2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. 5-Iodo-A-85380 dihydrochloride

5-Iodo-A-85380 dihydrochloride  (Synonyms: 5-I A-85380 dihydrochloride)

Cat. No.: HY-107686 Purity: 98.97%
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Handling Instructions Technical Support

5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with Kds of 12 and 14 pM,respectively.

For research use only. We do not sell to patients.

5-Iodo-A-85380 dihydrochloride Chemical Structure

5-Iodo-A-85380 dihydrochloride Chemical Structure

CAS No. : 1217837-17-6

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5-Iodo-A-85380 dihydrochloride Related Antibodies

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Description

5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with Kds of 12 and 14 pM,respectively[1].

Molecular Weight

363.02

Formula

C9H13Cl2IN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

IC1=CC(OC[C@@H]2CCN2)=CN=C1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (137.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7547 mL 13.7733 mL 27.5467 mL
5 mM 0.5509 mL 2.7547 mL 5.5093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7547 mL 13.7733 mL 27.5467 mL 68.8667 mL
5 mM 0.5509 mL 2.7547 mL 5.5093 mL 13.7733 mL
10 mM 0.2755 mL 1.3773 mL 2.7547 mL 6.8867 mL
15 mM 0.1836 mL 0.9182 mL 1.8364 mL 4.5911 mL
20 mM 0.1377 mL 0.6887 mL 1.3773 mL 3.4433 mL
25 mM 0.1102 mL 0.5509 mL 1.1019 mL 2.7547 mL
30 mM 0.0918 mL 0.4591 mL 0.9182 mL 2.2956 mL
40 mM 0.0689 mL 0.3443 mL 0.6887 mL 1.7217 mL
50 mM 0.0551 mL 0.2755 mL 0.5509 mL 1.3773 mL
60 mM 0.0459 mL 0.2296 mL 0.4591 mL 1.1478 mL
80 mM 0.0344 mL 0.1722 mL 0.3443 mL 0.8608 mL
100 mM 0.0275 mL 0.1377 mL 0.2755 mL 0.6887 mL
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5-Iodo-A-85380 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Iodo-A-853801217837-17-65-I A-85380nAChRNicotinic acetylcholine receptorsnAChRs Ligandα4β2 nAChRsInhibitorinhibitorinhibit

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