assay
Antiproliferative activity against human MCF7 cells treated for 48 hrs followed by refreshed every 96 hrs measured on day 10 by Lowry assay
[PMID: 26613635]
MCF7 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
MCF7 IC50
0.45 μM
Compound: 6; SAHA
Cytotoxicity against ER positive human MCF7 cells treated every 2 days for 4 days measured after 7 days by CellTiter-Glo luminescence assay
Cytotoxicity against ER positive human MCF7 cells treated every 2 days for 4 days measured after 7 days by CellTiter-Glo luminescence assay
[PMID: 30078609]
MCF7 IC50
0.493 μM
Compound: Vorinostat
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 37875056]
MCF7 IC50
0.58 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 26100440]
MCF7 IC50
0.65 μM
Compound: 1; SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 27541357]
MCF7 IC50
0.65 μM
Compound: 2
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 28953386]
MCF7 IC50
0.65 μM
Compound: 4
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
[PMID: 29945795]
MCF7 IC50
0.68 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
[PMID: 37875056]
MCF7 IC50
0.8 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32151834]
MCF7 IC50
0.81 μM
Compound: 4
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30243158]
MCF7 IC50
0.9 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
MCF7 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
MCF7 IC50
0.91 μM
Compound: 1; SAHA
Antiproliferative activity against human MCF7 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
MCF7 IC50
0.95 μM
Compound: 6; SAHA
Cytotoxicity against ER positive human MCF7 cells treated every 2 days for 4 days measured post last dose by CellTiter-Glo luminescence assay
Cytotoxicity against ER positive human MCF7 cells treated every 2 days for 4 days measured post last dose by CellTiter-Glo luminescence assay
[PMID: 30078609]
MCF7 IC50
1.03 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
[PMID: 37875056]
MCF7 IC50
1.04 μM
Compound: SAHA
Antiproliferative against human MCF-7 cells assessed as reduction in cell viability by MTT assay
Antiproliferative against human MCF-7 cells assessed as reduction in cell viability by MTT assay
[PMID: 33045329]
MCF7 IC50
1.1 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 24766560]
MCF7 IC50
1.11 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
MCF7 IC50
1.15 μM
Compound: SAHA, Vorinostat
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 21924799]
MCF7 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
MCF7 IC50
1.26 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells incubated for 96 hrs by resazurin assay
Antiproliferative activity against human MCF7 cells incubated for 96 hrs by resazurin assay
[PMID: 32435375]
MCF7 IC50
1.31 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK-8 assay
[PMID: 37057760]
MCF7 IC50
1.5 μM
Compound: SAHA
Inhibition of MCF7 cell proliferation (mean of two experiments)
Inhibition of MCF7 cell proliferation (mean of two experiments)
[PMID: 17095213]
MCF7 IC50
1.5 μM
Compound: SAHA
Inhibition of MCF7 cell proliferation (mean of two experiments)
Inhibition of MCF7 cell proliferation (mean of two experiments)
[PMID: 17107790]
MCF7 IC50
1.6 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 24296013]
MCF7 IC50
1.6 μM
Compound: Vor; SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
[PMID: 29360358]
MCF7 IC50
1.7 μM
Compound: SAHA; 112
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 31881454]
MCF7 IC50
1.7 μM
Compound: Vorinostat
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability
[PMID: 30660827]
MCF7 IC50
2 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 32738414]
MCF7 IC50
2.18 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 29396364]
MCF7 IC50
2.29 μM
Compound: Vorinostat
Cytotoxicity against human MCF7 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
[PMID: 23829483]
MCF7 IC50
2.36 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
[PMID: 35043615]
MCF7 IC50
2.43 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured for 48 hrs by MTT assay
[PMID: 37875056]
MCF7 IC50
2.5 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 22260166]
MCF7 IC50
2.5 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
[PMID: 25993269]
MCF7 IC50
2.5 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33965842]
MCF7 IC50
2.5 μM
Compound: SAHA; vorinostat
Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay
Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay
[PMID: 26725029]
MCF7 IC50
2.5 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay
[PMID: 37875056]
MCF7 IC50
2.6 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay
[PMID: 34624191]
MCF7 IC50
2.7 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CCK-8 assay
[PMID: 29317150]
MCF7 IC50
2.7 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability in presence of erlotinib by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability in presence of erlotinib by MTT assay
[PMID: 32320239]
MCF7 IC50
2.8 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after hrs by ATP content assay
Antiproliferative activity against human MCF7 cells after hrs by ATP content assay
[PMID: 20143778]
MCF7 IC50
2.8 μM
Compound: Vorinostat
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 32791404]
MCF7 IC50
2.81 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 21714538]
MCF7 IC50
2.9 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells by CCK8 assay
Antiproliferative activity against human MCF7 cells by CCK8 assay
[PMID: 30660827]
MCF7 IC50
2.92 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37875056]
MCF7 IC50
2.98 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
MCF7 IC50
28.66 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
10.1039/C5MD00247H
MCF7 IC50
3.13 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
[PMID: 37875056]
MCF7 IC50
3.26 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
10.1039/C4MD00203B
MCF7 IC50
3.27 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 28057407]
MCF7 IC50
3.27 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
[PMID: 31546197]
MCF7 IC50
3.47 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 28601509]
MCF7 IC50
3.49 μM
Compound: SAHA
Antiproliferative activity in human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 32061484]
MCF7 IC50
3.56 μM
Compound: 4; SAHA
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
[PMID: 37652098]
MCF7 IC50
3.57 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 38452727]
MCF7 IC50
3.78 μM
Compound: SA, SAHA
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24694055]
MCF7 IC50
3.78 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 25462271]
MCF7 IC50
354 nM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30629434]
MCF7 IC50
38.2 μM
Compound: SAHA
Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 29496367]
MCF7 IC50
4.1 μM
Compound: 5; SAHA
Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay
[PMID: 31117517]
MCF7 IC50
4.17 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
MCF7 IC50
4.2 μM
Compound: 1; SAHA
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 33077264]
MCF7 IC50
4.2 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by MTT assay
[PMID: 32320239]
MCF7 IC50
4.2 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 26741358]
MCF7 IC50
4.22 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 30245394]
MCF7 IC50
4.339 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
MCF7 IC50
4.4 μM
Compound: SAHA, vorinostat
Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23786452]
MCF7 IC50
4.48 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 29288941]
MCF7 IC50
4.5 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 26475519]
MCF7 IC50
4.69 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 28987602]
MCF7 IC50
4.78 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay
[PMID: 37116762]
MCF7 IC50
4.83 μM
Compound: 1; SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
[PMID: 30045621]
MCF7 IC50
5.15 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 35272009]
MCF7 IC50
5.15 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells measured after 72 hrs
Antiproliferative activity against human MCF7 cells measured after 72 hrs
[PMID: 35697181]
MCF7 IC50
5.43 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
MCF7 IC50
500 nM
Compound: SAHA
Growth inhibition of MCF7 cells
Growth inhibition of MCF7 cells
[PMID: 17958342]
MCF7 IC50
54.55 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
10.1039/C5MD00247H
MCF7 IC50
6 μM
Compound: 1; SAHA
Antiproliferative activity against human MCF7 cells up to 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells up to 72 hrs by MTT assay
[PMID: 27541357]
MCF7 IC50
6.17 μM
Compound: 1; SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 32180916]
MCF7 IC50
6.23 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 36996717]
MCF7 IC50
6.42 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 24185378]
MCF7 IC50
6.5 μM
Compound: Vorinostat
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
MCF7 IC50
6.7 μM
Compound: 2
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 17691763]
MCF7 IC50
60.2 μM
Compound: SAHA, Vorinostat
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
[PMID: 24095016]
MCF7 IC50
637.2 nM
Compound: SAHA
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 31177073]
MCF7 IC50
7.11 μM
Compound: 1; SAHA
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36242988]
MCF7 IC50
8.5 μM
Compound: 3, SAHA
Cytotoxicity against human MCF7 cells after 96 hrs by MTA reduction assay
Cytotoxicity against human MCF7 cells after 96 hrs by MTA reduction assay
[PMID: 23293738]
MCF7 IC50
8.5 μM
Compound: 81, SAHA
Antitumor activity against human MCF7 cells
Antitumor activity against human MCF7 cells
[PMID: 19534534]
MCF7 IC50
9.59 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
10.1039/C5MD00247H
MCF7 IC50
9.798 μM
Compound: SAHA
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
MCF7 IC50
939.97 nM
Compound: SAHA
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
[PMID: 30819618]
MCF7 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 34116381]
MCF7 IC50
> 100 μM
Compound: SAHA
Inhibition of human MCF7 cells
Inhibition of human MCF7 cells
[PMID: 18247554]
MCF7 IC50
> 150 μM
Compound: SAHA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
MCF7 IC50
> 50 μM
Compound: 1; SAHA
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
MCF7 IC50
> 50 μM
Compound: Vorinostat
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
MDA-MB-231 EC50
1.2 μM
Compound: 3; SAHA
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
[PMID: 31627059]
MDA-MB-231 EC50
1.5 μM
Compound: SAHA
Inhibition of human MDA-MB-231 cells
Inhibition of human MDA-MB-231 cells
[PMID: 18247554]
MDA-MB-231 EC50
1.5 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human MDA-MB-231 cells
Effective Concentration of compound to inhibit the growth of human MDA-MB-231 cells
[PMID: 15715470]
MDA-MB-231 GI50
0.66 μM
Compound: 1, SAHA
Growth inhibition of human MDA-MB-231 cells by SRB assay
Growth inhibition of human MDA-MB-231 cells by SRB assay
[PMID: 17477518]
MDA-MB-231 GI50
0.66 μM
Compound: 2, SAHA
Antiproliferative activity against human MDA-MB-231 cells by SRB assay
Antiproliferative activity against human MDA-MB-231 cells by SRB assay
[PMID: 16723227]
MDA-MB-231 GI50
0.89 μM
Compound: SAHA
Growth inhibition of human MDA-MB-231 cells after 21 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 21 hrs by MTT assay
[PMID: 17662606]
MDA-MB-231 GI50
0.97 μM
Compound: 1, SAHA
Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 22439863]
MDA-MB-231 GI50
1 μM
Compound: SAHA, Zolinza
Growth inhibition of human MDA-MB-231 cells after 72 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 22435669]
MDA-MB-231 GI50
1.81 μM
Compound: 1, SAHA
Growth inhibition of human MDA-MB-231 cells after 96 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 96 hrs by MTT assay
[PMID: 26814680]
MDA-MB-231 GI50
2 μM
Compound: 1, SAHA, Zolinza, Vorinostat
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition by SRB assay
[PMID: 23163332]
MDA-MB-231 GI50
2 μM
Compound: 2, SAHA
Growth inhibition of human MDA-MB-231 cells by SRB assay
Growth inhibition of human MDA-MB-231 cells by SRB assay
[PMID: 17904843]
MDA-MB-231 GI50
2 μM
Compound: SAHA
Growth inhibition of human MDA-MB-231 cells after 5 days by sulforhodamine B assay
Growth inhibition of human MDA-MB-231 cells after 5 days by sulforhodamine B assay
[PMID: 25811792]
MDA-MB-231 GI50
2 μM
Compound: SAHA
Growth inhibition of human MDA-MB-231 cells measured after 5 days by sulforhodamine-B assay
Growth inhibition of human MDA-MB-231 cells measured after 5 days by sulforhodamine-B assay
[PMID: 28011426]
MDA-MB-231 GI50
2.32 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 24015327]
MDA-MB-231 GI50
2.5 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
MDA-MB-231 GI50
2.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human MDA-MB-231 cells after 72 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells after 72 hrs by MTS assay
[PMID: 22435669]
MDA-MB-231 GI50
2.67 μM
Compound: 1; SAHA
Growth inhibition of human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
[PMID: 28395150]
MDA-MB-231 GI50
2.73 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay
[PMID: 36262394]
MDA-MB-231 IC50
0.16 μM
Compound: SAHA, Vorinostat
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 24095016]
MDA-MB-231 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
MDA-MB-231 IC50
0.201 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by resazurin dye based fluorescence assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by resazurin dye based fluorescence assay
[PMID: 29456804]
MDA-MB-231 IC50
0.21 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
MDA-MB-231 IC50
0.43 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 5 days by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 5 days by MTT assay
[PMID: 28601509]
MDA-MB-231 IC50
0.46 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of fedratinib by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of fedratinib by MTT assay
[PMID: 37796543]
MDA-MB-231 IC50
0.61 μM
Compound: 6; SAHA
Cytotoxicity against ER negative human MDA-MB-231 cells treated every 2 days for 4 days measured after 7 days by CellTiter-Glo luminescence assay
Cytotoxicity against ER negative human MDA-MB-231 cells treated every 2 days for 4 days measured after 7 days by CellTiter-Glo luminescence assay
[PMID: 30078609]
MDA-MB-231 IC50
0.61 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
[PMID: 34237620]
MDA-MB-231 IC50
0.61 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in cisplatin resistant human MDA-MB-231 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in cisplatin resistant human MDA-MB-231 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
MDA-MB-231 IC50
0.61 μM
Compound: SAHA, vorinostat
Inhibition of HDAC in cisplatin sensitive human MDA-MB-231 cells after 18 hrs by fluorescence assay
Inhibition of HDAC in cisplatin sensitive human MDA-MB-231 cells after 18 hrs by fluorescence assay
[PMID: 23252603]
MDA-MB-231 IC50
0.61 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
[PMID: 37875056]
MDA-MB-231 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
MDA-MB-231 IC50
0.9 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
MDA-MB-231 IC50
0.96 μM
Compound: 6; SAHA
Antiproliferative activity against human MDA-MB-231 cells treated for 48 hrs followed by refreshed every 96 hrs measured on day 10 by Lowry assay
Antiproliferative activity against human MDA-MB-231 cells treated for 48 hrs followed by refreshed every 96 hrs measured on day 10 by Lowry assay
[PMID: 26613635]
MDA-MB-231 IC50
0.97 μM
Compound: 6; SAHA
Cytotoxicity against ER negative human MDA-MB-231 cells treated every 2 days for 4 days measured post last dose by CellTiter-Glo luminescence assay
Cytotoxicity against ER negative human MDA-MB-231 cells treated every 2 days for 4 days measured post last dose by CellTiter-Glo luminescence assay
[PMID: 30078609]
MDA-MB-231 IC50
1.09 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
[PMID: 33586434]
MDA-MB-231 IC50
1.11 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
10.1039/C4MD00203B
MDA-MB-231 IC50
1.18 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 21733698]
MDA-MB-231 IC50
1.19 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 27541357]
MDA-MB-231 IC50
1.19 μM
Compound: 2
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 28953386]
MDA-MB-231 IC50
1.19 μM
Compound: 4
Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
[PMID: 29945795]
MDA-MB-231 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
MDA-MB-231 IC50
1.29 μM
Compound: SAHA
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 24702857]
MDA-MB-231 IC50
1.3 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
[PMID: 23906422]
MDA-MB-231 IC50
1.31 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 21476600]
MDA-MB-231 IC50
1.35 μM
Compound: Vorinostat
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
MDA-MB-231 IC50
1.45 μM
Compound: 1; SAHA
Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
[PMID: 33077264]
MDA-MB-231 IC50
1.49 μM
Compound: 4
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 30243158]
MDA-MB-231 IC50
1.54 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay
[PMID: 35041998]
MDA-MB-231 IC50
1.6 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs in presence of CF53 by CCK-8 assay
[PMID: 36622852]
MDA-MB-231 IC50
1.66 μM
Compound: SAHA, vorinostat
Cytotoxicity against cisplatin sensitive human MDA-MB-231 cells after 72 hrs by MTT assay
Cytotoxicity against cisplatin sensitive human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 23252603]
MDA-MB-231 IC50
1.72 μM
Compound: SA, SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 24694055]
MDA-MB-231 IC50
1.72 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 25462271]
MDA-MB-231 IC50
1.73 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 26907204]
MDA-MB-231 IC50
1.77 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34043359]
MDA-MB-231 IC50
1.8 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
10.1039/C4MD00211C
MDA-MB-231 IC50
1.91 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
[PMID: 38452727]
MDA-MB-231 IC50
1.91 μM
Compound: SAHA, Vorinostat
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 21924799]
MDA-MB-231 IC50
1.98 μM
Compound: SAHA
Anti-proliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Anti-proliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 28947154]
MDA-MB-231 IC50
1.98 μM
Compound: XII; SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
MDA-MB-231 IC50
12.3 μM
Compound: SAHA
Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)
Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)
[PMID: 17095213]
MDA-MB-231 IC50
12.3 μM
Compound: SAHA
Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)
Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)
[PMID: 17107790]
MDA-MB-231 IC50
13.48 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 26100440]
MDA-MB-231 IC50
1480 nM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
MDA-MB-231 IC50
1710 nM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 31177073]
MDA-MB-231 IC50
2 μM
Compound: 1, SAHA
Growth inhibition of human MDA-MB-231 cells
Growth inhibition of human MDA-MB-231 cells
[PMID: 20850971]
MDA-MB-231 IC50
2.02 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26149591]
MDA-MB-231 IC50
2.03 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
MDA-MB-231 IC50
2.11 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after hrs by ATP content assay
Antiproliferative activity against human MDA-MB-231 cells after hrs by ATP content assay
[PMID: 20143778]
MDA-MB-231 IC50
2.14 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
[PMID: 30245394]
MDA-MB-231 IC50
2.2 μM
Compound: 2
Cytotoxicity against human MDA-MB-231cells
Cytotoxicity against human MDA-MB-231cells
[PMID: 17691763]
MDA-MB-231 IC50
2.23 μM
Compound: SAHA
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
[PMID: 36244186]
MDA-MB-231 IC50
2.29 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 25311567]
MDA-MB-231 IC50
2.36 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
[PMID: 34847495]
MDA-MB-231 IC50
2.5 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by CCK-8 assay
[PMID: 36622852]
MDA-MB-231 IC50
2.59 μM
Compound: Vorinostat
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
MDA-MB-231 IC50
2.69 μM
Compound: SAHA, vorinostat
Cytotoxicity against cisplatin resistant human MDA-MB-231 cells after 72 hrs by MTT assay
Cytotoxicity against cisplatin resistant human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 23252603]
MDA-MB-231 IC50
2.8 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter blue-reagent based assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter blue-reagent based assay
[PMID: 30645113]
MDA-MB-231 IC50
2.9 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
[PMID: 38141287]
MDA-MB-231 IC50
2.92 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37875056]
MDA-MB-231 IC50
3 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 7 days
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 7 days
[PMID: 35643262]
MDA-MB-231 IC50
3.02 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 29787262]
MDA-MB-231 IC50
3.07 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36153841]
MDA-MB-231 IC50
3.26 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay
[PMID: 39145486]
MDA-MB-231 IC50
3.3 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 28601509]
MDA-MB-231 IC50
3.3 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells harboring wild type BRCA1 and wild BRCA2 assessed as reduction in cell viability
Cytotoxicity against human MDA-MB-231 cells harboring wild type BRCA1 and wild BRCA2 assessed as reduction in cell viability
[PMID: 36053318]
MDA-MB-231 IC50
3.31 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
MDA-MB-231 IC50
3.4 μM
Compound: SAHA
Antiproliferative activity in human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Antiproliferative activity in human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 32061484]
MDA-MB-231 IC50
3.4 μM
Compound: SAHA, vorinostat
Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23786452]
MDA-MB-231 IC50
3.52 μM
Compound: SAHA
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation
[PMID: 35944852]
MDA-MB-231 IC50
3.52 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 5 days by beckman coulter counting method
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 5 days by beckman coulter counting method
[PMID: 33261898]
MDA-MB-231 IC50
3.52 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 74 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 74 hrs by SRB assay
[PMID: 35255412]
MDA-MB-231 IC50
3.96 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
[PMID: 25874326]
MDA-MB-231 IC50
4.5 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells up to 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells up to 72 hrs by MTT assay
[PMID: 27541357]
MDA-MB-231 IC50
4.53 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 28757101]
MDA-MB-231 IC50
4.585 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
MDA-MB-231 IC50
4.61 μM
Compound: 1, SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 24525003]
MDA-MB-231 IC50
4.61 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 26216016]
MDA-MB-231 IC50
4.66 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 32180916]
MDA-MB-231 IC50
4.93 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 29954683]
MDA-MB-231 IC50
5.52 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay
[PMID: 35477142]
MDA-MB-231 IC50
5.6 μM
Compound: 1, SAHA
Inhibition of human MDA-MB-231 cell proliferation after 48 hrs by MTT assay
Inhibition of human MDA-MB-231 cell proliferation after 48 hrs by MTT assay
[PMID: 23493449]
MDA-MB-231 IC50
5.8 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
MDA-MB-231 IC50
6.04 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth measured after 2 days by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth measured after 2 days by CCK8 assay
[PMID: 34610548]
MDA-MB-231 IC50
6000 nM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 27665180]
MDA-MB-231 IC50
7.4 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 25815139]
MDA-MB-231 IC50
8.14 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay
[PMID: 32791401]
MDA-MB-231 IC50
8.25 μM
Compound: 1; SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
[PMID: 34656899]
MDA-MB-231 IC50
9.2 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37796543]
MDA-MB-231 IC50
> 100 μM
Compound: 1; SAHA
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 28885834]
MDA-MB-231 IC50
> 411 nM
Compound: Vorinostat
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
MDA-MB-238 IC50
4.92 μM
Compound: 1; SAHA
Anticancer activity against human MDA-MB-238 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
Anticancer activity against human MDA-MB-238 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
[PMID: 36215854]
MDA-MB-435 GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human MDA-MB-435 cells after 72 hrs by MTS assay
Growth inhibition of human MDA-MB-435 cells after 72 hrs by MTS assay
[PMID: 22435669]
MDA-MB-435 GI50
0.88 μM
Compound: 1, SAHA
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
[PMID: 24119555]
MDA-MB-435 GI50
1.18 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 25800646]
MDA-MB-435 IC50
1.9 μM
Compound: 3 (SAHA)
Antiproliferative activity against MDA-435 (human breast carcinoma) cell line.
