Cytokeratin 17 Antibody (YA5595)

Cytokeratin 17 Antibody (YA5595) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 17. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.

Cytokeratin 17 is a type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining the shape and orientation of hair (By similarity). It is essential for the correct growth of hair follicles, particularly for maintaining the anagen (growth) phase (By similarity). In the context of hair cycling, it modulates TNF-alpha function and regulates protein synthesis and epithelial cell growth by binding to the adapter protein SFN and stimulating the Akt/mTOR pathway (By similarity). Additionally, it participates in tissue repair and may serve as a marker of basal cell differentiation in complex epithelia, indicating a certain type of epithelial 'stem cells.' Cytokeratin 17 promotes epithelial proliferation by regulating immune responses in the skin, fostering a Th1/Th17-dominated immune environment that contributes to basaloid skin tumor development (By similarity). It may also act as an autoantigen in the immunopathogenesis of psoriasis, with specific peptide regions being primary targets for autoreactive T-cells, triggering their proliferation.

Q04695

Predicted band size: 48 kDa; Observed band size: 48 kDa

Protein G

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

IHC: 1:200-1000; WB: 1:500-2000; ICC/IF: 1:100-500; ELISA: 1:1000-5000

IHC-P, WB, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Synthesized peptide derived from human Cytokeratin 17 AA range: 300-432