2. Others Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Stem Cell/Wnt JAK/STAT Signaling Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Epigenetics
  3. Reference Standards Apoptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) STAT CDK Bcl-2 Family Aryl Hydrocarbon Receptor JAK Caspase IFNAR PD-1/PD-L1
  4. Icariside I (Standard)

Icariside I (Standard)  (Synonyms: Icarisid I (Standard))

Cat. No.: HY-N1939R
Handling Instructions Technical Support

Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape.

For research use only. We do not sell to patients.

Icariside I (Standard)

Icariside I (Standard) Chemical Structure

CAS No. : 56725-99-6

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5 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
10 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
25 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
50 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
100 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
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Information

Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

530.52

Formula

C27H30O11
CAS No.
SMILES

O=C1C(O)=C(C2=CC=C(OC)C=C2)OC3=C(C/C=C(C)\C)C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Icariside I (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icariside I (Standard)56725-99-6Icarisid I (Standard)Reference StandardsApoptosisReactive Oxygen Species (ROS)NOD-like Receptor (NLR)STATCDKBcl-2 FamilyAryl Hydrocarbon ReceptorJAKCaspaseIFNARPD-1/PD-L1Cyclin dependent kinaseAhRJanus kinaseInterferon-α/β receptorInterferon-alpha/beta receptor PD-1/Programmed death-ligand 1BMDMsBMMsIDILI4T1-luc cellsOVXosteoporosis mouseInhibitorinhibitorinhibit

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