Antiproliferative activity against MDA-435 (human breast carcinoma) cell line.
[PMID: 12749893]
MDA-MB-435 IC50
1900 nM
Compound: 1 (SAHA)
Inhibitory concentration against MDA-435 cells proliferation
Inhibitory concentration against MDA-435 cells proliferation
[PMID: 14613312]
MDA-MB-436 IC50
3.9 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-436 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human MDA-MB-436 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
MDA-MB-453 IC50
0.37 μM
Compound: 5; SAHA
Antiproliferative activity against human MDA-MB-453 cells after 96 hrs by MTT assay
Antiproliferative activity against human MDA-MB-453 cells after 96 hrs by MTT assay
[PMID: 31117517]
MDA-MB-468 GI50
0.63 μM
Compound: SAHA, Zolinza
Growth inhibition of human MDA-MB-468 cells after 72 hrs by MTS assay
Growth inhibition of human MDA-MB-468 cells after 72 hrs by MTS assay
[PMID: 22435669]
MDA-MB-468 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
MDA-MB-468 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
MDA-MB-468 IC50
0.95 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-468 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells incubated for 72 hrs by MTT assay
[PMID: 32961382]
MDA-MB-468 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human MDA-MB-468 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-468 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
MDA-MB-468 IC50
1.3 μM
Compound: 2
Cytotoxicity against human MDA-MB-468 cells
Cytotoxicity against human MDA-MB-468 cells
[PMID: 17691763]
MDA-MB-468 IC50
10.03 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
MDA-MB-468 IC50
2.3 μM
Compound: SAHA
Cytotoxicity against human MDA-MB-468 cells harboring wild type BRCA1 and BRCA2 mutant reduction in assessed as cell viability
Cytotoxicity against human MDA-MB-468 cells harboring wild type BRCA1 and BRCA2 mutant reduction in assessed as cell viability
[PMID: 36053318]
MDA-MB-468 IC50
2.69 μM
Compound: Vorinostat
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
MDA-MB-468 IC50
2.75 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
[PMID: 33586434]
MDA-MB-468 IC50
2.85 μM
Compound: SAHA
Anticancer activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
Anticancer activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
[PMID: 36244186]
MDA-MB-468 IC50
5 μM
Compound: SAHA
Antiproliferative activity against human MDA-MB-468 cells
Antiproliferative activity against human MDA-MB-468 cells
[PMID: 20143778]
MEF IC50
4.4 μM
Compound: SAHA
Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay
Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay
[PMID: 23570542]
MG-63 GI50
> 10 μM
Compound: SAHA, vorinostat
Antiproliferative activity against human MG63 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human MG63 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
MGC-803 IC50
1.54 μM
Compound: SAHA
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 33957387]
MGC-803 IC50
1.58 μM
Compound: SAHA
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 36996717]
MGC-803 IC50
1.7 μM
Compound: SAHA; 112
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 31881454]
MGC-803 IC50
1.7 μM
Compound: Vorinostat
Cytotoxicity against human MGC803 cells assessed as reduction in cell viability
Cytotoxicity against human MGC803 cells assessed as reduction in cell viability
[PMID: 30660827]
MGC-803 IC50
2.678 μM
Compound: SAHA
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition after 72 hrs by SRB assay
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition after 72 hrs by SRB assay
[PMID: 34454126]
MGC-803 IC50
2.82 μM
Compound: SAHA
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
[PMID: 37086699]
MGC-803 IC50
3.51 μM
Compound: SAHA
Antiproliferative activity against human MGC803 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC803 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
MGC-803 IC50
8.06 μM
Compound: SAHA
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
MGC-803 IC50
8.67 μM
Compound: Vorinostat
Antiproliferative activity against human MGC803 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC803 cells incubated for 72 hrs by MTT assay
[PMID: 33831778]
MGC-803 IC50
8.75 μM
Compound: SAHA
Antiproliferative activity against human MGC803 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC803 cells incubated for 72 hrs by MTT assay
[PMID: 28987602]
MGC-803 IC50
9.74 μM
Compound: SAHA
Cytotoxicity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34628244]
MIA PaCa-2 GI50
3500 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
MIA PaCa-2 GI50
790 nM
Compound: SAHA
Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells after 48 hrs by MTT assay
[PMID: 24999749]
MIA PaCa-2 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human MiaPaca2 cells after 72 hrs by MTT assay
Antiproliferative activity against human MiaPaca2 cells after 72 hrs by MTT assay
[PMID: 18642892]
MIA PaCa-2 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human MIAPaCa2 cells by MTT assay
Antiproliferative activity against human MIAPaCa2 cells by MTT assay
[PMID: 19419863]
MIA PaCa-2 IC50
1.1 μM
Compound: 1a, SAHA
Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay
Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay
[PMID: 20055418]
MIA PaCa-2 IC50
1.1 μM
Compound: SAHA
Cytotoxicity against human Mia Paca2 cells after 72 hrs by MTT assay
Cytotoxicity against human Mia Paca2 cells after 72 hrs by MTT assay
[PMID: 18494463]
MIA PaCa-2 IC50
2.2 μM
Compound: SAHA
Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
MIA PaCa-2 IC50
996 nM
Compound: 1; SAHA
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
MKN-45 GI50
7.3 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human MKN45 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human MKN45 cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
MKN-45 IC50
1.25 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human MKN45 cells by MTT assay
Cytotoxicity against human MKN45 cells by MTT assay
[PMID: 24766560]
MKN-45 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
MM1.S IC50
0.73 μM
Compound: SAHA
Antiproliferative activity against human MM.1S cells assessed as inhibition of cell growth incubated for 72 hrs by microplate photometer analysis
Antiproliferative activity against human MM.1S cells assessed as inhibition of cell growth incubated for 72 hrs by microplate photometer analysis
[PMID: 38116436]
MM1.S IC50
0.82 μM
Compound: SAHA
Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
[PMID: 26890114]
MM1.S IC50
1.54 μM
Compound: SAHA
Cytotoxicity against human MM1.S cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis
Cytotoxicity against human MM1.S cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis
[PMID: 35119267]
MM1.S IC50
2844 nM
Compound: SAHA
Antiproliferative activity against human MM1S cells after 72 hrs by MTS assay
Antiproliferative activity against human MM1S cells after 72 hrs by MTS assay
[PMID: 29795767]
MM1.S IC50
573 nM
Compound: SAHA
Antiproliferative activity against human MM1S cells after 72 hrs by MTT assay
Antiproliferative activity against human MM1S cells after 72 hrs by MTT assay
[PMID: 30629434]
MM1.S IC50
590.3 nM
Compound: SAHA
Antiproliferative activity against human MM1S cells after 72 hrs by MTT assay
Antiproliferative activity against human MM1S cells after 72 hrs by MTT assay
[PMID: 31177073]
MM473 IC50
8.2 μM
Compound: SAHA
Antiproliferative activity against human MM473 cells at 10 uM after 72 hrs by MTT assay relative to control
Antiproliferative activity against human MM473 cells at 10 uM after 72 hrs by MTT assay relative to control
[PMID: 29150335]
MM473 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human MM473 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human MM473 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
MM96L EC50
0.01 μM
Compound: 25a
Antiproliferative activity against human MM96L cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human MM96L cells assessed as cell growth inhibition by SRB assay
[PMID: 34591488]
MOLM-13 EC50
1.2 μM
Compound: SAHA
Growth inhibition of human MOLM13 cells after 44 hrs by MTT assay
Growth inhibition of human MOLM13 cells after 44 hrs by MTT assay
[PMID: 28337317]
MOLM-13 IC50
0.345 μM
Compound: 1; SAHA
Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay
Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay
[PMID: 31938464]
MOLM-13 IC50
984.9 nM
Compound: SAHA
Antiproliferative activity against human MOLM13 cells harboring wild type p53/FLT3-ITD mutant after 72 hrs by MTT assay
Antiproliferative activity against human MOLM13 cells harboring wild type p53/FLT3-ITD mutant after 72 hrs by MTT assay
[PMID: 27505848]
MOLM-14 EC50
0.54 μM
Compound: 3; SAHA
Antiproliferative activity against human MOLM14 cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human MOLM14 cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 31627059]
MOLT-4 GI50
0.4 μM
Compound: SAHA, Zolinza
Growth inhibition of human MOLT4 cells after 72 hrs by MTS assay
Growth inhibition of human MOLT4 cells after 72 hrs by MTS assay
[PMID: 22435669]
MOLT-4 GI50
0.68 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human MOLT4 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human MOLT4 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
MOLT-4 GI50
3.3 μM
Compound: 1
Growth inhibition of human MOLT-4 cells measured after 24 hrs by MTT assay
Growth inhibition of human MOLT-4 cells measured after 24 hrs by MTT assay
[PMID: 37429084]
MOLT-4 GI50
542 nM
Compound: SAHA
Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
[PMID: 26331334]
MOLT-4 GI50
670 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human MOLT4 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human MOLT4 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
MOLT-4 IC50
0.21 μM
Compound: Vorinostat
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
MOLT-4 IC50
0.33 μM
Compound: SAHA
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
[PMID: 28336407]
MOLT-4 IC50
0.33 μM
Compound: Vorinostat
Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability by MTT assay
[PMID: 38107170]
MOLT-4 IC50
0.36 μM
Compound: SAHA
Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay
Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay
[PMID: 29787262]
MOLT-4 IC50
0.38 μM
Compound: SAHA
Antiproliferative activity against human MOLT4 cells incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MOLT4 cells incubated for 24 hrs by CCK8 assay
[PMID: 32247729]
MOLT-4 IC50
0.4 μM
Compound: 3; SAHA
Antiproliferative activity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MOLT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30901208]
MOLT-4 IC50
0.41 μM
Compound: SAHA
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
[PMID: 29533873]
MOLT-4 IC50
0.41 μM
Compound: SAHA
Antiproliferative activity against human MOLT-4 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human MOLT-4 cells after 48 hrs by CCK-8 assay
[PMID: 35939996]
MOLT-4 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human MOLT-4 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human MOLT-4 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
MOLT-4 IC50
0.52 μM
Compound: Vor; SAHA
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
MOLT-4 IC50
0.56 μM
Compound: Vorinostat
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
[PMID: 28371677]
MOLT-4 IC50
0.57 μM
Compound: SAHA
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
[PMID: 37086699]
MOLT-4 IC50
0.7 μM
Compound: SAHA
Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
MOLT-4 IC50
1.08 μM
Compound: SAHA
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay
[PMID: 29500131]
MOLT-4 IC50
3.09 μM
Compound: XII; SAHA
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
MRC5 IC50
68.7 μM
Compound: SAHA
Anti-proliferative activity against human MRC5 cells after 48 hrs by MTT assay
Anti-proliferative activity against human MRC5 cells after 48 hrs by MTT assay
[PMID: 28947154]
MV4-11 EC50
0.53 μM
Compound: Vor; SAHA
Induction of cell death in human MV4-11 cells measured at 48 hrs by fluorescence based microplate reader analysis
Induction of cell death in human MV4-11 cells measured at 48 hrs by fluorescence based microplate reader analysis
[PMID: 29360358]
MV4-11 EC50
0.9 μM
Compound: Vor; SAHA
Induction of apoptosis in human MV4-11 cells assessed as increase in caspase 3/7 activity measured at 24 hrs in presence of Z-DEVD-R110 or (Z-Asp-Glu-Val-Asp)2-rhodamine110 by fluorescence based microplate reader analysis
Induction of apoptosis in human MV4-11 cells assessed as increase in caspase 3/7 activity measured at 24 hrs in presence of Z-DEVD-R110 or (Z-Asp-Glu-Val-Asp)2-rhodamine110 by fluorescence based microplate reader analysis
[PMID: 29360358]
MV4-11 EC50
418.1 nM
Compound: SAHA; Vor
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Blue dye based spectrophotometric analysis
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Blue dye based spectrophotometric analysis
[PMID: 32321249]
MV4-11 EC50
< 30 nM
Compound: Vorinostat
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-blue cell viability assay
[PMID: 27754681]
MV4-11 GI50
0.59 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
Antiproliferative activity against human MV4-11 cells assessed as growth inhibition after 48 hrs by CellTiter-Glo assay
[PMID: 25800646]
MV4-11 IC50
0.22 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
MV4-11 IC50
0.24 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs in presence of SHP099 by CCK-8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs in presence of SHP099 by CCK-8 assay
[PMID: 36097406]
MV4-11 IC50
0.26 μM
Compound: 10; SAHA
Antiproliferative activity against human MV4-11 cells assessed as cell viability after 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as cell viability after 72 hrs by CCK8 assay
[PMID: 33077265]
MV4-11 IC50
0.29 μM
Compound: SAHA
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis
[PMID: 35119267]
MV4-11 IC50
0.31 μM
Compound: 1; SAHA
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay
[PMID: 31938464]
MV4-11 IC50
0.37 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
[PMID: 37086699]
MV4-11 IC50
0.38 μM
Compound: SAHA
Cytotoxicity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by Cell titer-blue assay
Cytotoxicity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by Cell titer-blue assay
[PMID: 34101461]
MV4-11 IC50
0.4 μM
Compound: SAHA
Inhibition of cell viability in human MV4-11 cells incubated for 4 days in presence of GSK5032 by CCK8 assay
Inhibition of cell viability in human MV4-11 cells incubated for 4 days in presence of GSK5032 by CCK8 assay
[PMID: 39264152]
MV4-11 IC50
0.421 μM
Compound: Vorinostat
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
[PMID: 37659198]
MV4-11 IC50
0.43 μM
Compound: Vor; SAHA
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
[PMID: 29360358]
MV4-11 IC50
0.47 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by resazurin based microplate reader analysis
Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by resazurin based microplate reader analysis
[PMID: 37647727]
MV4-11 IC50
0.493 μM
Compound: Vorinostat
Cytotoxicity against human MV4-11 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 37875056]
MV4-11 IC50
0.5 μM
Compound: SAHA
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30034592]
MV4-11 IC50
0.5 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36097406]
MV4-11 IC50
0.51 μM
Compound: 1; SAHA
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days in presence of atamparib by celltiter-glo luminescent assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days in presence of atamparib by celltiter-glo luminescent assay
[PMID: 38456618]
MV4-11 IC50
0.55 μM
Compound: 1; SAHA
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
[PMID: 38456618]
MV4-11 IC50
0.68 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
[PMID: 36272186]
MV4-11 IC50
0.7 μM
Compound: 2; SAHA
Cytotoxicity against human MV411 cells
Cytotoxicity against human MV411 cells
[PMID: 26005563]
MV4-11 IC50
0.7 μM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells incubated for 96 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells incubated for 96 hrs by CCK8 assay
[PMID: 39264152]
MV4-11 IC50
0.7 μM
Compound: SAHA
Inhibition of cell viability in human MV4-11 cells incubated for 4 days by CCK8 assay
Inhibition of cell viability in human MV4-11 cells incubated for 4 days by CCK8 assay
[PMID: 39264152]
MV4-11 IC50
0.72 μM
Compound: 1; SAHA
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue assay
[PMID: 27142751]
MV4-11 IC50
0.85 μM
Compound: 1; SAHA
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36153841]
MV4-11 IC50
0.88 μM
Compound: SAHA; 6
Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by celltiter-glo luminescent assay
Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by celltiter-glo luminescent assay
[PMID: 39178382]
MV4-11 IC50
0.98 μM
Compound: 5; SAHA
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
[PMID: 28765013]
MV4-11 IC50
2.41 μM
Compound: SAHA
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
MV4-11 IC50
220 nM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
[PMID: 30629434]
MV4-11 IC50
230 nM
Compound: SAHA
Cytotoxicity against human MV4-11 cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human MV4-11 cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 27186676]
MV4-11 IC50
439 nM
Compound: SAHA
Growth inhibition of human MV4-11 cells assessed as ATP level after 72 hrs by CellTiterGlo assay
Growth inhibition of human MV4-11 cells assessed as ATP level after 72 hrs by CellTiterGlo assay
10.1039/C3MD00285C
MV4-11 IC50
471.4 nM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells
Antiproliferative activity against human MV4-11 cells
[PMID: 35580726]
MV4-11 IC50
483 nM
Compound: 1; SAHA
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
[PMID: 39047608]
MV4-11 IC50
496.1 nM
Compound: SAHA
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay
[PMID: 27505848]
MV4-11 IC50
537 nM
Compound: 1; SAHA
Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
[PMID: 38224650]
MV4-11 IC50
8.44 μM
Compound: 4; SAHA
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability
[PMID: 34314844]
MV4-11 IC50
85 nM
Compound: SAHA
Cytotoxicity against human MV4-11 cells after 72 hrs by MTT assay
Cytotoxicity against human MV4-11 cells after 72 hrs by MTT assay
[PMID: 26443078]
Malme-3M GI50
0.32 μM
Compound: SAHA, Zolinza
Growth inhibition of human MALME-3M cells after 72 hrs by MTS assay
Growth inhibition of human MALME-3M cells after 72 hrs by MTS assay
[PMID: 22435669]
Malme-3M GI50
0.37 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human MALME-3M cells after 48 hrs by SRB assay
Cytotoxicity against human MALME-3M cells after 48 hrs by SRB assay
[PMID: 24015327]
N2a IC50
1.45 μM
Compound: SAHA
Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability incubated for 24 hrs by Cell Titer-Glo 2.0 Luminescent cell assay
Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability incubated for 24 hrs by Cell Titer-Glo 2.0 Luminescent cell assay
[PMID: 33845233]
NALM-6 IC50
1.2 μM
Compound: SAHA
Antiproliferative activity against human NALM-6 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human NALM-6 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 36395680]
NAMALVA IC50
0.11 μM
Compound: 1; SAHA
Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
NAMALVA IC50
0.11 μM
Compound: Vorinostat
Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
NB-4 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
NB-4 IC50
0.6 μM
Compound: SAHA, vorinostat
Antiproliferative activity against human NB4 cells after 48 hrs
Antiproliferative activity against human NB4 cells after 48 hrs
[PMID: 18723349]
NB-4 IC50
0.7 μM
Compound: SAHA
Antiproliferative activity against human NB4 cells after 72 hrs
Antiproliferative activity against human NB4 cells after 72 hrs
[PMID: 19084294]
NB-4 IC50
0.7 μM
Compound: SAHA
Growth inhibition of human NB4 cells after 72 hrs
Growth inhibition of human NB4 cells after 72 hrs
[PMID: 26376355]
NB-4 IC50
0.7 μM
Compound: SAHA, vorinostat
Growth inhibition of human NB4 cells by SRB assay
Growth inhibition of human NB4 cells by SRB assay
[PMID: 17892933]
NB-4 IC50
0.71 μM
Compound: SAHA
Antiproliferative activity against human NB4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human NB4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
NB-4 IC50
0.98 μM
Compound: SAHA, Vorinostat
Induction of apoptosis in human NB4 cells after 48 hrs by Annexin V test
Induction of apoptosis in human NB4 cells after 48 hrs by Annexin V test
[PMID: 23792316]
NB-4 IC50
1.2 μM
Compound: SAHA
Antiproliferative activity against human NB-4 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human NB-4 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
NB-4 IC50
1.52 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human NB4 cells after 48 hrs by MTT assay
Cytotoxicity against human NB4 cells after 48 hrs by MTT assay
[PMID: 21476600]
NB-4 IC50
3.3 μM
Compound: SAHA
Antiproliferative activity against human NB4 cells after 72 hrs by MTT assay
Antiproliferative activity against human NB4 cells after 72 hrs by MTT assay
[PMID: 29150335]
NB-4 IC50
880 nM
Compound: Vorinostat
Cytotoxicity against human NB-4 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human NB-4 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
NB1 IC50
2.71 μM
Compound: Vorinostat
Antiproliferative activity against human NB-1 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
Antiproliferative activity against human NB-1 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
[PMID: 31391882]
NCI-H1299 IC50
0.55 μM
Compound: SAHA
Cytotoxicity against human NCI-H1299 by SRB assay
Cytotoxicity against human NCI-H1299 by SRB assay
[PMID: 20855208]
NCI-H1299 IC50
3.46 μM
Compound: Vorinostat
Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
NCI-H1299 IC50
4.92 μM
Compound: 1; SAHA
Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK8 assay
[PMID: 30045621]
NCI-H1299 IC50
5.1 μM
Compound: 5; SAHA
Antiproliferative activity against human NCI-H1299 cells after 96 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells after 96 hrs by MTT assay
[PMID: 31117517]
NCI-H1299 IC50
5.53 μM
Compound: Vorinostat
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
NCI-H1299 IC50
7.02 μM
Compound: SAHA
Antiproliferative activity against human H1299 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human H1299 cells incubated for 48 hrs by MTT assay
[PMID: 30851694]
NCI-H1299 IC50
7.24 μM
Compound: 3, SAHA
Antiproliferative activity against H1299 cells
Antiproliferative activity against H1299 cells
[PMID: 16904890]
NCI-H1299 IC50
7240 nM
Compound: SAHA (1)
Inhibitory activity against H1299 human lung carcinoma cell growth
Inhibitory activity against H1299 human lung carcinoma cell growth
[PMID: 14521422]
NCI-H1299 IC50
8200 nM
Compound: 1, SAHA
Antiproliferative activity against human H1299 cells
Antiproliferative activity against human H1299 cells
[PMID: 21650221]
NCI-H1373 IC50
0.13 μM
Compound: 1; SAHA
Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days in presence of atamparib by celltiter-glo luminescent assay
Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days in presence of atamparib by celltiter-glo luminescent assay
[PMID: 38456618]
NCI-H1373 IC50
1.46 μM
Compound: 1; SAHA
Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by celltiter-glo luminescent assay
Antiproliferative activity against human NCI-H1373 cells assessed as inhibition of cell growth incubated for 6 days by celltiter-glo luminescent assay
[PMID: 38456618]
NCI-H157 IC50
1.33 μM
Compound: Vorinostat
Antiproliferative activity against human NCI-H157 cells
Antiproliferative activity against human NCI-H157 cells
[PMID: 37875056]
NCI-H1581 IC50
2.501 μM
Compound: SAHA
Cytotoxicity against human NCI-1581 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-1581 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
NCI-H1650 IC50
5.5 μM
Compound: 1; SAHA
Antiproliferative activity against human NCI-H1650 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human NCI-H1650 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
NCI-H1975 GI50
0.98 μM
Compound: 1; SAHA
Growth inhibition of human NCI-H1975 cells incubated for 48 hrs by SRB assay
Growth inhibition of human NCI-H1975 cells incubated for 48 hrs by SRB assay
[PMID: 32058238]
NCI-H1975 GI50
1.41 μM
Compound: SAHA; 1
Antiproliferative activity against human NCI-H1975 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H1975 cells after 48 hrs by sulforhodamine B assay
[PMID: 29567459]
NCI-H1975 GI50
2.61 μM
Compound: 1; SAHA
Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 31655430]
NCI-H1975 IC50
1.7 μM
Compound: SAHA
Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs by Celltiter-glo assay
[PMID: 38141287]
NCI-H1975 IC50
1.9 μM
Compound: 8
Antiproliferative activity against human NCI-H1975 expressing EGFR T790M/L858R mutant assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 expressing EGFR T790M/L858R mutant assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 27769671]
NCI-H1975 IC50
2.04 μM
Compound: Vorinostat
Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
[PMID: 33493830]
NCI-H1975 IC50
2.08 μM
Compound: SAHA
Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
NCI-H2122 IC50
7.5 μM
Compound: SAHA
Antiproliferative activity against human NCI-H2122 cells
Antiproliferative activity against human NCI-H2122 cells
[PMID: 20143778]
NCI-H2126 IC50
1.319 μM
Compound: SAHA
Cytotoxicity against human NCI-H2126 by SRB assay
Cytotoxicity against human NCI-H2126 by SRB assay
[PMID: 20855208]
NCI-H226 EC50
2.6 μM
Compound: SAHA
Inhibition of human NCI-H226 cells
Inhibition of human NCI-H226 cells
[PMID: 18247554]
NCI-H226 EC50
2.6 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human NCI-H226 cells
Effective Concentration of compound to inhibit the growth of human NCI-H226 cells
[PMID: 15715470]
NCI-H226 GI50
4 μM
Compound: SAHA, Zolinza
Growth inhibition of human NCI-H226 cells after 72 hrs by MTS assay
Growth inhibition of human NCI-H226 cells after 72 hrs by MTS assay
[PMID: 22435669]
NCI-H226 IC50
3.48 μM
Compound: SAHA
Cytotoxicity against human NCI-H226 by SRB assay
Cytotoxicity against human NCI-H226 by SRB assay
[PMID: 20855208]
NCI-H226 IC50
8.33 μM
Compound: SAHA
Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
NCI-H23 GI50
0.92 μM
Compound: 1, SAHA
Growth inhibition of NCI-H23 cells by SRB assay
Growth inhibition of NCI-H23 cells by SRB assay
[PMID: 17477518]
NCI-H23 GI50
0.92 μM
Compound: 2, SAHA
Antiproliferative activity against human NCI-H23 cells by SRB assay
Antiproliferative activity against human NCI-H23 cells by SRB assay
[PMID: 16723227]
NCI-H23 GI50
1 μM
Compound: SAHA, Zolinza
Growth inhibition of human NCI-H23 cells after 72 hrs by MTS assay
Growth inhibition of human NCI-H23 cells after 72 hrs by MTS assay
[PMID: 22435669]
NCI-H23 GI50
1.34 μM
Compound: SAHA
Growth inhibition of human NCI-H23 cells after 21 hrs by MTT assay
Growth inhibition of human NCI-H23 cells after 21 hrs by MTT assay
[PMID: 17662606]
NCI-H23 GI50
2 μM
Compound: SAHA; NSC759852
Cytotoxicity against human NCI-H23 cells assessed as cell growth inhibition at 10 uM incubated for 24 hrs by MTT assay
Cytotoxicity against human NCI-H23 cells assessed as cell growth inhibition at 10 uM incubated for 24 hrs by MTT assay
[PMID: 36306372]
NCI-H23 GI50
2.34 μM
Compound: 1, SAHA
Growth inhibition of human NCI-H23 cells
Growth inhibition of human NCI-H23 cells
[PMID: 20850971]
NCI-H23 GI50
2.34 μM
Compound: 1, SAHA, Zolinza, Vorinostat
Cytotoxicity against human NCI-H23 cells assessed as growth inhibition by SRB assay
Cytotoxicity against human NCI-H23 cells assessed as growth inhibition by SRB assay
[PMID: 23163332]
NCI-H23 GI50
2.34 μM
Compound: SAHA
Growth inhibition of human NCI-H23 cells after 5 days by sulforhodamine B assay
Growth inhibition of human NCI-H23 cells after 5 days by sulforhodamine B assay
[PMID: 25811792]
NCI-H23 GI50
2.34 μM
Compound: SAHA
Growth inhibition of human NCI-H23 cells measured after 5 days by sulforhodamine-B assay
Growth inhibition of human NCI-H23 cells measured after 5 days by sulforhodamine-B assay
[PMID: 28011426]
NCI-H23 IC50
0.383 μM
Compound: SAHA
Cytotoxicity against human NCI-H23 by SRB assay
Cytotoxicity against human NCI-H23 by SRB assay
[PMID: 20855208]
NCI-H23 IC50
1.12 μM
Compound: Vorinostat
Antiproliferative activity against human NCI-H23 cells incubated for 72 hrs by colorimetric method
Antiproliferative activity against human NCI-H23 cells incubated for 72 hrs by colorimetric method
[PMID: 37875056]
NCI-H23 IC50
1.44 μM
Compound: SAHA
Cytotoxicity against human NCI-H23 cells by colorimetric method
Cytotoxicity against human NCI-H23 cells by colorimetric method
[PMID: 32916298]
NCI-H23 IC50
1.44 μM
Compound: Vorinostat
Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by colorimetric method
Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by colorimetric method
[PMID: 37875056]
NCI-H23 IC50
2.8 μM
Compound: Vorinostat
Cytotoxicity against human NCI-H23 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human NCI-H23 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
NCI-H23 IC50
3.2 μM
Compound: SAHA
Antiproliferative activity against human NCI-H23 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H23 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31546197]
NCI-H292 IC50
1.11 μM
Compound: SAHA
Growth inhibition of human NCI-H292 cells after 72 hrs by MTT assay
Growth inhibition of human NCI-H292 cells after 72 hrs by MTT assay
[PMID: 28108250]
NCI-H292 IC50
2.01 μM
Compound: SAHA
Growth inhibition of human NCI-H292 cells in LDL depleted FBS containing medium after 72 hrs using compound after sonication in presence of LDL by MTT assay
Growth inhibition of human NCI-H292 cells in LDL depleted FBS containing medium after 72 hrs using compound after sonication in presence of LDL by MTT assay
[PMID: 28108250]
NCI-H292 IC50
4.61 μM
Compound: SAHA
Growth inhibition of human NCI-H292 cells in FBS containing medium after 72 hrs using compound after sonication in presence of LDL by MTT assay
Growth inhibition of human NCI-H292 cells in FBS containing medium after 72 hrs using compound after sonication in presence of LDL by MTT assay
[PMID: 28108250]
NCI-H292 IC50
5.15 μM
Compound: SAHA
Growth inhibition of human NCI-H292 cells after 72 hrs in presence of LDL by MTT assay
Growth inhibition of human NCI-H292 cells after 72 hrs in presence of LDL by MTT assay
[PMID: 28108250]
NCI-H322M GI50
0.79 μM
Compound: SAHA, Zolinza
Growth inhibition of human NCI-H322M cells after 72 hrs by MTS assay
Growth inhibition of human NCI-H322M cells after 72 hrs by MTS assay
[PMID: 22435669]
NCI-H358 IC50
2.5 μM
Compound: SAHA
Antiproliferative activity against human NCI-H358 cells after hrs by ATP content assay
Antiproliferative activity against human NCI-H358 cells after hrs by ATP content assay
[PMID: 20143778]
NCI-H441 IC50
0.686 μM
Compound: SAHA
Cytotoxicity against human H441 by SRB assay
Cytotoxicity against human H441 by SRB assay
[PMID: 20855208]
NCI-H446 IC50
0.34 μM
Compound: 1; SAHA
Antiproliferative activity against human NCI-H446 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human NCI-H446 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
NCI-H460 GI50
0.79 μM
Compound: SAHA, Zolinza
Growth inhibition of human NCI-H460 cells after 72 hrs by MTS assay
Growth inhibition of human NCI-H460 cells after 72 hrs by MTS assay
[PMID: 22435669]
NCI-H460 GI50
0.85 μM
Compound: 1, SAHA
Antiproliferative activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 24119555]
NCI-H460 GI50
0.85 μM
Compound: SAHA
Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 25800646]
NCI-H460 GI50
1 μM
Compound: SAHA
Cytotoxicity against human NCI-H460 cells by MTT assay
Cytotoxicity against human NCI-H460 cells by MTT assay
[PMID: 23538115]
NCI-H460 GI50
8 μM
Compound: SAHA
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
[PMID: 20605448]
NCI-H460 IC50
0.425 μM
Compound: 1; SAHA
Antiproliferative activity against human NCI-H460 cells after 72 hrs by resazurin dye based fluorescence assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by resazurin dye based fluorescence assay
[PMID: 29456804]
NCI-H460 IC50
0.68 μg/mL
Compound: SAHA
Cytotoxicity against human NCI-H460 cells
Cytotoxicity against human NCI-H460 cells
[PMID: 22036991]
NCI-H460 IC50
0.82 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human H460 cells by MTT assay
Cytotoxicity against human H460 cells by MTT assay
[PMID: 24766560]
NCI-H460 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human NCI-H460 cells after 72 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by SRB assay
[PMID: 29150335]
NCI-H460 IC50
1 μM
Compound: Vorinostat
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability by SRB assay
[PMID: 30660827]
NCI-H460 IC50
1.2 μM
Compound: 2
Cytotoxicity against human NCI H460 cells
Cytotoxicity against human NCI H460 cells
[PMID: 17691763]
NCI-H460 IC50
1.7 μM
Compound: SAHA
Antiproliferative activity against human H460 cells after hrs by ATP content assay
Antiproliferative activity against human H460 cells after hrs by ATP content assay
[PMID: 20143778]
NCI-H460 IC50
1.7 μM
Compound: SAHA; 112
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 31881454]
NCI-H460 IC50
1.7 μM
Compound: Vorinostat
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability
[PMID: 30660827]
NCI-H460 IC50
100 μM
Compound: 5; SAHA
Antiproliferative activity against human NCI-H460 cells after 96 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells after 96 hrs by MTT assay
[PMID: 31117517]
NCI-H460 IC50
11.92 μM
Compound: SAHA
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
NCI-H460 IC50
2.77 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human NCI-H460 cells after 48 hrs by SRB assay
Antiproliferative activity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 24185378]
NCI-H460 IC50
3.04 μM
Compound: SAHA
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
NCI-H460 IC50
3.4 μM
Compound: 2, SAHA
Growth inhibition of human H460 cells after 48 hrs by SRB assay
Growth inhibition of human H460 cells after 48 hrs by SRB assay
[PMID: 21073160]
NCI-H460 IC50
3.4 μM
Compound: SAHA
Antiproliferative activity against human H460 cells after 72 hrs
Antiproliferative activity against human H460 cells after 72 hrs
[PMID: 19084294]
NCI-H460 IC50
3.4 μM
Compound: SAHA
Cytotoxicity against human H460 cells after 24 hrs by sulforhodamine B assay
Cytotoxicity against human H460 cells after 24 hrs by sulforhodamine B assay
[PMID: 19359173]
NCI-H460 IC50
3.4 μM
Compound: SAHA
Antiproliferative activity against human H460 cells assessed as growth inhibition after 72 hrs
Antiproliferative activity against human H460 cells assessed as growth inhibition after 72 hrs
[PMID: 24742384]
NCI-H460 IC50
3.4 μM
Compound: SAHA
Growth inhibition of human H460 cells after 72 hrs
Growth inhibition of human H460 cells after 72 hrs
[PMID: 26376355]
NCI-H460 IC50
3.4 μM
Compound: SAHA
Antiproliferative activity against human H460 cells assessed as reduction in cell number after 72 hrs by cell counter analysis
Antiproliferative activity against human H460 cells assessed as reduction in cell number after 72 hrs by cell counter analysis
[PMID: 26890116]
NCI-H460 IC50
3.4 μM
Compound: SAHA, Vorinostat
Cytotoxicity against human H460 cells
Cytotoxicity against human H460 cells
[PMID: 24345446]
NCI-H460 IC50
3.4 μM
Compound: SAHA, vorinostat
Growth inhibition of human H460 cells by SRB assay
Growth inhibition of human H460 cells by SRB assay
[PMID: 17892933]
NCI-H460 IC50
3.448 μM
Compound: SAHA
Cytotoxicity against human NCI-H460 by SRB assay
Cytotoxicity against human NCI-H460 by SRB assay
[PMID: 20855208]
NCI-H460 IC50
3400 nM
Compound: 1, SAHA
Cytotoxicity against human NCI-H460 cells
Cytotoxicity against human NCI-H460 cells
[PMID: 25563890]
NCI-H460 IC50
4.136 μM
Compound: SAHA
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
NCI-H460 IC50
4.2 μM
Compound: SAHA
Antiproliferative activity against human NCI-H460 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human NCI-H460 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
NCI-H460 IC50
5.46 μM
Compound: Vorinostat
Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
NCI-H460 IC50
6.29 μM
Compound: Vorinostat
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
NCI-H460 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
NCI-H460 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human H460 cells after 72 hrs by MTT assay
Cytotoxicity against human H460 cells after 72 hrs by MTT assay
[PMID: 26443078]
NCI-H522 GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human NCI-H522 cells after 72 hrs by MTS assay
Growth inhibition of human NCI-H522 cells after 72 hrs by MTS assay
[PMID: 22435669]
NCI-H522 IC50
0.832 μM
Compound: SAHA
Cytotoxicity against human NCI-H522 by SRB assay
Cytotoxicity against human NCI-H522 by SRB assay
[PMID: 20855208]
NCI-H522 IC50
1.72 μM
Compound: SAHA
Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based analysis
[PMID: 35984756]
NCI-H522 IC50
2.38 μM
Compound: SAHA
Anticancer activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
Anticancer activity against human NCI-H522 cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
[PMID: 36244186]
NCI-H526 GI50
0.481 μM
Compound: Vorinostat
Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay
Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay
[PMID: 36262394]
NCI-H661 IC50
0.13 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human NCI-H661 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
Antiproliferative activity against human NCI-H661 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
[PMID: 25874326]
NCI-H661 IC50
0.13 μM
Compound: Vorinostat
Antiproliferative activity against human NCI-H661 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H661 cells incubated for 72 hrs by MTT assay
[PMID: 25953722]
NCI-H661 IC50
1 μM
Compound: 1
Antiproliferative activity against human H661 cells after 48 hrs
Antiproliferative activity against human H661 cells after 48 hrs
[PMID: 17157009]
NCI-H661 IC50
5 μM
Compound: SAHA
Antiproliferative activity against H661 cells after 48 hrs
Antiproliferative activity against H661 cells after 48 hrs
[PMID: 17897824]
NCI-H661 IC50
> 5 μM
Compound: 3, SAHA
Antiproliferative activity against H661 cells
Antiproliferative activity against H661 cells
[PMID: 16904890]
NCI-H69 EC50
2.06 μM
Compound: SAHA
Cytotoxicity against human NCI-H69 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human NCI-H69 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19093884]
NCI-H69 IC50
0.6 μM
Compound: SAHA
Cytotoxicity against human H69 cells
Cytotoxicity against human H69 cells
[PMID: 23906422]
NCI-H727 IC50
1.37 μM
Compound: SAHA
Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 35858522]
NCI-H838 IC50
5.18 μM
Compound: Vorinostat
Antiproliferation activity against human NCI-H838 cells incubated for 72 hrs by MTT assay
Antiproliferation activity against human NCI-H838 cells incubated for 72 hrs by MTT assay
[PMID: 33493830]
NCI-H929 EC50
1.4 μM
Compound: 3; SAHA
Antiproliferative activity against human NCI-H929 cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human NCI-H929 cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 31627059]
NCI-H929 IC50
0.8 μM
Compound: SAHA
Antiproliferative activity against human NCI-H929 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H929 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25238284]
NCI-H929 IC50
2.83 μM
Compound: SAHA
Antiproliferative activity against human NCI-H929 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
Antiproliferative activity against human NCI-H929 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
[PMID: 26890114]
NCI-N87 IC50
1027 nM
Compound: 1; SAHA
Antiproliferative activity against human NCI-N87 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human NCI-N87 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
NCI/ADR-RES GI50
0.16 μM
Compound: SAHA, Zolinza
Growth inhibition of human NCI-ADR-RES cells after 72 hrs by MTS assay
Growth inhibition of human NCI-ADR-RES cells after 72 hrs by MTS assay
[PMID: 22435669]
NCI/ADR-RES IC50
1413.4 nM
Compound: SAHA
Cytotoxicity against human MCF7/ADR cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7/ADR cells after 72 hrs by SRB assay
[PMID: 30819618]
NFF IC50
5.5 μM
Compound: SAHA
Cytotoxicity against human NFF cells incubated for 72 hrs by SRB assay
Cytotoxicity against human NFF cells incubated for 72 hrs by SRB assay
[PMID: 39208744]
NFF IC50
5170 nM
Compound: SAHA
Cytotoxicity against human NFF cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human NFF cells after 72 hrs by sulforhodamine B assay
[PMID: 30245402]
NIH3T3 EC50
4.8 μM
Compound: SAHA
Cytotoxicity against mouse NIH/3T3 cells assessed as cell proliferation after 70 hrs by MTS assay
Cytotoxicity against mouse NIH/3T3 cells assessed as cell proliferation after 70 hrs by MTS assay
[PMID: 25974739]
NIH3T3 IC50
16.6 μM
Compound: SAHA
Antiproliferative activity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 3 days by CCK-8 assay
Antiproliferative activity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 3 days by CCK-8 assay
[PMID: 37463500]
NSC IC50
4 μM
Compound: Chemical Probe: Vorinostat
Cytotoxicity against human fetal NSC assessed as reduction in cell vaibility incubated for 48 hrs by alamar blue assay
Cytotoxicity against human fetal NSC assessed as reduction in cell vaibility incubated for 48 hrs by alamar blue assay
[PMID: 30559935]
NUGC-3 GI50
2.79 μM
Compound: 2, SAHA
Growth inhibition of human NUGC3 cells by SRB assay
Growth inhibition of human NUGC3 cells by SRB assay
[PMID: 17904843]
NUGC-3 GI50
2.94 μM
Compound: 1, SAHA
Growth inhibition of human NUGC3 cells
Growth inhibition of human NUGC3 cells
[PMID: 20850971]
NUGC-3 GI50
2.94 μM
Compound: 1, SAHA, Zolinza, Vorinostat
Cytotoxicity against human NUGC3 cells assessed as growth inhibition by SRB assay
Cytotoxicity against human NUGC3 cells assessed as growth inhibition by SRB assay
[PMID: 23163332]
NUGC-3 GI50
2.94 μM
Compound: SAHA
Growth inhibition of human NUGC3 cells after 5 days by sulforhodamine B assay
Growth inhibition of human NUGC3 cells after 5 days by sulforhodamine B assay
[PMID: 25811792]
NUGC-3 GI50
2.94 μM
Compound: SAHA
Growth inhibition of human NUGC3 cells measured after 5 days by sulforhodamine-B assay
Growth inhibition of human NUGC3 cells measured after 5 days by sulforhodamine-B assay
[PMID: 28011426]
Non-small cell lung cancer cell line IC50
> 1 μM
Compound: 1; SAHA
Antiproliferative activity against non-small cell lung cancer cell line (unknown origin)
Antiproliferative activity against non-small cell lung cancer cell line (unknown origin)
[PMID: 33077264]
OCI-AML-3 IC50
0.85 μM
Compound: 5; SAHA
Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay
Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay
[PMID: 28765013]
OCI-AML-3 IC50
1365 nM
Compound: SAHA
Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay
Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay
[PMID: 27505848]
OCI-AML-3 IC50
300 nM
Compound: SAHA
Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay
Antiproliferative activity against human OCI-AML3 cells after 72 hrs by MTT assay
[PMID: 30629434]
OCI-AML2 IC50
0.78 μM
Compound: 5; SAHA
Antiproliferative activity against human OCI-AML2 cells after 72 hrs by MTT assay
Antiproliferative activity against human OCI-AML2 cells after 72 hrs by MTT assay
[PMID: 28765013]
OCI-AML2 IC50
390 nM
Compound: SAHA
Antiproliferative activity against human OCI-AML2 cells after 72 hrs by MTT assay
Antiproliferative activity against human OCI-AML2 cells after 72 hrs by MTT assay
[PMID: 30629434]
OCI-Ly3 IC50
2.2 μM
Compound: SAHA
Antiproliferative activity against human OCI-LY3 cells after 72 hrs by MTT assay
Antiproliferative activity against human OCI-LY3 cells after 72 hrs by MTT assay
[PMID: 29150335]
OE19 GI50
1.42 μM
Compound: Vorinostat
Antiproliferative activity against human OE19 cells assessed as reduction in cell viability incubated for 72 hrs by presto blue assay
Antiproliferative activity against human OE19 cells assessed as reduction in cell viability incubated for 72 hrs by presto blue assay
[PMID: 31420257]
OE33 GI50
1.12 μM
Compound: Vorinostat
Antiproliferative activity against human OE33 cells assessed as reduction in cell viability incubated for 72 hrs by presto blue assay
Antiproliferative activity against human OE33 cells assessed as reduction in cell viability incubated for 72 hrs by presto blue assay
[PMID: 31420257]
ONS-76 IC50
2.04 μM
Compound: Vorinostat
Antiproliferative activity against human ONS76 cells after 72 hrs by Celltiter-Glo assay
Antiproliferative activity against human ONS76 cells after 72 hrs by Celltiter-Glo assay
[PMID: 28581289]
OPM-2 EC50
2.9 μM
Compound: 3; SAHA
Antiproliferative activity against human OPM2 cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human OPM2 cells incubated for 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 31627059]
OPM-2 IC50
2.91 μM
Compound: 1; SAHA
Antiproliferative activity against human OPM2 cells after 48 hrs by CellTiter-Glo assay
Antiproliferative activity against human OPM2 cells after 48 hrs by CellTiter-Glo assay
[PMID: 27541357]
OPM-2 IC50
2.91 μM
Compound: 2
Antiproliferative activity against human OPM2 cells after 48 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human OPM2 cells after 48 hrs by CellTiter-Glo luminescent assay
[PMID: 28953386]
OVCAR-3 GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human OVCAR3 cells after 72 hrs by MTS assay
Growth inhibition of human OVCAR3 cells after 72 hrs by MTS assay
[PMID: 22435669]
OVCAR-3 GI50
1.4 μM
Compound: SAHA
Antiproliferative activity against human OVCAR3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human OVCAR3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
OVCAR-3 GI50
2 μM
Compound: SAHA, Zolinza
Growth inhibition of human OVCAR3 cells after 72 hrs by MTS assay
Growth inhibition of human OVCAR3 cells after 72 hrs by MTS assay
[PMID: 22435669]
OVCAR-4 GI50
4 μM
Compound: SAHA, Zolinza
Growth inhibition of human OVCAR4 cells after 72 hrs by MTS assay
Growth inhibition of human OVCAR4 cells after 72 hrs by MTS assay
[PMID: 22435669]
OVCAR-5 GI50
0.79 μM
Compound: SAHA, Zolinza
Growth inhibition of human OVCAR5 cells after 72 hrs by MTS assay
Growth inhibition of human OVCAR5 cells after 72 hrs by MTS assay
[PMID: 22435669]
OVCAR-5 GI50
1.78 μM
Compound: 1, SAHA
Antiproliferative activity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay
[PMID: 24119555]
OVCAR-5 GI50
1.78 μM
Compound: SAHA
Antiproliferative activity against human OVCAR5 cells assessed as growth inhibition after 48 hrs by SRB assay
Antiproliferative activity against human OVCAR5 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 25800646]
OVCAR-8 GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human OVCAR8 cells after 72 hrs by MTS assay
Growth inhibition of human OVCAR8 cells after 72 hrs by MTS assay
[PMID: 22435669]
Osteoclast-like EC50
150 μM
Compound: SAHA
Compound was tested for anti-proliferative activity in human bone marrow cells
Compound was tested for anti-proliferative activity in human bone marrow cells
[PMID: 14698179]
PANC-1 GI50
678 nM
Compound: SAHA
Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay
Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay
[PMID: 24999749]
PANC-1 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
PANC-1 IC50
0.9 μM
Compound: Vorinostat
Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
PANC-1 IC50
2.43 μM
Compound: SAHA
Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
PANC-1 IC50
2.52 μM
Compound: SAHA
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
PANC-1 IC50
3.14 μM
Compound: SAHA
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 37116762]
PANC-1 IC50
450 nM
Compound: 5, Zolinza
Antiproliferative activity against human PANC1 cells
Antiproliferative activity against human PANC1 cells
[PMID: 17588744]
PANC-1 IC50
> 10 μM
Compound: SAHA
Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
PBL IC50
3.4 μM
Compound: Vorinostat
Cytotoxicity against human PBL cells assessed as cell growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human PBL cells assessed as cell growth inhibition after 72 hrs by MTS assay
[PMID: 30004697]
PBMC IC50
229 nM
Compound: SAHA
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha production incubated for 30 mins prior to LPS-challenge measured after overnight incubation
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha production incubated for 30 mins prior to LPS-challenge measured after overnight incubation
10.1039/C3MD00285C
PBMC IC50
955 nM
Compound: SAHA
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-stimulated IL-6 production incubated for 30 mins prior to LPS-challenge measured after overnight incubation
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-stimulated IL-6 production incubated for 30 mins prior to LPS-challenge measured after overnight incubation
10.1039/C3MD00285C
PBMC IC50
< 3.5 μM
Compound: Vorinostat
Cytotoxicity against human PBMC after 72 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human PBMC after 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 30365892]
PC-3 EC50
> 166.67 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 23820574]
PC-3 GI50
0.6 μM
Compound: 1; SAHA
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 28395150]
PC-3 GI50
0.71 μM
Compound: SAHA
Growth inhibition of human PC3 cells after 21 hrs by MTT assay
Growth inhibition of human PC3 cells after 21 hrs by MTT assay
[PMID: 17662606]
PC-3 GI50
0.73 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
[PMID: 27344487]
PC-3 GI50
0.89 μM
Compound: 1, SAHA
Growth inhibition of PC3 cells by SRB assay
Growth inhibition of PC3 cells by SRB assay
[PMID: 17477518]
PC-3 GI50
0.89 μM
Compound: 2, SAHA
Antiproliferative activity against human PC3 cells by SRB assay
Antiproliferative activity against human PC3 cells by SRB assay
[PMID: 16723227]
PC-3 GI50
0.96 μM
Compound: Vorinostat
Growth inhibition of human PC3 cells after 72 hrs by CellTiter Glo assay
Growth inhibition of human PC3 cells after 72 hrs by CellTiter Glo assay
[PMID: 25182565]
PC-3 GI50
1.02 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
[PMID: 21712146]
PC-3 GI50
1.21 μM
Compound: 1, SAHA
Growth inhibition of human PC3 cells after 48 hrs by SRB assay
Growth inhibition of human PC3 cells after 48 hrs by SRB assay
[PMID: 22439863]
PC-3 GI50
1.6 μM
Compound: SAHA, Zolinza
Growth inhibition of human PC3 cells after 72 hrs by MTS assay
Growth inhibition of human PC3 cells after 72 hrs by MTS assay
[PMID: 22435669]
PC-3 GI50
1.7 μM
Compound: Vorinostat
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay
[PMID: 37875056]
PC-3 GI50
1.77 μM
Compound: 1, SAHA
Growth inhibition of human PC3 cells after 96 hrs by MTT assay
Growth inhibition of human PC3 cells after 96 hrs by MTT assay
[PMID: 26814680]
PC-3 GI50
18.83 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 28629630]
PC-3 GI50
2 μM
Compound: SAHA, Zolinza
Growth inhibition of human PC3 cells after 72 hrs by MTS assay
Growth inhibition of human PC3 cells after 72 hrs by MTS assay
[PMID: 22435669]
PC-3 GI50
2.69 μM
Compound: 1, SAHA, Zolinza, Vorinostat
Cytotoxicity against human PC3 cells assessed as growth inhibition by SRB assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by SRB assay
[PMID: 23163332]
PC-3 GI50
2.69 μM
Compound: 2, SAHA
Growth inhibition of human PC3 cells by SRB assay
Growth inhibition of human PC3 cells by SRB assay
[PMID: 17904843]
PC-3 GI50
2.69 μM
Compound: SAHA
Growth inhibition of human PC3 cells after 5 days by sulforhodamine B assay
Growth inhibition of human PC3 cells after 5 days by sulforhodamine B assay
[PMID: 25811792]
PC-3 GI50
2.69 μM
Compound: SAHA
Growth inhibition of human PC3 cells measured after 5 days by sulforhodamine-B assay
Growth inhibition of human PC3 cells measured after 5 days by sulforhodamine-B assay
[PMID: 28011426]
PC-3 GI50
2000 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human PC3 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human PC3 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
PC-3 GI50
4.6 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
PC-3 GI50
5 μM
Compound: Vorinostat
Antiproliferative activity against human PC3 cells incubated for 72 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human PC3 cells incubated for 72 hrs by CellTiter-Glo luminescence assay
[PMID: 30802730]
PC-3 GI50
8.17 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 19822426]
PC-3 GI50
> 410 nM
Compound: Vorinostat
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
PC-3 IC50
0.21 μM
Compound: Vorinostat
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
PC-3 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
PC-3 IC50
0.85 μM
Compound: 1; SAHA
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 27541357]
PC-3 IC50
0.85 μM
Compound: 2
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 28953386]
PC-3 IC50
0.85 μM
Compound: 4
Antiproliferative activity against human PC3 cells
Antiproliferative activity against human PC3 cells
[PMID: 29945795]
PC-3 IC50
0.94 μg/mL
Compound: SAHA
Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
[PMID: 22036991]
PC-3 IC50
1 μM
Compound: 4
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 30243158]
PC-3 IC50
1.12 μM
Compound: Vorinostat
Antiproliferative activity against human PC-3 cells incubated for 72 hrs by colorimetric method
Antiproliferative activity against human PC-3 cells incubated for 72 hrs by colorimetric method
[PMID: 37875056]
PC-3 IC50
1.14 μM
Compound: SAHA
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
PC-3 IC50
1.21 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells
Antiproliferative activity against human PC3 cells
[PMID: 20451378]
PC-3 IC50
1.21 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human PC3 cells after 96 hrs by celltiter 96 assay
Antiproliferative activity against human PC3 cells after 96 hrs by celltiter 96 assay
[PMID: 21634430]
PC-3 IC50
1.33 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 21714538]
PC-3 IC50
1.34 μM
Compound: 1; SAHA
Antiproliferative activity against human PC-3 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human PC-3 cells incubated for 96 hrs by MTT assay
[PMID: 38503167]
PC-3 IC50
1.35 μM
Compound: Vorinostat
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
PC-3 IC50
1.41 μM
Compound: SAHA
Antiproliferative activity against human PC-3 cells incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human PC-3 cells incubated for 72 hrs by CCK-8 assay
[PMID: 37057760]
PC-3 IC50
1.42 μM
Compound: SAHA
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
10.1039/C4MD00203B
PC-3 IC50
1.44 μM
Compound: Vorinostat
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by colorimetric method
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by colorimetric method
[PMID: 37875056]
PC-3 IC50
1.5 μM
Compound: SAHA
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 29223096]
PC-3 IC50
1.56 μM
Compound: 1; SAHA
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
[PMID: 33077264]
PC-3 IC50
1.7 μM
Compound: SAHA; 112
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 31881454]
PC-3 IC50
1.7 μM
Compound: Vorinostat
Cytotoxicity against human PC3 cells assessed as reduction in cell viability
Cytotoxicity against human PC3 cells assessed as reduction in cell viability
[PMID: 30660827]
PC-3 IC50
1.74 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human PC3 cells by MTT assay
Cytotoxicity against human PC3 cells by MTT assay
[PMID: 24766560]
PC-3 IC50
1.81 μM
Compound: SAHA
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 96 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 96 hrs by MTT assay
[PMID: 31883490]
PC-3 IC50
1.82 μM
Compound: SAHA
Cytotoxicity against human PC3 cells by colorimetric method
Cytotoxicity against human PC3 cells by colorimetric method
[PMID: 32916298]
PC-3 IC50
1.86 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 30879863]
PC-3 IC50
1.9 μM
Compound: 2
Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
[PMID: 17691763]
PC-3 IC50
1.9 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 35152694]
PC-3 IC50
1.92 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 26100440]
PC-3 IC50
1.98 μM
Compound: SAHA, Vorinostat
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 21924799]
PC-3 IC50
10.4 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 26216016]
PC-3 IC50
13.91 μM
Compound: Vorinostat
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 28371677]
PC-3 IC50
16.28 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 28336407]
