ACE Antibody (YA5212)

ACE Antibody (YA5212) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ACE.

ACE (angiotensin-converting enzyme) is a dipeptidyl carboxypeptidase that regulates blood pressure, electrolyte homeostasis, and synaptic plasticity by cleaving C-terminal dipeptides from circulating hormones like angiotensin I, bradykinin, and enkephalins. Comprising two catalytic domains with distinct substrate selectivity (PubMed:10913258, PubMed:1320019), it converts angiotensin I to vasoconstrictive angiotensin II (PubMed:11432860, PubMed:1851160) while inactivating vasodilatory bradykinin (PubMed:15615692, PubMed:2558109). ACE also modulates synaptic transmission via neuropeptide (e.g., substance P, neurotensin) cleavage (PubMed:15615692, PubMed:6208535) and prevents amyloid plaque formation by degrading Amyloid-beta peptides (PubMed:11604391, PubMed:16154999). A testis-specific isoform (with a single catalytic domain) is essential for male fertility (PubMed:1651327, PubMed:1668266) and may mediate sperm-egg binding through putative GPIase activity (by similarity).

P12821

Observed band size: 190 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Mouse

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human Angiotensin Converting Enzyme 1 protein fragments expressed in E.coli.