2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK 3i

JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for  autoimmune disease research.

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JAK 3i

JAK 3i Chemical Structure

CAS No. : 1918238-72-8

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Based on 1 publication(s) in Google Scholar

JAK 3i Related Antibodies

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Description

JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for  autoimmune disease research[1].

IC50 & Target[1]

JAK3

0.43 nM (IC50)

JAK2

8680 nM (IC50)

JAK1

1520 nM (IC50)

Molecular Weight

354.34

Formula

C18H15FN4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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JAK 3i Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK 3i1918238-72-8JAKJanus kinaseJAK3Immune diseaseT-cell proliferationpSTAT5stat5Inhibitorinhibitorinhibit

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