PC-3 IC50
16.28 μM
Compound: Vorinostat
Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition
Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition
[PMID: 38107170]
PC-3 IC50
1791 nM
Compound: 1; SAHA
Antiproliferative activity against human PC-3 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human PC-3 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
PC-3 IC50
2.03 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells incubated for 96 hrs by resazurin assay
Antiproliferative activity against human PC3 cells incubated for 96 hrs by resazurin assay
[PMID: 32435375]
PC-3 IC50
2.38 μM
Compound: SAHA
Cytotoxicity against human PC-3 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human PC-3 cells incubated for 72 hrs by MTT assay
[PMID: 38452727]
PC-3 IC50
2.459 μM
Compound: SAHA
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
PC-3 IC50
2.58 μM
Compound: SAHA
Cytotoxicity against human PC3 cells
Cytotoxicity against human PC3 cells
[PMID: 30245394]
PC-3 IC50
2.69 μM
Compound: 1, SAHA
Growth inhibition of human PC3 cells
Growth inhibition of human PC3 cells
[PMID: 20850971]
PC-3 IC50
2.78 μM
Compound: 1, SAHA
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26122774]
PC-3 IC50
2.9 μM
Compound: Vorinostat
Antiproliferative activity against human PC3 cells by CCK8 assay
Antiproliferative activity against human PC3 cells by CCK8 assay
[PMID: 30660827]
PC-3 IC50
2.92 μM
Compound: SAHA
Anti-proliferative activity against human PC3 cells after 48 hrs by MTT assay
Anti-proliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 28947154]
PC-3 IC50
3 μM
Compound: 2; SAHA
Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 34634618]
PC-3 IC50
3 μM
Compound: SAHA
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
PC-3 IC50
3.02 μM
Compound: XII; SAHA
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
PC-3 IC50
3.07 μM
Compound: Vor; SAHA
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter-Glo luminescent assay
[PMID: 29360358]
PC-3 IC50
3.11 μM
Compound: SAHA
Inhibition of PC3 cell proliferation (mean of two experiments)
Inhibition of PC3 cell proliferation (mean of two experiments)
[PMID: 17095213]
PC-3 IC50
3.2 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31546197]
PC-3 IC50
3.22 μM
Compound: SAHA
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 37079967]
PC-3 IC50
3.31 μM
Compound: 1; SAHA
Cytotoxicity against human PC-3 cells
Cytotoxicity against human PC-3 cells
[PMID: 33077264]
PC-3 IC50
3.46 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
[PMID: 28987602]
PC-3 IC50
3.57 μM
Compound: SA, SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 24694055]
PC-3 IC50
3.57 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 25462271]
PC-3 IC50
3.6 μM
Compound: 1; SAHA
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36242988]
PC-3 IC50
3052.4 nM
Compound: SAHA
Inhibition of Class 2a histone deacetylase in human PC3 cells using Boc-Lys (triflouroacetyl)-AMC as substrate preincubated for 3 hrs followed by substrate addition measured after 3 hrs by fluorescence assay
Inhibition of Class 2a histone deacetylase in human PC3 cells using Boc-Lys (triflouroacetyl)-AMC as substrate preincubated for 3 hrs followed by substrate addition measured after 3 hrs by fluorescence assay
[PMID: 26349626]
PC-3 IC50
4.31 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay
[PMID: 24185378]
PC-3 IC50
403 nM
Compound: Vorinostat
Antiproliferative activity against human PC-3 cells
Antiproliferative activity against human PC-3 cells
[PMID: 37875056]
PC-3 IC50
447.6 nM
Compound: SAHA
Inhibition of Class 1 histone deacetylase in human PC3 cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 3 hrs followed by substrate addition measured after 3 hrs by fluorescence assay
Inhibition of Class 1 histone deacetylase in human PC3 cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 3 hrs followed by substrate addition measured after 3 hrs by fluorescence assay
[PMID: 26349626]
PC-3 IC50
5.36 μM
Compound: SAHA
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26349626]
PC-3 IC50
5.79 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 25311567]
PC-3 IC50
6.5 μM
Compound: SAHA
Concentration required to inhibit human PC-3 prostate carcinoma cells
Concentration required to inhibit human PC-3 prostate carcinoma cells
[PMID: 16033284]
PC-3 IC50
6.5 μM
Compound: vorinostat
Cytotoxicity against human PC3 cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 20403695]
PC-3 IC50
6.7 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 29533873]
PC-3 IC50
60.8 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human PC3 cells incubated for 24 hrs by CCK8 assay
[PMID: 32247729]
PC-3 IC50
7.26 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 26907204]
PC-3 IC50
7.3 μM
Compound: SAHA
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26149591]
PC-3 IC50
873.26 nM
Compound: 1; SAHA
Antiproliferative activity against human PC3 cells measured after 48 hrs by sulforhodamine-B assay
Antiproliferative activity against human PC3 cells measured after 48 hrs by sulforhodamine-B assay
[PMID: 27886544]
PC-3 IC50
9.79 μM
Compound: 1, SAHA
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 24525003]
PC-3 IC50
9.9 μM
Compound: 1, SAHA
Inhibition of human PC3 cell proliferation after 48 hrs by MTT assay
Inhibition of human PC3 cell proliferation after 48 hrs by MTT assay
[PMID: 23493449]
PC-3 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
PC-3 IC50
> 5 μM
Compound: SAHA
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 29787262]
PC-9 IC50
1.1 μM
Compound: SAHA; 6
Antiproliferative activity against human PC-9 cells incubated for 72 hrs by celltiter-glo luminescent assay
Antiproliferative activity against human PC-9 cells incubated for 72 hrs by celltiter-glo luminescent assay
[PMID: 39178382]
PC-9 IC50
1.15 μM
Compound: SAHA
Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay
[PMID: 39145486]
PC-9 IC50
1181 nM
Compound: 1; SAHA
Antiproliferative activity against human PC-9 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human PC-9 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
PLC IC50
1.534 μM
Compound: SAHA
Cytotoxicity against human PLC cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PLC cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
PLC-PRF-5 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human PLC-PRF-5 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human PLC-PRF-5 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
PLC-PRF-5 IC50
1.87 μM
Compound: Vor; SAHA
Antiproliferative activity against human PLC-PRF-5 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human PLC-PRF-5 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
PLC-PRF-5 IC50
2.22 μM
Compound: SAHA
Antiproliferative activity against human PLC-PRF-5 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human PLC-PRF-5 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
PT-45 IC50
4000 nM
Compound: 5, Zolinza
Antiproliferative activity against human drug-resistant PT45 cells
Antiproliferative activity against human drug-resistant PT45 cells
[PMID: 17588744]
RAW264.7 IC50
0.76 μM
Compound: 1, SAHA
Inhibition of LPS-stimulated TNFalpha production in RAW264.7 cells after 24 hrs by ELISA
Inhibition of LPS-stimulated TNFalpha production in RAW264.7 cells after 24 hrs by ELISA
[PMID: 17477518]
RAW264.7 IC50
1.88 μM
Compound: 1, SAHA
Inhibition of LPS-stimulated NO production in RAW264.7 cells after 24 hrs by ELISA
Inhibition of LPS-stimulated NO production in RAW264.7 cells after 24 hrs by ELISA
[PMID: 17477518]
RAW264.7 IC50
110 nM
Compound: SAHA, WR-308364
Antimalarial activity against Plasmodium falciparum infected in mouse RAW264.7 cells
Antimalarial activity against Plasmodium falciparum infected in mouse RAW264.7 cells
[PMID: 18644969]
RPMI-8226 GI50
1.5 μM
Compound: SAHA; NSC759852
Cytotoxicity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Cytotoxicity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 36306372]
RPMI-8226 IC50
0.43 μM
Compound: SAHA
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 72 hrs by alamar blue dye based assay
[PMID: 37660484]
RPMI-8226 IC50
0.57 μM
Compound: SAHA
Antiproliferative activity against human RPMI8226 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human RPMI8226 cells incubated for 48 hrs by MTT assay
[PMID: 31413795]
RPMI-8226 IC50
0.66 μM
Compound: SAHA
Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay
Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay
[PMID: 29534936]
RPMI-8226 IC50
0.684 μM
Compound: SAHA
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
[PMID: 31865013]
RPMI-8226 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human RPMI8226 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
Antiproliferative activity against human RPMI8226 cells after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
[PMID: 26890114]
RPMI-8226 IC50
1.25 μM
Compound: SAHA
Antiproliferative activity against human RPMI8226 cells after 72 hrs by CellTiter 96 AQueous Non-Radioactive assay
Antiproliferative activity against human RPMI8226 cells after 72 hrs by CellTiter 96 AQueous Non-Radioactive assay
[PMID: 28213282]
RPMI-8226 IC50
10.6 μM
Compound: SAHA
Growth inhibition of human RPMI8226 cells after 72 hrs by MTT assay
Growth inhibition of human RPMI8226 cells after 72 hrs by MTT assay
[PMID: 30594434]
RPMI-8226 IC50
2.39 μM
Compound: SAHA
Antiproliferative activity against human RPMI8226 cells after 72 hrs by WST8 assay
Antiproliferative activity against human RPMI8226 cells after 72 hrs by WST8 assay
[PMID: 25261927]
RPMI-8226 IC50
2.39 μM
Compound: SAHA
Cytotoxicity against human RPMI8226 cells assessed as cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human RPMI8226 cells assessed as cell viability after 72 hrs by CCK8 assay
[PMID: 26211462]
RPMI-8226 IC50
2.4 μM
Compound: SAHA
Cytotoxicity against human RPMI8226 cells after 72 hrs by MTS assay
Cytotoxicity against human RPMI8226 cells after 72 hrs by MTS assay
[PMID: 25490132]
RPMI-8226 IC50
423 nM
Compound: SAHA
Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay
Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay
[PMID: 26443078]
RPMI-8226 IC50
585.8 nM
Compound: SAHA
Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay
Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay
[PMID: 31177073]
RPMI-8226 IC50
870 nM
Compound: SAHA
Antiproliferative activity against human RPMI8226 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human RPMI8226 cells incubated for 48 hrs by MTT assay
[PMID: 32267687]
RS4-11 IC50
3.98 μM
Compound: SAHA
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 34954595]
RWPE-1 GI50
1.6 μM
Compound: SAHA
Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
[PMID: 37633202]
RWPE-1 IC50
0.48 μM
Compound: 1; SAHA
Cytotoxicity against human RWPE-1 cells
Cytotoxicity against human RWPE-1 cells
[PMID: 33077264]
RWPE-1 IC50
3.64 μM
Compound: SAHA
Cytotoxicity against human RWPE1 cells
Cytotoxicity against human RWPE1 cells
[PMID: 30245394]
RXF 393 GI50
1.3 μM
Compound: SAHA
Antiproliferative activity against human RXF393 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human RXF393 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
RXF 393 GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human RXF393 cells after 72 hrs by MTS assay
Growth inhibition of human RXF393 cells after 72 hrs by MTS assay
[PMID: 22435669]
RXF 631 GI50
2 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human RXF631L cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human RXF631L cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
Raji IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human Raji cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human Raji cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
Raji IC50
0.97 nM
Compound: SAHA
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
[PMID: 28325601]
Raji IC50
0.97 μM
Compound: SAHA
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
[PMID: 29534936]
Raji IC50
1.11 μM
Compound: Vor; SAHA
Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
Raji IC50
196 nM
Compound: SAHA
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
[PMID: 30629434]
Raji IC50
2 μM
Compound: SAHA
Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
Raji IC50
3 μM
Compound: Vorinostat
Antiproliferative activity against human Raji cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human Raji cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
Raji IC50
867.4 nM
Compound: SAHA
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
Antiproliferative activity against human Raji cells after 72 hrs by MTT assay
[PMID: 31177073]
Raji IC50
9.44 μM
Compound: SAHA
Antiproliferative activity against human Raji cells after 3 days by MTT assay
Antiproliferative activity against human Raji cells after 3 days by MTT assay
[PMID: 28601509]
Ramos IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
Ramos IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human Ramos cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human Ramos cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
Ramos IC50
0.52 nM
Compound: SAHA
Antiproliferative activity against human Ramos cells after 72 hrs by MTT assay
Antiproliferative activity against human Ramos cells after 72 hrs by MTT assay
[PMID: 28325601]
Ramos IC50
0.52 μM
Compound: SAHA
Antiproliferative activity against human Ramos cells after 72 hrs by MTT assay
Antiproliferative activity against human Ramos cells after 72 hrs by MTT assay
[PMID: 29534936]
Ramos IC50
0.62 μM
Compound: Vor; SAHA
Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
Ramos IC50
3.9 μM
Compound: SAHA
Antiproliferative activity against human Ramos cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human Ramos cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
Ramos IC50
5.3 μM
Compound: SAHA
Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38048697]
Ramos IC50
514.6 nM
Compound: SAHA
Antiproliferative activity against human Ramos cells after 72 hrs by MTT assay
Antiproliferative activity against human Ramos cells after 72 hrs by MTT assay
[PMID: 31177073]
Ramos IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human Ramos cells after 72 hrs by MTT assay
Cytotoxicity against human Ramos cells after 72 hrs by MTT assay
[PMID: 26443078]
Rec1 IC50
0.35 μM
Compound: SAHA; 6
Antiproliferative activity against human REC1 cells incubated for 72 hrs by celltiter-glo luminescent assay
Antiproliferative activity against human REC1 cells incubated for 72 hrs by celltiter-glo luminescent assay
[PMID: 39178382]
S2 IC50
59 nM
Compound: 4, SAHA
Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
[PMID: 19317450]
S9 IC50
120.5 nM
Compound: 6, SAHA
Inhibition of full length human recombinant HDAC2 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence assay
Inhibition of full length human recombinant HDAC2 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence assay
[PMID: 25906087]
S9 IC50
21.5 nM
Compound: 6, SAHA
Inhibition of full length human recombinant HDAC6 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fluorescence assay
Inhibition of full length human recombinant HDAC6 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fluorescence assay
[PMID: 25906087]
S9 IC50
34.5 nM
Compound: 6, SAHA
Inhibition of full length human recombinant HDAC11 expressed in baculovirus infected insect S9 cells after 30 mins by fluorescence assay
Inhibition of full length human recombinant HDAC11 expressed in baculovirus infected insect S9 cells after 30 mins by fluorescence assay
[PMID: 25906087]
S9 IC50
5.5 nM
Compound: 6, SAHA
Inhibition of full length human recombinant HDAC8 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fluorescence assay
Inhibition of full length human recombinant HDAC8 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fluorescence assay
[PMID: 25906087]
S9 IC50
58.5 nM
Compound: 6, SAHA
Inhibition of full length human recombinant HDAC3 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence assay
Inhibition of full length human recombinant HDAC3 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Ac)-AMC as substrate after 30 mins by fluorescence assay
[PMID: 25906087]
S9 IC50
> 100 nM
Compound: 6, SAHA
Inhibition of human recombinant HDAC4 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fluorescence assay
Inhibition of human recombinant HDAC4 expressed in baculovirus infected insect S9 cells using Ac-Leu-GlyLys(Tfa)-AMC as substrate after 30 mins by fluorescence assay
[PMID: 25906087]
SAOS-2 IC50
2.3 μM
Compound: 2
Cytotoxicity against human Saos2 cells
Cytotoxicity against human Saos2 cells
[PMID: 17691763]
SCC-15 IC50
2.49 μM
Compound: SAHA
Antiproliferative activity against human SCC15 cells
Antiproliferative activity against human SCC15 cells
[PMID: 20143778]
SCC-25 IC50
1.93 μM
Compound: SAHA
Antiproliferative activity against human SCC25 cells
Antiproliferative activity against human SCC25 cells
[PMID: 20143778]
SF-268 GI50
1.6 μM
Compound: SAHA, Zolinza
Growth inhibition of human SF268 cells after 72 hrs by MTS assay
Growth inhibition of human SF268 cells after 72 hrs by MTS assay
[PMID: 22435669]
SF-295 GI50
1.6 μM
Compound: SAHA, Zolinza
Growth inhibition of human SF295 cells after 72 hrs by MTS assay
Growth inhibition of human SF295 cells after 72 hrs by MTS assay
[PMID: 22435669]
SF-539 GI50
2 μM
Compound: SAHA, Zolinza
Growth inhibition of human SF539 cells after 72 hrs by MTS assay
Growth inhibition of human SF539 cells after 72 hrs by MTS assay
[PMID: 22435669]
SF-539 GI50
2 μM
Compound: SAHA; NSC759852
Cytotoxicity against human SF-539 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Cytotoxicity against human SF-539 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 36306372]
SGC-7901 IC50
0.64 μM
Compound: 1; SAHA
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay
[PMID: 34656899]
SGC-7901 IC50
1.03 μM
Compound: SAHA
Antiproliferative activity against human SGC7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 31400938]
SGC-7901 IC50
1.4 μM
Compound: Vorinostat
Antiproliferative activity against human SGC-7901 cells
Antiproliferative activity against human SGC-7901 cells
[PMID: 37875056]
SGC-7901 IC50
135.71 μM
Compound: SAHA
Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34628244]
SGC-7901 IC50
2.12 μM
Compound: SAHA
Antiproliferative activity against human SGC-7901 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells measured after 48 hrs by MTT assay
[PMID: 35041998]
SGC-7901 IC50
2.89 μM
Compound: SAHA
Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38261411]
SGC-7901 IC50
3.3 μM
Compound: Vorinostat
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 35608269]
SGC-7901 IC50
9.73 μM
Compound: SAHA
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
SH-SY5Y EC50
17.4 μM
Compound: SAHA
Antiproliferative activity against human SH-SY5Y cells after 72 hrs by XTT assay
