2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt JAK/STAT Signaling Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Bcr-Abl ERK STAT PARP Caspase Apoptosis
  4. VS1150

VS1150 (Compound 11) is a BCR-ABL-targeting phosphorylation-inducing chimeric small molecule (PHICS). VS1150 significantly inhibits oncogenic kinase BCR-ABL signaling by inducing inhibitory phosphorylation at its Y253 (EC50: 69 nM), subsequently triggering cell apoptosis. VS1150 also inhibits other oncogenic ABL fusions and drug-resistant mutants like T315I. VS1150 can be used for chronic myeloid leukemia (CML) and other ABL fusion-driven cancers research.

For research use only. We do not sell to patients.

VS1150 Chemical Structure

VS1150 Chemical Structure

CAS No. : 2855238-97-8

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VS1150 Related Antibodies

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Abl Bcr-Abl

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ERK ERK1 ERK2 ERK5 ERK8

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STAT3 STAT5 STAT6 STAT1

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

VS1150 (Compound 11) is a BCR-ABL-targeting phosphorylation-inducing chimeric small molecule (PHICS). VS1150 significantly inhibits oncogenic kinase BCR-ABL signaling by inducing inhibitory phosphorylation at its Y253 (EC50: 69 nM), subsequently triggering cell apoptosis. VS1150 also inhibits other oncogenic ABL fusions and drug-resistant mutants like T315I. VS1150 can be used for chronic myeloid leukemia (CML) and other ABL fusion-driven cancers research[1].

IC50 & Target

Bcr-Abl

69 nM (EC50)

STAT5

 

Caspase 8

 

Molecular Weight

844.58

Formula

C36H38Cl4N12O4
CAS No.
SMILES

O=C(C1=CN=C(NCCOCCOCCNC2=NC=C(C(NC3=NN(C4=CC=C(Cl)C(Cl)=C4)CC3)=O)C(C)=N2)N=C1C)NC5=NN(C6=CC=C(Cl)C(Cl)=C6)CC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VS1150 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VS11502855238-97-8VS 1150VS-1150Bcr-AblERKSTATPARPCaspaseApoptosisExtracellular signal regulated kinasespoly ADP ribose polymerase Phosphorylation-inducing chimeric small moleculePHICSBCR-ABLCMLK562 cellsInhibitorinhibitorinhibit

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