2. Academic Validation
  3. Research status of indole-modified natural products

Research status of indole-modified natural products

  • RSC Med Chem. 2023 Oct 17;14(12):2535-2563. doi: 10.1039/d3md00560g.
Song-Fang Duan 1,  Lei Song 2,  Hong-Yan Guo 1,  Hao Deng 1,  Xing Huang 1,  Qing-Kun Shen 1,  Zhe-Shan Quan 1,  Xiu-Mei Yin 1
Affiliations

Affiliations

  • 1 Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Interdisciplinary Program of Biological Functional Molecules, College of Integration Science, Yanbian University Yanji 133002 China zsquan@ybu.edu.cn yinxm@ybu.edu.cn +86 0433 243 6020 +86 0433 243 6019.
  • 2 Yanbian University Hospital, Yanbian University Yanji 133002 People's Republic of China.
PMID: 38107170 DOI: 10.1039/d3md00560g
Abstract

Indole is a heterocyclic compound formed by the fusion of a benzene ring and pyrrole ring, which has rich biological activity. Many indole-containing compounds have been sold on the market due to their excellent pharmacological activity. For example, vincristine and reserpine have been widely used in clinical practice. The diverse structures and biological activities of natural products provide abundant resources for the development of new drugs. Therefore, this review classifies natural products by structure, and summarizes the research progress of indole-containing natural product derivatives, their biological activities, structure-activity relationship and research mechanism which has been studied in the past 13 years, so as to provide a basis for the development of new drug development.

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