2. Academic Validation
  3. Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)

Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)

  • Bioorg Med Chem Lett. 2002 Oct 21;12(20):2919-23. doi: 10.1016/s0960-894x(02)00622-4.
Michael L Curtin 1,  Robert B Garland,  H Robin Heyman,  Robin R Frey,  Michael R Michaelides,  Junling Li,  Lori J Pease,  Keith B Glaser,  Patrick A Marcotte,  Steven K Davidsen
Affiliations

Affiliation

  • 1 Cancer Research Area, Abbott Laboratories, Dept. 47J, Bldg. AP10, 100 Abbott Park Road, Abbott Park, IL 60064, USA. mike.curtin@abbott.com
PMID: 12270175 DOI: 10.1016/s0960-894x(02)00622-4
Abstract

A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent.

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