Antiproliferative activity against human SH-SY5Y cells after 72 hrs by XTT assay
[PMID: 21548582]
SH-SY5Y EC50
25.6 μM
Compound: SAHA
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by XTT assay
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by XTT assay
[PMID: 21548582]
SH-SY5Y EC50
> 50 μM
Compound: SAHA
Antiproliferative activity against human SH-SY5Y cells after 24 hrs by XTT assay
Antiproliferative activity against human SH-SY5Y cells after 24 hrs by XTT assay
[PMID: 21548582]
SH-SY5Y IC50
0.5 μM
Compound: SAHA
Inhibition of HDAC in human SHSY5Y cells by fluorimetric cellular activity assay
Inhibition of HDAC in human SHSY5Y cells by fluorimetric cellular activity assay
[PMID: 19344175]
SH-SY5Y IC50
0.73 μM
Compound: SAHA
Antiproliferative activity against human SH-SY5Y cells harboring ALK F1174L mutant assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
Antiproliferative activity against human SH-SY5Y cells harboring ALK F1174L mutant assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay
[PMID: 34237620]
SH-SY5Y IC50
2 μM
Compound: SAHA
Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 19344175]
SH-SY5Y IC50
3.59 μM
Compound: Vorinostat
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MUH reagent based spectrophotometric analysis
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MUH reagent based spectrophotometric analysis
[PMID: 38911150]
SH-SY5Y IC50
32.2 μM
Compound: Vorinostat
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MUH reagent based spectrophotometric analysis
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MUH reagent based spectrophotometric analysis
[PMID: 38911150]
SH-SY5Y IC50
5.43 μM
Compound: Vorinostat
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MUH reagent based spectrophotometric analysis
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MUH reagent based spectrophotometric analysis
[PMID: 38911150]
SH-SY5Y IC50
7.87 μM
Compound: SAHA
Cytotoxicity against human SH-SY5Y cells assessed as cell viability measured after 36 hrs by CCK8 assay
Cytotoxicity against human SH-SY5Y cells assessed as cell viability measured after 36 hrs by CCK8 assay
[PMID: 36645952]
SK-BR-3 EC50
2.1 μM
Compound: 1a, SAHA
Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
SK-BR-3 GI50
1.2 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
[PMID: 24015327]
SK-BR-3 IC50
0.8 μM
Compound: SAHA
Antiproliferative activity against human SKBR3 cells
Antiproliferative activity against human SKBR3 cells
[PMID: 18247554]
SK-BR-3 IC50
1.19 μM
Compound: SAHA
Antiproliferative activity against human SK-BR-3 cells after hrs by ATP content assay
Antiproliferative activity against human SK-BR-3 cells after hrs by ATP content assay
[PMID: 20143778]
SK-BR-3 IC50
2.13 μM
Compound: Vorinostat
Antiproliferation activity against human SK-BR-3 cells incubated for 72 hrs by MTT assay
Antiproliferation activity against human SK-BR-3 cells incubated for 72 hrs by MTT assay
[PMID: 33493830]
SK-BR-3 IC50
2.58 μM
Compound: 8
Antiproliferative activity against human SK-BR-3 cells expressing HER2 assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human SK-BR-3 cells expressing HER2 assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 27769671]
SK-BR-3 IC50
2.6 μM
Compound: 2
Cytotoxicity against human SKBR3 cells
Cytotoxicity against human SKBR3 cells
[PMID: 17691763]
SK-BR-3 IC50
2.6 μM
Compound: 2a
Cytotoxicity against human SKBR3 cells overexpressing HER2 by resazurin dye reduction assay
Cytotoxicity against human SKBR3 cells overexpressing HER2 by resazurin dye reduction assay
[PMID: 21080629]
SK-BR-3 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human SKBR3 cells after 72 hrs by MTT assay
Cytotoxicity against human SKBR3 cells after 72 hrs by MTT assay
[PMID: 26443078]
SK-HEP1 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human SK-HEP1 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human SK-HEP1 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
SK-HEP1 IC50
1.85 μM
Compound: Vor; SAHA
Antiproliferative activity against human SK-HEP1 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human SK-HEP1 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
SK-HEP1 IC50
3.3 μM
Compound: 2; SAHA
Anticancer activity against human SK-HEP1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Anticancer activity against human SK-HEP1 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 34634618]
SK-HEP1 IC50
3.46 μM
Compound: SAHA
Antiproliferative activity against human SKHEP1 cells after hrs by ATP content assay
Antiproliferative activity against human SKHEP1 cells after hrs by ATP content assay
[PMID: 20143778]
SK-HEP1 IC50
36.93 μM
Compound: SAHA
Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
SK-MEL-2 GI50
1.3 μM
Compound: SAHA, Zolinza
Growth inhibition of human SK-MEL-2 cells after 72 hrs by MTS assay
Growth inhibition of human SK-MEL-2 cells after 72 hrs by MTS assay
[PMID: 22435669]
SK-MEL-28 GI50
1 μM
Compound: SAHA, Zolinza
Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTS assay
Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTS assay
[PMID: 22435669]
SK-MEL-28 IC50
0.482 μM
Compound: 1; SAHA
Antiproliferative activity against human SK-MEL-28 cells after 72 hrs by resazurin dye based fluorescence assay
Antiproliferative activity against human SK-MEL-28 cells after 72 hrs by resazurin dye based fluorescence assay
[PMID: 29456804]
SK-MEL-5 GI50
0.63 μM
Compound: SAHA, Zolinza
Growth inhibition of human SK-MEL-5 cells after 72 hrs by MTS assay
Growth inhibition of human SK-MEL-5 cells after 72 hrs by MTS assay
[PMID: 22435669]
SK-MES-1 EC50
2.42 μM
Compound: SAHA
Cytotoxicity against human SKMES1 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SKMES1 cells after 72 hrs by trypan blue exclusion assay
[PMID: 19093884]
SK-MES-1 IC50
2.42 μM
Compound: SAHA
Antiproliferative activity against human SKMES1 cells after 72 hrs by MTS assay
Antiproliferative activity against human SKMES1 cells after 72 hrs by MTS assay
[PMID: 22260166]
SK-N-AS IC50
0.7 μM
Compound: Vorinostat
Antiproliferative activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
Antiproliferative activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay
[PMID: 31391882]
SK-N-BE(2) IC50
0.21 μM
Compound: Vorinostat
Antiproliferative activity against human SK-N-BE(2) cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-N-BE(2) cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
SK-N-BE(2) IC50
4.58 μM
Compound: SAHA
Antiproliferative activity against human SK-N-BE(2) cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human SK-N-BE(2) cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 37079967]
SK-OV-3 EC50
2.5 μM
Compound: SAHA
Inhibition of human SKOV3 cells
Inhibition of human SKOV3 cells
[PMID: 18247554]
SK-OV-3 EC50
2.5 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human SK-OV-3 cells
Effective Concentration of compound to inhibit the growth of human SK-OV-3 cells
[PMID: 15715470]
SK-OV-3 GI50
1 μM
Compound: SAHA, Zolinza
Growth inhibition of human SKOV3 cells after 72 hrs by MTS assay
Growth inhibition of human SKOV3 cells after 72 hrs by MTS assay
[PMID: 22435669]
SK-OV-3 GI50
2.5 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
SK-OV-3 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
SK-OV-3 IC50
1.66 mM
Compound: vorinostat, SAHA
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay
[PMID: 20171895]
SK-OV-3 IC50
1130 nM
Compound: SAHA
Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay
[PMID: 31177073]
SK-OV-3 IC50
2.2 μM
Compound: 2
Cytotoxicity against human SK-OV-3 cells
Cytotoxicity against human SK-OV-3 cells
[PMID: 17691763]
SK-OV-3 IC50
2.2 μM
Compound: 2a
Cytotoxicity against human SKOV3 cells overexpressing HER2 by resazurin dye reduction assay
Cytotoxicity against human SKOV3 cells overexpressing HER2 by resazurin dye reduction assay
[PMID: 21080629]
SK-OV-3 IC50
2.3 μM
Compound: SAHA
Cytotoxicity against human SKOV3 cells
Cytotoxicity against human SKOV3 cells
[PMID: 23906422]
SK-OV-3 IC50
> 1000 nM
Compound: SAHA
Cytotoxicity against human SKOV3 cells after 72 hrs by MTT assay
Cytotoxicity against human SKOV3 cells after 72 hrs by MTT assay
[PMID: 26443078]
SMMC-7721 IC50
1.99 μM
Compound: SAHA
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
SMMC-7721 IC50
5.2 μM
Compound: SAHA
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
[PMID: 31120744]
SMMC-7721 IC50
5.23 μM
Compound: SAHA
Antiproliferative activity against human SMMC7721 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells incubated for 48 hrs by MTT assay
[PMID: 30851694]
SMMC-7721 IC50
5.274 μM
Compound: SAHA
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
SMMC-7721 IC50
5.46 μM
Compound: 1; CTCL
Cytotoxicity against human SMMC-7721 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Cytotoxicity against human SMMC-7721 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 33143937]
SMMC-7721 IC50
5.46 μM
Compound: 1; SAHA
Cytotoxicity against human SMMC-7721 cells
Cytotoxicity against human SMMC-7721 cells
[PMID: 33077264]
SMMC-7721 IC50
5.46 μM
Compound: Vorinostat
Cytotoxicity against human SMMC-7721 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human SMMC-7721 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
SMMC-7721 IC50
5.61 μM
Compound: SAHA
Antiproliferative activity against human SMMC7721 cells after 48 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 29288941]
SMMC-7721 IC50
5.61 μM
Compound: SAHA
Antiproliferative activity against human SMMC7721 cells after 48 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 30108831]
SMMC-7721 IC50
> 10 μM
Compound: SAHA
Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
SN12C GI50
2 μM
Compound: SAHA, Zolinza
Growth inhibition of human SN12C cells after 72 hrs by MTS assay
Growth inhibition of human SN12C cells after 72 hrs by MTS assay
[PMID: 22435669]
SNB-19 GI50
0.63 μM
Compound: SAHA, Zolinza
Growth inhibition of human SNB19 cells after 72 hrs by MTS assay
Growth inhibition of human SNB19 cells after 72 hrs by MTS assay
[PMID: 22435669]
SNB-75 GI50
0.79 μM
Compound: SAHA, Zolinza
Growth inhibition of human SNB75 cells after 72 hrs by MTS assay
Growth inhibition of human SNB75 cells after 72 hrs by MTS assay
[PMID: 22435669]
SNB-75 GI50
0.8 μM
Compound: SAHA
Antiproliferative activity against human SNB75 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human SNB75 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
SNB-78 EC50
16 μM
Compound: SAHA
Inhibition of human SNB78 cells
Inhibition of human SNB78 cells
[PMID: 18247554]
SNB-78 EC50
16 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human SNB-78 cells
Effective Concentration of compound to inhibit the growth of human SNB-78 cells
[PMID: 15715470]
SNB-78 GI50
16 μM
Compound: 2, (SAHA, vorinostat)
Growth inhibition of human SNB78 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SNB78 cells after 48 hrs by sulforhodamine B assay
[PMID: 19419205]
SNU-16 IC50
0.29 μM
Compound: 3; SAHA
Antiproliferative activity against human SNU-16 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human SNU-16 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36449947]
SNU-387 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human SNU-387 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human SNU-387 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
SNU-387 IC50
2.45 μM
Compound: Vor; SAHA
Antiproliferative activity against human SNU-387 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human SNU-387 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
SNU-398 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human SNU-398 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human SNU-398 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
SNU-398 IC50
1.39 μM
Compound: Vor; SAHA
Antiproliferative activity against human SNU-398 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human SNU-398 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
SNU-423 IC50
0.079 μM
Compound: SAHA
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 34509167]
SQ20B IC50
3 μM
Compound: SAHA
Inhibition of human SQ20B cells
Inhibition of human SQ20B cells
[PMID: 18247554]
SR GI50
0.4 μM
Compound: SAHA
Antiproliferative activity against human SR cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human SR cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
SR GI50
0.4 μM
Compound: SAHA, Zolinza
Growth inhibition of human SR cells after 72 hrs by MTS assay
Growth inhibition of human SR cells after 72 hrs by MTS assay
[PMID: 22435669]
SU-DHL-6 IC50
0.43 μM
Compound: Vorinostat
Cytotoxicity against human SU-DHL-6 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human SU-DHL-6 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
SU-DHL-6 IC50
0.58 μM
Compound: Vor; SAHA
Antiproliferative activity against human SU-DHL-6 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
Antiproliferative activity against human SU-DHL-6 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay/CellTiter Glo-luminescent assay
[PMID: 29360358]
SU-DHL10 IC50
0.47 μM
Compound: 1; SAHA
Antiproliferative activity against human SU-DHL-10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human SU-DHL-10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36153841]
SU.86.86 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human SU.86.86 cells after 72 hrs by MTT assay
Antiproliferative activity against human SU.86.86 cells after 72 hrs by MTT assay
[PMID: 18642892]
SU.86.86 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human SU-8686 cells by MTT assay
Antiproliferative activity against human SU-8686 cells by MTT assay
[PMID: 19419863]
SU.86.86 IC50
1.3 μM
Compound: 1a, SAHA
Growth inhibition of human SU-8686 cells after 72 hrs by MTS assay
Growth inhibition of human SU-8686 cells after 72 hrs by MTS assay
[PMID: 20055418]
SU.86.86 IC50
1.3 μM
Compound: SAHA
Cytotoxicity against human SU 86.86 cells after 72 hrs by MTT assay
Cytotoxicity against human SU 86.86 cells after 72 hrs by MTT assay
[PMID: 18494463]
SUM-159-PT IC50
1.381 μM
Compound: SAHA
Cytotoxicity against human SUM159PT cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SUM159PT cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
SUM-159-PT IC50
3 μM
Compound: SAHA
Cytotoxicity against human SUM159PT cells harboring wild type BRCA1 and wild type BRCA2 assessed as reduction in cell viability
Cytotoxicity against human SUM159PT cells harboring wild type BRCA1 and wild type BRCA2 assessed as reduction in cell viability
[PMID: 36053318]
SW-620 GI50
0.54 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human SW620 cells after 48 hrs by SRB assay
Cytotoxicity against human SW620 cells after 48 hrs by SRB assay
[PMID: 24015327]
SW-620 GI50
0.63 μM
Compound: SAHA, Zolinza
Growth inhibition of human SW620 cells after 72 hrs by MTS assay
Growth inhibition of human SW620 cells after 72 hrs by MTS assay
[PMID: 22435669]
SW-620 GI50
0.63 μM
Compound: SAHA, Zolinza
Growth inhibition of human SW620 cells after 72 hrs by MTS assay
Growth inhibition of human SW620 cells after 72 hrs by MTS assay
[PMID: 22435669]
SW-620 IC50
0.5 μg/mL
Compound: SAHA
Cytotoxicity against human SW620 cells
Cytotoxicity against human SW620 cells
[PMID: 22036991]
SW-620 IC50
0.6 μM
Compound: SAHA
Inhibition of human SW620 cells
Inhibition of human SW620 cells
[PMID: 18247554]
SW-620 IC50
1.12 μM
Compound: SAHA
Cytotoxicity against human SW620 cells by colorimetric method
Cytotoxicity against human SW620 cells by colorimetric method
[PMID: 32916298]
SW-620 IC50
1.12 μM
Compound: Vorinostat
Antiproliferative activity against human SW620 cells incubated for 72 hrs by colorimetric method
Antiproliferative activity against human SW620 cells incubated for 72 hrs by colorimetric method
[PMID: 37875056]
SW-620 IC50
1.44 μM
Compound: Vorinostat
Antiproliferative activity against human SW620 cells incubated for 48 hrs by colorimetric method
Antiproliferative activity against human SW620 cells incubated for 48 hrs by colorimetric method
[PMID: 37875056]
SW-620 IC50
1.7 μM
Compound: SAHA; 112
Antiproliferative activity against human SW620 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human SW620 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 31881454]
SW-620 IC50
1.7 μM
Compound: Vorinostat
Cytotoxicity against human SW620 cells assessed as reduction in cell viability
Cytotoxicity against human SW620 cells assessed as reduction in cell viability
[PMID: 30660827]
SW-620 IC50
2.8 μM
Compound: Vorinostat
Cytotoxicity against human SW620 cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human SW620 cells assessed as inhibition of cell growth by MTT assay
[PMID: 32791404]
SW-620 IC50
3.2 μM
Compound: SAHA
Antiproliferative activity against human SW620 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31546197]
SW-620 IC50
3.7 μM
Compound: SAHA, Vorinostat, Zolinza
Antiproliferative activity against human SW620 cells after 48 hrs by SRB assay
Antiproliferative activity against human SW620 cells after 48 hrs by SRB assay
[PMID: 24185378]
SW-620 IC50
3.87 μM
Compound: SAHA
Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay
[PMID: 28987602]
SW-620 IC50
4.31 μM
Compound: Vorinostat
Cytotoxicity against human SW620 cells assessed as inhibition of cell growth by SRB assay
Cytotoxicity against human SW620 cells assessed as inhibition of cell growth by SRB assay
[PMID: 32791404]
SW-620 IC50
4.32 μM
Compound: SAHA
Antiproliferative activity against human SW620 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26555243]
SW-620 IC50
403 nM
Compound: Vorinostat
Antiproliferative activity against human SW620 cells
Antiproliferative activity against human SW620 cells
[PMID: 37875056]
SW-620 IC50
6.94 μM
Compound: SAHA
Antiproliferative activity against human SW620 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
[PMID: 32153186]
SW1990 IC50
3.8 μM
Compound: 5; SAHA
Antiproliferative activity against human SW1990 cells after 96 hrs by MTT assay
Antiproliferative activity against human SW1990 cells after 96 hrs by MTT assay
[PMID: 31117517]
SW1990 IC50
5.72 μM
Compound: SAHA
Antiproliferative activity against human SW1990 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human SW1990 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36097406]
SW480 IC50
1.89 μM
Compound: SAHA
Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
SW480 IC50
2.12 μM
Compound: SAHA
Antiproliferative activity against human SW480 cells measured after 72 hrs
Antiproliferative activity against human SW480 cells measured after 72 hrs
[PMID: 35697181]
SW480 IC50
3.97 μM
Compound: SAHA
Antiproliferative activity against human SW480 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 26555243]
Sf21 IC50
0.037 μM
Compound: 2a
Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domain
Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domain
[PMID: 21080629]
Sf21 IC50
0.26 μM
Compound: SAHA
Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
[PMID: 26890116]
Sf21 IC50
0.306 μM
