RelB Antibody (YA5890)

RelB Antibody (YA5890) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RelB. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

RelB is a pleiotropic transcription factor belonging to the Rel-like domain protein family, forming NF-kappa-B heterodimers (e.g., RelB-p50 and RelB-p52) that function as transcriptional activators by binding to kappa-B sites in target gene DNA, regulating processes like inflammation, immunity, and cell differentiation. RelB does not directly associate with DNA, RELA/p65, or REL but stimulates promoter activity in the presence of NFKB2/p49. As part of the NUPR1/RELB/IER3 survival pathway, RelB may confer remarkable resistance to cell stress (e.g., starvation or gemcitabine treatment) in pancreatic ductal adenocarcinoma. Additionally, RelB represses the transcriptional activity of the CLOCK-BMAL1 heterodimer independently of CRY1/CRY2, with enhanced repression observed with NFKB2/p52. RelB is essential for the maturation and function of T and B lymphocytes.

Q01201

Predicted band size: 62 kDa; Observed band size: 62 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:200-1:1000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG