2. Apoptosis
  3. TNF Receptor
  4. Frexalimab

Frexalimab  (Synonyms: SAR441344; INX-021)

Cat. No.: HY-P99625 Purity: 99.00%
SDS
COA
Technical Support

Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the CD40 ligand (CD40L) with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sj gren’s syndrome and type I diabetes research.

For research use only. We do not sell to patients.

CAS No. : 2515463-86-0

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Based on 1 publication(s) in Google Scholar

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Frexalimab Related Antibodies

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  • Biological Activity

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  • Customer Review

Description

Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the CD40 ligand (CD40L) with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sj gren’s syndrome and type I diabetes research[1][2][3][4][5].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric
In Vitro

Frexalimab is a second-generation anti-CD40L humanized IgG1 monoclonal antibody that has been Fc-engineered. The Fc engineering abrogates the platelet activation that is triggered by FcγRIIa stimulation by immune complexes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Frexalimab Related Antibodies
Clinical Trial
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.698 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Frexalimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human CD40 Ligand/TNFSF5 Protein (His Tag) can bind Frexalimab. The EC50 for this effect is 2.43 ng/mL.
  • Loaded Frexalimab on AHC2 biosensor, can bind CD40L/CD154/TRAP Protein, Human (HEK293, Tag free, HY-P70609) with an affinity constant of 4.117E-10 M as determined in BLI assay.
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (232 KB) SDS-PAGE (120 KB) SEC-HPLC (197 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Frexalimab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Frexalimab2515463-86-0SAR441344 INX-021SAR 441344SAR-441344INX021INX 021INX-021TNF ReceptorTumor Necrosis Factor ReceptorTNFRsecond-generationmonoclonal antibodyCD40 ligand (CD40L)immune responsemultiple sclerosislupus erythematosusSj gren’s syndrometype 1 diabetesInhibitorinhibitorinhibit

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