Compound: 1; SAHA
Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells preincubated with enzyme followed by fluorogenic Arg-His-Lys-Lys(Ac)-AMC substrate addition measured after 2 hrs by fluorescence assay
Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells preincubated with enzyme followed by fluorogenic Arg-His-Lys-Lys(Ac)-AMC substrate addition measured after 2 hrs by fluorescence assay
[PMID: 27541357]
Sf21 IC50
1.2 μM
Compound: 2a
Inhibition of Flag tagged human recombinant HDAC8 expressed in Sf21 cells
Inhibition of Flag tagged human recombinant HDAC8 expressed in Sf21 cells
[PMID: 21080629]
Sf21 IC50
1.6 μM
Compound: SAHA
Inhibition of recombinant human N-terminal GST-tagged/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf21 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
Inhibition of recombinant human N-terminal GST-tagged/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf21 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
[PMID: 30245394]
Sf9 IC50
0.0058 μM
Compound: 1; SAHA
Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 5 hrs by electrophoretic mobility shift assay
Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 5 hrs by electrophoretic mobility shift assay
[PMID: 31938464]
Sf9 IC50
0.00657 μM
Compound: 1; SAHA
Inhibition of recombinant full length human HDAC3 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 3 hrs by electrophoretic mobility shift assay
Inhibition of recombinant full length human HDAC3 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 3 hrs by electrophoretic mobility shift assay
[PMID: 31938464]
Sf9 IC50
0.0097 μM
Compound: Vorinostat
Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-acetyl)-AMC as substrate incubated for 90 mins by fluorescence assay
Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-acetyl)-AMC as substrate incubated for 90 mins by fluorescence assay
[PMID: 31762274]
Sf9 IC50
0.02 μM
Compound: 1; SAHA
Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed by fluorogenic Arg-His-Lys-Lys(Ac)-AMC substrate addition measured after 2 hrs by fluorescence assay
Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed by fluorogenic Arg-His-Lys-Lys(Ac)-AMC substrate addition measured after 2 hrs by fluorescence assay
[PMID: 27541357]
Sf9 IC50
0.029 μM
Compound: SAHA
Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
[PMID: 26890116]
Sf9 IC50
0.032 μM
Compound: SAHA
Inhibition of recombinant full length human HDAC6 expressed in Baculovirus infected insect Sf9 cells incubated for 30 mins measured by fluorescence assay
Inhibition of recombinant full length human HDAC6 expressed in Baculovirus infected insect Sf9 cells incubated for 30 mins measured by fluorescence assay
10.1039/C4MD00203B
Sf9 IC50
0.038 μM
Compound: Vorinostat
Inhibition of recombinant human full length C-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
Inhibition of recombinant human full length C-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
[PMID: 31420257]
Sf9 IC50
0.051 μM
Compound: SAHA
Inhibition of recombinant full length human HDAC1 (1 to 482 amino acids) expressed in Baculovirus infected insect Sf9 cells incubated for 30 mins measured by fluorescence assay
Inhibition of recombinant full length human HDAC1 (1 to 482 amino acids) expressed in Baculovirus infected insect Sf9 cells incubated for 30 mins measured by fluorescence assay
10.1039/C4MD00203B
Sf9 IC50
0.081 μM
Compound: SAHA
Inhibition of C-terminal GST-tagged human recombinant HDAC2 expressed in Sf9 cells after 30 mins by microtiter plate reader analysis
Inhibition of C-terminal GST-tagged human recombinant HDAC2 expressed in Sf9 cells after 30 mins by microtiter plate reader analysis
[PMID: 26907204]
Sf9 IC50
0.089 μM
Compound: Vorinostat
Inhibition of recombinant human full length C-terminal Flag/His-tagged HDAC1 expressed in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
Inhibition of recombinant human full length C-terminal Flag/His-tagged HDAC1 expressed in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
[PMID: 31420257]
Sf9 IC50
0.102 μM
Compound: Vorinostat
Inhibition of human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells ZMAL as substrate incubated for 90 mins by fluorescence assay
Inhibition of human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells ZMAL as substrate incubated for 90 mins by fluorescence assay
[PMID: 31762274]
Sf9 IC50
0.105 μM
Compound: Vorinostat
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 residues) in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 residues) in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
[PMID: 31420257]
Sf9 IC50
0.111 μM
Compound: Vorinostat
Inhibition of recombinant human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate incubated for 90 mins by fluorescence assay
Inhibition of recombinant human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate incubated for 90 mins by fluorescence assay
[PMID: 31762274]
Sf9 IC50
0.146 μM
Compound: Vorinostat
Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-acetyl)-AMC as substrate incubated for 90 mins by fluorescence assay
Inhibition of recombinant human full length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-acetyl)-AMC as substrate incubated for 90 mins by fluorescence assay
[PMID: 31762274]
Sf9 IC50
0.183 μM
Compound: Vorinostat
Inhibition of recombinant human full length C-terminal Flag-tagged HDAC2 expressed in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
Inhibition of recombinant human full length C-terminal Flag-tagged HDAC2 expressed in baculovirus infected Sf9 cells using ZMAL as substrate incubated for 90 mins by fluorometric method
[PMID: 31420257]
Sf9 IC50
0.23 μM
Compound: SAHA
Inhibition of recombinant full length human HDAC8 expressed in Baculovirus infected insect Sf9 cells preincubated for 30 mins followed by substrate addition measured after 15 to 45 mins by luminescence assay
Inhibition of recombinant full length human HDAC8 expressed in Baculovirus infected insect Sf9 cells preincubated for 30 mins followed by substrate addition measured after 15 to 45 mins by luminescence assay
10.1039/C4MD00203B
Sf9 IC50
0.497 μM
Compound: 1; SAHA
Inhibition of recombinant full length human HDAC8 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
Inhibition of recombinant full length human HDAC8 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
[PMID: 31938464]
Sf9 IC50
0.78 μM
Compound: SAHA
Inhibition of recombinant full-length human C-terminal HDAC8 expressed in baculovirus infected Sf9 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
Inhibition of recombinant full-length human C-terminal HDAC8 expressed in baculovirus infected Sf9 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
[PMID: 30245394]
Sf9 IC50
0.8 μM
Compound: SAHA
Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
[PMID: 30245394]
Sf9 IC50
101 nM
Compound: Vorinostat
Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay
Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay
[PMID: 31391882]
Sf9 IC50
102 nM
Compound: Zolinza
Inhibition of full length recombinant GST-tagged N-terminal human HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL (Z-Lys(Ac)-AMC) as substrate incubated for 90 mins by fluorescence based assay
Inhibition of full length recombinant GST-tagged N-terminal human HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL (Z-Lys(Ac)-AMC) as substrate incubated for 90 mins by fluorescence based assay
[PMID: 31531206]
Sf9 IC50
11 nM
Compound: SAHA
Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as release of AMC preincubated for 15 mins followed by substrate addition measured after 1 hr by fluorescence assay
Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as release of AMC preincubated for 15 mins followed by substrate addition measured after 1 hr by fluorescence assay
[PMID: 27186676]
Sf9 IC50
13 nM
Compound: SAHA
Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells preincubated for 5 mins followed by biotinylated H3K9-Ac substrate addition and measured after 60 mins by HTRF assay
Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells preincubated for 5 mins followed by biotinylated H3K9-Ac substrate addition and measured after 60 mins by HTRF assay
[PMID: 30594434]
Sf9 IC50
144.7 nM
Compound: SAHA; Vor
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 residues) in baculovirus infected Sf9 cells using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs by fluorescence based micro plate reader analysis
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 residues) in baculovirus infected Sf9 cells using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs by fluorescence based micro plate reader analysis
[PMID: 32321249]
Sf9 IC50
170 nM
Compound: SAHA
Inhibition of recombinant full length N-terminal FLAG-tagged human HDAC10 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence assay
Inhibition of recombinant full length N-terminal FLAG-tagged human HDAC10 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence assay
[PMID: 30629434]
Sf9 IC50
174 nM
Compound: SAHA
Inhibition of recombinant C-terminal His-tagged full length human HDAC2 expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
Inhibition of recombinant C-terminal His-tagged full length human HDAC2 expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
[PMID: 25815139]
Sf9 IC50
19 nM
Compound: SAHA
Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay
Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay
[PMID: 31505452]
Sf9 IC50
208 nM
Compound: SAHA
Inhibition of recombinant N-terminal FLAG-tagged human HDAC10 (2 to 631 residues) expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant N-terminal FLAG-tagged human HDAC10 (2 to 631 residues) expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
23 nM
Compound: SAHA
Inhibition of recombinant N-terminal GST-tagged full length human HDAC6 expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
Inhibition of recombinant N-terminal GST-tagged full length human HDAC6 expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
[PMID: 25815139]
Sf9 IC50
23 nM
Compound: SAHA
Inhibition of recombinant full length human HDAC1 (1 to 482) expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
Inhibition of recombinant full length human HDAC1 (1 to 482) expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
[PMID: 25815139]
Sf9 IC50
29 nM
Compound: SAHA
Inhibition of recombinant full length human HDAC2 expressed in sf9 insect cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant full length human HDAC2 expressed in sf9 insect cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
3.7 μM
Compound: SAHA
Inhibition of C-terminal His-tagged human recombinant HDAC8 expressed in Sf9 cells after 30 mins by microtiter plate reader analysis
Inhibition of C-terminal His-tagged human recombinant HDAC8 expressed in Sf9 cells after 30 mins by microtiter plate reader analysis
[PMID: 26907204]
Sf9 IC50
32 nM
Compound: 5; SAHA
Inhibition of recombinant C-terminal His/FLAG-tagged HDAC1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr
Inhibition of recombinant C-terminal His/FLAG-tagged HDAC1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr
[PMID: 31117517]
Sf9 IC50
328 nM
Compound: SAHA
Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 240 mins by fluorescence based assay
Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 240 mins by fluorescence based assay
[PMID: 31505452]
Sf9 IC50
33 nM
Compound: SAHA
Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
34.3 nM
Compound: Vorinostat
Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay
Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay
[PMID: 31391882]
Sf9 IC50
35 nM
Compound: SAHA
Inhibition of full length recombinant human C-terminal FLAG-tagged HDAC1 expressed in sf9 cells preincubated for 5 mins followed by biotinylated H3K9-Ac substrate addition and measured after 60 mins by HTRF assay
Inhibition of full length recombinant human C-terminal FLAG-tagged HDAC1 expressed in sf9 cells preincubated for 5 mins followed by biotinylated H3K9-Ac substrate addition and measured after 60 mins by HTRF assay
[PMID: 30594434]
Sf9 IC50
370 nM
Compound: SAHA
Inhibition of His-tagged human HDAC11 expressed in Sf9 cells using Ac-Arg-Gly-Lys(Ac)-AMC as substrate by fluorometric assay
Inhibition of His-tagged human HDAC11 expressed in Sf9 cells using Ac-Arg-Gly-Lys(Ac)-AMC as substrate by fluorometric assay
[PMID: 27055940]
Sf9 IC50
47 nM
Compound: Zolinza
Inhibition of full length recombinant FLAG/His-tagged C-terminal human HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL (Z-Lys(Ac)-AMC) as substrate incubated for 90 mins by fluorescence based assay
Inhibition of full length recombinant FLAG/His-tagged C-terminal human HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL (Z-Lys(Ac)-AMC) as substrate incubated for 90 mins by fluorescence based assay
[PMID: 31531206]
Sf9 IC50
49 nM
Compound: SAHA
Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay
Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay
[PMID: 31505452]
Sf9 IC50
51 nM
Compound: SAHA
Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay
Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay
[PMID: 31505452]
Sf9 IC50
56 nM
Compound: SAHA
Inhibition of recombinant C-terminal His-tagged full length human HDAC3/NcoR2 complex expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
Inhibition of recombinant C-terminal His-tagged full length human HDAC3/NcoR2 complex expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC substrate 3 after 30 mins by fluorescence assay
[PMID: 25815139]
Sf9 IC50
682 nM
Compound: SAHA
Inhibition of recombinant full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected in Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected in Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
8.7 μM
Compound: SAHA
Inhibition of recombinant full-length human HDAC11 expressed in baculovirus infected Sf9 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
Inhibition of recombinant full-length human HDAC11 expressed in baculovirus infected Sf9 insect cells using 7-AMC-labelled HDAC substrate measured after 30 mins by fluorescence assay
[PMID: 30245394]
Sf9 IC50
8.8 nM
Compound: SAHA
Inhibition of recombinant C-terminal His-tagged full length human HDAC8 expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC class 2a substrate after 30 mins by fluorescence assay
Inhibition of recombinant C-terminal His-tagged full length human HDAC8 expressed in baculovirus infected insect Sf9 cells using fluorogenic HDAC class 2a substrate after 30 mins by fluorescence assay
[PMID: 25815139]
Sf9 IC50
> 1 μM
Compound: 1; SAHA
Inhibition of recombinant full length human HDAC11 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 17 hrs by electrophoretic mobility shift assay
Inhibition of recombinant full length human HDAC11 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 17 hrs by electrophoretic mobility shift assay
[PMID: 31938464]
Sf9 IC50
> 1000 nM
Compound: SAHA
Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence assay
Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence assay
[PMID: 30629434]
Sf9 IC50
> 10000 nM
Compound: SAHA
Inhibition of recombinant C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
> 10000 nM
Compound: SAHA
Inhibition of recombinant N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
> 10000 nM
Compound: SAHA
Inhibition of recombinant full length N-terminal GST-tagged human HDAC5 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant full length N-terminal GST-tagged human HDAC5 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
> 10000 nM
Compound: SAHA
Inhibition of recombinant full length human HDAC11 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant full length human HDAC11 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
Sf9 IC50
> 10000 nM
Compound: SAHA
Inhibition of recombinant full length human HDAC4 expressed in sf9 insect cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
Inhibition of recombinant full length human HDAC4 expressed in sf9 insect cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assay
[PMID: 31177073]
SiHa IC50
4.34 μM
Compound: XII; SAHA
Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth by MTT assay
[PMID: 38776806]
St-4 EC50
5.2 μM
Compound: SAHA
Inhibition of human St4 cells
Inhibition of human St4 cells
[PMID: 18247554]
St-4 EC50
5.2 μM
Compound: Suberoylanilide hydroxamic acid (SAHA)
Effective Concentration of compound to inhibit the growth of human St-4 cells
Effective Concentration of compound to inhibit the growth of human St-4 cells
[PMID: 15715470]
T-24 EC50
0.12 μM
Compound: SAHA, Zolinza
Induction of histone H3 acetylation in human T24 cells after 3 hrs by ELISA
Induction of histone H3 acetylation in human T24 cells after 3 hrs by ELISA
[PMID: 19084395]
T-24 EC50
0.25 μM
Compound: SAHA, Zolinza
Induction of alpha tubulin acetylation in human T24 cells after 3 hrs by ELISA
Induction of alpha tubulin acetylation in human T24 cells after 3 hrs by ELISA
[PMID: 19084395]
T-24 IC50
2.4 μM
Compound: SAHA
Antiproliferative activity against human T24 cells after 72 hrs by CellTiter blue-reagent based assay
Antiproliferative activity against human T24 cells after 72 hrs by CellTiter blue-reagent based assay
[PMID: 30645113]
T-cell EC50
0.6 μM
Compound: SAHA, Vorinostat
Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis
Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis
[PMID: 24495105]
T47D GI50
0.5 μM
Compound: SAHA
Antiproliferative activity against human T47D cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human T47D cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
T47D GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human T47D cells after 72 hrs by MTS assay
Growth inhibition of human T47D cells after 72 hrs by MTS assay
[PMID: 22435669]
T47D IC50
1.25 μM
Compound: SAHA
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
[PMID: 28601509]
T47D IC50
1.5 μM
Compound: 4; SAHA
Antiproliferative activity against human T47D cells
Antiproliferative activity against human T47D cells
[PMID: 37652098]
T47D IC50
2.243 μM
Compound: SAHA
Cytotoxicity against human T47D cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human T47D cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32823005]
T47D IC50
3.01 μM
Compound: Vorinostat
Cytotoxicity against human T47D cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
Cytotoxicity against human T47D cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
[PMID: 29518312]
T47D IC50
3.21 μM
Compound: SAHA
Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
TAMH IC50
7.86 μM
Compound: 1; SAHA
Antiproliferative activity against mouse TAMH cells after 24 hrs by CellTiter-Glo assay
Antiproliferative activity against mouse TAMH cells after 24 hrs by CellTiter-Glo assay
[PMID: 27541357]
TAMH IC50
7.86 μM
Compound: 2
Cytotoxicity against TAMH cells assessed as cell viability after 24 hrs by CellTiter-Glo assay
Cytotoxicity against TAMH cells assessed as cell viability after 24 hrs by CellTiter-Glo assay
[PMID: 28953386]
TE-1 IC50
2.25 μM
Compound: SAHA
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth by MTT assay
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth by MTT assay
[PMID: 39102466]
THP-1 GI50
15.4 μM
Compound: 1
Growth inhibition of human THP-1 cells
Growth inhibition of human THP-1 cells
[PMID: 37429084]
THP-1 GI50
15.5 μM
Compound: SAHA
Growth inhibition of human THP-1 cells
Growth inhibition of human THP-1 cells
[PMID: 32320239]
THP-1 IC50
0.18 μM
Compound: Vorinostat
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37979441]
THP-1 IC50
0.5 μg/mL
Compound: SAHA
Antileishmanial activity against amastigote stage of Leishmania donovani infected in human THP1 cells after 48 hrs by Alamar blue assay
Antileishmanial activity against amastigote stage of Leishmania donovani infected in human THP1 cells after 48 hrs by Alamar blue assay
[PMID: 25240614]
THP-1 IC50
0.62 μM
Compound: SAHA
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
THP-1 IC50
1.03 μM
Compound: SAHA
Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay
[PMID: 39145486]
THP-1 IC50
1.1 μM
Compound: SAHA
Cytotoxicity against human THP1 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human THP1 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 28368585]
THP-1 IC50
18 μM
Compound: SAHA, Vorinostat
Cytotoxicity against human THP1 cells assessed as reduction in cell viability
Cytotoxicity against human THP1 cells assessed as reduction in cell viability
[PMID: 26264503]
THP-1 IC50
2.9 μM
Compound: SAHA
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo assay
[PMID: 37086699]
THP-1 IC50
3.9 μM
Compound: SAHA
Antiproliferative activity against human THP-1 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human THP-1 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
THP-1 IC50
9.5 μM
Compound: 5; SAHA
Antiproliferative activity against human THP1 cells after 96 hrs by MTT assay
Antiproliferative activity against human THP1 cells after 96 hrs by MTT assay
[PMID: 31117517]
THP-1 IC50
> 10 μg/mL
Compound: SAHA
Cytotoxicity against human THP1 cells after 48 hrs by Alamar blue assay
Cytotoxicity against human THP1 cells after 48 hrs by Alamar blue assay
[PMID: 25240614]
TK-10 GI50
0.63 μM
Compound: SAHA, Zolinza
Growth inhibition of human TK10 cells after 72 hrs by MTS assay
Growth inhibition of human TK10 cells after 72 hrs by MTS assay
[PMID: 22435669]
TPC1 IC50
3 μM
Compound: Vorinostat
Antiproliferative activity against human TPC1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human TPC1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37875056]
TSGH IC50
2.09 μM
Compound: 1, SAHA, Vorinostat
Cytotoxicity against human TSGH cells by MTT assay
Cytotoxicity against human TSGH cells by MTT assay
[PMID: 24766560]
U-251 GI50
1.53 μM
Compound: Zolinza, NSC 701852
Cytotoxicity against human U251 cells after 48 hrs by SRB assay
Cytotoxicity against human U251 cells after 48 hrs by SRB assay
[PMID: 24015327]
U-251 GI50
1.6 μM
Compound: SAHA
Antiproliferative activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
Antiproliferative activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
[PMID: 32212730]
U-251 GI50
1.6 μM
Compound: SAHA, Zolinza
Growth inhibition of human U251 cells after 72 hrs by MTS assay
Growth inhibition of human U251 cells after 72 hrs by MTS assay
[PMID: 22435669]
U-251 GI50
2 μM
Compound: SAHA
Cytotoxicity against human U251 cells by MTT assay
Cytotoxicity against human U251 cells by MTT assay
[PMID: 23538115]
U-251 GI50
6.5 μM
Compound: SAHA
Cytotoxicity against human U251 cells after 48 hrs by MTT assay
Cytotoxicity against human U251 cells after 48 hrs by MTT assay
[PMID: 20605448]
U-251 IC50
1 μM
Compound: Vorinostat
Cytotoxicity against human U251 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human U251 cells assessed as reduction in cell viability by SRB assay
[PMID: 30660827]
U-251 IC50
17.87 μM
Compound: 1; SAHA
Cytotoxicity against human TMZ-sensitive U251 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human TMZ-sensitive U251 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 35005974]
U-251 IC50
2.58 μM
Compound: SAHA
Cytotoxicity against human U-251 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human U-251 cells incubated for 72 hrs by MTT assay
[PMID: 38452727]
U-251 IC50
8.94 μM
Compound: SAHA
Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37399711]
U-266 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
U-266 IC50
0.59 μM
Compound: SAHA
Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
[PMID: 31865013]
U-266 IC50
0.88 μM
Compound: SAHA
Antiproliferative activity against human U266 cells after 48 hrs by MTT assay
Antiproliferative activity against human U266 cells after 48 hrs by MTT assay
[PMID: 28757101]
U-266 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
U-266 IC50
1.09 μM
Compound: SAHA
Antiproliferative activity against human U266 cells after 48 hrs by MTT assay
Antiproliferative activity against human U266 cells after 48 hrs by MTT assay
[PMID: 25462271]
U-266 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human U-266 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human U-266 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
U-266 IC50
1.35 μM
Compound: SAHA
Cytotoxicity against human U266 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human U266 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26349626]
U-266 IC50
3070 nM
Compound: SAHA
Antiproliferative activity against human U266 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human U266 cells incubated for 48 hrs by MTT assay
[PMID: 32267687]
U-266 IC50
42.6 μM
Compound: SAHA
Growth inhibition of human U266 cells after 72 hrs by MTT assay
Growth inhibition of human U266 cells after 72 hrs by MTT assay
[PMID: 30594434]
U-266 IC50
581 nM
Compound: SAHA
Cytotoxicity against human U266 cells after 72 hrs by MTT assay
Cytotoxicity against human U266 cells after 72 hrs by MTT assay
[PMID: 26443078]
U-87MG ATCC IC50
1.949 μM
Compound: SAHA
Antiproliferative activity against human U-87 MG cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human U-87 MG cells incubated for 48 hrs by MTT assay
[PMID: 37563016]
U-87MG ATCC IC50
10 μM
Compound: 5; SAHA
Antiproliferative activity against human U87 cells after 96 hrs by MTT assay
Antiproliferative activity against human U87 cells after 96 hrs by MTT assay
[PMID: 31117517]
U-87MG ATCC IC50
11 μM
Compound: 2
Cytotoxicity against human U87MG cells
Cytotoxicity against human U87MG cells
[PMID: 17691763]
U-87MG ATCC IC50
15.71 μM
Compound: 1; SAHA
Antiproliferation activity against human U-87 MG cells assessed as growth inhibition measured after 1 hr by MTT assay
Antiproliferation activity against human U-87 MG cells assessed as growth inhibition measured after 1 hr by MTT assay
[PMID: 33744690]
U-87MG ATCC IC50
15.71 μM
Compound: I; SAHA
Cytotoxicity against human U-87 MG cells assessed as inhibition of cell growth by MTT assay
Cytotoxicity against human U-87 MG cells assessed as inhibition of cell growth by MTT assay
[PMID: 36630883]
U-87MG ATCC IC50
4.19 μM
Compound: Vorinostat
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 37875056]
U-87MG ATCC IC50
52 μM
Compound: SAHA
Antiproliferative activity against human U-87 MG cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human U-87 MG cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
U-937 CC50
0.78 μM
Compound: Vorinostat
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 29541372]
U-937 CC50
1050 nM
Compound: 1
Antiproliferative activity against human U937 cells after 72 hrs by celltiter-blue cell viability assay
Antiproliferative activity against human U937 cells after 72 hrs by celltiter-blue cell viability assay
[PMID: 19441846]
U-937 EC50
0.82 μM
Compound: 1a, SAHA
Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
U-937 EC50
0.88 μM
Compound: SAHA
Growth inhibition of human U937 cells after 44 hrs by MTT assay
Growth inhibition of human U937 cells after 44 hrs by MTT assay
[PMID: 28337317]
U-937 EC50
0.88 μM
Compound: SAHA
Cytotoxicity against human U937 cells assessed as decrease in cell viability after 44 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as decrease in cell viability after 44 hrs by MTT assay
[PMID: 29150330]
U-937 EC50
33 μM
Compound: SAHA
Compound was tested for anti-proliferative activity in U-937 human leukemia cell line
Compound was tested for anti-proliferative activity in U-937 human leukemia cell line
[PMID: 14698179]
U-937 GI50
1.42 μM
Compound: vorinostat, SAHA
Antiproliferative activity against human U937 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Antiproliferative activity against human U937 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
[PMID: 25218912]
U-937 GI50
1460 nM
Compound: SAHA
Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
[PMID: 26331334]
U-937 GI50
390 nM
Compound: SAHA
Growth inhibition of human U937 cells after 72 hrs by SRB assay
Growth inhibition of human U937 cells after 72 hrs by SRB assay
[PMID: 20884208]
U-937 GI50
450 nM
Compound: SAHA, vorinostat
Antiproliferative activity against human U937 cells after 72 hrs by WST-1 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-1 assay
[PMID: 21080647]
U-937 IC50
0.19 μM
Compound: Vorinostat
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
U-937 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
U-937 IC50
0.37 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
[PMID: 26100440]
U-937 IC50
0.52 μM
Compound: 1; SAHA
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo luminescent assay
[PMID: 38456618]
U-937 IC50
0.54 μM
Compound: SAHA
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
[PMID: 28419930]
U-937 IC50
0.54 μM
Compound: SAHA
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
[PMID: 28601509]
U-937 IC50
0.72 μM
Compound: SAHA
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
[PMID: 29954683]
U-937 IC50
0.73 μM
Compound: 1; SAHA
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days in presence of atamparib by celltiter-glo luminescent assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 3 days in presence of atamparib by celltiter-glo luminescent assay
[PMID: 38456618]
U-937 IC50
0.88 μM
Compound: Vorinostat
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37875056]
U-937 IC50
0.97 μM
Compound: SAHA
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
[PMID: 25462271]
U-937 IC50
1 μM
Compound: SAHA
Antiproliferative activity against human U-937 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37660833]
U-937 IC50
1.235 μM
Compound: SAHA
Antiproliferative activity against human U-937 cells assessed as cell growth inhibition after 72 hrs by CCK8 assay
Antiproliferative activity against human U-937 cells assessed as cell growth inhibition after 72 hrs by CCK8 assay
[PMID: 34454126]
U-937 IC50
1.24 μM
Compound: Vorinostat
Antiproliferative activity against human U-937 cells measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human U-937 cells measured after 72 hrs by CCK-8 assay
[PMID: 37875056]
U-937 IC50
1.41 μM
Compound: Vorinostat
Antiproliferative activity against human U-937 cells by MTT assay
Antiproliferative activity against human U-937 cells by MTT assay
[PMID: 37875056]
U-937 IC50
1.45 μM
Compound: SA, SAHA
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
[PMID: 24694055]
U-937 IC50
1.53 μM
Compound: SAHA
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
[PMID: 29500131]
U-937 IC50
1.53 μM
Compound: SAHA
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
[PMID: 30879863]
U-937 IC50
1.58 μM
Compound: SAHA
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 36996717]
U-937 IC50
1.64 μM
Compound: SAHA
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
Antiproliferative activity against human U937 cells after 48 hrs by MTT assay
[PMID: 28757101]
U-937 IC50
100 μM
Compound: SAHA, Vorinostat
Cytotoxicity against human U937 cells assessed as reduction in cell viability
Cytotoxicity against human U937 cells assessed as reduction in cell viability
[PMID: 26264503]
U-937 IC50
2.3 μM
Compound: 1, SAHA
Inhibition of human U937 cell proliferation after 48 hrs by MTT assay
Inhibition of human U937 cell proliferation after 48 hrs by MTT assay
[PMID: 23493449]
U-937 IC50
2.83 μM
Compound: SAHA, Zolinza
Antiproliferative activity against human U937 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
Antiproliferative activity against human U937 cells assessed as inhibition of cell growth after 72 hrs by MTT-based assay
[PMID: 25874326]
U-937 IC50
2.83 μM
Compound: Vorinostat
Antiproliferative activity against human U937 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human U937 cells incubated for 72 hrs by MTT assay
[PMID: 25953722]
U-937 IC50
3.35 μM
Compound: SAHA
Cytotoxicity against human U937 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26349626]
U-937 IC50
4.33 μM
Compound: SAHA
Cytotoxicity against human U937 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
10.1039/C4MD00203B
U-937 IC50
4.82 μM
Compound: 1, SAHA
Cytotoxicity against human U937 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay
[PMID: 26122774]
U-937 IC50
5.49 μM
Compound: 6, SAHA
Cytotoxicity against human U937 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 25906087]
U-937 IC50
907.5 nM
Compound: SAHA
Antiproliferative activity against p53 null human U937 cells after 72 hrs by MTT assay
Antiproliferative activity against p53 null human U937 cells after 72 hrs by MTT assay
[PMID: 27505848]
U2932 IC50
1.1 μM
Compound: SAHA
Antiproliferative activity against human U2932 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human U2932 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
U2932 IC50
2.7 μM
Compound: SAHA
Antiproliferative activity against human U2932 cells after 72 hrs by MTT assay
Antiproliferative activity against human U2932 cells after 72 hrs by MTT assay
[PMID: 29150335]
U2OS IC50
2.23 μM
Compound: SAHA
Anticancer activity against human U2OS cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
Anticancer activity against human U2OS cells assessed as cell growth inhibition incubated for 3 days by methylene blue staining based colorimetric assay
[PMID: 36244186]
U2OS IC50
5.7 μM
Compound: Vorinostat
Cytotoxicity against human U2OS cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human U2OS cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
[PMID: 32791404]
UACC-257 GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human UACC257 cells after 72 hrs by MTS assay
Growth inhibition of human UACC257 cells after 72 hrs by MTS assay
[PMID: 22435669]
UACC-62 GI50
0.4 μM
Compound: SAHA, Zolinza
Growth inhibition of human UACC62 cells after 72 hrs by MTS assay
Growth inhibition of human UACC62 cells after 72 hrs by MTS assay
[PMID: 22435669]
UO-31 GI50
0.5 μM
Compound: SAHA, Zolinza
Growth inhibition of human UO31 cells after 72 hrs by MTS assay
Growth inhibition of human UO31 cells after 72 hrs by MTS assay
[PMID: 22435669]
Vero EC50
5.2 μM
Compound: SAHA
Cytotoxicity against african green monkey Vero cells cells assessed as cell proliferation after 70 hrs by MTS assay
Cytotoxicity against african green monkey Vero cells cells assessed as cell proliferation after 70 hrs by MTS assay
[PMID: 25974739]
Vero IC50
0.9 μM
Compound: SAHA, vorinostat
Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23786452]
Vero IC50
1.03 μM
Compound: SAHA
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 28057407]
Vero IC50
1.375 μg/mL
Compound: SAHA
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS assay
[PMID: 20669972]
Vero IC50
1.45 μM
Compound: 1; SAHA
Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
[PMID: 33077264]
Vero IC50
1.45 μM
Compound: SAHA
Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
[PMID: 30245394]
Vero IC50
1200 ng/mL
Compound: SAHA
Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
[PMID: 19914074]
Vero IC50
2.85 μM
Compound: SAHA
Antiproliferative activity against green monkey Vero cells assessed as inhibition of cell growth incubated for 3 to 5 days by CCK-8 assay
Antiproliferative activity against green monkey Vero cells assessed as inhibition of cell growth incubated for 3 to 5 days by CCK-8 assay
[PMID: 38367494]
Vero IC50
261.6 ng/mL
Compound: SAHA
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
[PMID: 19914074]
Vero IC50
4.1 μM
Compound: SAHA
Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay
[PMID: 25993269]
Vero IC50
4.1 μM
Compound: SAHA
Antiproliferative activity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33965842]
Vero IC50
4.465 μM
Compound: SAHA
Cytotoxicity against African Green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTS assay
Cytotoxicity against African Green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTS assay
[PMID: 32061484]
Vero IC50
478.9 ng/mL
Compound: SAHA
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
[PMID: 19914074]
WI-38 GI50
6080 nM
Compound: SAHA
Antiproliferative activity against human WI38 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human WI38 cells after 72 hrs by CCK8 assay
[PMID: 26331334]
WI-38 IC50
10.07 μM
Compound: 1; SAHA
Cytotoxicity against human WI-38 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36242988]
WI-38 IC50
49.87 μM
Compound: SAHA
Cytotoxicity against human WI-38 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34628244]
WI-38 IC50
> 30 μM
Compound: SAHA; NSC759852
Cytotoxicity against human WI-38 cells assessed as reduction in cell survival incubated for 30 mins by methylene blue staining based analysis
Cytotoxicity against human WI-38 cells assessed as reduction in cell survival incubated for 30 mins by methylene blue staining based analysis
[PMID: 36306372]
YAC-1 IC50
0.199 μM
Compound: Vorinostat
Antiproliferative activity against mouse YAC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against mouse YAC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37875056]
Z-138 IC50
0.7 μM
Compound: SAHA
Antiproliferative activity against human Z138 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
Antiproliferative activity against human Z138 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
[PMID: 34772529]
ZR-75-1 IC50
1629 nM
Compound: 1; SAHA
Antiproliferative activity against human ZR-75-1 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human ZR-75-1 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 36934335]
ZR-75-1 IC50
6.86 μM
Compound: SAHA; 6
Antiproliferative activity against human ZR-75-1 cells incubated for 72 hrs by celltiter-glo luminescent assay
Antiproliferative activity against human ZR-75-1 cells incubated for 72 hrs by celltiter-glo luminescent assay
[PMID: 39178382]
Clinical Trial
Molecular Weight

264.32

Formula

C14H20N2O3

CAS No.
SMILES

O=C(NC1=CC=CC=C1)CCCCCCC(NO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Vorinostat (GMP)
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